The technology involves delivering a human chemokine on site in wounds, increasing immune cell recruitment and specialization to accelerate healing. In preclinical studies, the treatment demonstrated potent effects on acceleration of wound healing in mice and models of diabetes and peripheral ischemia.
Researchers found that soils with more than 18% clay are associated with a steep drop in cases of chronic wasting disease. Additionally, soils with pH above 6.6 also show higher incidence rates of the disease. These findings could inform future management schemes to prevent disease transmission.
Research suggests that EGR3 and brain-derived neurotrophic factor (BDNF) play critical roles in the impaired cellular resilience seen in bipolar disorder. The study's findings may lead to new therapeutic strategies by modulating EGR3 expression.
The study reveals differences in oxidation behavior between crude oil and its SARA fractions, with saturated hydrocarbons oxidizing well under low temperatures. Asphaltenes emit more heat under higher temperatures, highlighting the direct link between SARA fraction ratios and oxidation behavior.
A recent study at the University of Jyväskylä found a surprisingly high level of mental well-being among middle-aged individuals. The research examined multiple dimensions of mental well-being and identified four groups with varying levels of mental well-being. Individuals on the high-wellbeing trajectories had more satisfying relation...
A study by University of South Florida researchers found that animal species are shifting the timing of their seasonal activities in response to changing temperatures and precipitation patterns. This shift can have adverse effects on ecosystems, human food supplies, and diseases.
Researchers at Arizona State University have discovered that ibrutinib can also target ERBB4, a lesser-studied member of the RTK family, potentially thwarting solid tumor growth. The compound limits growth in human cancer cells and reduces tumor size in mice.
A research team from Kumamoto University has discovered that ribosomes, the protein synthesizing organelle, can induce somatic cells to acquire pluripotency. This finding suggests a potential new approach for treating cancer and regenerating cells, as previously differentiated cells can be reprogrammed into multipotent stem cells.
A new study found that millions of unapproved antibiotics are being sold in India, with multinational companies manufacturing nearly 20% of the unapproved formulations. The researchers argue that banning the sale of unapproved FDC antibiotics and improving access to healthcare are crucial steps to controlling antimicrobial resistance.
Researchers at Osaka University have developed a novel CRISPR-Cas9 method that can introduce precise modifications to defective genes with fewer safety drawbacks. The new technique, called Single Nicking in the target Gene and Donor (SNGD), reduces unintended genetic mutations by up to 95%.
Researchers from Kumamoto University and VIMS used sediment samples to evaluate the effectiveness of marine anammox bacteria in removing excess nitrogen. The study found that adding a bicarbonate supplement and high nitrogen content was necessary for anammox bacteria to thrive, and that symbiotic relationships between other microorgani...
The study reveals that flowering plants diversified suddenly in the Cretaceous period, while molecular-clock dating suggests an older origin. The discrepancy is attributed to false precision on both palaeontological and molecular evolutionary timescales.
A Canadian Medical Association Journal study has found genetic variants associated with diseases and adverse drug reactions in 56 healthy participants. The results suggest that whole genome sequencing can benefit Canada's health care, but also highlight potential pitfalls and the need for careful evaluation.
Aalto University researchers have developed a new method called DALI (DNA-assisted lithography) to fabricate precise metallic nanostructures with designed plasmonic properties. The technique uses self-assembled DNA origami shapes as 'stencils' to create millions of fully metallic nanostructures. These structures have intriguing optical...
Researchers at U.S. Army Research Laboratory and University of Texas at Austin developed a new algorithm called Deep TAMER to train robots using human feedback. The algorithm enables robots to learn tasks in a short amount of time with accurate critique, improving performance on complex tasks like Atari Bowling.
Researchers have developed a quantum linear system algorithm that enables faster analysis of large data sets, outperforming classical computers. The new algorithm has the potential to revolutionize fields like commodities pricing, social networks, and chemical structures.
Researchers at Oregon State University discovered that compounds derived from hops can improve glucose intolerance, insulin resistance, and sensitivity to leptin in people with metabolic syndrome. The findings suggest that these compounds may be a promising treatment option for the condition.
A team of neuroscientists has discovered that specific taste neurons located in the fruit fly's proboscis are responsible for its protein craving. The study, published in eLife, identifies two groups of neurons that regulate the fly's feeding behavior.
Researchers detected objects in extragalactic galaxies with masses ranging from the Moon to Jupiter using microlensing. The discovery marks the first time planets have been found outside the Milky Way galaxy.
A new algorithm developed at the University of Waterloo will help first responders and home care providers identify elderly individuals who are most vulnerable during natural disasters. The algorithm uses data from interRAI's home care assessment to generate an up-to-date list of those who may need assistance.
