Associate Professor Jeffrey Rimer received the award for his pioneering research on crystallization, including the discovery of a natural fruit extract that can dissolve calcium oxalate crystals. His work has transformative implications for drug development and has led to human clinical trials underway.
The employment-to-population ratio for working-age people with disabilities increased by 10.3 percent, while the labor force participation rate rose by 7.1 percent in January 2018. Targeted funding initiatives are helping employers connect with jobseekers with disabilities, leading to a record trend of two years of job growth.
Tropical Cyclone Cebile maintained its status as a major hurricane with sustained winds of 126.6 mph and an estimated eye visible through NASA's MODIS instrument. The storm is expected to weaken and turn southeast under adverse conditions.
Researchers developed a novel probabilistic approach to mine big data, enabling the creation of an 'Optimal Information Network' (OIN) for assessing health outcomes in U.S. cities. The OIN identified poor and favorable health metrics, with some cities showing high variability over time.
A new study by NYU Langone Health found that extending natalizumab dosing intervals from every 4 weeks to 5-12 weeks significantly reduced the risk of developing progressive multifocal leukoencephalopathy (PML), a rare but potentially fatal brain infection. The extended dosing regimen resulted in a 94% reduction in PML risk.
Researchers at EPFL have developed a systematic understanding of sequential deposition reaction for metal halide perovskite formation. The study used X-ray diffraction analysis, scanning electron microscopy, and cross-sectional photo-luminescence mapping to investigate the crystallization of lead iodide and perovskite film formation.
Scientists have identified the OTUD7A gene as a key contributor to the clinical characteristics of 15q13.3 microdeletion syndrome, a complex neurological condition. The study found that mice deficient in the gene Otud7a have fewer dendritic spines, which may be related to the neurological deficits observed in patients.
A rare 200-million-year-old ichthyosaur specimen of the new species Wahlisaurus massarae has been discovered in a UK private collection. This fossil is only the second known example of this species, previously discovered by Dean Lomax in 2016.
The Clinical Pharmacogenetics Implementation Consortium has published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in women with early-stage estrogen receptor-positive breast cancer. The guidelines recommend alternative hormonal therapies based on CYP2D6 genotype, aiming to improve tre...
Researchers discover piRNAs, small RNA molecules that identify and silence foreign genetic sequences in cells. The study sheds light on a basic mechanism affecting fertility in animals.
A widely used parental guidance program has been shown to reduce domestic conflict and boost economic resilience in South Africa's poorest communities. The Sinovuyo Caring Families Programme for Parents and Teens transformed family relationships in severely at risk communities, improving teenagers' safety and family relationships.
A study published in Biological Conservation found that widespread insects are threatened with a decline in species diversity, genetic diversity, and ability to adapt to environmental changes. The research highlights the importance of maintaining genetic diversity through population exchange for common species.
Researchers at UT Southwestern's Simmons Cancer Center have made a historic breakthrough in CAR-T therapy for acute lymphoblastic leukemia (ALL) in children and young adults. Eighty-one percent of patients treated with CAR-T therapy went into remission, offering new hope for those previously untreatable.
Researchers at Harvard Medical School have identified the molecular machinery responsible for precise dopamine release in the brain, challenging current models of dopamine signaling. The study found specialized active release sites that enable fast and spatially precise secretion of dopamine.
A new study suggests that wastewater injection depth is a critical factor in inducing earthquakes. Simulations using an advanced computer model reveal that limiting depth to 500 meters above the basement can reduce seismic energy release by a factor of 2.8.
A comprehensive genetic study reveals that multidrug-resistant malaria parasites emerged and spread aggressively in Cambodia, under-reporting for years. Ongoing genomic surveillance is vital to inform public health malaria control strategies and detect patterns of resistance.
The Berlin Institute of Health (BIH) recognizes Professors Louise Pilote and Rhonda Voskuhl for their pioneering work on sex and gender differences in cardiovascular diseases and multiple sclerosis. Their research focuses on incorporating gender aspects into medical practice.
Researchers found patients and doctors disagree on surgical scarring evaluation 28% of the time, with patients focusing on depth and physicians on coloration and texture. This highlights the need for better assessment methods and improved preoperative counseling.
Researchers have developed a method for mass preparing cellular aggregates called 'hair follicle germs' that may lead to new treatment for hair loss. The therapy involves regenerating hair follicles, the tiny organs that grow and sustain hair, on a large scale.
