Researchers found that radiation therapy after lumpectomy and tamoxifen treatment significantly reduced the risk of cancer recurrence and new tumors in older women with early breast cancer. The study's findings support providing high-quality care to all patients, regardless of age.
Researchers found graded associations between psychosocial factors and inflammatory markers, with cynical distrust strongly linked to increased inflammation. The study suggests that behaviors such as smoking may mediate the link between psychosocial factors and cardiovascular disease risk.
US physicians tend to start treatment sooner and are more aggressive in controlling blood pressure, with 63% of patients having their blood pressure under control. However, vast room for improvement exists, with less than two-thirds of patients reaching guideline-set goals.
A study of 5,008 adults found that daily use of selective serotonin reuptake inhibitors (SSRIs) is associated with a doubled risk of certain fractures. The use of SSRIs was also linked to an increased risk of falls and decreased bone mineral density.
Researchers have found that motor protein myosin X travels along the actin filament of a neuron's backbone, delivering the DCC receptor to its periphery where it interacts with netrin-1. This process enables axons to grow in the right direction and form synapses.
Researchers found that some dogs are responding to seizures caused by psychological conditions, rather than epilepsy. People with psychogenic seizures need psychiatric evaluation and treatment, not specialized training for epileptic seizures.
Researchers at VBI have identified a potential target for inhibiting excessive glucose production in type 2 diabetics by modulating the activity of key enzyme phosphoenolpyruvate carboxykinase. This approach could lead to the development of novel therapeutics to slow down but not eliminate glucose overproduction.
A study found that rapid influenza testing led to decreased antibiotic use among hospitalized adults, with a 14% reduction in antibiotic discontinuation compared to those without positive test results. The findings suggest that prompt diagnosis and targeted therapy can help minimize unnecessary antibiotic use.
The study reveals that PTEN-deficient intestinal stem cells can lead to changes increasing the number of stem cells and altering their position, resulting in crypt fission and budding. This process can initiate intestinal polyposis and uncontrolled tumor growth.
A study found that providing regular acupressure treatment sessions twice a day for five days a week significantly reduced verbal and physical attacks, wandering, and agitation levels in dementia patients. The benefits were seen after four weeks of treatment, but agitation levels rose again once the treatment ended.
A study found that selenium supplements increased blood selenium levels and suppressed HIV viral load in patients with HIV. The results suggest that selenium may be a safe and inexpensive adjunct therapy to conventional pharmacotherapy.
Researchers have adapted bacteria in the human gut to produce human growth factors that repair colon cells, reducing inflammation in IBD. The treatment uses a plant sugar called xylan, found in tree bark, to control the release of the medicine.
Researchers found maternal cells in children with type 1 diabetes that produce insulin and may aid in pancreas repair. The study indicates that microchimerism, the transfer of mother's cells to child during pregnancy, might have therapeutic benefits.
Researchers at Duke University Medical Center discovered that brain region activation predicts altruistic behavior, suggesting that the ability to perceive meaningful interactions is critical for altruism.
Researchers found that blocking TGF-beta activity with losartan restores normal muscle structure and function in genetically engineered mice with Marfan syndrome and Duchenne muscular dystrophy. The treatment improved strength, reduced fatigue, and restored muscle architecture.
Marine scientists discovered that baby fish can find their way back to their home coral reef by using their sense of smell, braving strong currents and predators. This unique ability has major implications for how reefs are managed and drives evolution on the Reef.
Researchers have identified a set of genes controlled by Foxp3 that lie at the core of autoimmune disease. The discovery provides an initial map of regulatory T cell circuitry and may help develop new methods for manipulating immune system activity.
Researchers developed Interferometric Synthetic Aperture Microscopy, a novel technique that produces crisp three-dimensional images from out-of-focus data. This method can perform high-speed, micron-scale imaging without time-consuming processing or sectioning of tissue.
Scientists at Oxford University have identified a surprising way to switch off a gene involved in cell division using a previously unknown type of RNA. This discovery could lead to new anti-cancer treatments by inhibiting the production of an enzyme that controls thymine production.
A new study published in the European Heart Journal has found that high-level endurance athletes with ventricular arrhythmias often have dysfunctional right ventricles. The research suggests that endurance exercise may contribute to changes in the heart that lead to dysfunction and heart rhythm disturbances.
