Researchers from ETH Zurich have defined the three-dimensional structure of ABCG2, a human multi-drug transporter. The protein recognizes and transports over 200 substances, including toxins and medications, making it a double-edged sword in cancer treatment and drug development.
A new study by an international team of economists found that urban heat islands could increase the economic costs of climate change in cities by up to 2.6 times, with the worst-off city facing losses of 10.9% of GDP by the end of the century
A recent study found that self-regulation skills are a significant predictor of resilience in young people at risk of social exclusion. Helping these students acquire self-regulation skills, such as setting goals and coping with adversity, can equip them to do better in school and life.
Researchers have discovered that all entangled states of two particles have a unique classical fingerprint. This breakthrough enables the certification of quantum computers and encryption devices, ensuring their authenticity. The discovery uses a simple set of measurements to act as an identity check for any two-particle entangled state.
Researchers found that raising the age limit for Lynch syndrome genetic testing can detect new affected families who would not have been identified previously. This can lead to a reduction in deaths from the disease by over 60% over 15 years.
A recent study reveals that many children with inflammatory bowel disease (IBD) are not meeting the recommended daily intake of calcium and vitamin D. Experts warn that this can lead to poor bone health, development issues, and increased risk of permanent height deficits.
A high-fat diet from childhood may increase sensitivity to dopamine later in adulthood, leading to increased reward-seeking behavior. The study found that male rats exhibited increased locomotor activity and dopamine cell activity after a high-fat diet exposure.
Researchers found that soil microbes respond differently to shifts in moisture, with those from wetter areas respiring twice as much carbon to the atmosphere. This discovery suggests historical rainfall levels can impact climate modeling, improving predictions of local or regional differences in soil respiration and climate history.
Researchers at Osaka University found that the immune system promotes spontaneous heart regeneration after myocarditis. Cardiomyocytes can proliferate under specific conditions, such as inflammation, and this process is mediated by factors like STAT3 and interleukin 11.
Researchers identified a risk locus for urinary incontinence near the endothelin gene, which is involved in bladder contraction. The study suggests that drugs targeting this pathway may help alleviate symptoms, offering new hope for women suffering from stress and isolated urgency incontinence.
Researchers use aGPS tool to reconstruct ancient DNA, revealing complex and dynamic migration patterns across Europe. The study confirms the theory of massive Yamnaya migration to Central Europe and sheds light on ancient city-state formation.
A recent study reveals a 400% surge in premature and potentially preventable deaths of Australian nursing home residents over the past decade. Falls and choking were responsible for most unintentional deaths, with a smaller number attributed to clinical care complications or intentional acts such as suicide and assault.
Researchers found that higher body mass index (BMI) can cause worse cardiovascular health in young adults as young as 17, according to a study using data from the Avon Longitudinal Study of Parents and Children. The study suggests that tackling obesity from an early age may help prevent cardiovascular changes that are precursors to car...
A new titania photocatalyst has been developed to convert carbon dioxide into methane three times more efficiently than existing catalysts. The photocatalyst's controlled band gap improves light absorption and charge separation, increasing the conversion rate of CO2 into methane.
Researchers have created artificial viruses that can specifically target and destroy cancer cells by stimulating the immune system. The unique combination of alarm signals and cancer cell proteins enables the creation of a powerful army of killer cells to identify and destroy cancer cells.
A 10-year, $2.7 million project in Ontario reduced turtle deaths on a causeway by 89%, offering global lessons for protecting endangered species. The initiative included fencing, culverts, and public awareness campaigns to reduce roadkill, with significant success.
As ocean waters warm at a rate two to three times faster than the global average, commercially important species will continue to shift their distribution. This shift is expected to impact local fishing communities, as species now landed at those ports move out of range and new species move in.
Researchers discovered a biochemical signaling process that causes densely packed cancer cells to break away and spread the disease. The combined use of two existing drugs disrupts this process, significantly slowing cancer's tendency to travel.
Studies show a prevalence rate of 50-82% among hospitalized patients in Egypt's largest cities, while community-acquired MRSA rates range from 19-47%. Molecular characterization reveals various SCCmec types, highlighting the need for national surveillance and awareness.
Researchers at MIT developed a composite material inspired by conch shells, showing 85% better crack propagation prevention than traditional materials. The 3-tiered structure combines strength and toughness, allowing for individualized, personalized helmets and body armor.
