A major new analysis from the Global Burden of Disease Study 2013 reveals that nearly 20 people in 100 worldwide had no health problems in 2013. Over 2.3 billion individuals experienced more than five ailments, with low back pain and depression ranking as top contributors to disability.
Researchers at Helmholtz Munich have identified FKBP10 as a potential new target molecule for treating idiopathic pulmonary fibrosis (IPF), a chronic lung disease. Analysis of patient data revealed elevated levels of the protein in IPF patients, which may lead to a new therapeutic approach.
IBM researchers have successfully fabricated futuristic components on silicon chips using a new technique. The breakthrough allows for the integration of III-V materials onto silicon wafers, which may enable further miniaturization and cost reduction in computer chips.
Researchers found an association between cholesterol-lowering drugs and memory loss in the initial 30 days following medication initiation. The link may be due to increased contact with physicians among users of these medications, leading to earlier detection of memory issues.
The TECOS study found that adding sitagliptin to usual care did not increase the risk of major adverse cardiovascular events or hospitalization for heart failure in patients with type 2 diabetes and established cardiovascular disease. Researchers also reported no significant link between sitagliptin and an increased risk of acute pancr...
A $10 million grant from the USDA will support a 5-year research project to develop treatments for citrus greening disease, which threatens the US citrus industry. The project aims to use systems biology approaches to block the transmission of the disease-causing bacterium and develop resistant citrus varieties.
Researchers use 'Google Maps' for cancer genome analysis, identifying potential drug targets and monitoring treatment response. They provide a comprehensive view of the patient's multiple myeloma genome, showing notable mutations and larger-scale changes over time.
A study published in the June issue of Health Affairs found that PEPFAR funding was associated with a 13% increase in male employment in ten sub-Saharan African countries. The authors suggest that these findings could inform future aid allocation decisions, potentially generating significant economic benefits.
A new study reveals that weathering rates over the past 2 million years have remained relatively stable between glacial and interglacial periods. This finding contradicts previous assumptions that weathering rates should slow down during ice ages due to lower temperatures.
A new molecular imaging scan detects dangerous protein deposits in the heart, significantly increasing cardiac risk. The scan uses a widely available agent to assess amyloid buildup and predict future heart attacks.
Researchers used whole genome sequencing to investigate a bacterial outbreak in a neonatal unit, finding all but one baby were infected with the same strain of Pseudomonas aeruginosa. The technology enabled rapid response infection control protocols, stopping the spread of infection and protecting vulnerable patients.
Researchers used remote sensing technology to study the impact of foreclosure on urban yards in Phoenix, Arizona. They found that foreclosed homes can become either greener or browner due to changes in yard management.
A team of UW graduate students has found a way to detect volcanic activity in the atmospheres of exoplanets during their transits. This could help choose worlds to study for possible life and determine if they are habitable. Volcanism regulates planetary temperatures, making it a key element in habitability.
Researchers from Brown University have detected deposits of glass within impact craters on Mars, suggesting that it could preserve signs of life. The study found large glass deposits in several ancient yet well-preserved craters, including Hargraves near Nili Fossae trough.
A University of Illinois study finds that developing relationships with young adults and modeling professional behaviors can improve their leadership development. By establishing mentorship opportunities, businesses can help emerging adults grow into confident leaders.
A new study by Cancer Research UK found that breast cancer patients are disproportionately affected, with only 20% having surgery after an emergency diagnosis in hospital. In contrast, those diagnosed via urgent GP referrals have a much higher likelihood of receiving lifesaving surgery.
A team of scientists has identified an enzyme called Kit, which plays a key role in the development of obesity and metabolic disorders. In mice with functioning Kit, fed a high-fat diet, obesity and insulin resistance were prevented.
Researchers found that warming temperatures are disrupting rainfall patterns, leading to more extreme and destructive storms. The study suggests that this could result in increased flash flood risks, particularly in urban areas.
The Person-Event Data Environment (PDE) database captures financial, health, medical and other data for every soldier from entry to separation. The database includes information on soldiers' military experience, contractors and dependents, representing a heterogeneous population with various socioeconomic backgrounds.
A novel radionuclide drug, PSMA-617, has been developed to target prostate-specific membrane antigen (PSMA) on prostate cancer cells, allowing for personalized diagnosis and therapy. The drug showed promising results in a human clinical trial, with effective imaging and therapeutic effects.
Researchers have identified a gene that may help reactivate insulin-producing beta cells in diabetics. The team, led by Professor Tessem and including four students with Type 1 diabetes, has made significant breakthroughs in understanding the molecular pathways involved.
