Researchers at Harvard University have discovered a molecule that can halt the growth of cancerous AML cells without harming healthy cells. The molecule, cortistatin A, works by inhibiting two specific kinases that play a key role in the growth of AML cells.
Researchers have developed an automated drone-based approach to monitor forest regeneration, reducing costs and labor intensity. The method uses low-cost drones equipped with cameras to create 3D images of vegetation, providing accurate results comparable to human monitoring.
Researchers detect melanin in fossilized tissues of fish, frogs, and other ancient animals, revealing their original color patterns. The discovery sheds light on the evolution of color recognition in ancient life forms.
Scientists have discovered seven new land snail species in China, including two that are among the world's smallest, measuring less than 1 mm in height. These tiny creatures pose challenges for scientists studying biodiversity and evolution.
A new study maps deer migration patterns across Georgia, revealing peak collision times and areas for increased vigilance. By knowing these dates, drivers can be more cautious and avoid deadly accidents.
A large national BCSC study found that computer-aided detection (CAD) of breast cancer screening does not improve accuracy or patient outcomes. CAD raised screening costs and increased false positives, but did not detect more cancers or improve outcomes for women in screening programs.
A decision aid helped primary care clinicians and patients with moderate to severe depression select antidepressants together, improving decisional comfort and knowledge. However, its effect on depression control and medication use was not discernible.
A new study by the University of Toronto's Rotman School of Management suggests that truly innovative breakthroughs need in-depth knowledge in a narrow domain. Most high-impact innovations occur through cross-collaboration, but this research shows that recombining existing knowledge is only one part of the puzzle.
Stroke patients with spatial neglect are at higher risk of falls, have longer hospital stays, and are less likely to return home. The study found that screening for spatial neglect and early intervention can help mitigate these negative outcomes.
Researchers at Queen Mary University of London developed a method for self-assembling organic molecules into complex tissue-like structures without moulds or 3D printing. This discovery could enable the engineering of tissues like veins, arteries, or the blood-brain barrier, facilitating disease research and implant development.
A six-year ASU experiment found that extreme weather events affect plant species differently, with grasses declining and shrubs flourishing under alternating wet and dry years. This shift could have serious consequences for humans relying on grasslands for food, particularly cattle ranchers.
A novel approach for identifying patients with undiagnosed clinically-significant COPD has been developed. The new tool consists of several questions that can be used to aid clinicians in finding people with moderate or severe COPD, or those at risk of exacerbations before loss of lung function occurs.
Kansas State University has upgraded its nuclear reactor control console with a new system funded by a $1.5 million grant from the US Department of Energy. The upgrade will improve compatibility with current equipment and enable researchers to access data more easily for lab experiments.
HIV-infected patients are excluded from early-phase clinical trials of new anti-tuberculosis drugs, resulting in slower development and potential drug interactions with antiretroviral therapy. Experts urge including HIV patients in relevant trials to accelerate development and address drug resistance.
Researchers found that sedentary time was associated with higher risks of heart and diabetes problems, regardless of exercise levels. The study suggests that reducing sedentary time can be beneficial for Hispanic adults' overall health.
A new study published in Surgery for Obesity and Related Diseases found that laparoscopic sleeve gastrectomy resulted in significant weight loss in obese pediatric patients with Prader-Willi Syndrome. The surgery showed no apparent negative impact on growth, offering a promising treatment option for these patients.
A new Atlantic tropical depression formed on September 28, with cloud top temperatures reaching -63 Fahrenheit/-53 Celsius, indicating potential heavy rainfall. The National Hurricane Center forecasts the depression to strengthen into a tropical storm later in the day.
Researchers developed an algorithm to automatically tune powered prosthetic legs, tracking joint angles while walking. The system allows patients to walk comfortably with reduced prosthesis-related costs and easier adjustments.
NASA's Solar Dynamics Observatory captured an image of a mid-class solar flare on September 28, 2015, which peaked at M7.6 intensity. The event is expected to disturb the atmosphere in layers where GPS and communications signals travel.
A University of Delaware study reveals that non-native plants support fewer herbivores and less diverse communities compared to native plants. The research found a compounding effect where non-native trees with no close native relative supported even lower diversity of herbivores.
An international study of nearly 70,000 women found that genes involved in DNA repair play a crucial role in determining when a woman enters menopause. The research also confirmed a link between earlier menopause and lower breast cancer risk, with increased risk associated with delayed menopause.