The City College of New York is partnering with the University of Texas at El Paso to educate Hispanic doctoral students in environmental sciences and engineering. A $3.7 million NSF grant will fund the project, which aims to train and transition students to STEM instructional faculty positions.
A new study found that warmer nights due to climate change can lead to increased instances of insufficient sleep, with the poor and elderly being most affected. The research shows that a single month of nightly temperatures averaging 1 degree Celsius higher than normal could result in 9 million more nights of insufficient sleep.
Researchers at Penn State have created inexpensive molecular rulers for DNA research using new, license-free DNA ladders. These plasmids can estimate DNA fragment sizes between 50 and 5,000 base pairs in length, offering a cost-effective alternative to commercially available methods.
A Brown University study finds that HIV patients persisting with treatment has increased by more than 50% since 2001, with median duration reaching 35.4 months in 2004-2006. Despite progress, significant disparities remain, with certain groups facing higher discontinuation rates.
The LRO camera captured a wild and jittery image due to a sudden cross-track oscillation, indicating a brief violent movement of the left Narrow Angle Camera.
The INCA-Peru study developed an ultrafast CMR protocol, reducing scan time to 10 minutes and cost to $150, improving diagnosis and treatment outcomes in Peru. The test revealed new diagnoses in 20% of patients, changing clinical management in 33%.
Researchers will drill boreholes to study firn layer's structure and temperature, shedding light on heat absorption and sea level rise implications.
The study shows that open-access BRCA testing to Ashkenazi women enables the identification of carriers who would otherwise have been missed. Carrying one of the mutations for the BRCA genes means that women affected have a 50-80% risk of developing breast cancer and a 20-50% risk for ovarian cancer.
A study by the University of Seville found that laptop users tend to be older students with experience in pre-university education, while tablet users are typically younger females. The researchers warn of a potential 'Trojan horse' effect of devices on academic engagement, and emphasize the need for universities to invest in mobile le...
The 2015-2016 El Niño event was characterized by warmer ocean temperatures in the Pacific, with blue regions representing colder and red regions warmer temperatures. The El Niño-inducing westerlies caused eastward currents to occur in pulses.
TU Dresden will establish two new Collaborative Research Centres (CRCs) and continue a third CRC, receiving significant funding from the German Research Foundation (DFG). The new CRCs focus on interdisciplinary research topics such as vituperations and insults, and the adrenal's role in stress and disease.
Researchers from MIT, Harvard University, and Sandia National Laboratories report a new technique for creating targeted defects in diamond materials, which can function as qubits in quantum computing. The defects produced by the technique were found to be within 50 nanometers of their ideal locations.
Researchers developed a self-healing catalyst film that regenerates under water electrolysis conditions, enhancing hydrogen production efficiency. The film forms and regenerates through electrostatic attraction forces, allowing it to remain stable for several days.
Researchers have developed a chemical array technique that can identify and culture malignant stem-like cells within melanoma tumors. This allows for the creation of patient-specific models for individualized cancer treatment.
The Solar Dynamics Observatory (SDO) caught a partial solar eclipse in space when the moon passed in front of the sun. The lunar transit lasted almost an hour and covered about 89% of the sun's surface. The moon's rugged terrain, sprinkled with craters and mountains, influenced what was seen during the event.
Researchers found that squamous cell carcinoma is remarkably dependent on glucose as an energy source, with a protein called GLUT1 being highly active in the cancer. Elevated GLUT1 levels were also linked to other types of squamous cell cancers, including head and neck, esophageal, and cervical cancers.
Researchers found associations between Native American ancestry and various causes of death in Latin Americans. Mapuche ancestry was linked to gallbladder cancer and asthma, while Aymara ancestry was associated with increased risk of certain cancers.
Researchers have discovered that early lineages of fungi can form protein complexes capable of degrading plant biomass, teaming up to work more efficiently. The findings, enabled by a collaborative science initiative, could help advance sustainable biofuels production.
A new drug, sofosbuvir, has been found to significantly reduce liver transplant and mortality rates in patients with advanced stages of liver disease due to hepatitis C. This study involving nearly 1,900 patients showed a 40% reduction in the need for transplants after treatment with sofosbuvir.
Researchers found that statin users had improved left ventricular mass and volume, and reduced thickened heart muscle and large heart chambers. This suggests that statins may lower the risk of future heart attacks, heart failure, or stroke by reversing negative changes in the heart.
Research has found a strong association between particulate matter (PM2.5) and increased risk of heart attack, heart failure, and death. Higher education was found to be protective against the negative effects of PM2.5 on heart structure and function.