Researchers at Lobachevsky University have synthesized a multifunctional compound with anti-tumor properties, achieved through the combination of a photoactive organic dye, biological vector, linker, and hydrophilizing fragments. The new compound selectively accumulates in tumor tissues due to its ability to bind to growth factor recep...
Mutations in p63 protein lead to severe genetic disease AEC syndrome, which resembles Alzheimer's, Parkinson's or ALS more closely than other syndromes. The research lays groundwork for causal therapies by showing that protein aggregates underlie the disorder.
A recent study found that patients who lost at least 8 percent of their excess weight just one month before undergoing bariatric surgery had a 7.5 percent greater weight loss at the 12-month post-surgery mark compared to those who did not achieve this goal.
Researchers found genetic clues to distinct susceptibility to virus infection in congenital Zika syndrome, using Brazilian twin babies with different outcomes. The study revealed a single gene cannot explain the cases of CZS development nor brain resistance to Zika virus.
A new study highlights the need for more structured educational programmes and information on disease progression to prepare informal carers. The research found that existing health and social care services are often fragmented, leading to communication challenges between healthcare professionals and caregivers.
Researchers analyzed blood samples from nearly 10,000 people and found gene variants associated with intrinsic and extrinsic epigenetic age acceleration. Variants in the TERT gene were linked to older epigenetic aging rates and longer telomeres, highlighting its critical role in regulating the epigenetic clock.
A Wits University PhD student has solved part of the evolutionary puzzle of multicellularity by studying the genomic sequence of a four-celled algae. The research identified the ubiquitin proteasomal pathway as a process controlling cell division, which played a key role in the evolution of multicellularity.
Researchers found naturally occurring circular rotation in an atomic monolayer crystal of tungsten diselenide, a promising candidate for valleytronics. Controlling this rotation could provide a stable mechanism to carry and store information. The discovery opens possibilities for creating rotors at the molecular scale.
Grape-derived polyphenols, such as DHCA and Mal-gluc, may attenuate depression by targeting inflammation and synaptic plasticity. The study found that these compounds can promote resilience in mouse models of depression by modulating immune responses and brain function.
Scientists developed a new technique to precisely measure the temperature and behavior of two-dimensional materials, enabling the design of smaller and faster microprocessors. They used scanning transmission electron microscopy combined with spectroscopy to measure the temperature at the atomic level.
Researchers at University of Copenhagen develop edible QR code technology that enables precise dosing and storage of medical data, reducing wrong medication and fake medicine. The technology has the potential to transform the pharmaceutical supply chain and enable innovative production of personalized medicine.
Researchers identified unique mitochondrial defects and alterations in metabolic gene expression associated with aggressive triple-negative breast cancers. The findings provide new molecular biomarkers to identify patients at risk for metastasis and offer potential therapeutic targets.
Researchers found that genes in neural progenitor cells of affected babies were more active or less active in key signaling pathways, contributing to the development of congenital Zika syndrome. The study used twins and induced pluripotent stem cell technology to replicate the virus's effects in vitro.
Researchers at Georgia Tech and Oak Ridge National Laboratory use neutron beams to illuminate presenilin, an intramembrane protease that chops protein building blocks. The study reveals a simpler protein structure than expected, with two chemical knives for cutting peptides.
A recent study found that men who endorse male dominance tend to view women as either chaste and good or promiscuous and bad, leading to objectification and restricted sexuality. This reinforces gender inequality and negatively affects both men and women's well-being.
Studies found tumors in tissues surrounding nerves in male rat hearts at high radiofrequency radiation levels, but not female rats or mice. Researchers also noted damage to heart tissue and increased cancer risk in exposed animals.
A review explores the applications of neuroscience in law, highlighting the need for clear guidelines to balance potential benefits with civil liberties. The use of neuroscientific evidence raises concerns about individual rights and privacy, particularly in determining guilt and intent.
Engineers at Rigetti Computing have developed a technique to reduce qubit interference, allowing for the creation of larger practical quantum processors. This breakthrough enables the retention of logical operations independent of the state of a large quantum register.
A new study at D'Or Institute for Research and Education uses Magnetic Resonance machine to read participants' minds and identify the song they're listening to. The computer achieves 85% accuracy in identifying the correct song, paving the way for future research on brain decoding and communication.
Researchers studied woodpecker brains for tau protein accumulation, a sign of brain damage in humans. The study suggests that the accumulation might be a protective adaptation rather than indicative of injury, which could have implications for human neurodegenerative diseases.
