Researchers identified a key role for dendritic cells in responding to Leishmania parasites, which cause illness in developing nations and have been detected in US soldiers. The study provides insights into the early stages of the immune response and has implications for vaccine development.
Researchers used a new technique to measure the precise size of WASP-10b, a planet thought to have an unusually large diameter. The team's use of the OPTIC camera resulted in a finding that the planet is one of the densest known, rather than bloated.
Employees with high levels of job autonomy are more likely to blur the lines between work and family life, according to new research. The study found that having greater control over schedules is associated with more frequent work-family role blurring, particularly among men.
UBC researchers have discovered a gene mutation in GNAQ that is responsible for 45% of uveal melanoma cases. This finding may lead to the development of therapeutic interventions against some melanomas.
Researchers at UC San Diego are creating a new imaging process, MoBI, to study human brain and body dynamics during natural activities. This technology combines EEG recordings with motion capture, allowing scientists to explore distributed brain dynamics supporting human behavior.
Researchers developed a novel technique called Early Photon Tomography (EPT) to image lung tumors in living mice. EPT combines early arriving photons with tomographic principles, resulting in sharper and more accurate images compared to conventional methods.
A recent government survey reveals that 38 percent of U.S. adults and 12 percent of children use complementary and alternative medicine (CAM) for various health issues. CAM therapies commonly used by adults include herbal supplements, meditation, chiropractic, and acupuncture, while children often rely on nonvitamin, nonmineral product...
New research by Cardiff University's Common Cold Centre found that hot fruit cordial provides immediate relief from cold symptoms. The study of 30 volunteers with common cold symptoms showed a 'hot' version of the drink to be effective in reducing symptoms such as runny nose and cough.
A new study found that a third of people with brain abnormalities similar to MS developed the disease within five years. Researchers monitored participants to determine whether they developed symptoms, and 30% had developed MS by average age 5.4 years.
A study of 1833 HIV patients found that specific mitochondrial DNA genotypes accelerate AIDS development, while others delay it. This suggests that genetic tests could provide accurate prognoses and guide early treatment initiation.
Researchers identified a small molecule called sfRNA that controls host response to viral infection. Targeting this molecule could lead to effective antiviral therapy for flavivirus diseases.
A study of almost 91,000 Japanese men and women found that living in a household with multiple generations increases the risk of serious heart disease in women. Women who lived with parents, children, or spouses were twice as likely to be diagnosed with coronary heart disease.
A Phase I study combining Revlimid and Vidaza found the combination was well-tolerated and had high activity in treating higher-risk myelodysplastic syndromes (MDS). The therapy resulted in a 39% complete response rate and 72% overall response rate among patients.
Using a three-dimensional image-guided system to help place screws in the spine results in safe and accurate surgery with decreased nerve injuries and misplaced screws compared to traditional operations.
Researchers successfully recreate a functional stem-cell niche in adult mice, enabling further study of stem cell development and fate. The discovery has potential implications for leukemia treatment and bone healing.
A subanalysis of the AZA-001 phase III trial reveals Vidaza extends overall survival and reduces death risk in elderly higher-risk MDS patients. The treatment also improves one-year survival rates in all response categories.
The majority of oral cancers are found late, causing high mortality rates, but early diagnosis improves survivability to 95% and reduces morbidity. Prosthodontists must change their practice paradigm by performing regular oral cancer screening examinations on all patients.
A new study found that overweight and obese children are more likely to suffer injuries to their upper and lower extremities after a car crash. The study, published in Injury Prevention, analyzed data from over 9,000 children aged 9-15 who were involved in motor vehicle crashes.
New treatments for advanced kidney cancer have shown promising results but are unlikely to be adopted in the UK due to high costs. The National Institute for Health and Clinical Excellence has provisionally ruled out using four new drugs, citing cost-effectiveness concerns.
Researchers have discovered an experimental drug that successfully blocks an enzyme causing certain bone marrow cancers. The oral drug, CYT387, was tested in mice and human cells, blocking the growth of myeloproliferative disorders and normalizing blood counts.
A new study by the University of Illinois found that fructose metabolism is more complex than previously thought, inducing a broader range of genes in the liver. This can lead to increased glycogen and triglycerides in the liver, as well as insulin resistance.