Researchers found a link between metalworking fluid exposure and lymphocytic bronchiolitis, a condition causing immune cell overgrowth in the lungs, leading to irreversible damage. The study suggests that workers with higher exposure levels reported more symptoms despite similar lung function.
A recent study by researchers found that FDA's 'breakthrough' designation significantly increases the percentage of people who rate a drug as effective and believe in its strong evidence. The study suggests that neutral terms with clear explanations may help consumers make more accurate judgments about these drugs.
Researchers identify and map a light-sensing protein that uses vitamin B12 to regulate gene expression in response to light exposure. The discovery expands the biological role of vitamin B12 and offers insights into novel modes of gene regulation.
The new algorithm enables filmmakers to determine the optimal number and location of cameras for capturing a scene, amassing data that can be used during post-production. It allows for virtual relighting, generating new viewpoints, and digitally recovering detailed 3D shapes and layouts.
A recent study found that a costly computer-aided detection tool used in nearly all mammograms does not improve cancer detection rates and may even result in missed cancers. The study's findings have led some researchers to advocate for ending Medicare coverage of the tool, which could save millions annually.
The TAILORx trial found that 99.3% of patients with low Oncotype DX scores had no distant recurrence at 5 years after treatment with hormonal therapy alone. This study provides evidence supporting the clinical utility of Oncotype DX to risk-stratify patients with early stage breast cancer.
Researchers found that just 10 minutes of walking after six hours of sitting can restore impaired vascular function and improve blood flow to the legs. This simple break can offset the harm caused by prolonged sitting and reduce the risk of cardiovascular complications.
Researchers found that overcrowded conditions protect against developing a particular type of Hodgkin lymphoma, while female patients in the 20-24 age group have a higher incidence rate. The study also suggests that oestrogens may be responsible for this increased risk.
A major study published in the New England Journal of Medicine has identified a 21-gene test that can determine which breast cancer patients can safely avoid chemotherapy. The test, called Oncotype DX Recurrence Score, analyzes tumor samples and assigns scores between 0-100, indicating the risk of cancer recurrence.
Researchers have obtained the first nanometer-resolved image of individual tobacco mosaic virions using low-energy electron holography, a non-destructive single-particle imaging technique. This breakthrough could lead to improved drug design by providing detailed knowledge of biomolecular structures.
A team of scientists created a new single-molecule tool to observe enzymatic proteins at work, providing fast and reliable characterization of their interactions with DNA. This tool offers picometer-resolution nanopore tweezers, enabling detection of minute differences in protein binding and motion.
The Endocrine Society releases a scientific statement linking endocrine-disrupting chemical exposure to increased risk of developing diabetes and obesity. The statement highlights the need for regulation and education to minimize further exposure and protect public health.
Researchers have created a three-fingered soft robotic hand with embedded optical sensors, allowing it to detect forces of less than a tenth of a newton and determine where its fingertips are in contact. The new stretchable optical sensing material could be used in a soft robotic skin for even more feedback.
Researchers warn of the dangers of talc exposure in the food processing industry, highlighting a case of talcosis in workers who inhaled talcum dust. The study led to effective control measures being implemented at the company, emphasizing the importance of comprehensive surveillance programmes and structured medical evaluation.
A new method has been developed to standardize ratings of cohesivity for hyaluronic acid (HA) gel fillers, allowing plastic surgeons to choose the product best suited for each procedure. The Gavard-Sundaram scale provides a scientific rationale for selecting fillers with properties that match specific clinical objectives.
Researchers used a gel-like substance called Carbopol to study the resistance of rock formations in the middle crust to fracturing. The study provides insight into how large earthquakes and slower moving events interact, with potential implications for predicting seismic activity.
Researchers at Children's Hospital Los Angeles found that an admission hematocrit can identify pediatric patients at high risk for bleeding after injury. The study showed a reliable screening tool with low false negative rate and high specificity.
The immune system marks pathogen-containing vacuoles with ubiquitin to trigger destruction, a process that could lead to new therapeutic strategies. Highly virulent strains block this tagging, making them more resistant to host response.
Research published in Gut found that a high-fiber diet is associated with increased levels of health-promoting short-chain fatty acids, which may help reduce the risk of inflammatory diseases, diabetes, and cardiovascular disease. The study also showed that vegans and vegetarians had higher levels of these beneficial compounds.
Dr Jonathan Pritchard has secured a prestigious fellowship to support his research into the direct exploitation of quantum phenomena. His project aims to develop a hybrid device combining atoms and superconducting circuits for scalable quantum networking, with potential applications in computing, finance, and more.
