A 69-year-old male patient was conscious during CPR after a cardiac arrest, despite efforts to restore a pulse and circulation. The study suggests that the high level of patient awareness was due to good peripheral and cerebral blood flow, but raises questions about proper sedation during resuscitation.
Researchers found evidence that the Earth's continental crust could have formed hundreds of millions of years earlier than previously thought, suggesting a habitable environment for life. The study used unique instruments to count strontium atoms in ancient rocks and found silica presence, altering the classic view of early Earth.
Scientists have developed a new technique using nanoparticles called NanoFlares to quickly and accurately predict excessive scarring. The method involves applying the nanoparticles to closed wounds and using a fluorescence microscope to detect signals given out by the nanoparticles' interaction with target biomarkers.
Researchers have discovered an experimental drug that can restore some bladder function after spinal cord injury in mice, potentially reducing the risk of bladder infections and incontinence. The drug works by blocking abnormal neural communication and appears to maintain near-normal bladder pressure and reduce unexpected urine expulsion.
Researchers have made a groundbreaking discovery of accelerating activity before a 2016 earthquake in central Alaska. The study found evidence for very low-frequency earthquakes, which do not typically exhibit the usual P and S waves associated with typical earthquakes.
Researchers discovered that a gene associated with human intellectual ability is necessary for normal memory formation in mice. Mice with the gene deletion replay shorter fragments of their previous experiences during periods of rest, impairing their ability to consolidate memories.
A recent analysis published in Health Affairs estimates that eight million amenable deaths occurred globally in 2015, costing $6 trillion in lost economic welfare. The study highlights the need to strengthen health care systems to boost quality of care and address economic disparities.
Tropical Cyclone 05W formed near Vietnam on June 2, moving northwest and intensifying into a tropical depression. NASA's satellite imagery shows the storm's center south of Hainan Island, with forecasters predicting landfall in southeastern Hainan by June 5.
A quality improvement initiative at Boston Medical Center used non-pharmacologic approaches to care for infants with neonatal abstinence syndrome, resulting in decreased medication use, length of stay, and health care costs. The new approach included skin-to-skin contact, breastfeeding, and parental presence, leading to significant imp...
A new study suggests that wild swings in oxygen levels may have sent life scrambling to adapt, leading to a major burst of diversity during the Cambrian period. The research, published in Geology, proposes that extreme fluctuations in oxygen levels, rather than gradual increases, triggered the explosion of life forms.
By replacing cysteine with selenocysteine, researchers have created biologically stable proteins that can survive longer in the human body. This breakthrough could lead to smaller, less frequent doses of medicine, lower healthcare costs, and fewer side effects for patients with cancer and other diseases.
A clinical trial shows that an immune checkpoint inhibitor can shrink tumors in nearly half of patients with advanced cutaneous squamous cell carcinoma. The drug, cemiplimab, works by blocking PD1, a surface receptor on T cells that shuts down immune response to cancer.
A new clinical trial analysis found that combining an aromatase inhibitor with ovarian function suppression yields a 10-15% improvement in freedom from distant recurrence for high-risk younger breast cancer patients. Women at low risk saw minimal benefit, while those at intermediate risk gained a 4-5% advantage.
A randomized clinical trial found that a preschool home visiting program improved child academic performance, social-emotional adjustment, and reduced home problems in third grade. The intervention promoted gains in these domains, mediating significant reductions in child need for educational and mental health services.
Recent study reveals supports in atomically dispersed catalysts play a significant role in catalysis, not just as ligands. The findings suggest that metal atoms on the support can directly participate in the activation of reactants.
A new blood test using cardiac myosin-binding protein C (cMyC) can rapidly rule out heart attacks in more people than the standard troponin test, freeing up hospital bed space and resources. The test is sensitive enough to give an almost immediate diagnosis, which could save hundreds of thousands of pounds per UK hospital every year.
Pilot data shows that short sleep duration is associated with a double risk of hospital readmission in acute coronary syndrome patients. The study found that patients with less than 6 hours of sleep per night were two times more likely to be rehospitalized within 30 days.
Research published in the European Journal of Preventive Cardiology found that stressful jobs are associated with a higher risk of atrial fibrillation. The study included 13,200 participants and found that employees with stressful jobs were almost 50% more likely to develop the condition.
Researchers found ancient lake mud and fly species that record two interglacial periods in northwest Greenland, revealing warmer temperatures than previously thought. This discovery could improve climate models and predictions of how the ice sheet might respond to man-made global warming.