Researchers at Mayo Clinic Cancer Center found that giving patients both radiation and chemotherapy after completely removing invasive pancreatic cancer significantly improves patient survival rates. More than half of the 454 patients who received adjuvant therapy survived two years, with a five-year survival rate of 28%.
Glenn Micalizio, Yale Assistant Professor, has been awarded the Eli Lilly Grantee Award for his research on simplifying organic chemistry. His work focuses on developing new methods for forming carbon–carbon bonds to facilitate drug discovery.
Researchers at NIST created nanodot arrays with uniform response to magnetic fields, reducing variation by 5% and identifying key design cause. This breakthrough enhances prospects for commercially viable nanodot drives with increased storage capacity.
Researchers at NIST developed a copper bullet with unique markings to aid in tracing guns used in multiple crimes. The Standard Bullet enables crime labs to optimize their computerized optical imaging instruments, improving the quality of gun trace analysis.
Researchers at Rush University Medical Center found significant differences between antihypertensive drugs and their risk of new-onset diabetes. ACE-inhibitors and ARBs prevent diabetes, while diuretics and beta-blockers increase the risk. The study analyzed 22 long-term randomized clinical trials and included 143,153 patients.
Researchers developed a new screening process using chemiluminescent light and toluidine blue dye to improve diagnosis accuracy for early-stage oral cancer. The study found that this approach can reduce unnecessary biopsies and false negatives, leading to better patient outcomes.
Researchers at the Hollings Marine Laboratory have uncovered a subtle chemical pathway by which Pfiesteria piscicida can produce a lethal toxin. The discovery resolves a long-standing mystery surrounding occasional mass fish kills on the East Coast.
The National Institute of Standards and Technology has developed a new set of Standard Reference Materials to improve workplace safety by accurately measuring respirable quartz dust. These materials cover the range between 5 micrograms and 1000 micrograms of quartz per filter, typical of the field's range.
MIT researchers have developed a new method to produce strong and stretchy nanocomposite materials, similar to spider silk. These materials can be used to strengthen packaging materials and develop tear-resistant fabrics or biomedical devices.
Researchers at University of Texas M. D. Anderson Cancer Center found that aspirin significantly improves survival rates among cancer patients with low platelet counts who experience heart attacks, even when taking anticoagulants. Aspirin also showed benefits for patients with normal platelet counts.
A study presented at a symposium found that 80% of advanced head and neck cancer patients responded well to chemotherapy and radiation, eliminating detectable disease in the neck. Of these, 85% maintained long-term remission without needing further invasive surgery.
A large international study involving 83 sites will test 3,000 patients to evaluate the impact of exercise training on death and hospitalization in heart failure patients. The trial, called HF-ACTION, is the largest randomized clinical trial of exercise training ever performed.
A recent Pittsburgh ear study has found no significant impact of fluid in the middle ear on developmental outcomes in children up to age 11. The study, which tracked over 6,300 children, suggests that most children with fluid can wait without intervention.
Researchers at NIST found that optimal work surface heights of 26 inches for image quality and 36 inches for speed can improve fingerprint capture. Participants preferred using their right hands, which reduced processing time.
A six-month study found that teens who completed a comprehensive intervention program significantly reduced their substance abuse and depression, and increased their social stability. The program offered 12 individual therapy sessions and four HIV education/skills practice sessions, adapted for teens living on the streets.
A novel form of trypanosomiasis has been identified in India, resulting from a deficiency in apolipoprotein L-1. Analysis revealed that the patient's serum lacked the protein's trypanolytic activity, which normally destroys parasites.
The New Horizons spacecraft is on course to swing past Jupiter, accelerating its speed and testing its systems ahead of its Pluto encounter. The mission will collect valuable science data on Jupiter's atmosphere, magnetic field, and moons.
Researchers in Morocco found that combining cypress with lavender or mycorrhizal fungi increases survival rates and growth of young saplings. This approach also reduces soil erosion and improves tree development.
Researchers at NIST have developed a miniaturized technique for separating minute samples of proteins, amino acids, and other chemical mixtures. The new 'gradient elution moving boundary electrophoresis' (GEMBE) method works by opposing the movement of mixture components with a stream of buffering solution flowing at a variable rate.
A new study by Harvard researchers estimates that US polio vaccination has saved over $180 billion in medical costs, preventing approximately 1.1 million cases of paralytic polio and 160,000 deaths between 1955 and 2005.