New research from the University of Manchester has shown that even water-soluble statins can affect placental development, leading to worse pregnancy outcomes. Current guidelines recommend avoiding statins during pregnancy due to their potential risks, and this study supports these recommendations.
Researchers at the University of Illinois have developed self-healing coatings that can automatically repair themselves and prevent corrosion. The coatings use a dual capsule system to deliver a catalyst and healing agent, which react to fix damaged areas within minutes or hours.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a new three-drug combination therapy that spares patients from prolonged myelosuppression, a potentially lethal side effect of traditional treatments. The treatment achieved a remission rate of 96% in patients with indolent B cell lymphoma.
Researchers evaluated REVLIMID's clinical benefit in relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients, demonstrating improved response durations and safety profiles. The study's results support the use of REVLIMID as a treatment option for these patients.
A study found that dexamethasone effectively reduces postoperative nausea and vomiting after tonsillectomies, but also increases the risk of bleeding in children. The largest dose was associated with a nearly 7 times higher risk of bleeding.
A new study concludes that long-acting beta2-agonists (LABAs) offer no additional benefit to conventional preventative medications in children. LABAs, such as salmeterol and formoterol, can improve lung function but do not reduce asthma symptoms or hospital admissions.
A new study by NCAR and University of Colorado warns that developing countries will struggle to afford and implement efficient technologies, exacerbating global warming. The research suggests that even advanced nations are worsening the outlook for global warming due to increasing emissions.
Research by Philip Rodkin reveals that unpopular boys are more likely to bully popular girls, challenging the classic 'whipping boy' syndrome. The study found that both bullies and victims are highly disliked by their peers, highlighting the need for educators to take reports of harassment from popular girls seriously.
A Phase 2 clinical trial of pralatrexate found a complete or partial response in 27 percent of patients with recurrent or resistant peripheral T-cell lymphoma. The treatment, which mimics folic acid, showed durable responses in patients who had failed multiple prior treatments.
The European Society of Cardiology recommends echocardiography as the first-line test for patients suspected of cardiovascular disease. Echocardiography provides accurate images of the heart's chambers, valves, and coronary arteries, allowing for diagnosis and prognosis without invasive procedures.
Professor Hamid Hadim has received a grant to develop an introductory level training course on pressurized water reactor nuclear power plants. The course will provide EPRI staff with better understanding of fundamental principles and design methodologies, enabling more valuable research and development.
A subset analysis of the AZA-001 trial demonstrated that Vidaza significantly improved overall survival in patients with WHO-defined acute myeloid leukemia (AML) compared to conventional care regimens. The study also showed reduced infections, hospitalizations, and red blood cell transfusions.
SMU chemist Brent Sumerlin has received a $475,000 NSF Faculty Early Career Development Award for two related nanotechnology research projects. His work focuses on developing novel materials with composite properties, including automatic insulin release technology for diabetics and self-repairing coatings for airplane wings.
Researchers found that siblings with mental illnesses are 63% more likely to experience depressive episodes, while those with low IQs are 18% more likely to live near their sibling but have lower emotional attachment. Environmental and social factors also play a role in poor mental health among these siblings.
A leading academic from Durham University argues that patients must comply with moral duties to look after themselves and others when accessing free healthcare. This includes promoting one's own health, using NHS resources responsibly, and cooperating with medical advice and treatment.
A new spinal deformity classification system has been developed to define the range of normalcy for spine alignment. The system, published in Neurosurgery, uses a systematic approach to define neutral upright spinal alignment across different age groups.
Two studies estimate the economic burden of cancer mortality using lost years of work and willingness-to-pay approaches. The estimated cost of cancer mortality in the US is high, with lung cancer accounting for 25% or more of costs.
A study found that most unintentional overdose deaths in West Virginia were associated with the nonmedical use and diversion of pharmaceuticals, primarily pain relievers. The majority of decedents had a history of substance abuse and used multiple contributory substances.
A recent study found that powerful individuals make better decisions when they engage in unconscious thinking, similar to the way most people process information. The research suggests that having power changes how people think and approach complex decision-making.
