A transgenic pig model has been developed allowing for the first time the in vivo fluorescent labeling of age-distinct insulin secretory granule pools. This model enables researchers to study insulin turnover in normoglycemic conditions, closing the translational gap between humans and rodents.
Researchers developed a dynamic respirator that modulates pore size in response to changing conditions like exercise and air pollution. The device features an AI-powered system that adjusts filtration characteristics wirelessly, providing improved breathability and comfort.
Researchers will use data and solutions to engage businesses, policymakers, and consumers in reducing wasted food. The project aims to create knowledge and drive sustainable solutions for the US food system.
A study published in Cell Metabolism identified a protein called neurturin as crucial for muscle health, improving metabolic rates, motor function and exercise capacity. Mice genetically modified to produce more neurturin had increased resistance to degeneration in neurons associated with ALS.
A new Northwestern Medicine study found that over half of US women and people who menstruate experienced changes in their menstrual cycle due to COVID-19 pandemic stress. Individuals with higher levels of stress reported heavier bleeding and longer periods.
A new study found that urban park use declined in North Carolina during the pandemic, disproportionately affecting minorities and lower-income backgrounds. The study used survey responses and cell phone tracking data to analyze outdoor park use across the state.
A 16,000-25,000-year-old jawbone from Sulawesi provides conclusive evidence of Pleistocene-era humans in the region. The fossil exhibit unusual dental wear patterns, offering insights into the daily lives and dietary habits of early Homo sapiens.
Researchers found that newer formulas considering lexical sophistication, syntactic complexity, and cohesion predict ESL reading effort more accurately than traditional formulas. Eye-tracking data revealed that longer fixations, shorter movements, skipped words, and regressions indicate higher reading difficulty.
Researchers tracked fruit flies' ability to interpret information while asleep, discovering a specific brain region involved in processing salient smells. The study used defined fly brains to analyze neural connections, finding that aversive odors woke the flies up more often than attractive ones.
A team of researchers at the Marine Biological Laboratory has developed a system called HySyn, which uses neuropeptides from Hydra to synthetically reconnect neural circuits in the C. elegans brain. This allows for the creation of an artificial synapse that rewires a behavioral circuit, enabling the worm to communicate more effectively.
A new study of 51,000 UK adults found that COVID-19 lockdowns had differential impacts on people's income, time use, and subjective well-being based on their gender, ethnicity, and educational level. The study suggests that these inequalities may persist even after lockdown restrictions eased.
Scientists identified several FDA-approved drugs, including metformin and inhaled anesthetics, that may prevent or treat noise-related hearing loss. The study analyzed changes in gene expression in mouse ears after damage caused by loud noise.
Researchers aim to create a flexible security feature that learns from past cyberattacks and requires minimal human intervention. They'll collaborate with device developers to share solutions and improve future responses to attacks.
A new study published in Prehospital and Disaster Medicine found that prehospital ketamine administration for excited delirium with concomitant cocaine intoxication significantly increases the risk of subsequent emergency department intubation. The study's findings suggest that cocaine may deplete excitatory neurotransmitters, leading ...
Scientists use specific self-assembling peptides to organize silica nanoparticles into larger structures, demonstrating a new approach to self-assembly. The researchers' method enables the creation of novel materials with various applications, including drug delivery systems and nanocatalysts.
A new study found that trust and understanding hindered adoption of the NHS App, with BAME participants having particularly negative views. Despite high compliance rates, older adults were less likely to download the app, while those who deleted it cited concerns over tracking and effectiveness.
A major research project addressing male suicide and depression in the UK and Europe found the Men's Shed concept improves health and wellbeing for men at high-risk of social isolation. The project, Step-by-Step, has been adopted by various groups across four countries, promoting peer-support and autonomy.
A new study found that every extra 1cm in waist circumference increases the odds of advanced fibrosis by 5% in people with type 2 diabetes. Advanced fibrosis is a late stage of non-alcoholic fatty liver disease (NAFLD), which can lead to serious liver damage.
