A gene therapy strategy has shown encouraging early results against Angelman syndrome, a neurodevelopmental disorder affecting approximately one in every 20,000 children. The therapy restores function of the UBE3A gene in neurons, preventing key signs of the condition and improving motor skill-learning and behaviors.
A new study reveals significant gaps in the representation of women and pregnant individuals in research used to inform nutrition reference values. The study's findings highlight the need for increased diversity and inclusion in nutritional research to provide accurate guidance for Americans and Canadians.
Scientists aim to create sustainable materials for optical applications by leveraging polylactide, a renewable resource with good optical properties. The project addresses issues like CO2 emissions and microplastics to develop cost-effective high-performance polymers.
Scientists have identified the molecular origins of recombination in RNA viruses, a process that can lead to the emergence of new variants. The study reveals a new class of antiviral drugs that target this mechanism, but warns of potential risks when used in large quantities.
Researchers examine the accelerating expansion of the Universe, a phenomenon driven by dark energy. The study reveals disparities between observations and theoretical models, highlighting the need for new understanding and precision experiments.
Researchers discovered a significant impact on executive functioning, processing speed, and memory encoding in patients treated for COVID-19. Cognitive impairments persisted several months after the initial infection.
Rice University researchers have developed a method to control the growth of tetrahedron-shaped nanoparticles, which can be used as building blocks for unique metamaterials. The team discovered that balancing thermodynamic and kinetic forces during crystallization allows for symmetry breaking, forming pyramid-shaped nanocrystals.
Researchers at INRAE found that drought conditions do not trigger esca leaf symptoms in vines. The scientists used controlled drought conditions to monitor the physiological state of 51 Sauvignon blanc vines, half under drought, and found no correlation between drought and disease development.
A CU Cancer Center member is developing a decision aid for breast cancer patients, gathering data on well-being outcomes after surgery. The study found that women who underwent lumpectomies reported better psychosocial and sexual well-being than those who had mastectomies.
Researchers have identified a specific molecular mechanism that controls the transition from acute to chronic pain. Disabling an intracellular enzyme called N-acylethanolamine acid amidase (NAAA) can halt chronic pain development in mice, suggesting a new class of drugs to treat various forms of chronic pain.
A new study found that most incarcerated individuals' in-prison experiences lessen their perceptions of procedural justice and fairness, regardless of the length of time served. The research used a nationally representative sample of over 31,000 adults and examined various in-prison experiences on inmates' perceptions of staff members'...
Researchers have overcome significant barriers to developing safe and long-life lithium metal batteries by creating a new structure in the negative electrode that can regulate lithium ion flux. The results show high capacity retention of over 80% after more than 200 cycles of recharging.
Burt's Bees research finds that natural origin ingredients like bakuchiol, aloe, and rice milk improve skin health for all skin types and tones. The studies also show that these ingredients can restore skin barrier function and lead to positive subject-reported improvements.
Research found that warming water temperatures and browning increase methylmercury transfer to phytoplankton, reducing essential polyunsaturated fatty acids. This impacts the food chain, exposing higher organisms to toxic mercury and compromising nutrition, posing a threat to human health.
Researchers at Rutgers University have linked Fragile X and SHANK3 deletion syndrome, both associated with autism and health problems, to walking patterns. The study used motion-sensored sneakers to detect gait problems 15-20 years before clinical diagnosis, offering a potential framework for early intervention.
A case study evaluated the experience of a deafblind adult using three wayfinding support tools on an urban college campus. The tactile map proved to be the most successful tool, while the mobile application yielded the lowest performance and confidence. Simplifying wayfinding tools and tailoring information to individual preferences a...
The attoscience community has clarified points of tension through discussions among researchers, exploring the scope and nature of analytical and ab-initio approaches. Researchers also investigated the physical observables of quantum tunnelling experiments, aiming to explain differing conclusions.
The KU Center for Community Health and Development monitored and evaluated the COVID-19 response in Douglas County, finding factors that delayed and controlled outbreaks. Local school closures, stay-at-home orders, and mask-wearing mandates were key in bending the curve of cases.
A recent study published in eLife reveals that the shape of the respiratory syncytial virus (RSV) plays a crucial role in determining infection outcomes. Researchers found that RSV viruses change from long, rod-shaped particles to more rounded ones during infection, which affects the activation of complement proteins by the immune system.
The Toarcian Ocean Anoxic Event was found to have occurred in the eastern Tethys, displaying similar carbon-isotope excursion patterns to other regions. This suggests a global expression of the event, with climatic change controlling organic matter accumulation and sediment supply.
