A study published in Brain Connectivity found significant differences in functional architecture and interactivity of the default mode network in adolescent and young adult males with autism spectrum disorder compared to those without ASD. These findings could lead to the development of new imaging-based diagnostic markers for autism.
Aric Rogers' research discovered that NMD plays a critical role in extending lifespan under dietary restriction conditions. The grant will help expedite the development of 'DR mimetics,' drugs that mimic the effects of DR on longevity, potentially leading to new therapies.
A new sensor molecule allows researchers to visualize calcium concentrations in living animals without genetic modification or radiation exposure. This breakthrough enables better understanding of disease processes and has potential applications in improving medical treatments.
A high prevalence of complications related to opioid use disorders has been seen in emergency radiology patients, with skin and soft tissue infections, respiratory issues, and back pain being common. Imaging results often provided critical information to aid management plans and reduce mortality rates.
Scientists in Canada converted adult mouse respiratory tract cells into large populations of induced progenitor-like cells using an interrupted reprogramming strategy. These cells retained a residual memory of their parental cell lineage and showed potential as a cell replacement therapy in mice with cystic fibrosis.
The partnership aims to apply advanced chemical engineering research to industrial-scale chemical manufacturing, reducing waste generation, utility, and energy costs. The University of Pittsburgh's Chemical and Petroleum Engineering Department is developing new educational programs and internships to prepare students for the industry.
Researchers discovered that chemotherapy can stimulate tumor growth by inducing an inflammatory reaction in the body. Resolvins, a family of molecules, have been found to suppress this response, suggesting new ways to enhance cancer therapy effectiveness.
Researchers have imaged ATR kinase protein at unprecedented resolution using electron microscopy, revealing regulatory sites poised to activate in response to DNA damage. The high-resolution structural information may aid in developing new therapeutics for cancer treatments and improving cellular health.
The NIH has launched a Phase 2b proof-of-concept study called Imbokodo to assess the safety and efficacy of an experimental HIV vaccine regimen. The study aims to enroll 2,600 HIV-negative women in sub-Saharan Africa and will test the quadrivalent mosaic vaccine against placebo.
Research reveals a concerning relationship between excessive screen time and mental health issues, including depression and suicidal behaviors, particularly among teenage girls. Limiting screen time to an hour or two daily may help reduce the risk of depressive symptoms and suicidal attempts.
Researchers found genes associated with B cell receptor signaling and activation in tolerant kidney transplant recipients, suggesting an active immune regulation of B cells. The study provides insights into the mechanisms behind tolerance induction in renal transplantation, potentially leading to minimization of immunosuppression.
Research from Australia's NICM Health Research Institute finds large nutritional deficits in blood levels of critical nutrients among individuals with early psychosis. Vitamin B9 (folate) and D were found to be particularly low, associated with poorer mental health outcomes.
Researchers developed a system that allows citizens to monitor water temperatures and noise levels in real-time, generating live music from the marine world. The Sonic Kayak project demonstrates potential for transdisciplinary research, merging biosciences, remote sensing, sound art, coding, and sports.
The study reveals that protein ZO-1 perceives mechanical signals and activates cellular responses accordingly, influencing epithelial cell proliferation and differentiation. Targeted inhibition of ZO-1 in tumors could be a potential pathway to explore for cancer treatment.
Two Corynebacteria species have been identified as potential targets to improve skin appearance, with one associated with younger people and the other with older people. The 'old skin' bacteria was found to be associated with skin redness, wrinkles, and age spots.
The new Connectivity Map includes over 1.3 million gene expression profiles from multiple cell lines treated with chemical or genetic perturbations, enabling the study of small molecule and gene function. This expanded resource accelerates drug discovery efforts by predicting how small molecules work and discovering compounds with spec...
A team of researchers at Brigham Young University has identified a specific gene variant that protects people with high-risk genetic factors from developing Alzheimer's disease. The study reveals that this genetic function could be targeted with drugs to reduce the risk of Alzheimer's.
The Human Vaccines Project has reported high-level outcomes from two concurrent clinical studies aimed at deciphering the components and mechanisms of human immunity. The findings may provide important new insights into human immunity, which will be leveraged to launch expanded studies in 2018.
A recent study by Hokkaido University found that the global risk of Madagascar's pneumonic plague epidemic is limited, with an estimated risk of less than 0.1 person per country between August and October. The basic reproduction number was calculated at 1.73, and case fatality risk was 5.5 percent.
Teenage cannabis use at least 2-3 times weekly is directly associated with suffering from symptoms of hypomania in later years. The study found that adolescent cannabis use is an independent risk factor for future hypomania, suggesting a potential causal link.
