Scientists have found that nearly all antibiotic resistance genes came from bacteria that cause disease, not antibiotic-producing bacteria. The rapid evolution of resistance is fueled by the use and overuse of antibiotics, threatening modern healthcare.
A new study by the University of Basel found that lockdowns affect mental health variably across countries, with factors like social support and financial stability playing a crucial role. The research suggests that public health initiatives should target those without social support and those whose finances worsen during lockdowns.
A new drug combination using Selinexor and Nutlin-3a has shown promising results in increasing susceptibility to chemotherapy in cases of severe neuroblastoma. The treatment targets the p53 gene mutation, which is rare in neuroblastoma but present in other cancer forms.
Researchers at Tohoku University and Toshiba Corporation developed a new analytical technology for hard disk drives, enabling precise analysis of write head operations. The method achieves high spatial and temporal resolutions, potentially leading to further increases in HDD capacity and higher data transfer rates.
A study by University of Pennsylvania researchers found that humorously presented news clips enhance memory retention and sharing among young adults, making them more likely to engage with politics. This social nature of comedy is linked to increased brain activity related to thinking about others' opinions.
Researchers found that rising lizard temperatures and predation by snakes are changing the thermal biology of lizards, making them more active at warmer body temperatures. The study suggests that lizard body temperatures and running speeds have increased accordingly, helping them escape snakes.
A large-scale electronic health record study found that functional seizures are prevalent and often misdiagnosed as epileptic seizures. The study also discovered novel associations between functional seizures and cerebrovascular disease, including stroke, as well as psychiatric disorders such as PTSD and depression.
Researchers found that propylene glycol and vegetable glycerol cause gut inflammation by breaking down zipper-like junctions between cells. Chronic e-cigarette use can lead to a 'leaky gut,' allowing microbes and molecules to seep out, resulting in chronic inflammation.
Early humans showed complex behavioural adaptations in fluctuating environments, using reliable stone toolkits to exploit multiple habitats. Hominin occupation of varied and unstable environments is a unique example for this early time period.
A cross-sectional study maps overlapping evidence syntheses on imaging findings of children with COVID-19, highlighting shortcomings in the field. The study aims to improve the quality and consistency of imaging-based research in pediatric COVID-19.
A new study by Anglia Ruskin University found that spending time outdoors is associated with higher levels of happiness during COVID-19 restrictions. The research also showed that daily screen time and loneliness are linked to lower happiness levels, but outdoor activities can mitigate these effects.
A study suggests that sharing excess protein-rich meat from hunted prey species could have contributed to the early domestication of dogs. Humans feeding lean meat to wolves during severe ice age winters enabled companionship and potentially paved the way for full dog domestication.
Scientists at The Wistar Institute have developed an ACSS2 inhibitor that impairs cancer growth in preclinical models by depriving malignant cells of a critical nutrient source. This approach targets acetate metabolism, which is essential for tumor growth under conditions of low nutrient and oxygen availability.
A recent study investigated attitudes towards long-acting injectable (LAI) HIV therapies among women with a history of injection, including medical purposes and substance use. The research found that LAIs may improve adherence by reducing treatment fatigue and reminders associated with daily pill-taking.
A team of researchers has developed a novel approach to measuring magnetic fields using 'damaged' polymer optical fibers. The sensor can detect small magnetic field changes, several hundreds of times smaller than conventional methods, and is suitable for applications in electric power systems.
A study published in Information and Organization found that employees who master technology can use everyday organizational IT to create new ideas. This increases the return on investment on existing technologies, saving organizations money by reducing the need for specialized technology.
A recent study published in Science Advances analyzed genomic data from archaeological remains in northeastern Asia, revealing complex migration patterns and disease-related bacteria. The research provides new insights into the demographic history of the region and its connection to the Paleo-Inuit groups.
Researchers at Mount Sinai identified three major molecular subtypes of Alzheimer's disease using RNA sequencing data from over 1,500 brain samples. These subtypes were independent of age and disease stage and corresponded to different combinations of dysregulated biological pathways leading to brain degeneration.
Researchers analyzed 2,121 hospitalized COVID-19 patients and found no significant association between immunosuppression and worse outcomes. The study suggests that immunosuppressive drugs may not increase the risk of severe COVID-19 for patients with chronic conditions.
A team of Penn Medicine researchers identified five categories of curriculum that misrepresented race in class discussions, presentations, and assessments. They recommend medical schools standardize language, contextualize racial differences, and generate evidence-based medical knowledge to dismantle structural racism.