A new UK Biobank study has identified six independent genetic variants associated with lung health and chronic obstructive pulmonary disease (COPD). The findings also suggest that genetic variations affecting gene regulation may play a role in COPD, providing potential targets for novel therapeutic strategies.
The AAO-HNS Foundation is developing a clinical data registry for otolaryngology, with Regent being the first registry of its kind. The registry will help improve patient care by tracking care outcomes and identifying gaps in clinician knowledge and performance.
A team of ETH Zurich researchers has created a biomimetic dental prosthesis that replicates the structure and properties of teeth and seashells. The material, produced using magnetically assisted slip casting, exhibits improved durability and complexity, with potential applications in dentistry and beyond.
Researchers identified distinct characteristics among non-smoking patients with NSCLC, such as lower chronic obstructive pulmonary disease and heart disease rates. Non-smokers also exhibited longer survival periods after diagnosis compared to smokers.
Research at the American Academy of Otolaryngology's annual meeting finds that tobacco smoke exposure correlates with severity of sinusitis symptoms. Additionally, studies show a link between tobacco smoke exposure and an increased risk of oropharyngeal cancers and eustachian tube disorders in children.
A large study found that aspirin use after a cancer diagnosis significantly increases overall survival rates for patients with gastrointestinal tumours. The researchers analysed data from nearly 14,000 patients and discovered a strong association between aspirin use and improved survival.
Researchers at Toyohashi University of Technology discovered that immersing a zinc-based buffer layer in ammonia water doubles the conversion efficiency of CIGS solar cells, improving their performance from 6.8% to 13.7%. The study reveals the importance of the buffer layer structure and composition for next-generation solar cells.
New study results show atezolizumab has remarkable activity in large number of patients with refractory lung cancer, regardless of treatment line. Efficacy is correlated with PD-L1 expression on tumours and immune cells.
The CheckMate 057 trial shows that nivolumab improves overall and 12-month survival rates compared to docetaxel in non-squamous non-small cell lung cancer patients. Nivolumab also demonstrated better patient-reported outcomes, including quality of life and slower disease deterioration.
Researchers found that infants infected with rhinovirus had lower respiratory microbiota diversity, while asymptomatic infections did not. Frequent early-life viral infections were also associated with reduced overall microbiota diversity.
Researchers found that adding hormonal treatment during chemotherapy reduced the risk of premature ovarian failure by 45% and increased pregnancy rates among young breast cancer patients. The use of LHRHa could be a potential standard strategy to preserve ovarian function and fertility in hormone receptor positive breast cancers.
A study by Mrs Lee Koh found that walking on side-street routes instead of main roads can reduce peaks in harmful air pollution. By avoiding busy streets, individuals can minimize their short-term and long-term exposure to black carbon particulate matter, a major component of urban air pollution.
A combination of dabrafenib and trametinib significantly prolongs median overall survival time for advanced melanoma patients to over two years, with 51% remaining alive after two years. The treatment also improves disease-free progression and quality of life compared to vemurafenib alone.
Researchers found that shielding parenteral nutrition from light significantly decreases oxidative stress and cell damage in premature infants, improving their survival rates. The study's findings suggest a potential solution for reducing mortality rates in preterm infants born between 26-31 weeks of gestation.
Shigeki Watanabe has developed a novel ultrafast technique called 'flash-and-freeze' to visualize nerve cell activity on a rapid time scale. The technique reveals that vesicle recycling in neurons occurs through two mechanisms, an ultrafast one and a slower clathrin-dependent process.
A two-drug combination of venlafaxine and aripiprazole relieved depression in 44% of treatment-resistant patients over 60, while reducing suicidal thoughts. The study's findings suggest that older adults may respond to this treatment strategy, offering new hope for those with hard-to-treat depression.
Researchers found that the combination therapy improved progression-free survival across various sub-groups, including those with poor prognostic factors. The study also showed similar efficacy regardless of BRAF mutation status and disease stage.
A global shortfall in radiotherapy resources has led to millions of unnecessary deaths, but investing in radiotherapy services could bring economic benefits of up to $365 billion over the next 20 years. Access to radiotherapy is currently unacceptably low, especially in Africa, where most countries have no facilities.
The study found that everolimus improved progression-free survival by 52% and increased median progression-free survival by over seven months in patients with advanced, nonfunctional neuroendocrine tumors. The treatment was well-tolerated, with common side effects including aphthous ulceration, rash, diarrhea, fatigue, and infections.