Researchers at Tokyo Medical and Dental University found that laser stimulation inhibits sclerostin expression in bone without causing inflammation, providing a new treatment possibility for osteoporosis. This method may aid the development of laser-based therapies to promote bone regeneration.
A new radioimmunotherapy has proven effective in reversing resistance to the most commonly used lymphoma drug, rituximab. In a non-Hodgkin's lymphoma mouse model, the treatment substantially increased rituximab binding and antibody-dependent cellular cytotoxicity activity, resulting in significant tumor growth delay.
Researchers discovered a new approach to control chemical reaction reactivity using a single gold electrode, which can behave like multiple functional groups by switching applied voltage. This 'electro-inductive effect' enables in-situ tuning of electronic property and reactivity in the middle of a reaction.
Severe COVID-19 cases linked to hyperactivated T cells in lungs, suggesting brake mechanism failure. Protein Foxp3 inhibition may lead to new treatment options.
Researchers from Cornell University and North Carolina State University are developing 'microcleaners' - self-propelled biomaterials that can capture and decompose microplastics in waterways. The project aims to design inexpensive, non-toxic microsystems to collect and break down microplastic particles.
The Vaccination Game, developed by University of Oxford researchers, challenges players to deploy limited doses of a virtual vaccine to control the spread of a disease modelled on influenza. By replaying the game, players can improve their strategy and save more lives.
The University of Guam is surveying and monitoring invasive pests of solanaceous crops, including Tuta absoluta, a moth that can destroy entire crops, and Ralstonia solanacearum race 3 biovar 2, a bacterial wilt that infects through the roots. The work aims to prepare the island for management if these pests arrive.
A new solar panel design using checkerboard lines can absorb up to 125% more light, leading to the creation of thinner, lighter, and more flexible panels. This breakthrough could enable a rapid expansion of photovoltaics and greatly reduce carbon footprint.
A broadband graphene detector has been created to reveal the polarization of terahertz radiation. The device relies on plasma wave interference and has potential applications in next-generation information transmission systems and medical diagnostics.
A study published in The BMJ found that high-intensity training intervals twice a week improved physical and mental quality of life in people over 70. Fitness levels were maintained throughout the five-year period, with a notable drop in mortality rates compared to moderate exercise.
Researchers at UT Health San Antonio have discovered lactate, a metabolite elevated during exercise and diseases, acts as a signal to activate magnesium ions. This finding is expected to lead to the development of novel therapies for cardiovascular disease, metabolic disorders like diabetes, and other conditions.
A Brazilian research team developed a model to describe the spatial and temporal evolution of epidemic diseases. The SIR model predicts that contagion occurs discontinuously but follows a fractal pattern, which can help plan more effective social isolation programs with less socio-economic impact.
Hurricane Delta showed enhanced convection near its center, but was obscured by a central dense overcast. The storm strengthened with maximum sustained winds reaching near 105 mph, and NASA provides data to tropical cyclone meteorologists for forecast purposes.
Researchers designed a compact UV camera capable of recording photons in the ultraviolet range in real time, achieving an imaging speed of 0.5 trillion frames per second. The system uses compressed ultrafast photography to capture unparalleled resolution with just one click.
A recent survey by Research!America reveals broad bipartisan support for a stronger focus on science, with 88% of Americans believing science benefits them. The survey also shows that Americans are willing to pay more taxes to support scientific research and that basic scientific research should be supported by the federal government.
Researchers are using climate projection studies to understand the impact of changing temperatures and precipitation on snail populations, which carry the parasite causing schistosomiasis. The study aims to inform strategies for reducing the spread of this debilitating infection, affecting 220 million people globally.
A newly discovered quality control system in protein production prevents the translation of faulty messenger RNA fragments, thereby preventing the formation of toxic incomplete protein products. The discovery has implications for understanding neurodegenerative diseases and may shed light on the underlying causes of such conditions.
Researchers at Politecnico di Torino have developed a new composite material that can store heat during the summer and release it during the winter using a low-cost technology. The innovative material combines cement, salt, and water to produce heat through hydration, offering an affordable solution to balance energy supply and demand.
Researchers are collecting detailed health information from people with atypical forms of diabetes to understand their causes and differences from common types. The study aims to provide critical insight into the emerging spectrum of diabetes, potentially leading to new targets for prevention and treatment.
A new model describes optical properties of high-density plasma, accurately predicting experimental results and outperforming previous models. The generalized Quasi Independent Particle (QUIP) model takes into account plasma microfield inhomogeneity, making it suitable for high-density plasma.
