Researchers analyzed 10,225 patient samples from 32 different cancers to better understand TP53 mutations. They found that TP53 mutations were more frequent in patients with poorer survival rates but also identified a way to predict prognosis based on four upregulated genes.
A study by the American Heart Association found that less-invasive leg artery procedures are as effective as open surgery in preventing amputations and improving survival rates. Patients who received endovascular procedures first had longer periods of amputation-free survival compared to those treated with open surgery.
A large cohort study found that babies with persistent fluid-filled areas in their kidneys during gestation are at higher risk of urinary tract problems and hospital admissions in early childhood. The study used data from over 21,000 children and showed a strong link between renal pelvis dilatation and increased risk of hospital admiss...
The research team derived precise values of enthalpy and entropy of numerous silver compounds, enabling predictions of chemical processes in the gas phase. The findings will help manage thin film and pure sample deposition from the gas phase.
A team of UC Santa Barbara researchers have discovered a new phase in block copolymers, expanding the range of possible options for material design. The newly found phase, known as A15, belongs to a class of tetrahedrally close-packed structures and has been observed in both metal and polymer materials.
A study of 812 ADPKD patients found that 9% had undiagnosed brain aneurysms, with those with hypertension and smoking more likely to have aneurysms. The overall rupture rate was approximately 5 times higher than in the general population.
The soft and conformable monitor can broadcast ECG, heart rate, respiratory rate, and motion activity data up to 15 meters. It avoids signal issues created by traditional metal-gel electrodes, providing accurate signals even during movement.
Researchers found that a soybean antioxidant compound blocked damage to blood vessels in laboratory tests, potentially preventing cardiovascular side effects of recreational and medical marijuana use. The study suggests JW-1 could be a new way to protect blood vessels without psychiatric side effects.
Hybrid organic-inorganic perovskites, used in optoelectronic devices, have improved efficiency after solution-treating with benzylamine. The treatment creates a two-dimensional material that restructures the material and reduces defect states.
Researchers at UT Austin aim to develop a lithium-ion battery that requires no cobalt while maintaining high energy density. A $3 million collaborative project funded by the US Department of Energy seeks to demonstrate low-cobalt battery technology in large cells and create a cobalt-free battery.
Children's Hospital of Philadelphia researchers have developed a new AAV vector screening method that captures the full range of gene expression patterns caused by AAV vectors. This innovative technique is expected to significantly advance the field of gene therapy by providing a more sensitive approach to detecting gene transfer sites.
A new study reveals that school fitness tests have little association with students' enjoyment of PE and emotions towards the subject. Despite polarized views, research suggests that fitness testing is not effective in promoting a positive outlook or discouraging participation.
A new study found that when public interest in CSR is high, investors place a premium on companies involved in CSR activities, perceiving greater value despite fundamentals. Companies respond by upping their CSR efforts to boost stock market performance, especially for firms with transient investors and higher share turnover.
International experts pinpoint areas central to understanding the complex relationship between nutrition and cancer. Research gaps in diet, physical activity, and metabolic factors are highlighted, with a call for improved funding and institutional support for cancer prevention and nutrition research.
Researchers at MIT have developed a new gel-like material that can create a stable cushion for more than an hour, reducing the risk of tearing the colon lining during polyp removal. This innovation could greatly improve the safety and effectiveness of colonoscopies.
Researchers at the University of Arizona Cancer Center successfully repeated findings from a study that challenged current approaches to colon cancer treatment. The team validated therapeutic targeting of LRP6 as a potential strategy for blocking progression of colon cancer, offering new hope for patient care.
NASA's Aqua satellite detected coldest cloud top temperatures as cold as minus 63 degrees Fahrenheit, indicating strong storms capable of heavy rain. The storm's center has migrated southward toward the strongest convection, positioning just north of the coldest cloud tops.
A new study by Cass Business School academic Dr Janina Steinmetz confirms that people tend to judge entire groups based on the performance of their first member. The research found that a bad experience at the 'first' register or position leads to harsher judgments about the group, while a good experience results in greater positivity.
A new study at the University of Leeds suggests that transcutaneous vagus nerve stimulation (tVNS) may help slow down an important effect associated with ageing. The therapy, which delivers a small electrical current to the ear, has been shown to improve physiological and wellbeing outcomes in over-55s.
Researchers at the University of Würzburg are developing a social-VR platform called ViLeArn to explore the potential of virtual reality in education. The platform allows students to engage in fully equipped virtual teaching environments, fostering collaboration and creativity.
