Researchers catalogued plant surveillance tools to detect disease-causing microbes across an entire species, providing a blueprint for disease surveillance. The findings have major implications for agriculture and plant evolution, highlighting the importance of genetic diversity in understanding a plant's immune system.
A study by University of Wyoming scientists found that energy development leads to a significant loss of deer forage due to human disturbance, with indirect losses exceeding direct habitat loss. Deer favor areas with high sagebrush growth but avoid areas near oil and gas infrastructure, resulting in a 10.5% decrease in forage use.
A Mayo Clinic study found that 44% of screened first-degree relatives had celiac disease, with 94% displaying no classic symptoms. The study advocates for proactive screening among family members to prevent malabsorption, nutritional deficiencies and autoimmune conditions.
Research reveals dietary zinc intake protects against Streptococcus pneumoniae, a primary cause of pneumonia. Zinc deficiency increases susceptibility to bacterial infections.
A team of biologists has shed new light on a crucial aspect of the plant immune response, revealing how plant resistance proteins trigger localized cell death. By understanding this mechanism, scientists may develop strategies for engineering disease-resistant crops.
A genomics study reveals an undetected Zika outbreak in Cuba in 2017, which peaked around the same time international health agencies thought the epidemic was nearing its end. The study uses genomic sequencing and travel patterns to reconstruct virus ancestry and outbreak dynamics, providing insights into how viruses can spread silently.
Scientists at the Paul Scherrer Institute deciphered the structure of CCR7 receptor, which plays a crucial role in cancer cell migration. They identified an artificial molecule that blocks this receptor, preventing signaling protein from triggering a chain reaction leading to cell migration.
The Indiana 5G Zone will drive the testing and development of 5G-enabled technologies, leveraging faster speeds, lower data latency, and increased reliability. Businesses and innovators can develop next-generation technological advancements in the Indianapolis-based site.
A new UNC School of Medicine study found elevated levels of protease enzymes in e-cigarette users' lungs, similar to those seen in smokers with emphysema. Nicotine is believed to be the cause of this reaction, which could lead to chronic obstructive pulmonary disease (COPD) and shortness of breath.
A study published in Evolution Letters reveals that many carnivorous species share a common ancestor dating back 800 million years, while herbivory is more recent. The research suggests that animals tend to adopt the same dietary category as their closely related species, implying that switching diets may not be easy.
Tropical Storm Chantal formed despite strong winds, with eastward storms exhibiting vertical wind shear and cold cloud top temperatures. The storm is forecast to slow and turn southward, potentially weakening into a tropical depression.
Archaeologists re-examine the remains of a medieval male found at Prague Castle, who was identified as Viking by Nazis and Slavonic warrior by Soviets. The team analyzes the sword and grave goods to determine his identity, which may have fueled modern political conflicts.
Researchers designed an app called BabyMind to improve parent-baby interaction by prompting parents to think from their baby's perspective. The study found that mothers who used the app were significantly more attuned to their babies' thoughts and feelings than those in a control group.
Tropical Depression Bailu forms in Northwestern Pacific Ocean, located about 674 nautical miles south-southwest of Kadena Air Base, Okinawa, Japan. The storm is moving northwest with maximum sustained winds near 30 knots (34.5 mph/55.5 kph) and expected to make landfall in Taiwan and then southeastern China.
Children's National Hospital's NICU staff underwent evacuation simulation training to improve their skills and knowledge. The training, which included hands-on practice with mannequins and equipment, resulted in significant improvements in evacuation times and staff confidence.
Researchers created an all-aqueous, water-in-water construct that achieves compartmentalization in a synthetic biologic system. The system uses electrical charge to separate functions and materials, mimicking the behavior of living cells.
Images taken by Hayabusa2's lander on Ryugu's surface show rocks bearing similarities to primitive meteorites called carbonaceous chondrites, supporting theories that the asteroid formed during a cataclysmic event. The findings also reveal an unusual lack of fine particles or dust on the surface.
By creating a microdevice that mimics the behavior of human airways, researchers have discovered how muscle contraction in the airway causes breathing difficulties in people with asthma. This breakthrough could lead to new treatment strategies for respiratory diseases.
Researchers use integrated exploration tools to detect multiple hydrothermal feed zones in Lake Ngozi, Tanzania, by combining bathymetry, thermal mapping and gas emission measurements. The approach provides spatial information on the location of hydrothermal vents, their abundance and current state of activity.
A study using cryoEM revealed the structural effect of a human mutation that made us immune to simian immunodeficiency virus (SIV). The mutation disrupted the ability of an SIV protein to bind human proteins, giving humans a grace period of tens to hundreds of thousands of years without the disease. This finding could provide clues for...