Research shows that low-income families are forced to choose safest locations for immediate survival rather than taking time to find neighborhoods with great schools and job opportunities. Policymakers must reconsider assumptions about how families decide where to live and send their children to school.
A new study reveals that athletes using legal sport supplements are more likely to dope than those using food and superfoods. Researchers surveyed 573 athletes and found a significant correlation between the use of ergogenic and medical supplements and doping attitudes.
An elderly population study from Sweden found a higher risk of suicide among women born outside the Nordic region with untreated depression. The study also highlighted gender differences in factors related to suicide, including the protective effect of marriage in men and social isolation in both genders.
A study by NYU School of Global Public Health researchers found that traditional media, government websites, and social media are leading sources of COVID-19 information. However, trust in these sources varies greatly among different demographic groups.
UT Southwestern Medical Center's COVID-19 adjustments streamlined clinical trials, allowing for remote consents and telehealth visits. A survey of UTSW clinical research professionals found positive experiences with these changes, with over 90% supporting continued use after the pandemic ends.
Researchers developed tiny optically powered machines that self-assemble and can manipulate tiny cargo for applications like nanofluidics and particle sorting. The machines use circularly polarized light from a laser to create a nanoparticle array acting like a gear, influencing nearby particles to orbit the array.
Research published in BMJ Global Health found that viewers who trust right-wing US TV media are less likely to engage in preventive behaviors and more likely to report risky behaviors. This association was observed despite health behaviors becoming more cautious over time.
Sandia's successful full-scale crash test marks a significant achievement for the nuclear deterrence program, delivering results despite COVID-19 challenges. The test involved propelling a semitruck into a prototype transporter, gathering over 400 channels of data to ensure its safety and security.
Researchers discovered two genetic mutations in moles that lead to the development of ovarian and testicular tissues, resulting in high levels of testosterone and aggression. The study sheds light on how DNA changes contribute to evolution and the formation of unique sexual features in mammals.
Research examines telehealth, health care disparities and patient-centered care during COVID-19 pandemic. Key findings include high patient satisfaction with telehealth visits and increased morbidity and mortality among cardiovascular patients hospitalized with COVID-19.
A recent study shows that rare terrestrial mammals and birds are more threatened by human activities than common species, with many facing extinction within 40 years due to climate change. Conservation efforts must account for the ecological rarity of these species to ensure their survival.
Researchers found that providing text message reminders and redesigning the summons form improved court appearance rates by 21% and 13%, respectively. The interventions avoided at least 30,000 arrest warrants and resulted in about 20,000 fully dismissed cases.
The UN Decade of Ocean Science for Sustainable Development has an ambitious agenda to transform ocean health. The initiative provides a non-prescriptive framework for transformational action across geographies, sectors, disciplines, and generations.
NASA's Aqua satellite gathered water vapor data on Hurricane Delta, revealing highest concentrations of water vapor and coldest cloud top temperatures around the center of circulation. The storm is expected to produce heavy rainfall and flash flooding in the northern Yucatan Peninsula.
MUSC researchers have identified a new biomarker that may predict which patients are at risk of graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. High levels of plasmacytoid dendritic cells expressing ICOS ligand are associated with increased severity of GVHD and lower survival rates.
A new UC Riverside study found that same-gender couples have higher-quality interactions both inside and outside their relationships compared to heterosexual couples. The study also showed that women in male-dominated relationships tend to have the largest social networks, while men with men have smaller ones.
Research led by UTSW scientists finds that endocannabinoids can shut down genes needed for pathogenic intestinal bacteria to colonize and cause disease. The study suggests that these native chemicals similar to those found in cannabis may eventually lead to new ways to fight gastrointestinal infections.
Research suggests that pregnancy complications such as miscarriage, pre-eclampsia, and diabetes in pregnancy are associated with a higher risk of cardiovascular disease in later life. Women who experienced early menarche, polycystic ovary syndrome, or low birth weight also showed an increased risk of heart disease.
Researchers found that too many crossover events can lead to flawed chromosome segregation, resulting in increased infertility. The study provides fundamental insights into the mechanisms of fertility and may lead to potential clinical applications.
A new study finds that infectious diseases in livestock can lead to increased methane emissions, exacerbating climate change. Ruminant animals infected with intestinal worms or suffering from mastitis release up to 33% and 8% more methane per kilogram of feed or milk produced.
The University of Missouri is receiving $5.45 million to improve literacy in Missouri schools through the Show Me Literacies Collaborative. The grant will support early childhood educators in extending family literacy practices into the classroom, with a focus on inclusive and multilingual literacies.