Researchers recruited 61 PTLDS patients and 26 healthy controls for a comprehensive clinical and laboratory evaluation. They found significant differences in questionnaire results, with PTLDS patients reporting severe fatigue, pain, cognitive complaints, and sleep difficulties.
A new study reveals how basal cell cancer responds to treatment and offers new ideas for controlling this disease. The researchers found that the relative location of a cell within a tumor can have a big effect on its sensitivity to drug treatment.
Researchers from the University of Tokyo have discovered a molecule called progranulin that plays a crucial role in strengthening and eliminating synapses in the brain. This process is essential for developing neural circuits, but genetic or environmental mutations can disrupt it, leading to disorders such as autism and dementia.
A large Finnish cohort study found that the risk of death by suicide among hospitalized patients with depression has decreased by half since 1991. The study tracked 56,826 patients and attributed the decline to various factors, including improved treatment for depression and increased access to psychotherapy.
Researchers from Trinity College Dublin have developed new tools to circumvent the reactivity of cubane, a widely used pharma industry molecule. This breakthrough enables the creation of tailored compounds with improved drug efficacy and reduced side effects.
Young people in care benefit from social media by maintaining healthy birth family relationships and friendships, making new connections, and easing transitions. Social media provides emotional support, increased self-esteem, and mental well-being, helping reduce stigma and shame associated with being in care.
Scientists at the University of Waterloo have captured the first images of ultrafast photons that are energy-time entangled, enabling direct applications for quantum cryptography and communication protocols. This technique will allow for establishing highly secure communication channels over long distances.
Researchers have developed 'hairy' nanoparticles that can assemble and disassemble on demand, allowing for simultaneous delivery of therapeutic drugs and heating to cancer cells. This technology combines light-sensitive materials with water-repelling yet light-absorbing materials to create photo-responsive gold nanoparticles.
A new study by the University of Bristol found that Oklahoma's seismicity is strongly linked to fluid injection depth. The team used a powerful computer model to examine the connections between injection volume, depth, and location, as well as geological features.
A new supplement in Pediatrics synthesizes research on congenital Zika syndrome, exploring prevention, development profiles, and family support. It highlights the need for accurate information, active surveillance, and formal support services to address the ongoing health impact of Zika virus.
A study published by NYU Steinhardt School finds that all children with disabilities experience violence from birth in West Africa. Violence begins as soon as children are born, and varies depending on the type of impairment.
A new study by the University of Sheffield found that adults with acute lymphoblastic leukaemia living in deprived areas have a 15-20% higher risk of dying. Hospitals treating small numbers of leukaemia cases also have significantly lower survival rates.
A study by the University of Sheffield found China has more football statues than any nation apart from the UK and boasts the world's largest football statue. The design and location of these statues reflect China's failure to join football's top nations and its future ambitions.
Researchers found that 14 out of 16 satellite galaxies of Centaurus A orbit in a single plane and rotate coherently. This synchronized movement contradicts standard cosmology simulations, suggesting flaws in current theories of galaxy formation.
A new study from the University of Missouri found that Instagram users are drawn to social news and entertainment content, but less likely to engage with political or controversial images. Researchers identified strategies for increasing engagement with audiences, including presenting news images in aesthetically pleasing ways.
Researchers have developed a method to selectively mark multipotent stromal cells in mice using the CD73 gene, allowing for the analysis of their distribution pattern and function in living organisms. This breakthrough enables the study of these stem cells in their original state, providing insights into their role in regenerative medi...
A new study found that geese reduce their metabolic rate to cope with winter by lowering their heart rate and body temperature. By doing so, they can conserve energy in the harsh cold conditions.
The study's findings highlight the importance of radio channel characteristics in optimizing smart agricultural sensor network performance. By analyzing these characteristics, researchers can minimize interference and increase system capacity.
Researchers develop MARIO, a fluorescent probe that measures magnesium ion concentration, showing its critical role in chromosome condensation. The study provides a new mechanism for chromosome organization and may help understand diseases like cancer.
Researchers have used novel infrared laser techniques to study methane scattering on a nickel surface with full quantum-state resolution. This breakthrough allows for the observation of vibrational energy redistribution during surface scattering, which can be tested by state-of-the-art quantum theories.
A study by Toyohashi University of Technology found that cell membrane components form isolated domains within an artificial lipid bilayer, separated from the surrounding membrane. The findings provide valuable information for understanding membrane protein functions and developing experimental techniques.