Autoimmune diseases like T1D, SLE, MS, and RA exhibit common genetic risk, chronic inflammation, and tissue damage mechanisms. Target tissues participate in a deleterious dialogue with the immune system, contributing to disease progression.
Researchers have developed a novel method for visualizing the intricate structure of 'mini-brains' using high-resolution 3D imaging, shedding light on brain development and disease progression. This breakthrough could accelerate personalized medicine studies and reduce animal testing.
Researchers found that cooling vests reduced heat stress in COVID-19 nurses by lowering heart rates and improving subjective perceptions. The study showed that while core temperature increased slightly, the cooling vest had a minimal effect on overall heat stress.
The European Research Council (ERC) has funded a new platform leveraging crowd-sourced image classification to train AI algorithms. This innovation addresses the gap in current market platforms, providing users with a tailored, quality-controlled crowdsourcing experience for efficient and fair data collection.
A new study by Hayden Noel found that emotionally arousing advertisements can have a negative effect on immediate memory but a positive effect on delayed memory if the level of emotional arousal is congruent with the ad's claims. The research has practical implications for advertisers seeking to develop effective message strategies.
A leading expert on queen conch aquaculture has published a manual to culture and restore the species, which is facing decline due to overfishing and habitat damage. The manual provides a comprehensive guide to hatchery and nursery phases, with the goal of producing sustainable seafood, conservation, and restoration.
Researchers at UC Santa Barbara offer approaches for sustainable expansion of the US seafood industry, citing challenges from trade wars and COVID-19. They recommend 'precise and strategic fisheries reforms' to address complexities and promote growth.
A recent study found that policymakers reference new and highly cited COVID-19 research papers extensively in their policy documents. The researchers analyzed scientific citations in 37,725 papers and discovered that these documents use the newest science at an unusually high rate, citing papers with 40 times higher citation counts.
Researchers found that glycylation, a rare modification of tubulin protein, is essential for maintaining straight swimming motion in sperm cells. Without this modification, sperm swim in circles due to uncoordinated activity of molecular motors.
A novel approach to COVID-19 screening was developed by using a drive-through intraocular pressure (IOP) clinic, allowing for safe measurement of eye pressure in a public health setting. This innovative method minimizes the risk of COVID-19 transmission between patients and clinicians.
The University of Texas at Arlington has seen significant success with the Eisenhower Transportation Fellowship Program, with over 40 students earning merit-based awards in recent years. The fellowships are designed to attract top talent to the field of transportation and promote workforce development.
A cancer center implemented a virtual care program in response to the COVID-19 pandemic, resulting in improved patient outcomes. The study examined the effectiveness of this approach and found positive results.
Researchers at Otto von Guericke University Magdeburg aim to understand brain cognitive potential, variability, and neurobiological processes that prevent full utilization. The goal is to develop interventions improving cognitive performance in healthy individuals and those with hidden disease processes.
A recent study found that seventy percent of participants lacked understanding of palliative care, while forty-four percent believed it conflicted with their values. Despite this, many agreed that better quality of life was crucial when dealing with a serious illness. The study highlights the need for culturally competent palliative ca...
Researchers at Emory University developed a shape-shifting nanomaterial made of synthetic collagen that can be triggered to change its form from flat sheets to tubes and back again. The material has biomedical applications such as controlled-release drug delivery and tissue engineering.
A team of biologists and mathematicians developed a new software tool to analyze cell migration processes in zebrafish embryos. The study identified physical barriers that influence cell migration and found a tissue-specific expression of green fluorescent protein, which serves as a reference structure for image registration.
Researchers estimated that more than half of SARS-CoV-2 transmission occurs among asymptomatic individuals, suggesting a significant role for these carriers in the spread of the virus. The study's findings have important implications for public health strategies and contact tracing efforts.
A new study reveals that traditional performing arts can drastically reduce the fatal threat of diarrhoea and pneumonia in young children. The intervention, led by the University of Birmingham, improved mothers' food safety and hygiene behaviours, resulting in a 60% reduction in hospital admissions for diarrhoea and a 30% reduction in ...
Researchers at Rice University have created a lab tool that simplifies simulations of the human intestine, allowing for more practical studies on diseases like infectious diarrhea. The device enables the real-time growth of bacterial infections and provides a mechanical model for studying how invading bacteria cause disease.
Researchers from the University of Bath highlight the flaws in the current open-source system, where design process is not open, leading to duplicated efforts and hindered collaboration. They call for universities to support staff in open design and governments to clarify liability for individual teams contributing to open designs.