Researchers at Kanazawa University discovered that thymoquinone selectively kills prostate cancer cells with a SUCLA2 gene deletion. This finding offers a promising therapeutic option for advanced prostate cancer patients who have developed resistance to hormone therapy.
A national study found that COVID-19 symptoms in pregnant women can last two months or longer, impacting health and wellbeing. Researchers analyzed 594 women who tested positive for SARS-CoV-2 virus during pregnancy, discovering that half had symptoms after 3 weeks and 25 percent had symptoms persisting beyond 8 weeks.
Researchers found that teenagers diagnosed with depression show a significant decline in educational attainment, especially in GCSEs. Targeted support for children struggling with depression could benefit vulnerable groups, such as boys and those from disadvantaged backgrounds.
A pay-for-performance program increased prescriptions of high-quality, evidence-based cancer drugs by 5.1 percentage points without significantly changing total spending on care. The program improved the rate of high-value prescribing in oncology, leading to better patient outcomes and longer life expectancy.
The COVID-19 pandemic has shifted from a single disease entity to a 'syndemic', with concurrent co-morbidities and social determinants of health contributing to collateral morbidities.
A new study describes a vaccine that triggers an immune response against an influenza protein segment rarely mutated by the virus, raising the possibility of effective protection against seasonal and pandemic strains. The vaccine uses nanoparticles coated with flu proteins to train the immune system to create desired antibodies.
A magnitude 4.9 earthquake triggered by hydraulic fracturing in a Chinese shale gas field occurred along a fault about one kilometer deep. The event challenges current understanding of seismic risk for shallow faults, highlighting the need to reassess evaluation strategies.
A new study has discovered that accumulated DNA damage in skin cells can be used to estimate the risk of deadly skin cancer. Researchers sequenced DNA from individual melanocytes and found a significant number of mutations associated with melanoma, even in people without visible moles.
A Dartmouth-Gallup study found that women are more concerned about COVID-19 than men, with significant differences in views on precautions, workplace return, and risk perception. The study's findings have important implications for workplace reopenings and the 2020 election.
Primate lentiviruses, such as HIV-1, overcome species barriers through viral infectivity factor (Vif) and APOBEC3 protein interactions. A study by the University of Tokyo found that gorilla APOBEC3G can restrict SIVcpz replication but a specific amino acid substitution in Vif can evade this restriction.
A new study published in Nature shows that rodents rely on a combination of innate instincts and learning to recognize unique infant cries. Experienced caregivers were found to be more effective at identifying subtle variations in distress calls and retrieving crying pups, while inexperienced animals required extensive training.
A NIH-funded mouse study reveals that parents have an innate capacity to respond to infant cries, which can adapt over time. The research found that experienced and novice babysitters showed improved responses to altered cries, suggesting a plastic mechanism in the auditory cortex.
A study in STEM CELLS Translational Medicine suggests that amniotic fluid stem cell-derived secretome can restore neuronal plasticity and improve cognition after an ischemic stroke. The findings offer a potential new avenue of treatment for ischemic stroke, which affects 87% of all strokes.
Researchers discovered that remote ischemic postconditioning therapy can lead to better recovery outcomes for people who have received clot-busting drugs after a stroke. In the study, 72% of participants who received the therapy had favorable recovery scores compared to 50% of those who did not.
Researchers discovered that N-acetylglucosamine activates myelin stem cells to promote primary myelination and myelin repair. The study suggests that N-acetylglucosamine deficiency may contribute to disease severity in multiple sclerosis patients.
A review of 35 studies found a lifetime prevalence of 17.4% for suicidal thoughts and 1.8% for attempts among physicians. Geographic region was linked to variations in suicidal behavior rates, with Europe showing higher prevalence than the US.
The Global Pandemic App Watch tracks the uptake of COVID-19 contact-tracing and exposure-notification apps worldwide. The website offers maps and country pages detailing app adoption, voluntariness, and privacy concerns, shedding light on the socio-ethical dimensions of these technologies.
A new poll shows that over half of older adults take two or more non-prescription drugs or supplements, and two in ten take five or more prescription medications. Many are unaware of the importance of comprehensive medication reviews, which can identify potential interactions and help save money. The poll suggests opportunities for pro...
A new study finds N2O emissions are increasing faster than any emission scenario developed by the IPCC, posing a significant threat to climate goals. Human-induced emissions dominate releases, with East Asia, South Asia, Africa, and South America being the largest contributors.