Researchers discovered EGR4 acts as a critical brake on immune activation, promoting killer T cell activation and boosting anticancer immunity. EGR4 knockout mice showed reduced lung tumor burden and fewer metastases, raising new possibilities for immunotherapy.
Iowa State University engineers develop a closed-form solution for the inverse chirp z-transform, enabling efficient computation on the unit circle and lifting restrictions of existing algorithms. The algorithm achieves high accuracy with 64-bit floating-point numbers and operates in O(n log n) time.
Three new species of toothed pterosaurs have been identified in Africa, providing a window into the world of pterosaurs during the Cretaceous period. The fossils suggest that these flying reptiles were similar to those found on other continents and preyed on a superabundance of fish.
Scientists discover ninth species of dragon lizard in genus Smaug, previously mistaken for similar-looking species S. barbertonensis. The new species, Smaug swazicus, is the largest southern African lizard species described since 82 years ago, with up to 13 inches from snout to tail tip.
A new study by Florida Atlantic University shows that kangaroo care improves infant brain development, particularly in full-term babies, through skin-to-skin touch and contact. The method also increases oxytocin levels in mothers and decreases stress reactivity.
The article highlights the potential for COVID-19 to evolve into a chronic condition similar to influenza, with links to cardiovascular disease. Researchers warn of the risk of reemergence or emergence of other coronaviruses due to genetic recombination.
A recent study from Oregon State University found that parents who model and support physical activity in daily life can help children with developmental disabilities improve their motor skills. Parents can make a difference by spending quality time with their child, engaging in activities together and providing opportunities for them ...
Researchers examined changes in adolescent mental health problems and care settings, finding shifts towards more specialized services and online care. The study highlights the need for improved mental health support for adolescents, particularly in rural areas where access to care is limited.
A team of scientists led by Michelle Staudinger calls for increased study of sand lance, a crucial food source for seabirds and marine mammals. The research highlights the need for better understanding of sand lance's biology and populations to inform conservation efforts.
Researchers have introduced a method to rapidly cycle through staining, destaining, and restaining of cell samples using black hole quenchers in under 1 hour. This allows for precise characterization of immune cells in tumors, enabling the selection of suitable treatments.
Researchers at Kazan Federal University have made significant progress in developing CAR T-cell therapy for solid tumors. The treatment uses genetically modified lymphocytes to target and destroy tumor cells, showing promising results in animal models.
In a phase I study, fam-trastuzumab deruxtecan-nxki (Enhertu) demonstrated clinical activity in patients with non-breast/non-gastric cancer types with HER2 overexpression or mutation. The overall objective response rate was 28.3 percent, with greatest response rates for NSCLC and HER2-mutant NSCLC.
Researchers discovered web-like patterns in whiskey droplets that can identify different brands of American whiskey, potentially used to detect counterfeits. The unique web patterns arise from the combination of solutes in each whiskey and can be matched with over 90% accuracy.
Researchers uncovered symbolic stone carvings and artifacts suggesting a fixed domestic space and cultural practices in highland New Guinea. The findings indicate the region independently developed hallmarks of the Neolithic around 1000 years before Lapita farmers arrived.
Researchers outline robots' potential roles in clinical care, logistics, and reconnaissance to combat COVID-19. They suggest robots for disinfection, delivery, and monitoring compliance with quarantines.
Researchers from OIST discovered that as exciton density increased, exciton-exciton annihilation shifted from 1D to 2D due to phosphorene's anisotropic properties. Temperature also played a role, with exciton annihilation reverting to 1D at lower temperatures.
Researchers identified a novel mutation in the S6K1 enzyme that affects protein synthesis and is associated with altered cognitive abilities in children with autism spectrum disorder. The study found that this mutation changes the course of normal neural development and memory forming capacity.
A large study published in Neurology found that taking a low-dose aspirin daily does not reduce the risk of thinking and memory problems caused by mild cognitive impairment or probable Alzheimer's disease. The study involved 19,114 participants and was supported by various funding sources.
A team of researchers from Universities of Bonn and Ulm has investigated how a cell's proteasome can be programmed to degrade proteins that fuel cancer cell growth. By customizing molecular hybrids called PROTACs, they successfully targeted a protein essential for tumor cells to multiply.
A pair of new studies indicate parents are more reluctant to have opioids prescribed for their children than doctors, citing fears of addiction and side-effects. Pediatricians emphasize the importance of treating children's pain while acknowledging the unknown risks of opioid treatment.