Mercury is a toxic contaminant with significant health risks to humans and wildlife, primarily through methylmercury in fish consumption. The international treaty on mercury, the Minamata Convention, has been ratified by 84 nations, emphasizing the need for scientific understanding to inform policy decisions.
Scientists successfully detected holes and identified their trapping sites after photoexcitation, revealing that photo-excited holes become trapped in substrate at singly charged oxygen vacancies. The detection opens up new insights for the development of devices and nanodevices based on transition metal oxides.
Researchers have created a new surface design featuring rigid scales assembled into soft, ferromagnetic micropillars on a flexible substrate. The nanostructured silicon scales enable fluid and light manipulation, with tunable wetting, droplet manipulation, and structural coloration demonstrated.
The IMAGE mission used novel techniques like energetic neutral atom imaging to render the invisible visible, capturing large-scale images of the surrounding plasma and revealing new discoveries about Earth's magnetosphere and plasmasphere. This groundbreaking research continues to guide science today.
A mass grave uncovered in Repton, Derbyshire, has been dated to the late 9th century, consistent with the Viking Great Army's presence in England. The graves contain a mix of men and women, including several with signs of violent injury, suggesting a possible ritual burial site.
Researchers found that multiple motor proteins work together to deliver cargo, similar to ants carrying a large item. In mutant worms, fewer carriers were observed, weakening cargo transport and causing mis-location of synapses.
A new study suggests that analyzing street drugs can serve as an early warning system for the opioid crisis. The University of Pittsburgh Graduate School of Public Health has developed a method to quickly analyze stamp bags, which contain mixtures of illicit drugs, to detect fentanyl and other high-lethality substances.
Researchers from NSF LTER sites present findings on coastal and ocean ecosystems, including salt marsh resilience and the impact of sea ice patterns on penguin populations. The study also investigates the diet of blue whales in the California Current and the effects of El Niño events on marine ecosystems.
Researchers have discovered that modern cheetahs possess a distinct vestibular system in their inner ear, which enhances sensitivity and rapid responses to head motions. This unique anatomy allows the cheetah to maintain its gaze locked on prey during high-speed hunts.
Researchers at MSU have discovered a molecular timer that regulates protein synthesis, preventing extra molecules from being produced. The mechanism uses stalling ribosomes to control protein production, which could help combat cancerous tumors.
Researchers found that adding cetirizine to standard therapy significantly reduced annualized relapse rates in patients with neuromyelitis optica, a rare disease causing inflammation and demyelination. The study suggests that cetirizine may be beneficial in preventing relapses by modulating eosinophil activity.
Researchers identified TNF-alpha and VEGF as key cytokines in tumor vascularization. Targeting these molecules simultaneously could significantly increase the efficacy of existing cancer treatments.
Researchers found that Bacteroides fragilis and Escherichia coli bacteria work together to create a microenvironment that induces chronic inflammation and DNA damage, supporting tumor formation. This discovery could lead to more effective screening and prevention strategies for colon cancer.
A new study published in Scientific Reports suggests that low doses of alcohol may be beneficial for brain health, reducing inflammation and improving the brain's ability to remove waste. This finding adds to growing research linking lower levels of drinking with a reduced risk of cardiovascular diseases and certain cancers.
The University of Pennsylvania School of Nursing article highlights the importance of carefully using language when discussing end-of-life futility with patients and families. Clear communication can alleviate suffering and provide comfort during a challenging time.
NASA and Japan's GPM core satellite tracked heavy rainfall from Tropical Cyclone Fehi's remnants in New Zealand. Rainfall rates exceeded 268 mm/h, with some areas experiencing intense storms that dropped over 10 inches of rain in just 12 hours.
Researchers have discovered a new mechanism by which mitochondria regulate protein synthesis in response to oxidative stress. Using quantitative mass spectrometry and biochemical methods, the team identified redox-active thiols that can slow down cellular protein synthesis machinery when reactive oxygen species are present.
A recent study by University of Exeter researchers has identified three main themes influencing GPs' decisions to leave or remain in direct patient care. The findings highlight concerns about the under-value of general practice within the healthcare system, professional risk in delivering care, and considerations about career options.
A new study from City, University of London, University of Oxford, and Yale University shows that people exhibit an 'optimism bias' when learning about others, with stronger vicarious optimism for those they care about. This bias affects how much people change their beliefs after receiving good or bad news.
The GOLD mission provides unprecedented measurements of Earth's upper atmosphere, tracking day-to-day changes in temperature and composition. By imaging ultraviolet light, GOLD will create a map of the hemisphere revealing how these forces impact our technological society.