A new study published in PLOS Medicine found that women who developed pre-eclampsia during pregnancy were nearly five times more likely to develop end stage kidney disease (ESKD) than those who did not. The study analyzed data from over 1 million healthy women and revealed a significant association between pre-eclampsia and ESKD risk.
A study from the University of Texas at Austin found a strong correlation between marital infidelity and professional misconduct. Researchers analyzed data from police officers, financial advisers, and CEOs to discover that individuals who cheated on their spouses were more likely to engage in corporate misconduct.
Researchers have identified a specific role for astrocyte proteins in directing neural connections, using nanoparticles to deliver corrective proteins to replace missing proteins in neurodegenerative diseases. The study offers new hope for regrowing and repairing damaged brain networks.
A UW study found that moving to a new home during the first three months of pregnancy increases the risk of low birthweight, premature birth, and smaller-than-expected babies. Despite limitations, the researchers suggest counseling patients on stress-mitigating techniques and care continuity may be beneficial.
Attending NHS health checks is associated with increased risk management interventions and decreased risk factors for cardiovascular disease. Health check participants had lower baseline BMI, blood pressure, and fewer smokers, and were more likely to receive weight management and smoking cessation advice.
A new multi-national survey found that nearly one-tenth of work hours are missed by asthma sufferers, resulting in significant productivity loss. Additionally, workers reported feeling embarrassed, ashamed, and inferior when using inhalers at work.
The National Cancer Institute has recognized Sylvester Comprehensive Cancer Center as a top-tier US cancer center due to its outstanding research and clinical care. The designation is a testament to the dedication of every member of the cancer center.
Researchers discovered that Par3 regulates contractility of keratinocytes, essential for accurate cell division and preventing DNA damage. The findings suggest that Par3 plays a key role in maintaining skin self-renewal capacity, with dysfunction linked to premature aging and skin cancer.
Researchers at James Cook University have successfully 3D printed fuel grains for hybrid rockets, testing six compounds including Acrylonitrile Butadiene Styrene (ABS), to optimize performance and safety.
Researchers have identified a molecule called Gas6 that induces macrophages to clean up cellular debris and reduce inflammation. Boosting Gas6 levels in macrophages has been shown to resolve inflammation in mouse models of acute lung injury, holding promise for treating diseases such as heart disease, cancer, and rheumatoid arthritis.
Researchers at UMass Amherst have expanded the functions of conducting microbial nanowires, developing them into sustainable chemical and biological sensors. The new nanowires can be modified with peptides to specifically bind chemicals or biologics, offering promising possibilities for biomedical and environmental applications.
Agrivoltaics combines solar panels and agriculture to create a more efficient and sustainable system. This practice reduces evaporation of irrigation waters in summer and increases photosynthesis, leading to improved crop growth and reduced water usage.
Researchers warn that a modest warming of the climate could lead to a significant increase in global energy demands, with potential implications for greenhouse gas emissions. The study suggests that understanding this interaction is crucial to developing effective solutions to mitigate climate change.
Researchers found that babies as young as six months old show empathy towards a bullied victim, preferring to choose the distressed figure over the bully. This discovery debunks the theory that babies only develop empathy after one year of age.
Researchers at the University of Warwick have developed a new polymeric cryoprotectant that protects cells during freezing, leading to more cells being recovered and less solvent-based antifreeze being required. The material was shown to be very potent in protecting cell monolayers, which is crucial for biomedical research.
Artificial cells have been created by Imperial College London scientists that can sense changes in their surroundings and respond with drug molecules or harm removal. This breakthrough uses a simpler approach to mimic complex biological responses, making it easier to engineer artificial cells for various biotechnological applications.
Researchers blocked dopamine receptors in rats to reduce cocaine-seeking behavior, with varying longevity. The study reveals the unique roles of the basolateral and central amygdala in cocaine reward behaviors.
A Stanford study found that assigning newly arrived refugees to live in areas with larger ethnic networks increases their chances of finding employment. In contrast, smaller ethnic networks are associated with lower employment rates.
A new study by University of Exeter researchers shows that pathogens can evolve to become more virulent without increasing their rate of replication. This suggests that manipulating host immune systems may play a role in generating symptoms necessary for transmission.
A team of fusion researchers successfully demonstrated alpha particle confinement in a plasma for the first time in helical systems. This achievement is significant as it promises the alpha particle confinement required for realizing fusion energy in a helical reactor.
Researchers at NC State University have developed a portable technology that can identify plant diseases in the field by analyzing airborne volatile organic compounds (VOCs). The device, which can be plugged into a smartphone, works by measuring the type and concentration of VOCs released by plants to determine if they are diseased.