New scientific statement highlights potential heart damage from breast cancer treatments and suggests strategies to minimize risks. Lifestyle choices, such as diet and exercise, can also help decrease the risks of developing both diseases.
Scientists analyzed geochemical and isotopic markers to suggest a cosmic impact triggered the disaster, which consumed 10% of the Earth's land surface in fires. The study provides evidence for human cultural shifts and population declines during this period.
PSMA PET/CT detects prostate cancer recurrence earlier than current imaging modalities, enabling more effective salvage radiotherapy. Nearly half of patients with biochemical recurrence show positive results, with lesions often found in bone and perirectal lymph nodes.
Researchers analyzed daily social encounters of 1,450 residents to better understand epidemic growth. They found that age and day-to-day variation play a significant role in shaping these patterns.
Researchers discovered complex patterns of electrical impulses in brain neurons, with repeating rumblings and spikes sustaining activity for hundreds of milliseconds. These findings suggest that neurons may not fire randomly, but rather follow structured rhythms that could influence our understanding of their function.
Researchers at the University of Alberta discovered that injecting a drug called chondroitinase ABC into the spinal cord can enhance recovery in stroke victims. The therapy, combined with rehabilitative training, showed significant improvements in sensorimotor deficits and allowed subjects to perform tasks at pre-stroke levels.
A study of 9500-year-old bone samples found that people from western Norway were genetically similar to those east of the Baltic Sea in Russia, while eastern Scandinavians were more similar to central and western Europe. The discovery highlights multiple waves of migration to Scandinavia.
Agroforestry systems have been shown to significantly increase soil organic carbon stocks, with an average increase of 34% from agriculture to agroforestry. The transition also showed increases in deeper layers, especially when including perennial plants.
A recent study published in the Journal of Epidemiology and Community Health found that people with anxious personalities are more likely to be bitten by dogs. The survey revealed nearly three times the actual number of dog bites as hospital records indicate, suggesting a higher risk for anxious individuals.
Exercising regularly before surgery for lung cancer halves the complication rate afterwards, with a 48% reduction in postoperative complications. Exercise also reduces the length of hospital stay by almost three days, according to a pooled analysis of 13 clinical trials involving 806 participants.
Platelets have been found to act as the immune system's first responders when a virus, bacterium, or allergen enters the bloodstream. They release serotonin, which triggers an inflammatory response in mice with antigen-antibody complexes, leading to septic or anaphylactic shock.
A randomized trial found that induced labor at 39 weeks significantly reduced cesarean birth rates compared to expectant management. Healthy, first-time mothers who underwent elective induction had lower rates of preeclampsia and respiratory support for their newborns.
Researchers have developed a new therapeutic approach to enhance bone healing by delivering additional Jagged-1 protein at the site of injury. In a study published in npj Regenerative Medicine, rodents treated with Jagged-1 showed improvements in skull and femoral bone injuries, unlike BMPs which caused excessive bone growth.
Researchers developed a new self-efficacy scale to assess employees' ability to manage tasks, negative emotions, and interpersonal relationships. The findings show that high self-efficacy in these areas leads to better job performance, reduced counterproductive behavior, and improved well-being.
The discovery suggests that the increase in oxygen in the biosphere triggered the addition of supplementary amino acids to form more functional proteins. The newer amino acids have systematically softer chemistry, making them more reactive and prone to undergo chemical changes.
Physicists at Aalto University found friction in superfluid helium-3 isotopes despite being in laminar motion at zero temperature. The discovery could help understand turbulence in classical fluids and improve aerodynamics, as well as contribute to studying neutron stars.
A genetic study reveals that multidrug-resistant malaria in southeast Asia originated from a single mutation combination in 2008, which spread rapidly across the region before becoming apparent in 2013. The study highlights the need for close monitoring of genetic mutations to mitigate resistance and prevent further outbreaks.
Researchers demonstrated reliable transmission of stable frequency references over 300km fiber optic networks, enabling synchronization of radio telescopes. This technology could benefit astronomy, particularly for the Square Kilometer Array (SKA), allowing scientists to access the frequency standard anywhere.
Researchers Jos Jonkers and Helen Piwnica-Worms receive a grant to investigate how the immune system recognizes breast cancer. They will use imaging mass cytometry and patient-derived models to devise new treatment combinations, accelerating promising therapies to patients.
Researchers have developed a new method to quantify protein-metabolite interactions, discovering hundreds of new interactions and binding sites. The approach has the potential to identify new regulatory mechanisms, enzymes, and metabolic reactions in cells.