A recent dog DNA study has uncovered a genetic mutation linked to flatter faces in breeds like pugs and bulldogs. Researchers used CT scans to measure skulls and compared the results with genetic data, identifying variations associated with brachycephaly.
A study by UCL and University of Oxford researchers found that people tend to align their confidence levels when working in teams, even when one person has more expertise. This 'confidence matching' behavior can lead to poor decisions if individuals do not calibrate their confidence levels to the reliability of their opinions.
The University of Huddersfield has launched MIAMI-2, a £3.5 million microscope and ion accelerator facility, one of only three in Europe, enabling nanoscale investigation of radiation damage and advanced materials analysis.
Researchers found elevated levels of PFOA in Mid-Ohio River Valley residents, with 99.9% of samples testing positive for the contaminant. The study suggests that use of granular activated carbon filtration reduced exposure by up to 60%.
Scientists have developed a new technique to date ancient meteorite strikes using tiny crystal fragments. By analyzing the atomic nanostructure of these crystals, researchers can determine the age of impact and gain insight into the beginnings of life on Earth.
A study published in Plastic and Reconstructive Surgery found that motorcycle helmet laws in Michigan doubled the rate of facial and head injuries, including skull fractures. The researchers analyzed data from 4,643 trauma patients and found that unhelmeted riders were twice as likely to sustain CMF injuries.
A new study from WashU Medicine shows that stroke patients can regain some control over their paralyzed hands using a brain-computer interface. After 12 weeks of therapy, participants' scores increased an average of 6.2 points on a scale measuring motor skills.
A study found that coroners are unable to agree on cause of death or whether an inquest is needed, even with same information. This inconsistency can lead to delayed prevention of future deaths.
A team of scientists has provided a new evolutionary tree for Archaea, resolving their deepest relationships. The study suggests that early Archaea likely used the Wood-Ljungdahl pathway to make energy, dating back over 3.5 billion years.
Researchers at Scripps Research Institute have designed a mimic of the viral protein from a different HIV subtype, subtype C, to combat many strains of HIV. The new immunogen was tested in non-human primates and showed promising results in eliciting neutralizing antibodies.
For patients undergoing intestinal or multi-organ transplantation, closing the abdominal wall poses a difficult surgical challenge. Total abdominal wall transplantation provides an alternative for abdominal closure in these complex cases, according to a state-of-the-art approach presented in Plastic and Reconstructive Surgery.
A recent study by the University of Huddersfield found that a smartphone-based traffic light app can reduce drivers' stress levels, but its reliability is a major concern. The app's countdown feature frequently failed, leading to higher stress and slower response times to green lights.
A double-blind, placebo-controlled trial tested the 100-year-old drug suramin in boys with autism, showing significant improvements in language, social interactions, and restricted behaviors. The study's findings challenge the conventional view of autism as a fixed, genetically-driven condition and suggest a treatable metabolic syndrome.
A small clinical trial found improvements in language and social behavior, restricted repetitive behaviors, and coping skills in children with autism spectrum disorder after a single dose of suramin. The study suggests the cell danger hypothesis as a possible unifying theory for ASD, highlighting a potential new approach to treatment.
Tornadoes spawned severe weather in Florida, Georgia, and the Southeastern US on May 24, 2017, with intense rain showers reaching rates of over 8.5 inches per hour. The GPM satellite's data revealed powerful storms dropping heavy rain over the Gulf of Mexico and reaching heights above 9 miles.
Researchers at Nagoya University have developed a highly efficient catalyst that can break down even the toughest amide bonds in plastics under mild conditions. This breakthrough has significant implications for the recovery of materials from waste plastics and could help realize an anthropogenic chemical carbon cycle.
Scientists have discovered a genetic variant that enables the Mylopotamos Greek population to live long and healthy lives despite consuming an animal-rich diet. The variant, rs145556679, is associated with lower levels of 'bad' natural fats and cholesterol, reducing the risk of cardiovascular disease.
Scientists at the University of Cambridge have identified a plant protein crucial for communication with fungi, enabling mutually beneficial symbiosis. The study found that a transporter molecule helps plants signal to fungi, promoting nutrient exchange and improving crop yields.
Research from University of East Anglia and University of Glasgow highlights the positive impact of government intervention on angel investing in Portugal during economic crisis. The study found that fiscal incentives were not effective, while co-investment schemes and network support improved take-up rates.