Researchers have identified a repurposed compound, bithionol, with selective membrane-targeting properties that effectively kill MRSA persister cells without harming mammalian cell membranes. This breakthrough suggests potential therapeutic applications for bithionol in treating recalcitrant MRSA persister-caused infections.
The study provides insight into how the Komodo dragon's DNA encodes its astounding characteristics, including its ability to detect prey from far away. The team discovered changes in genes that increase the lizard's aerobic capacity, allowing it to achieve near-mammalian metabolism.
Researchers from the University of Warwick have discovered that deformations and defects in solar cell structures can prevent photo-excited carriers from recombining, leading to enhanced conversion efficiency. This finding has potential applications in improving UV light sensor sensitivity and increasing solar cell efficiency.
Researchers at Yokohama National University developed an efficient method to generate hair growth in nude mice using a three-dimensional tissue culture called hair follicle germ. The new approach produces a high rate of hair generation and shows promise for clinical applications in human hair regenerative therapy.
A study of over 165,000 US military veterans has identified multiple genetic locations associated with the risk of re-experiencing traumatic memories, a hallmark symptom of post-traumatic stress disorder. The research also found genetic overlap with conditions such as hypertension and psychiatric disorders.
Mothers with pre-pregnancy diabetes are at a four to five times increased risk of stillbirth. High maternal blood sugar levels and BMI emerged as key risk factors for increased stillbirth risk, particularly in babies born small or large for gestational age.
Scientists studied how garfish regrow fins and found genes and mechanisms responsible for this process. These findings suggest that the last common ancestor of fish and tetrapods had a specialized response for appendage regeneration.
New research challenges long-held assumptions about whole-tree harvesting, finding it does not deplete soil and lead to weaker forest ecosystems. The study demonstrates that residue removal has few effects on forest ecology in managed stands, making biomass energy from whole trees a more sustainable option.
A new AI-powered tool, scGen, accurately models cellular response to perturbations, enabling reliable predictions for different systems. This breakthrough has the potential to revolutionize the understanding and treatment of common human diseases.
Researchers at Purdue University have developed a new software called Emap2sec that can identify secondary structures in proteins from lower-resolution cryo-EM maps. This technique has the potential to speed up protein structure analysis and improve accuracy, enabling researchers to develop more effective drugs for various diseases.
Researchers developed a model forecasting earthquake hazards in Oklahoma due to fluid injection, highlighting the importance of pore pressure diffusion and poroelastic stresses. The study found that mandatory reduction in injection volumes substantially reduced earthquake probability in western Oklahoma but not central Oklahoma.
Researchers have successfully created stable, cancer-like cells in the lab by simultaneously infecting white blood cells with two viruses, Epstein-Barr Virus and Kaposi's sarcoma-associated herpesvirus. This breakthrough opens up new opportunities for understanding the progression of this rare blood cancer and developing treatments.
Researchers developed an implantable microneedle skin patch containing an HIV subunit vaccine, which led to sustained intradermal vaccine release and improved antibody responses in mice. The study suggests that microneedle patches may enhance vaccine effectiveness.
Researchers at Arizona State University have developed a method to predict seismic activity from wastewater disposal, which can help the energy industry manage injection-caused earthquakes and reduce risks. The team's physics-based framework successfully reproduces the distribution of actual earthquakes by frequency, magnitude, and time.
A new meta-analysis of 31 studies found that parent-based interventions increase condom use among adolescents and have specific features that enhance their effectiveness. These include targeting younger adolescents, culturally specific programs, equal involvement of parents and teens, and longer program durations.
A new combination treatment regimen enhances the immune system's ability to kill leukemias that do not respond to standard treatments. The regimen includes a therapeutic antibody designed to attract natural killer immune cells to cancer cells, resulting in increased killing of acute lymphoblastic leukemia cells by up to 35%.
Researchers at RMIT University have developed a simple pressure pump made from balloons and nylon stockings that can be used to test water contaminants and blood samples. The low-cost device has been tested in various experiments, including detecting aquatic parasites and cancer cells.
Tracy Langkilde has been recognized for her research on how animals adapt to changes in their environments. She has studied the behavior of lizards towards fire ants and explored the impact of noise pollution on frogs' communication abilities.
The U.S. Department of Energy has approved the next phase of the $815M upgrade of the Advanced Photon Source, a premier national research facility that will enable scientists to see things at a scale they have never seen before with storage-ring X-rays. The upgrade positions the APS to be a global leader among the new generation of sto...