A LSU Health New Orleans study found that DHA in fish oil 'preconditions' photoreceptor and RPE cells to survive future insults, reducing the risk of retinal degeneration. The researchers also discovered that daily omega-3 supplementation may provide an opportunity for halting debilitating eye diseases.
Researchers trained staff in Tanzania to assess facial cleanliness and found reliable measures of clean faces. These findings suggest adding facial cleanliness assessments to trachoma surveys in developing countries where the infection is a public health problem.
A team of scientists discovered that a major cause of variation between genetically identical C. elegans worms is their mother's age, particularly in younger mothers. The study found that the youngest mothers produce offspring with impaired characteristics such as size, growth rate, and starvation resistance.
A recent study has found that a cancer drug called nivolumab can drastically decrease the reservoirs of HIV-infected cells in the body, a key step towards potentially eradicating the virus. This breakthrough has been observed in a single patient with lung cancer, who showed a sustained reduction in HIV reservoirs after treatment.
Tropical Storm Dahlia formed under strong vertical wind shear, displacing its clouds north of the center. Infrared imagery revealed strongest thunderstorms north of the center, with cloud top temperatures as cold as minus 63 degrees Fahrenheit.
Research suggests that people's daily frustration with life can lead to recurring nightmares, where they experience falling, failing, or being attacked in their dreams. The study found that those whose psychological needs were not met reported more negative dream themes and struggled to interpret their dreams positively.
Researchers have obtained a detailed view of a scallop's visual system, which is strikingly similar to a reflecting telescope. The complex arrangement of up to 200 eyes allows the scallop to achieve spatial vision through a layered mirror structure that reflects specific wavelengths of light.
A collaborative study has identified a novel cluster of dysregulated genes in the pancreatic islets of patients with type 2 diabetes. The findings suggest that these altered genes are responsible for beta cell failure in diabetes and may hold new insights into how to prevent and treat the disease.
iScience is an open-access, peer-reviewed journal publishing on a continuous basis starting early 2018. It will promote rigorous research that advances a field and reporting with transparent methods, replication studies, and negative results. The editorial board harnesses experts across many different fields.
Researchers at Stellenbosch University found that HIV affects the brain in early stages of infection, leading to decreased blood flow and brain functional impairment. The study used fMRI scans to compare brain activity of people with and without HIV, revealing a link between frontal lobe atrophy and cognitive symptoms.
Research at Cornell University found that people with disabilities are nearly 44% more likely to be arrested by age 28 compared to those without disabilities. Black men with disabilities face a disproportionately high risk of arrest, highlighting the need for police training and healthcare improvements.
Researchers have validated five new genes responsible for Amyotrophic Lateral Sclerosis (ALS), a fatal neurological disorder. The study uses AI-powered technology to accelerate the discovery of new treatments by identifying key proteins linked to the disease.
A new study found that breast cancer proteins can have altered functions in tumor cells due to changes in protein interaction networks. This shift affects the number of genes performing each function, not their expression levels. The study predicts patient survival and cancer subtype based on these functional shifts.
Researchers have found a mechanism that prevents the formation of HIV's protein shell, which is essential for infection. The discovery could lead to the development of new anti-HIV drugs by targeting specific molecular processes.
Research shows that longer stays in the neonatal ICU are linked to behavioral problems and impaired emotional regulation in preterm babies. The study highlights the importance of developmental care programs to reduce stressful experiences and promote protective strategies during early development.
Researchers from QUT, KIT, and Ghent University create a light-switchable chemical reaction system to revolutionize chip printing. The system uses visible light to reversibly switch certain chemical processes, potentially making it cheaper, simpler and safer.
Researchers found that equatorial regions on planets like Proxima b and TRAPPIST-1d might trap ozone, hiding signs of life from telescopic observations. This discovery highlights the challenges in detecting life beyond Earth, requiring a more nuanced strategy for searching for life.
A 3D stem cell-derived intestine model has been developed that closely mimics the natural human response to gut infection. The model displayed key small intestine characteristics and exhibited an antibacterial response upon E. coli infection.
Researchers at Caltech have created bacteria that can produce chemical compounds with boron-carbon bonds, a breakthrough in synthetic biology. The findings could lead to more economical and environmentally friendly ways to manufacture pharmaceuticals and other products.
Solid-state batteries have the potential to replace flammable liquid electrolytes with solids, improving safety and energy density. Industry leaders like Toyota, Apple, and Bosch are investing in this technology, but high costs remain a major obstacle to widespread commercialization.