Researchers Amandine Aftalion and Emmanuel Trélat found that shorter straights and larger radii can improve running performance. Their mathematical model predicts that these track designs could potentially break long-standing records, with improvements of up to 4 hundredth of a second.
Research from a global team of scientists found that diverse rock types at New Zealand's largest fault contribute to varying earthquake types. Slow slip events and tsunami-generating tremors are linked to the unique properties of each rock type.
A high-salt diet can significantly weaken the immune system by reducing the function of granulocytes, a type of immune cell that attacks bacteria. This is according to a new study published in Science Translational Medicine, which found that mice fed a high-salt diet suffered from more severe bacterial infections.
A recent study by Rafael C. Bernardi at the University of Illinois uses computational tools to explain the mechanism behind streptavidin and biotin binding, which varies depending on the lab's conditions. The analysis shows that the tethering geometry significantly influences the unbinding mechanics.
The Joint Monitoring Programme (JMP) has secured a grant to develop data collection techniques for assessing the scale of challenge in safely dealing with sewage waste. On-site sanitation, such as pit latrines, is used by 3.1 billion people worldwide, but few countries keep data on waste treatment, posing major health risks.
Researchers have developed highly selective ligands to label opioid receptors, shedding light on their behavior in living cells. The study reveals that most opioid receptors exist as individual entities, but a small proportion forms pairs, which may contribute to the receptor's function.
The researchers have developed a computational model of a human cell that simulates its behavior for up to 15 minutes, revealing the effects of spatial organization on genetic processes. The study provides new insights into how genes are regulated and developed, and how diseases such as cancer are formed.
A new mathematical model developed by Princeton and Carnegie Mellon researchers improves epidemic tracking by accounting for disease mutations. The model provides critical insights into the effects of countermeasures, such as quarantines, on epidemic spread.
A recent study published in Ophthalmology found no virus detected in the tears of infected patients with COVID-19, suggesting a low risk of transmission through this route. The study's authors hope their findings will guide further research into preventing virus transmission through more significant routes.
Researchers warn of 'exaggerated' AI study claims, highlighting poor quality evidence and methodological flaws in studies. The majority of deep learning medical imaging studies have high bias and lack transparency, fueling hype for rapid implementation.
Researchers at Stanford University created an ankle exoskeleton that assists running with powered assistance. Powered mode reduces the energy cost of running by 15%, making it 25% easier than running without assistance, while spring-like mode has limited benefits due to increased energy demand.
Researchers found reduced glucose metabolism in the brain stem and primary auditory cortex of patients with asymmetric hearing loss. Long duration of hearing impairment was associated with higher glucose metabolism on the contralateral side.
The NETTER-2 study is a Phase III clinical trial evaluating Lutathera's efficacy and safety in treating Grade 2 and 3 advanced GEP-NETs. The primary objective is to prolong Progression Free Survival in patients with high proliferation rate tumors.
A recent study published in the Journal of Thoracic Oncology found that lung cancer clinical trials funded by the pharmaceutical industry demonstrate no more bias compared to studies funded by other sources. The analysis, led by Dr. Pedro Aguiar, assessed 477 studies and found that pharmaceutical-backed trials had stronger evidence, ev...
Researchers developed a theoretical framework to estimate metal ultimate strength without fit parameters. The new model was able to accurately predict the strengths of nearly 20 different metals.
A new study reveals the extent to which high-yielding rice varieties favored in the Green Revolution have evolved into weedy populations worldwide, outcompeting cultivated varieties. The scientists found that over a third of Asian weed strains originated from elite cultivars developed during this era.
A statistical analysis predicts that a highly purified fish oil therapy could prevent thousands of cardiovascular events each year. The study used data from the National Health and Nutrition Examination Survey and showed a 25% reduction in cardiovascular events for patients with elevated triglyceride levels.
A new Cornell University study found that students with more video game experience learned better using VR than those with little experience, with males showing greater advantage. The study suggests that either prior video game experience or gender may impact the success of VR-based learning.
Scientists discovered a novel transport protein in TB bacteria that imports vitamin B12 and bleomycin with a large water-filled cavity. This non-selective transporter may be common in bacteria and human cells, offering new insights into tuberculosis physiology and potential treatment strategies.
A team of researchers suggests using a drug commonly used for blood clots, tissue plasminogen activator (tPA), to help Covid-19 patients with severe respiratory distress. The approach is based on emerging data from China and Italy showing a disorder of blood clotting contributing to respiratory failure.
A new decontamination method developed by OSU and NC State University uses hydrogel beads containing bacteria and a slow-release food source to transform toxic contaminants into harmless compounds. The system has functioned continuously for over 300 days without maintenance, removing more than 99% of contaminants from groundwater.
