Researchers from Mumbai Institute of Chemical Technology developed a simple and efficient method to synthesize unsymmetrical N,N'-disubstituted urea and N-substituted urea derivatives using L-proline as a catalyst. The methodology enables the synthesis of various phenylurea derivatives with excellent yield at mild conditions.
SourceBentham Science Publishers·JournalLetters in Organic Chemistry·DateJan 12, 2019
Bioactive compounds 5 and others were found to be potent inhibitors of ROS and NO. Most active compounds showed good anti-inflammatory potential without toxicity on NIH-3T3 cells.
SourceBentham Science Publishers·JournalMedicinal Chemistry·DateJan 12, 2019
Researchers developed new chromenone-based derivatives with potent AChE and BChE inhibitory activity. These dual inhibitors may be effective in treating neurodegenerative disorders like Alzheimer's disease.
SourceBentham Science Publishers·JournalMedicinal Chemistry·DateJan 12, 2019