A study by Japan Advanced Institute of Science and Technology reveals that bone-conducted (BC) speech transmission affects perception similarly to air-conducted speech. The team found that RT vibrations support frequencies up to 1 KHz, while EC pressure accentuates frequencies in the 2-3 KHz range.
Researchers at the Max Born Institute developed a novel laser-driven X-ray source generating femtosecond copper K° pulses with unprecedented flux of 10^12 photons per second. This breakthrough enables investigating ultrafast structure changes in condensed matter by time-resolved X-ray scattering.
The harbor porpoise population is declining in the German North Sea, with a decline of 1.79% per year reported over two decades. Conservation efforts are needed to protect the species, which has been affected by human activities at sea, including shipping routes and wind farms.
A regional study from Dartmouth College found increases in extreme streamflow events across the US and Canada, including more frequent floods and droughts. The research analyzed records dating back to 1910 and identified significant changes in precipitation levels on river systems.
A new study published in GSA Today suggests that the Yellowstone hotspot is derived from a deep mantle plume, with magmatism extending to at least 56 million years ago. The study's findings indicate a long-lived and robust hotspot that has migrated across northeastern California, northern Nevada, and into Yellowstone National Park.
Engineers developed a new technique to eliminate particularly tough blood clots by using engineered nanodroplets and an ultrasound drill to break up the clots from the inside out. In vitro testing showed promising results, with the use of nanodroplets, ultrasound, and drug treatment reducing clot mass by 40%, plus or minus 9%.
Researchers from Osaka University developed a new method for analyzing brain tissue with mass spectrometry imaging, enabling the identification of biochemicals at high spatial resolution. This technique may help diagnose brain diseases such as cancer by providing molecular information in high-resolution images.
Researchers have found that a protein called transthyretin (TTR) can break toxic amyloid beta clumps associated with Alzheimer's disease. The study suggests that modified TTR peptides may prevent or slow progression of the disease in mouse models, offering new hope for patients.
A new study published in JAMA Network Open shows that deep learning can help predict occult peritoneal metastasis in stomach cancer. The researchers developed a deep learning model called Peritoneal Metastasis Network (PMetNet) to predict clinically occult peritoneal metastasis using preoperative computed tomography images.
A study identifies three molecular subtypes in HNSCC, suggesting different therapy options for EGFR, CDK, and immunotherapy. Biomarkers like EGFR ligands and Rb phosphorylation status may help select patients for targeted treatments.
Researchers identified two novel genetic variants in the Siglec-10 protein that predispose individuals to polyneuropathy after gut infection. These variants impair the protein's ability to bind gangliosides, leading to autoantibody production and damage to neurons.
Researchers at Uppsala University have discovered a link between faulty L-Dopa metabolism and severe side effects in Parkinson's patients. Abnormally elevated levels of L-Dopa and its metabolite were detected in brain regions outside the striatum, suggesting alternative mechanisms underlying motor disorders.
Virtual care during COVID-19 accelerated at Princess Margaret Cancer Centre, showing high patient and physician satisfaction. The study found significant cost savings for patients and comparable or better quality of care.
A new mouse model created by researchers at the University of Bonn reveals that GPI anchor deficiencies, a group of rare diseases, are caused by impaired transmission of stimuli at brain synapses. The mice exhibited cognitive deficits, altered social behavior, and increased susceptibility to epilepsy, mirroring human symptoms.
Research by international experts recommends decriminalizing all illicit drugs, including crack cocaine and heroin, as a matter of urgency. The 'war on drugs' disproportionately targets Black communities, damaging communities and violating human rights.
A new paper from Global TIES for Children presents a review of opportunities and challenges in designing rigorous research on the impact of conflict on child development and education. The study found positive impacts of remedial education and social-emotional learning programs on academic skills.
Researchers have mapped the origins of the embryonic mouse heart at single-cell resolution, identifying a pool of progenitor cells that form heart muscle cells and the early epicardium. This understanding could improve regenerative heart therapies and inform congenital heart defect research.
Researchers found that continuing commonly used blood pressure medications like ACE inhibitors and ARBs did not affect COVID-19 patient outcomes. The study supports international recommendations to continue these medications in hospitalized patients unless there is a clear medical issue.
A significant number of patients with sudden loss of consciousness require pre-hospital critical care, according to a recent study. The research found that air ambulance dispatch teams can select patients needing HEMS-specific interventions and identify opportunities to improve triage.
Researchers propose a framework to evaluate climate change impacts on California's water-energy nexus. The framework identifies key stressors and adaptations, revealing potential synergies in mitigating climate change.