The University of Delaware is part of an international team building the IceCube neutrino telescope, which will study high-energy cosmic events. The $150 million project will detect neutrinos passing through the Antarctic ice, opening new insights into astrophysics.
Studies show Keppra XR reduces nervous system side effects compared to levetiracetam immediate release, and a new dosing schedule may offer improved tolerability. The once-daily formulation also demonstrates bioequivalence in healthy adults.
A major study of over 14,000 male physicians found that long-term vitamin E and C supplementation had no significant impact on prostate cancer or total cancer risk. The study suggests that these supplements may not be effective in preventing cancer in middle-aged and older men.
A new combination of medications has improved or stabilized disease in 76% of patients with relapsed multiple myeloma. Pomalidomide combined with dexamethasone showed promising results, with minimal side effects.
An analysis of a phase III clinical trial showed that VIDAZA can improve patient responses, achieving an overall response rate of 51% in higher-risk MDS patients. Continued treatment with VIDAZA led to better outcomes for almost half of responders.
Researchers have developed a transparent resistive random access memory (TRRAM) chip, enabling see-through electronic systems. The technology may drive new directions in electronics, allowing for more compact devices and cheaper manufacturing.
A team of Princeton researchers found that molybdenum is crucial for controlling the biological conversion of nitrogen in tropical rainforests, supporting plant growth. The discovery has implications for global climate change policy, as it may limit the amount of carbon dioxide that tropical rainforests can absorb.
A review of nine clinical trials found that cholinesterase inhibitors significantly reduced behavioral symptoms like aggression, wandering, and paranoia in Alzheimer's disease patients. The medications are safe and produce no major side effects, making them a potential alternative to antipsychotic drugs.
Research by University of Chicago psychologist Sian L. Beilock reveals that math anxiety can be debilitating due to the consumption of working memory resources by worries and stereotypes. Individuals with higher working memory capacity are more prone to 'choke under pressure' when stressed.
Smokers carrying a specific gene variant are more susceptible to concentration problems and cognitive deficits during abstinence, increasing the risk of relapse. The study paves the way for novel medications to treat nicotine addiction.
Researchers estimate RASD affects 25-30% of children with an autistic disorder. Children with RASD typically develop normally until 18-24 months, then regress and lose previously acquired skills. Identifying early signs is crucial to address potential neurological development issues.
Early investigational studies show anti-tumor activity in ZOLINZA (vorinostat) and bortezomib combination for relapsed or refractory multiple myeloma. Clinical trials are underway to further evaluate this combination, offering new hope for advanced multiple myeloma patients.
Scientists have obtained the first 3D images of the Mcm10 protein, which is essential for DNA replication in eukaryotic cells. The structure reveals unique features that allow it to interact with single-stranded DNA and position other proteins on the DNA strand.
The study found an ORR of 53% and CR/CRu of 20% in evaluable patients, while pooled data showed a 57% ORR and 21% CR. REVLIMID is being evaluated as a treatment option for heavily pretreated MCL patients.
The Lancet report identifies key right-to-health features and indicators, highlighting gaps in data and progress towards universal access to healthcare. The study emphasizes the importance of non-discrimination, mental health allocation, and health information availability.
A genetic modification has prolonged the life of mice with amyotrophic lateral sclerosis (ALS) by boosting antioxidant production. The discovery offers new hope for treating ALS and other neurodegenerative diseases.
Researchers at University of Leeds have identified a promising new target for hepatitis C treatment: the p7 protein. The study found that genetic variations among HCV strains affect sensitivity to certain drugs, highlighting the need for tailored combination treatments.
Researchers found that unconscious thought was not always effective in making the best choices. Instead, thinking about a decision at one's own pace and focusing on the problem led to larger payoffs. The study suggests that relying on self-paced conscious thought can be a more reliable approach for complex decisions.
A large cancer prevention trial found no association between supplementation with vitamin E or selenium and a reduced risk of prostate cancer. The study included 35,533 men and followed them for up to 7 years, concluding that these supplements were ineffective in preventing prostate cancer.
Researchers are fitting lobsters with transmitters to track their migrations year-round, providing more accurate information about juvenile lobster sources and interactions between populations. The study aims to improve management of the economically valuable fishery, allowing lobsters to remain a staple in New England cuisine.