Recent developments in dendritic cell vaccines and oncolytic immunotherapy have led to improved outcomes in melanoma patients. Various vaccine candidates are being developed and tested in clinical trials, offering new avenues for treating this malignancy.
Researchers at TSRI have designed precision medicines that target disease-causing RNAs with high selectivity and potency. The study demonstrates the ability to track RNA movement in diseased cells using imaging techniques.
A study published in Nature Medicine identifies bone marrow-derived immature myeloid cells as the source of suPAR, a reliable marker for chronic kidney disease. Elevated suPAR levels have been linked to future chronic kidney disease, potentially enabling early intervention and prevention of recurrence after transplant.
Researchers at Ulsan National Institute of Science and Technology (UNIST) have made a groundbreaking discovery in cancer treatment. They developed novel Iridium(III) complexes that utilize red light to attack and kill cancer cells, providing a promising new approach for photodynamic therapy (PDT).
The new guidelines recommend forego routine axillary lymph node dissection in most women with no evidence of cancer on sentinel node biopsy. This approach can reduce the risk of painful and costly side effects such as lymphedema, infections, and reduced range of motion.
New research shows that when focused, information is processed continuously, while ignoring stimuli is perceived in waves. This study provides insights into how the brain prioritizes attention and processing of time and space.
A new study published in the Journal of Nutrition Education and Behavior found that college students experience significant weight gain, averaging around 10 pounds over their four-year college career. This excessive weight gain is associated with an increased risk of health problems, including diabetes and hypertension.
A new study suggests that male students' likelihood of becoming a perpetrator increases when they attend parties or bars more than usual. Researchers found that almost 18% admitted to sexually assaulting a woman during the study period, with frequent bar-goers being more likely to be perpetrators.
Early research led by Queen Mary University of London found that neutrophils play a role in promoting blood vessel growth and normal placental development. Treating pre-eclamptic neutrophils with hormone therapy may help improve fetal growth, according to the study.
Patients with advanced non-small-cell lung cancer survived four months longer on immunotherapy drug atezolizumab compared to chemotherapy, with atezolizumab also having fewer side effects. The trial found that the drug worked best for patients with high levels of PD-L1 protein, doubling their survival.
Researchers discovered a chain reaction of energy redistribution in quasicrystals, resembling a lightning strike's forked branches. This unique behavior has implications for the development of low-energy computing devices.
Researchers found that ice surface melts in layers, with the first layer melting at -38° C and the second at -16° C. The team also discovered a distinct spectroscopic response between the quasi-liquid layer and supercooled water.
Researchers found the Antarctic Ice Sheet plays a significant role in regional and global climate variability. The ice sheet's dynamic behavior over the past 8,000 years has cascading effects on the entire climate system.
Researchers have solved the mystery of DNA replication by identifying a ring of proteins that binds to origin DNA, causing it to melt and initiate replication. This discovery could lead to understanding genetic duplication and potentially blocking viral pathogens and cancer cells.
Researchers have discovered a mysterious crater on the King Baudoin ice shelf, revealing hidden meltwater lakes and confirming that East Antarctica is also vulnerable to climate change. The findings suggest that the region's ice shelves are extremely sensitive to warming temperatures.
The technology platform, Phenotypic Personalized Medicine, uses visual representations to identify optimal drug and dose combinations for patients with acute lymphoblastic leukemia. This approach reduces side effects while maintaining or enhancing efficacy, offering a game-changer for cancer treatment.
A new study from the University of Missouri found a link between working memory and how children learn, suggesting that teaching techniques can be tailored to individual needs. The study suggests that educators can help children with language learning disabilities by reducing information overload and focusing their attention on one task.
Dome A's extreme dryness allows for terahertz observations, previously hindered by Earth's atmosphere. Researchers can now gain new insights into star and galaxy formation.
The ASSURE2 project explores belt casting technology to reduce steel production costs and energy consumption by over 300%. This innovative approach can also produce commercially attractive advanced high strength strip (AHSS) steel grades, such as TWIP and TRIP steels.
Researchers at St. Jude Children's Research Hospital discovered that NLRC3 protein plays a central role in inhibiting colon cells from becoming cancerous. The study found that deleting the protective NLRC3 protein exacerbates colon cancer development, but also identified key molecular components of its tumor suppressing pathway.