A new study suggests inadequate sleep has grave economic consequences, affecting over 33% of Australian adults and costing billions. The financial cost of $17.88 billion represents 1.55% of the country's GDP.
A recent study by a multi-institutional team identifies new linkages between quorum sensing activity and sugar metabolism in the gut, using AI-2 as an autoinducer secreted by various species of bacteria.
Researchers found that activating inflammatory signaling in heart cells can lead to abnormal electrical patterns similar to those observed in atrial fibrillation. This suggests a potential new target for therapies aiming to treat the condition.
Researchers at the University of Tsukuba and the University of Dayton discovered a novel gene, Newtic1, expressed in red blood cells that may contribute to adult newt limb regeneration. The study found that Newtic1-expressing erythrocytes play a crucial role in releasing growth factors into regenerating blood vessels.
Researchers have successfully replicated ovarian tumors inside chicken eggs, paving the way for patient-centred cancer treatment. The 'chicken egg tumour model' allows for rapid testing of anti-cancer drugs tailored to each patient's needs.
A study found that providing chocolate cookies to students improved their evaluation of teachers and teaching materials. This simple intervention had a significant effect on course evaluation results, suggesting that standardized tools like end-of-course evaluation surveys may not accurately measure the quality of education.
Researchers at North Carolina State University have created ChemMaps, a webserver that allows users to interactively navigate the chemical space of over 8,000 drugs and 47,000 environmental compounds in 3D. The platform features two main maps: DrugMap and EnvMap, which include approved drugs and environmental chemicals, respectively.
A study published in the Journal of the American Academy of Child and Adolescent Psychiatry found an association between preschool and school-age irritability and aberrant reward-related brain connectivity. This suggests possible mechanisms underlying mood dysregulation in youth with increased irritability during these developmental st...
Researchers at the University of Toronto found that vervet monkeys use heuristics to plan their routes when foraging for food, finding relatively short paths without much thought. This ability is similar to that of humans and highlights the cognitive abilities of these primates.
European countries showed no short-term aggravation of health inequalities following the 2008 financial crisis. In fact, mortality trends among low and high education levels remained steady in western European countries, while a decline in less-than-good self-assessed health accelerated in some eastern European nations.
Researchers developed a statistical approach combining astronomical theory and rock formation data to estimate Earth's axial precession rate and distance from the Moon. The study also reconstructed periods of astronomically influenced climate cycles, providing insights into ancient Solar System behavior.
A novel actuating material system, nickel hydroxide-oxyhydroxide, has been developed at HKU Engineering that can be triggered by visible light and electricity. This material can exert a force equivalent to 3000 times its own weight, making it suitable for various applications in micro-robotics, human assist devices, and medical devices.
A quality playground experience is crucial for elementary school children's physical, cognitive, social and emotional development. Researchers found that engaged adults, smooth transitions, and abundant play equipment are key factors in a high-quality recess experience.
The ILLUMINATE-204 trial shows an overall response rate of 38% with 2 complete responses, suggesting a promising strategy for treating patients with metastatic melanoma unresponsive to PD-1 therapy. The combination regimen is generally well-tolerated, with fewer than a quarter of patients experiencing immune-related toxicities.
Researchers have developed a new approach using synthetic hydrogel particles to educate the immune system to accept transplanted insulin-producing islets. The technique could allow for an 'off-the-shelf' therapy for type 1 diabetes without long-term immune suppression, potentially treating millions of people worldwide.
Review papers explore how technology will change cardiovascular care, with artificial intelligence enhancing personalized medicine and digital health accelerating clinical research. Mobile health advances track physical activity and fitness, promoting heart-healthy habits.
Researchers used ESMD and BGSA to study temporal and spatial patterns of drought in the Yellow River basin. The results showed that drought frequency varied by season, with summer being the driest, and suggested targeted drought resistance measures for the region.
A study led by Drexel University's Amanda Lough has shown that East Antarctica is seismically active, contradicting the long-held assumption that its inactivity was caused by ice. The seismic array detected 27 earthquakes in 2009, tripling the total number of recorded events.
A survey of Russian teachers found that those using performance-based contracts are more satisfied with their finances and have greater trust in the system. However, excessive assessment procedures can reduce teaching time.
A recent study found that sleep paralysis and dream-like hallucinations are prevalent in student athletes, with 18% and 24% of the sample reporting occasional experiences. These symptoms were independently associated with symptoms of depression, even after controlling for sleep duration and quality.