Chronic kidney disease, linked to heat exposure and dehydration, is expected to surge globally as temperatures rise. Climate change also threatens to increase cardiovascular disease, Lyme disease, and other illnesses in vulnerable communities.
Researchers find that opsin proteins and retinal enzymes have independent biological functions beyond vision, including hearing. This discovery challenges current understanding of eye evolution and highlights the importance of molecular components in multiple sensory pathways.
Researchers found exoplanet oceans with efficient upwelling rates could host globally abundant and active life. The discovery suggests that Earth might not be optimally habitable and life elsewhere may enjoy a more hospitable planet.
Researchers at Moffitt Cancer Center have developed a model called GARD that uses genomic data to predict the risk of local tumor recurrence and optimize radiation doses for breast cancer patients. The study found that a personalized approach to radiation therapy can reduce overdosing certain patients and improve treatment outcomes.
Research from Michigan Medicine identified anxiety as a key factor linked to more opioid use after surgery. The study also found younger age, non-white race, and sleep disturbance to be associated with increased opioid consumption. Clinicians may target these factors to personalize pain management and reduce opioid misuse.
Research finds that ketone bodies activate Notch signaling pathway, enhancing intestinal stem cell regeneration and function. A ketogenic diet boosts stem cell proliferation and repair damaged intestinal tissue.
A study found psychiatric illnesses are prevalent in children and adults with kidney failure, with hospitalizations associated with a higher risk of early death. The prevalence of psychiatric diagnoses increased over time across age groups.
Quantifying physicochemical properties is crucial for understanding drug interactions and mechanisms. The article highlights the importance of using contemporary methods to improve subpar testing outcomes, enabling better structure-property relationships and accelerated predictive models.
Drosophila melanogaster forms a stable long-term memory for its body size and reach after hatching from the pupal case. The insects learn to estimate distance across gaps by linking visual information with their body size, retaining this knowledge for life.
Researchers at MIT's Picower Institute have developed a new way to classify brain cells based on electrical signals. By analyzing data from nearly 2,500 neurons, they identified four distinct classes of cells with different properties and functions in various regions of the brain.
A new tool called ProtFus screens scientific literature to validate predictions about fusion protein activity, which can help improve personalized cancer treatment. The tool identified 2,908 interactions across 18 cancer types, aiding in the study of alterations of protein networks for individual patients.
Ion beams use ions to create complex atomic effects, releasing slow electrons that destroy DNA of cancer cells. Researchers at TU Wien discovered interatomic Coulombic decay, a previously little-observed effect, plays a pivotal role in this context.
Researchers found that memory T cells in bone marrow enriched with fat tissue protected mice from bacterial infections and tumors when fed restricted diets. The study suggests how the immune system may have evolved to survive limited food availability.
Despite a decline in overall health insurance coverage for US youth, the number of well-child visits rose from 81% to 85%, thanks to ACA provisions covering preventive services. Racial disparities in access to care narrowed slightly, although Latino youth still lag behind.
A large-scale study has identified a robust new signal and fine-mapped previously reported genetic variants associated with childhood obesity. The findings suggest that genetic influences on obesity operate across the lifespan and provide valuable insights into potential treatments.
The CRISPR Journal has published new articles on iCas9, a tool that enables precise gene editing without DNA breakage. Researchers also developed BEAT, a computational program to quantify base editing outcomes. Additionally, the journal reported on identifying genetic vulnerabilities in cancer cells via CRISPR-Cas9.
Researchers found that UV radiation damages skin by weakening cell bonds, leading to structural degradation and increased tissue fragility. The study suggests using sunscreen to protect not only against skin cancer but also to maintain skin health and prevent infections.
A team of researchers at Georgetown University Medical Center has identified a chain of molecules critical for pancreatic ductal adenocarcinoma (PDAC) growth and survival. Inhibiting this 'Yap' biological network may effectively regress early-stage PDAC, and pairing it with other drugs could halt more advanced stage tumors.
Researchers have demonstrated a loophole-free Bell test with the measurement settings determined by remote cosmic photons, verifying the completeness of quantum mechanics with high-confidence probability. The experiment closed loopholes that had long confounded tests of quantum mechanics, providing new evidence of quantum interactions.
Researchers discovered a spike in Zika cases among travelers returning from Cuba in 2017, which was not reported locally. The study found that mosquito control measures may have initially mitigated transmission but need to be maintained.