Researchers use informatics to analyze over 39,000 consumer products and identify 30% containing endocrine-disrupting chemicals. The approach complements gas chromatography-mass spectrometry analysis, enabling detection of unlisted chemicals and predicting cumulative exposure
A new study published in JAMA Pediatrics found that rural communities have seen a dramatic increase in newborns diagnosed with neonatal abstinence syndrome due to opioid exposure. The rate of diagnosis increased by nearly 80% between 2003 and 2013, compared to urban areas.
A recent study published in BMJ Global Health reveals that children from low-income countries are at a significantly higher risk of dying after emergency abdominal surgery. The likelihood of dying is up to 7 times greater than for children from rich nations.
Researchers have shown that macrocyclic MRI contrast agents may reduce the risk of gadolinium brain deposition, a concern for patients with multiple sclerosis. Macrocyclic agents were found to minimize deposits in the cerebellum, whereas linear agents posed a higher risk.
A new study by the American Museum of Natural History estimates that there are approximately 18,000 bird species worldwide, nearly twice as many as previously thought. The researchers used a combination of morphology and genetic studies to highlight birds with separate evolutionary histories.
Patients enrolled in a program to address unmet socioeconomic needs saw significant improvements in blood pressure and cholesterol levels, according to a study by Massachusetts General Hospital. The Health Leads intervention helped patients with hypertension and elevated LDL cholesterol levels, but not diabetes.
Researchers from Moscow Institute of Physics and Technology develop a method to connect two electrons in a qudit, paving the way for compact high-level quantum structures. This breakthrough could lead to practical applications such as efficient solar cells and new drugs.
Scientists can now map the speed of glaciers and ice sheets globally, tracking unique patterns and identifying areas with rapid change. This near-real-time data enables researchers to understand the impact on sea level and coastal communities.
Researchers at Tomsk State University developed a universal method for calculating the most efficient operation of systems with incoming flow. This approach can be used to eliminate queues in shops and banks, as well as reduce mobile communication congestion during holidays.
A study by the University of Edinburgh found that wind farms prevented 36 million tonnes of greenhouse gas emissions from coal and gas sources in Great Britain. The research suggests that a greater investment in wind energy could help meet Scottish and UK government targets for carbon emissions reduction.
A team of scientists at Australian National University has successfully created a diamond that is predicted to be harder than regular diamonds. The new material, called nano-crystalline hexagonal diamond, was made using a high-pressure diamond anvil and has the potential to be used in mining sites to cut through ultra-solid materials.
Global methane concentrations have grown faster than at any point in the past two decades, posing a significant threat to climate change mitigation efforts. The rapid increase in methane emissions is attributed primarily to agricultural sources, particularly rice paddies and cattle pastures.
Research found that blood flow in fetuses of diabetic mothers is redirected to the placenta, diverting away from the brain. The study used foetal Doppler echocardiography and a computerized model to analyze blood circulation.
A study presented at EuroEcho-Imaging 2016 found that chemotherapy caused heart damage in cancer patients with diabetes, leading to a higher risk of heart failure. The researchers also discovered that patients with diabetes experienced a significant decrease in global longitudinal strain, an early predictor of heart failure.
A new advanced theoretical tool has been developed to design and analyze complex beam lines with strong coupling. This breakthrough enables the creation of high-intensity beams that can be used in fusion reactors and nuclear waste management, as well as study the origin of the universe.
Researchers identified two drug combinations that could improve survival rates for breast cancer patients, including anti-inflammatory and lipid modifiers. The study analyzed data from nearly 10,000 women with breast cancer and found three pairs of drug interactions associated with better outcomes.
Research reveals that macaques possess the physical attributes necessary to produce intelligible human speech, yet their brains lack the neural circuitry required for this ability. This finding debunks the idea that vocal anatomy alone limits speech in nonhumans, highlighting the importance of brain evolution in human language.
A Cardiff University study found that home-based rehabilitation significantly improves visual function and daily life for people with low vision. Home visits by visual rehabilitation officers led to a greater improvement in visual function compared to standard hospital appointments.
Scientists have discovered a new mutation in the PKD1L1 gene associated with laterality defects and complex congenital heart disease. The study provides hope for affected families by offering prenatal or pre-implantation genetic diagnosis to prevent the condition from being passed on.
A new study reveals that many breast cancer survivors experience unmet needs for symptom management, leading to increased levels of anxiety and depression. Researchers are calling on healthcare providers to incorporate symptom management into routine follow-up care.
Michigan State University researchers have developed a low-cost nanogenerator that can harness energy from human motion, powering devices such as smartphones and headsets without batteries. The device, called FENG, is flexible, biocompatible, and scalable, with advantages including being lightweight and robust.