The development of agricultural microbiome metadata standards aims to standardize recording and sharing practices, enabling researchers to integrate data across studies. By establishing a shared consensus on what needs to be reported about microbiome samples, the long-term value of microbiome data can increase.
A recent observational study of 416 patients with confirmed COVID-19 in Wuhan, China, reveals that cardiac injury is a common condition among hospitalized patients and significantly associated with an increased risk of in-hospital mortality. The findings highlight the importance of cardiac care for COVID-19 patients in need.
A recent study found that only half of all surfaces in an animal hospital were adequately cleaned during a 5.5-week period, with human-touch surfaces being the least likely to be disinfected. The researchers recommend creating checklists and educating staff on proper cleaning practices to protect animal and human health.
Gero's AI platform identifies 9 potential COVID-19 treatments among existing drugs, including Niclosamide and Nitazoxanide. The list enables urgent clinical trials to begin in weeks.
A study published in PLOS ONE found that hotter temperatures increase the probability of reporting bad mental health in the US. People are willing to pay several dollars to avoid each additional hot day in terms of its impact on self-reported mental health.
A new study suggests that snake venom did not evolve primarily as a defense mechanism, but rather to overpower and kill prey. Researchers surveyed nearly 400 people who work with snakes and found that only a minority of bites cause immediate pain, implying that the venom's composition has not been optimized for defensive purposes.
Scientists have identified a crucial protein called SKP1 that drives a key transition step in male meiosis, the process resulting in sperm production. Without this protein, meiosis cannot proceed, and defects can occur, leading to male infertility, pregnancy loss, or birth defects.
Researchers found that incineration and landfilling of municipal solid waste releases bacteria and antibiotic-resistance genes into the air, posing a risk to human health. The study suggests that these systems could be a reservoir of resistant genes, which can spread to nearby residents through airborne transmission.
A study using CRISPR-Cas9 gene editing technology has identified potential treatments for facioscapulohumeral muscular dystrophy by targeting genes involved in hypoxia signaling. The research found that knocking out key genes can desensitize cells to DUX4 toxicity, preventing cell death and improving muscle function.
Researchers argue that robots can help combat COVID-19 by performing 'dull, dirty and dangerous' jobs such as disinfection and temperature checking. The use of robots in pandemic response could reduce human exposure to pathogens and be essential for future epidemics.
A recent study from North Carolina State University found that people who balance living in the moment with planning for the future are better equipped to handle daily stress. The researchers discovered that a combination of proactive coping and high mindfulness significantly reduces the impact of daily stressors on negative moods.
Researchers found higher levels of pharmaceutical industry-related substances in wastewater from a manufacturing site compared to domestic wastewater treatment plants. The team detected 25 compounds, including antidepressants and opioids, in treated water samples from both facilities, with peak levels in the industrial wastewater sample.
An international team of scientists has identified the conditions that lead to slow motion earthquakes by drilling down to 1km deep in water depths off New Zealand. The study revealed a unique mix of different rock types and topography that causes slow slip events, which can trigger larger earthquakes and tsunamis.
A new stem cell delivery system using mussel adhesive protein has been developed to efficiently deliver mesenchymal stem cells to damaged cardiac muscular tissues. The system enables prolonged transplantation and promotes rapid integration of transplanted stem cells into surrounding tissues.
Researchers estimated SARS-CoV-2 infection rate in cancer patients at a Wuhan hospital, revealing potential risks and health concerns. The study found that SARS-CoV-2 transmission occurred among cancer patients, emphasizing the need for enhanced precautions.
The new dataset, published in PLOS ONE, analyzed 15,506 instances of social scientists' testimony and found that economists testified more than four times as often as political scientists and over 10 times as often as sociologists. Economists also represented think tanks, while anthropologists had the lowest rate of testimony.
Research shows that bats rely on listening to their fellow bats' echolocation calls when hunting over insect-poor farmland. In contrast, they hunt individually in forest areas with more abundant prey. The study highlights the importance of population density for successful joint hunting and potential extinction threats
Research found that regular screening and access to new treatments have significantly reduced new hepatitis C infections among HIV-positive men in London and Brighton. The study analyzed data from over 9,000 men at risk of hepatitis C and showed a decline in new cases, with the lowest recorded since 2008.
Researchers at MD Anderson Cancer Center developed a combination therapy that reprograms effector T cells into persistent central memory T cells capable of self-renewal and effective cancer cell killing. This approach addresses the persistence challenge in cellular therapies, increasing their effectiveness.