Researchers at TU Wien have successfully disentangled the interplay of several electron properties in complex materials. By influencing different characteristics separately, they have uncovered a system where order can be switched on and off individually in relation to two closely interwoven degrees of freedom.
Researchers discovered a scorpion toxin that targets the 'wasabi receptor', a protein found in nerve cells responsible for pain and inflammation. The toxin, WaTx, can be used to probe and study chronic pain and may lead to new non-opioid pain relievers.
Researchers compared three frontline breast cancer drugs and found significant differences in their biological activity. Abemaciclib was shown to be more effective than other drugs at high doses, affecting proteins beyond CDK4/6, suggesting it may work differently for patients who don't respond to other treatments.
A team of Brown University researchers developed a new computer model to simulate the way red blood cells become misshapen in sickle cell disease. The model can be used to quickly and inexpensively pre-screen new drug candidates, potentially identifying promising treatments for the genetic disorder that affects millions worldwide.
Researchers have identified a specialized pathway in the spinal cord that transmits mechanical itch signals to the brain. The study, published in Cell Reports, reveals that a specific population of neurons, known as Y1 spinal neurons, play a key role in transmitting these signals.
Researchers developed a fluorescent nano-thermometer that can detect temperature changes inside single cells by monitoring the light-emitting properties of molecular motors. The technique could be useful for identifying cancer cells and measuring the effects of tumor ablation therapy.
A study from the University of California, Davis, identifies the specific strains of Toxoplasma gondii killing southern sea otters as connected to a bobcat and domestic cats from nearby watersheds. The researchers found that infectious agents can spread from cat feces on land to the sea, harming marine wildlife.
Researchers have created the first high-resolution atlas of malaria parasite gene expression, revealing new insights into gene function and regulation. The Malaria Cell Atlas provides potential targets for future treatments and a better understanding of the spread of drug resistance.
A new study finds that climate change could make the Hajj pilgrimage in Saudi Arabia unsafe for participants due to extreme heat and humidity. The study warns that even with mitigation measures, conditions will become harsher and more dangerous, potentially leading to health problems and fatalities.
Researchers found that climate change has a net zero effect on Svalbard barnacle goose populations, with benefits from warmer springs offset by increased predation. Warmer winters also led to increased egg production and gosling survival, benefiting both geese and predators like Arctic foxes.
The study identified a novel protein interface in the polymerase complex that is pivotal for regulating polymerase activity, providing a new objective for target-based antiviral drug discovery. The findings reveal a vulnerability in the viral genome that could be exploited as a target for small-molecule antiviral drugs.
Researchers have made the world's first real physical measurements of carbon nanotube conductivity, validating theoretical models and paving the way for improved electrical power cables. The new approach uses identical carbon nanotubes with varying diameters to measure conductivity between them.
The TEMPLATES team will study four galaxies using gravitational lensing to magnify light and gain insights into star formation. They aim to measure star-formation rates, map galaxy distributions, compare young and old stellar populations, and reveal how galaxies grow over time.
This special issue in the Journal of Pediatric Rehabilitation Medicine highlights the importance of multidisciplinary care in managing cerebral palsy. The articles cover various topics, including scoliosis care, goal setting, exercise programs and nutritional care, to improve outcomes for individuals with CP.
Researchers have discovered common ways human and plant cells bring about cell suicide, which may lead to new treatments for neurodegenerative diseases. The study found that a particular protein plays a crucial role in the breakdown of brain cells across different diseases, paving the way for potential drugs.
Research reveals that storm clouds on Jupiter affect the planet's white zones and colorful belts, changing their flow and even altering their colors. The study tracked the effects of these storms using coordinated observations from six telescopes and NASA's Hubble Space Telescope.
Research finds that a warming planet will alter ocean waves along more than 50% of the world's coastlines, leading to significant implications for coastal flooding and erosion. The study projects changes in wave patterns under different climate scenarios, with some areas experiencing increases in mean wave heights and others decreases.
Research from Columbia University's Mailman School of Public Health finds that exposure to the criminal justice system increases certain risk factors, including antisocial attitudes and behaviors. This challenges the use of risk assessments for predicting recidivism in individuals without prior system exposure.
Researchers have created a detailed map of individual malaria parasite behavior, giving the highest resolution view of malaria parasite gene expression to date. The Malaria Cell Atlas presents possible targets for developing antimalarial drugs, vaccines, and transmission blocking strategies.
Researchers have determined the first atomic structure of the V/A-ATPase family, a key energy machine in cells. The enzyme's structure reveals a turbine-like structure with two or three peripheral stalks and additional connecting protein subunits, enabling greater plasticity and flexibility in its rotation mechanism.