Recent evidence suggests a link between the gut microbiome and colorectal cancer development, with specific types of intestinal bacteria contributing to disease progression. Dietary-based therapeutic interventions, such as probiotics and prebiotics, may help modify the gut microbiome to reduce CRC risk.
Researchers at Massachusetts General Hospital have developed a significant improvement in brain implant technology, allowing for selective activation of targeted neurons. Microcoil implants generate magnetic fields that extend in specific directions, reducing the risk of activation of passing nerve fibers.
Scientists have found that Jupiter's massive gravity may have formed rare, high-velocity meteorites called CB chondrites. These meteorites suggest Jupiter was near its current size and in the asteroid belt when they were formed, about 5 million years after the solar system solidified.
Researchers study organizing principles behind high Z' crystal structures to understand material properties like solubility and bioavailability. By analyzing complex structures, they identify organization principles tied to chemical molecule details.
Researchers from Berkeley Lab will present various talks on climate modeling challenges, permafrost, induced seismicity and drought sensitivity in mountainous watersheds. They aim to map regions sensitive to drought conditions using historical data and identify environmental controls.
A UNIST research team led by Professor Joonbum Bae received a commendation from the Minister of Public Safety and Security for their groundbreaking collaborative rescue robots. The award recognizes their work on humanoid avatar robots with a teleoperating system that can be deployed in disaster response.
Global breast cancer mortality rates declined between 1987-2013, with 39 countries showing a decrease, including the US and most developed European nations. However, South Korea experienced an 83% increase, while Latin America saw scattered increases in mortality, except for Argentina and Chile.
A new study found that smoking intensity and duration are crucial factors in coronary heart disease (CHD) risk. Researchers discovered that smokers with longer exposure to cigarettes face a higher relative risk of heart disease compared to those who smoke the same number of cigarettes over a shorter period.
The EPA awards $1.1 million in grants to Virginia's VIMS and DEQ to protect and restore its wetlands, advancing the state's goal of preventing net loss and increasing ecological function. The funding will support efforts to identify vulnerable wetlands, develop management plans, and inform decision-making for development and preservation.
A team of researchers used neutron scattering to study the origins of unusual magnetic behavior in a rare earth metal oxide, revealing three key features: antiferromagnetic interactions, spin space anisotropy, and chemical disorder. These findings provide a better understanding of how quantum spin liquids exhibit exotic behaviors.
A study of 129,535 Americans aged 50+ found that never-smoking older African American women had the highest COPD prevalence, with 7% and 5.2% in White women, respectively. Hormones and second-hand smoke exposure may contribute to this vulnerability.
A deadly avalanche in 2016 killed nine nomadic yak herders in western Tibet, with climate change cited as a likely cause. Researchers found that meltwater lubricated the ice, allowing it to flow quickly down the mountain.
A recent study by University of Illinois researcher Dorothy L. Espelage found that nearly half of middle school students reported experiencing verbal sexual harassment, with 43% saying they were targeted in the past year. The study also revealed that students who dismissed their experiences with sexual harassment were more likely to pe...
A pilot study at MD Anderson Cancer Center found that image-guided biopsies accurately predicted residual disease in breast cancer patients after chemotherapy and/or targeted therapy. The study suggests that certain patients may be able to avoid surgery, paving the way for personalized treatment.
Scientists at NIFS successfully measure flow reversal of negative ions, revealing U-turn trajectory and beam extraction point. The study's findings improve performance of negative ion sources, essential for future fusion devices.
A Michigan State University research team discovered that Campylobacter jejuni in undercooked chicken triggers Guillain-Barre Syndrome, an autoimmune disease causing paralysis. The study offers new information for a cure and suggests that treatment with some antibiotics could worsen the disease.
The VENEX project offers an alternative solution to road humps by reducing vehicle speed through energy extraction, ensuring safety and minimizing impact on drivers. The award-winning innovation aims to reduce traffic-related victims and costs, promoting a safer transportation system globally.
A $3 million NIH grant will help UTHealth researcher Nitin Tandon decode how the brain processes written words into language. The study, using intracranial electroencephalogram (icEEG), aims to understand the mechanisms of reading and its connection to the broader language system.
Researchers found that Atlantic killifish populations can adapt to lethal levels of pollution due to the aryl hydrocarbon receptor signaling pathway. The study suggests that desensitization of this pathway is a key factor in adaptation, but also highlights potential risks and compensatory adaptations.