Scientists have developed a novel PET tracer that can pinpoint thrombi throughout the body with over 97% accuracy. The tracer, Cu-64 FBP8, targets fibrin in blood clots and reflects thrombus age, enabling clinicians to choose more effective treatments.
The formation of the ASEAN Economic Community will likely lead to more deforestation, large-scale commercial monoculture crops, and environmental degradation if nations fail to address gaps in policies and enforcement. The region's agricultural land covers 1.26 million hectares, with forests covering 50% of ASEAN's total area.
Researchers found that genomic mutations in the TP53, APC, and CDKN2A genes were present in 75% of progressors with Barrett's esophagus. This ability to detect mutations in non-neoplastic mucosa can improve early detection and surveillance for patients at heightened risk for esophageal cancer.
Researchers at NYU Langone Health have successfully halted and reversed the growth of certain cancerous white blood cells in T-cell acute lymphoblastic leukemia (T-ALL) by blocking a specific protein receptor called CXCR4.
A study published in Nature Medicine found that enhancing a specific immune response can kill infection-causing fungi, such as Candida albicans, which causes life-threatening bloodstream infections. The researchers discovered that stimulating the transcription factor HIF-1α with L-mimosine led to increased production of natural antibio...
A new study from Australian and Singaporean scientists has discovered that each subtype of dendritic cell has its own unique parent cell. This discovery could lead to more efficient treatments for autoimmune diseases like lupus and rheumatoid arthritis by targeting the progenitor cells that produce these immune cells.
Massey researchers have identified three patterns of lymphocyte recovery following stem cell transplantation that are significantly associated with clinical outcomes. The study found Group B patients experienced the best clinical outcomes, while Groups A and C had poorer survival rates. The discovery builds on previous research into th...
Tropical Storm Blanca weakened before making landfall in Baja California, Mexico, with maximum sustained winds decreasing to near 40 mph. The storm's eye had disappeared by June 7, and it was expected to degenerate into a remnant low by Tuesday.
A five-year phase II clinical trial testing the ability of BCG to clinically improve type 1 diabetes in adults will be conducted at Massachusetts General Hospital. The trial aims to create a lasting therapeutic response and has received $19 million out of $25 million needed for the study.
A new study by engineers at the University of Sheffield has proven conclusively that contaminants can enter pipes through leaks and be transported through the pipe network. Groundwater with harmful contaminants can be sucked in and remain in the pipe, potentially reaching consumers' taps at low concentrations.
A fully renewable energy system featuring high shares of wind and solar energy is economically feasible for Finland by 2050, producing over 166 TWh of electricity annually. The system also includes power-to-gas technology and energy storage solutions, with total annual costs estimated at around 25 billion euros.
A study of 7,000 participants from 75 countries found that most people want access to genes linked to serious conditions and want to be 'forewarned' about their future health risk. Participants also expressed interest in having raw genomic data, despite its limited usefulness for predicting health outcomes.
Townsend's contributions to nuclear medicine have been transformative, introducing 3D PET imaging and the combined PET/CT scanner. His work has improved the signal-to-noise of reconstructed images without increasing detector material cost.
Phelps was recognized for his contributions to nuclear medicine and molecular imaging, including the invention of PET scanners. His work has improved outcomes for patients with cancer, neurological disorders, and cardiovascular disease.
Researchers at Arizona State University identify five foundations of multicellularity that cancer cells bypass to fulfill their selfish needs, leading to disastrous outcomes for the organism. The study provides clues about how to diagnose and treat cancer, a disease with rapid evolution capabilities.
Current mobile contracts are causing significant environmental damage through frequent upgrades and waste. Researchers propose a cloud-based product service system to reduce precious resources needed for mobile devices.
Diabetes research has made significant progress over the past 50 years, transforming treatment options and patient lives. The development of human insulin, improved glucose testing methods, and advanced delivery systems have greatly enhanced management of the condition.
According to a study by the University of the Basque Country, cognitive decline starts at age 20 but may not be noticeable. Episodic memory deteriorates with age, while semantic and procedural memories remain relatively stable or even improve in some cases.
A recent study published in the Journal of Personality and Social Psychology found that anticipating a potential ethical dilemma can lead to improved ethical behavior. Participants who identified similar past incidents and anticipated temptation were more likely to behave honestly than those who didn't.