Researchers create efficient, designer infrared light sources with near-arbitrary spectral output, enabling molecular sensing technologies and various applications. The innovative process leverages heat-driven design and machine learning, reducing optimization time from weeks to minutes.
A study published in Scientific Reports found fossilized remains of sauropodomorphs, including eggs and skeletal remains, that suggest the earliest evidence of herd living in dinosaurs. The fossils, dated to approximately 193 million years old, show age-specific clusters of individuals, indicating possible herding behavior.
A new method enables efficient discovery of reliable control system designs comparable to human experts, applicable to 'black box' systems without clear internal behavior. This research aims to reduce design costs and improve safety in various industries.
Researchers at Queen Mary University of London have discovered a new way to analyze diseased and healthy cells from the same patient, revealing potential targets for individualized treatments. The study's findings could also help predict patient response to current drugs, leading to improved survival rates.
Lakes in the Northern Hemisphere are warming at an alarming rate, with some losing up to two months of ice cover since records began. The study, led by York University, found that lakes are losing on average 17 days of ice cover per century.
A national network has been launched to promote understanding of planetary limits, envision scenarios for humanity to thrive within limits, and advise governments on developing effective responses. The essay warns that current economic growth, energy use, and resource consumption will overshoot Earth's finite limits if not addressed.
Research by Michigan State University scientists highlights the importance of balancing built and green infrastructure to address water insecurities and climate change. The study found that natural infrastructure, such as protected forests and wetlands, plays a crucial role in sustaining freshwater flows to cities.
The study introduces a novel approach to attenuate the limitation of the energy gap law, achieving high-efficiency NIR emissions through intermolecular charge-transfer aggregates. The developed material exhibits widely-tunable emissions and high photoluminescence quantum yields.
A study of over 143,000 patients found significant racial and ethnic disparities in COVID-19 outcomes, with minorities more likely to be hospitalized or die from the virus. American Indian or Alaska Native, Latino, Black, Asian, or Pacific Islander individuals had higher rates of severe illness compared to white individuals.
Researchers discovered that living cell interiors become softer and more fluid during mitosis, a process crucial for life. The findings could help ensure precise separation of cellular structures into daughter cells.
The researchers developed a catalyst that achieves high selectivity and stability in the reduction of CO2 to formic acid. The catalyst, containing indium sulfide and zinc, demonstrates excellent catalytic stability even at industrial current density for extended periods.
A Rutgers-led study found that banning right-wing extremists from Twitter significantly reduces the spread of anti-social ideas and conspiracy theories. Removing these individuals from social media platforms leads to a nearly 92% decline in tweets referencing them, as well as a 90% decrease in new users tweeting about them.
A new study by ISGlobal provides robust evidence that COVID-19 is a seasonal infection linked to low temperatures and humidity. The research team found a negative relationship between the transmission rate of SARS-CoV-2 and both temperature and humidity at the global scale.
The study analyzed data from 8,502 genetically high-risk children and found that half developed type 1 diabetes before age 6, while the other half developed it between ages 6 and 12. The findings suggest a different form of type 1 diabetes emerges in children as they grow older.
Researchers at USTC have successfully synthesized small-sized Pt intermetallic nanoparticle catalysts with ultralow Pt loading and high mass activity. These catalysts exhibited excellent electrocatalytic performance for oxygen reduction reaction in proton-exchange membrane fuel cells, potentially decreasing the cost of fuel cells.
Researchers at the University of Bonn discovered a novel resistance mechanism in Staphylococcus aureus, which protects the bacteria from vancomycin. By binding vancomycin to its cell wall, the strain prevents the antibiotic from reaching the membrane and killing the bacteria.
The Icahn School of Medicine at Mount Sinai has received a five-year, $16 million grant from the National Institutes of Health (NIH) to foster inclusive excellence in the biomedical sciences. The grant aims to recruit and hire faculty members from underrepresented groups across four research areas.
A research team developed a new material platform by transferring chirality from molecular to microscale through self-assembly. The resulting chiral nanomaterials exhibit broad optical activity in the short-wave infrared region, enabling applications such as infrared neural stimulation and imaging.
Researchers at the University of Tsukuba have developed a strong, flexible conductive fiber using bagworm silk and synthetic polymers. The composite fibers exhibit promising properties for wearable electronic devices, tissue engineering, and microelectronics.