Researchers at UCLA have developed a personalized glioblastoma vaccine that shows promise in increasing long-term survival. The vaccine, known as DCVax-L, has been shown to extend median survival time from 15-17 months to 23.1 months.
Researchers at the University of Illinois have developed an algorithm that combines high-resolution and high-frequency satellite data to produce continuous, daily images. This allows for near-real-time monitoring of various applications, including agriculture, urban development, environmental quality, and economic development.
A recent study found that virtually all of Madagascar's native predators are highly sensitive to the toxic bufadienolides secreted by invasive Asian toads. This could have a significant impact on the island's already threatened fauna, including iconic species like tenrecs and fossa.
A new study reveals that ultracold paired particles called fermions behave even weirder than expected, flying with unique trajectories carved by spins, momenta, and energies. The researchers predict that fermions can mimic the behavior of bosons, adding new weirdness to the already established particle-wave duality.
Researchers found that proxies who viewed a 12-minute advanced care planning video were more likely to have residents with advance directives indicating tube-feeding should be withheld. When proxies preferred comfort care, advance directives aligned with that preference.
Researchers found that T cells can establish and maintain HIV infection in the brain, suggesting a reservoir for future HIV cure approaches.
A new Canadian guideline recommends screening for hepatitis C virus (HCV) in people born between 1945 and 1975 due to high rates of infection. The guideline also advocates for curative therapy for all individuals affected by HCV, aiming to prevent premature death.
A Rutgers-led team has developed a new material that conducts electricity without energy loss, paving the way for low-power electronics and potentially faster quantum computing. The material, which combines magnetic and insulator properties, can be used for electronic interconnections within silicon chips.
The multicenter phase II trial assessed the safety and efficacy of lurbinectedin in different solid tumors, with an ORR of 39.3% seen in recurrent small-cell lung cancer patients. The median duration of response was 6.2 months and the median overall survival was 12 months.
Researchers discovered that aspirin blocks TIF-IA, a molecule essential for the nucleolus to function, driving tumour formation and dysfunction. Regular use of aspirin may help pinpoint those most likely to benefit from the treatment.
A comprehensive analysis of Medicaid expansion found significant improvements in various health outcomes, including increased insurance coverage among adults without a college degree, higher use of primary care and preventive services, and reduced reliance on emergency departments. The study also reported declines in short- and long-te...
Researchers observed radio waves to measure carbon monoxide gas in distant galaxies, revealing that stars born during intense starbursts are massive. The findings challenge classical ideas about star formation and galaxy evolution over cosmic time.
A new Collaborative Research Center will investigate complex interactions between platelets and inflammatory processes. The project aims to develop novel treatment concepts for diseases associated with platelet dysfunction, such as stroke and acute respiratory failure.
New research from Michigan State University suggests that abusive supervisors are motivated to repair relationships by engaging in more effective leader behaviors. This is driven by feelings of guilt and a desire to restore moral credit, which can lead to positive changes in workplace dynamics.
The study uses archaeological evidence and physics-based processes to describe how the islanders placed the hats on the statues. The researchers propose that workers would rotate, leverage, and pivot the hats onto the statue tops using small wooden levers.
A recent study by the American Academy of Sleep Medicine found that NFL teams perform better at night due to their circadian rhythms. The research revealed fewer turnovers and mental errors during late evening games compared to afternoon games, suggesting a significant impact of circadian timing on game-day statistics.
Updated phase 1 clinical trial results of crizotinib against MET-amplified non-small cell lung cancer show a 40 percent response rate and 6.7-month median progression-free survival. The study defines new criteria to define 'highly MET-amplified' cancer, suggesting that crizotinib may benefit more patients than previously thought.
The ALEX trial results show alectinib achieving a median progression-free survival of 34.8 months compared to 10.9 months for crizotinib in ALK-positive non-small cell lung cancer patients. Alectinib also demonstrated an improved overall response rate and fewer side effects than crizotinib.
A landmark study published in the New England Journal of Medicine found that most breast cancer patients with intermediate scores on a 21-gene test can safely avoid chemotherapy. The study's results have significant implications for doctors and patients, allowing for more personalized treatment options.
Research suggests that police officers on night shifts are more likely to receive public complaints due to elevated fatigue. Going to court during the day after a night shift further increases this risk, highlighting the need for duty schedules to consider court appearances.
Researchers at Kyoto University found that bonobos show a strong aversion to food contaminated with feces or soil, indicating an adaptive system of disgust. This instinctual response helps protect against parasites and pathogens in the environment.