A new model language has been developed to guide clinical researchers in properly disclosing their financial interests in research, providing guidance on risks and benefits to participants. The language includes specific wording for various types of financial interests, aiming to minimize potential risks to research subjects.
The Sistema Interamericano de Metrologia (SIM) network enables faster time comparisons between countries, allowing small nations to evaluate their measurements against world standards. National metrology institutes in member OAS nations participate in the network, which currently compares times between Brazil, Canada, Mexico, and the US.
A new class of aluminum-hydrogen compounds has been synthesized with potential applications in solid rocket fuel and the hydrogen economy. The compounds' relative stability may enable more efficient propulsion systems and cleaner energy production.
Researchers have identified a new class of lipids in tears and oleamide, a previously unknown lipid, shedding light on the complex design of tears. The discovery may help scientists better understand eye-related disorders like dry eye disease, which affects millions Americans.
Scientists at Brookhaven National Laboratory have successfully generated extremely short light pulses using a new technique that could be used in the next generation of light source facilities. The team observed superradiance, a phenomenon where light intensity grows as it interacts with an electron beam.
Researchers developed a simple and non-invasive gene probe to diagnose early stage lung cancer in current and former smokers. The test identified 76% of stage I lung cancer patients whose tumors also showed the same genetic loss, outperforming existing sputum cytology tests.
Researchers at USC are exploring a novel way to manipulate the body's natural defense system to produce antibodies that can neutralize HIV. By targeting hematopoietic stem cells and using an HIV-based lentiviral vector, they aim to create 'designer immune cells' that can combat the virus.
A new study found that breast cancer patients with lower household income and less education are more likely to receive reduced doses of chemotherapy. Severely obese women were four times as likely to receive a reduced dose, while those with less than a high school education were three times as likely.
A Johns Hopkins study finds that individuals entering drug treatment programs are more likely to be female, unemployed, and HIV-positive, with a history of mental illness. This highlights the need for strong linkages between needle exchange programs and treatment services to address co-occurring health problems.
A new study finds that nitrogen release from decaying plant material follows a predictable pattern worldwide, driven by initial nitrogen concentration. This discovery improves understanding of nutrient dynamics, vegetation growth, and carbon sequestration, essential for predicting climate change impacts.
A team of researchers at UC Riverside has successfully designed a molecule that can move in a straight line and carry tiny shopping bags with up to two CO2 molecules. The new molecule carrier runs on a copper surface and requires precise energy control, making it an essential step towards molecular-scale machinery.
A new study published in The Lancet found that folic acid supplementation can improve memory and information processing speed in older adults. Researchers randomly assigned participants to receive either 800 micrograms of folic acid daily or a placebo for 3 years, with significant improvements observed in those receiving the supplement.
Researchers investigated how specific body characteristics affect the elderly's ability to regulate temperature during cold stress. The study found that certain traits, such as percent body fat and skeletal muscle mass, become more important with age, suggesting changes in the body's thermoregulatory responses.
The LSU School of Social Work is offering group interventions to reduce long-term consequences of post-hurricane trauma in elementary school-aged children. The program aims to help caregivers cope with their children's emotions and reactions to the disaster.
A comprehensive immunization strategy has reduced global measles mortality by 60% over the past six years, saving nearly 7.5 million lives. The strategy's four components have been instrumental in achieving this goal, particularly in high-burden countries.
Researchers have identified a neural bottleneck in the brain that prevents simultaneous processing of multiple tasks, such as driving and talking on a cell phone. The lateral frontal and prefrontal cortex regions were found to be responsible for this limitation, which causes a delay in neural activity when performing two demanding tasks.
Researchers at Rice University have developed a novel way to deliver drugs directly into cancer cells using buckyball nanoparticles as passkeys. The technique, which mimics viral proteins, shows promise in penetrating the defenses of liver and neuroblastoma cancer cells, two types often difficult to treat.
Researchers found that replacing SH2B1 only in the brain of mice lacking it prevents obesity and diabetes. The study implicates SH2B1 as a potential target for treating obesity and type II diabetes.
Most fertility clinics fail to adhere to advertising guidelines, leading to potential misinformation for patients. Private clinics were more likely to publish success rates and use comparative marketing, but often failed to provide accurate information.
A recent study by researchers at Rice University has identified a key role for the protein Ras in promoting nerve cell growth and tumorigenesis in individuals with neurofibromatosis. The study found that defects in the Nf1 gene disrupt the normal regulatory mechanism, leading to an overactive signaling pathway.