Researchers at St. Michael's Hospital tested a new drug that prevents blood vessels from leaking into the lungs, reducing mortality rates in mice infected with influenza. The treatment, Vasculotide, was effective against multiple strains of flu and worked when administered days after infection began.
A new national study in the Netherlands reveals that non-invasive prenatal testing (NIPT) is accurate and preferred by pregnant women at high risk of having a baby with Down's syndrome. The TRIDENT study found 89 cases of trisomy 21, 11 of trisomy 18, and ten of trisomy 13, with only nine false positives.
The American Diabetes Association, American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics have released a joint position statement outlining when and how to deliver diabetes self-management education and support (DSME/S) to patients. The guidelines highlight four critical life junctures: diagnosis, annua...
At least 6.5% of de novo genetic mutations now known to arise during post-zygotic development, affecting clinical outcomes and recurrence risk. Better information on mutation origin will enable more informed reproductive choices.
Research reveals that nearly a third of low-risk pregnancies experience unexpected complications requiring non-routine obstetric or neonatal care. The study analyzed data from over 10 million birth certificates and found that women without prenatal risk factors may still face unexpected complications during delivery or postpartum.
A new genetic mutation in the TGFB3 gene has been discovered, linking it to serious aortic disorders. This finding allows for improved diagnostic screening, enabling early identification of patients at risk and potentially preventing aortic aneurysm formation through preventive treatment.
A new study found that coral reefs in Palau's naturally acidic waters are thriving, despite the expected negative impacts of ocean acidification. However, increased bioerosion was observed, threatening the long-term survival of these ecosystems. The research team hopes to better understand how corals adapt to low pH conditions.
A national survey found that most Americans disclose their personal data for discounts because they believe marketers will harvest the data anyway. The study's lead author argues that marketers misrepresent consumers' behaviors as rational acceptance of 'tradeoffs,' which is not true.
Researchers have discovered a rabbit virus that can deliver a one-two punch, killing some kinds of cancer cells while eliminating a common complication of bone marrow transplants. The myxoma virus can quell graft-versus-host disease and destroy cancer cells, offering new hope for patients with blood cancers.
A Swiss Federal Laboratories for Materials Science and Technology (EMPA) project developed an innovative hybrid-electric powertrain for road sweepers, reducing energy consumption by 45% compared to diesel-powered vehicles. The new system also decreases CO2 emissions by 60%, thanks to natural gas's lower carbon content.
Research finds that powerful individuals respond faster to unfair treatment when they're the victims, but slower to notice when others are victimized. This disparity suggests that the powerful are more empathetic towards their own experiences and less so towards others.
A new study suggests that having a stroke can reduce brain function by 8 years, affecting memory and thinking speed equally in black and white patients. The research analyzed data from over 4,900 seniors and found that strokes have serious consequences for cognitive health.
A new study led by Dr. Jinbo Bi at the University of Connecticut School of Engineering aims to find the genetic causes of specific symptoms of substance addiction. The study will use a database of over 11,000 subjects and develop new statistical tools to classify substance dependence more effectively.
A new study found that infants who can resettle themselves after waking up are more likely to sleep for prolonged periods at night. By three months of age, most infants develop this ability, which is associated with longer sleep durations and reduced crying at night.
Rockefeller University scientists have uncovered crucial steps in the nuclear pore complex's dilation and constriction mechanism. Transport factor karyopherin initiates ring dilation by stabilizing Nup58, allowing larger molecules to pass through.
The study highlights seven potential benefits of pairing territorial use rights in fisheries (TURFs) and marine reserves, including increased fish abundance, reduced IUU fishing, and improved conservation. TURFs grant exclusive access to designated areas, promoting local ownership and conservation measures.
Researchers found that autologous bone marrow stem cells significantly reduced cranial pressure and therapeutic intensity in TBI patients, decreasing neurointensive care time by nearly 60%.
Abelardo Colon and Jennifer Gill from the University of Puerto Rico won the top honors with their video explaining a new method for disinfecting drinking water using a nanodiamond powder. The process has promising results, reducing fecal E. coli colonies and increasing density.
Researchers from the UCL Institute of Child Health and Great Ormond Street Hospital found non-invasive prenatal testing to be highly effective and acceptable to parents. Over 2,500 women underwent NIPT for high and medium risk pregnancies with Down's syndrome, showing a sharp decrease in invasive tests and increased detection rates.
Researchers at NHGRI create high-throughput gene editing system in zebrafish, allowing for simultaneous targeting and mutation of multiple genes. This method accelerates discovery of gene function and identification of disease genes in humans.