A new study found that US gun violence increased by 30% during the COVID-19 pandemic, with 28 states experiencing significantly higher numbers of shootings. The researchers attribute this increase to added stress, worry, and fear, as well as increased access to firearms.
A new approach to measuring financial and digital literacy is proposed by a team of researchers led by Angela Lyons. The study finds that while promoting literacy is important, it may not be enough to ensure resilience, particularly for vulnerable groups such as women and those living in poverty.
Scientists have shown that applying an electric field to the skin affects collagen pathways, temporarily reducing production and increasing degradation. This opens new therapeutic perspectives for the topical treatment of skin fibrosis characterized by excessive collagen deposition.
The University of Minnesota Medical School will host a statewide center for spinal cord injury research and education, aiming to provide clinical care and expand research on the condition. The center will conduct studies and educate local physicians on their findings, particularly in reducing below-level neuropathic pain.
Stem cell researchers have developed a new method to identify and develop personalized therapies for Cystic Fibrosis patients with rare mutations. By growing precursor lung cells from patients' own blood, they can screen for new drugs and validate responses in mature airway cells.
A recent study used gene-targeting drugs to suppress areas of the brain and then imaged brain activity, revealing how this affects other complex operational networks. The research team found that silencing specific brain regions can cause stimulatory and inhibitory changes in brain activity, which can be identified using fMRI.
Researchers monitored the temporal niche partitioning of 73 cameras over six years in Malaysia's Sabah state. The study found that some species, like wild cats and civets, segregate their activities by time of day to avoid competition.
Erica Ollmann Saphire and her team at the La Jolla Institute for Immunology have received a $2.6 million grant to develop a pan-coronavirus vaccine. The team aims to create a single vaccine that can protect against future outbreaks of any coronavirus, including SARS-CoV-2 variants.
Researchers measured brain activity of freely interacting Egyptian fruit bats to understand how they process group communication. They found that 'friendlier' bats induced higher correlations across the brains of group members, suggesting a connection between social behavior and neural activity.
A recent study using survey data estimates the proportion of US adults with a disability, revealing significant disparities in health and well-being. The research also sheds light on the prevalence of disabilities among different age groups and populations.
Researchers have established that the Pontic-Caspian steppes and northern Caucasus are the center of horse domestication in Eurasia. The study reveals that domesticated horses spread throughout Asia at the same time as spoke-wheeled chariots and Indo-Iranian languages.
Researchers have been exploring tribocatalysis as an alternative clean energy technology. The process converts mechanical energy into electrical energy through the triboelectric effect, with potential applications in material synthesis and energy conversion. Further research is needed to fully develop this promising field.
Researchers created a shape-shifting material that can morph into any stable shape, enabling independent control of geometry and mechanics. The totimorphic structural materials have the potential to be used in robotics, biotechnology, architecture, and other applications.
Scientists studied rats in a virtual reality maze to gain a deeper understanding of the hippocampus' circuit-level functions. They discovered that hippocampal neurons encoded multiple aspects of an animal's location, including distance traveled and body direction.
Researchers at Berkeley Lab have successfully engineered microbes to produce novel chemicals and developed a new technique for studying enzyme reactions in real-time. This breakthrough could lead to the production of sustainable fuels, pharmaceuticals, and renewable plastics.
Researchers found a higher burden of infection, more inflammation, and lower diversity of microorganisms in children with cystic fibrosis compared to disease controls. This divergence was noted as early as toddlerhood, suggesting potential for earlier treatment and prevention of severe lung disease.
A new AI tool pairs protein pathways with clinical side effects and patient comorbidities to suggest targeted Covid-19 treatments. The tool, MOATAI-VIR, predicts 24 out of 26 major clinical manifestations of Covid-19 and their underlying disease-protein-pathway relationships.
Researchers have developed new qPCR assays to quantify the transmission of antimicrobial resistance (AMR) using water and wastewater samples. These methods provide a more exact way to determine AMR by measuring DNA in wastewater samples.
Researchers are developing a standardized training program to address physician bias and improve equity in advanced heart failure treatments. The program, called SOCIAL HF, aims to reduce barriers to equitable treatment through evidence-based bias training and objective criteria.
A study found that gun violence rates in the US increased by 31.2% during the pandemic period compared to the pre-pandemic period. The authors speculate that increased access to firearms and depressive symptoms may be contributing factors.
A targeted drug, cabozantinib, has shown activity against brain metastases from kidney cancer, achieving a 50% response rate. The drug's ability to reach the brain through the blood-brain barrier offers a promising systemic option for patients with poor life expectancy and intervention tolerability.