The HADES system creates a simulated environment that alters certain data points, leading hackers to doubt the authenticity of the information. This allows researchers to gather actionable intelligence and detect malware more effectively.
Researchers developed a computational simulation method to predict protein sequence changes for efficient membrane insertion, correlating improved insertion efficiency with increased protein yield. The new approach offers a way forward for membrane protein researchers struggling to express their proteins.
Researchers developed a novel model to study liver transplantation reperfusion and its impact on organ function. The new technique simulates the reperfusion stage of transplantation, allowing for better understanding of organ preservation and potential improvements in liver transplantation outcomes.
A €1.9 million research project will explore the complex roles played by marine planktonic fungi, known as mycoplankton, in the cycling of carbon in the sea. The MYCO-CARB project will use innovative approaches to assess active mycoplankton diversity and abundance across various ecosystems.
Researchers used drones to take aerial photographs of leopard seals, finding they can accurately estimate body size and mass. This non-invasive method could be used to assess body condition in other pinnipeds, tracking responses to environmental changes and managing marine ecosystems.
Research highlights the need to understand long-term health effects of extreme weather, including chronic psychological impacts and vulnerability in local infrastructure. Coordinated programs are essential for recovery and rebuilding, with healthcare facilities needing to ensure they can withstand disruptions.
Researchers at Kansas State University have developed a method to shield piglets from the devastating porcine reproductive and respiratory syndrome (PRRS) virus. The technique relies on eliminating the CD163 protein in pregnant sows, which acts as the virus's receptor.
Researchers at UNH used scientific sleuthing to better understand magma movement in Mount Etna, finding that ancient and present-day magma sources are similar. The study also revealed that crystals formed beneath the volcano were virtually chemically identical to erupted lavas, suggesting short crystal storage times.
A new study reveals the location of 20 whale shark aggregation sites globally, increasing knowledge of abundance and geographic range. The research also identifies sex-ratio bias, site fidelity and hotspot sites, improving conservation efforts for this endangered species.
A research team led by Prof. Robert Qi uncovered a previously overlooked mechanism controlling the organization of microtubule cytoskeletons. They found that PolD1 physically associates with γTuRCs, blocking microtubule nucleation and regulating various cellular activities such as Golgi assembly and cell polarization.
Research analyzed 43 trials involving 8,406 women and found that vitamin D supplementation increased birth weight and reduced small baby risk, but results were inconsistent and limited by study quality. Further large-scale trials are needed to determine the effectiveness of prenatal vitamin D supplementation.
Researchers have successfully grown graphene nanoribbons with a regular armchair edge, exhibiting a precisely defined energy gap. This enabled the integration of these structures into nanotransistors, overcoming previous challenges related to dielectric layers and ribbon alignment.
According to a new study, more than half of US children will have obesity as adults if current trends in child obesity continue. The study found that excess weight in childhood is predictive of adult obesity and that only children at a healthy weight have less than a 50% chance of having obesity as adults.
NIFA's Agriculture and Food Research Initiative program supports research, education, and extension projects that promote a safe, nutritious food supply. The funding enables scientists to investigate innovative approaches to detect and control contaminants in food, contributing to the production of high-quality, nourishing food.
Physicists at MIT and Harvard University have developed a new technique to manipulate quantum bits by trapping and arranging individual atoms. This breakthrough enables the simulation of complex systems like materials and optimization problems, such as the traveling salesman problem, exponentially faster than classical computers.
A new chemical imaging method allows for precise measurement of substances in human skin, providing opportunities to develop pharmaceuticals and cosmetics while minimizing animal experiments. The technology enables researchers to design products with controlled skin absorption and determine safe limits for harmful levels of substances.
Researchers investigate electronic charges that form stripe patterns in lanthanum nickelate, discovering unexpected dynamics when using terahertz laser pulses to disrupt microscopic order. The study provides fundamental insights into the interactions between electrons and crystal lattice vibrations.
A California survey found that physicians and pharmacists significantly increased their use of the state's prescription drug monitoring program, CURES, following a law mandate update and registration requirement. The study suggests that education and outreach efforts can drive greater compliance with the law.
Research by Jaehoon Lee suggests that lower class individuals are more likely to assume food will be less delicious due to poor service, while higher class people do not typically make this assumption. This holistic view of life creates a 'carryover effect', leading to negative judgments about other aspects of the consumer experience.
A new study by Vanderbilt University researchers found that dogs have significantly more cortical neurons than cats, indicating a higher level of intelligence. Dogs possess about 530 million neurons, while cats have around 250 million, suggesting that dogs are brainier than cats.