A new $3 million study will investigate the link between weight loss and bone frailty in diabetics. The research aims to identify metabolomic changes causing increased fracture risk and explore ways to prevent bone loss during intentional weight loss.
Researchers believe that wind and hydropower are the most promising renewable energy sources in Russia, with suitable areas for installation identified. However, the transition to these energy sources has been slow due to reliance on fossil fuels and nuclear energy.
Researchers create a novel framework for generating and detecting Lamb waves in transparent materials without damaging the sample. They use laser-induced plasma shock waves and high-speed polarization cameras to spot microscopic scratches, demonstrating potential for non-contact damage detection.
Researchers at Stanford University found that exoskeletons work best when users are given time to learn how to use the device, with customized control improving performance by around half. Participants who received optimized training saw significant reductions in energy expenditure, with benefits persisting even after they became experts.
Researchers develop a highly accurate method to assemble multiple micron-scale optical devices on a single chip, enabling practical manufacturing of chip-based optical systems. The new approach allows integration of different materials on a single chip, paving the way for compact optical communications and imaging devices.
By analyzing pitch, length, octaves, chords, dynamics, and main theme of four pieces from the mid-1800s Romantic era of classical music, researchers created protein songs with improved musicality. The study found that using a specific music style guided the structure of proteins to produce more pleasant melodies and harmonies.
A study published in Academy of Management Discoveries found that visual information, including body language and facial expressions, plays a crucial role in investor decision-making. Researchers played silent videos of entrepreneurial pitches to expert investors and novices, who correctly identified the original winners. The study sug...
Researchers have developed a quadruplet codon system that could encode 256 distinct amino acids, allowing for the creation of proteins with tailored characteristics. The system uses tRNAs to translate information from DNA and RNA into amino acid building blocks, with promising results in translating segments of a protein.
A team of researchers has developed a low-cost and low-waste device that uses Tootsie Roll candy as an electrode to monitor ovulation status or kidney health. The sensor works by detecting changes in salt levels in saliva, with preliminary tests showing promising results.
A large UK study found no overall associations between menopausal hormone therapy and risk of dementia, regardless of hormone type or duration. However, oestrogen-progestogen therapy may slightly increase risk in women with Alzheimer's disease, particularly for long-term use.
Millions of Europeans depend on fishing for food and livelihood, with ocean warming affecting fish distribution and abundance. Regional differences in climate risk highlight the need for locally adapted approaches, including social safety nets and income support.
A new study reveals marked socio-economic inequalities in Scotland's type 2 diabetes prevalence, with the gap widening over time. Women in the most deprived areas are almost 2.5 times more likely to have type 2 diabetes than those in the least deprived areas.
Researchers have discovered a new approach to prime the tumor environment to make chemotherapy more effective for pancreatic ductal adenocarcinoma. By reducing stiffness and density of connective tissue, cancer spread was reduced by up to 50%. The study paves the way for a clinical trial to assess the therapy approach's effectiveness.
Researchers found that providing patients with a clinician team roster increased recognition of each clinician's name and face, with an average increase of 4.57 out of 5 on a five-point Likert scale. This improvement was particularly notable during the COVID-19 pandemic when universal masking made facial recognition more challenging.
Scientists have discovered two new species of spinosaurid dinosaurs on the Isle of Wight, providing significant insights into the UK's spinosaurid population. The newly found fossils, including Ceratosuchops and Riparovenator, measure around nine meters in length and suggest a diverse ecosystem with multiple predators.
Researchers at Rice University and the US Army are developing a portable skullcap that analyzes cerebrospinal fluid flow during sleep to clear metabolic waste. The goal is to noninvasively measure and modulate brain health in soldiers, potentially treating sleep disorders in real time.
Researchers at Karolinska Institutet developed an AI-based tool to improve breast cancer diagnosis and predict recurrence risk. The method divides patients with grade 2 tumours into high-risk and low-risk sub-groups, enabling personalized treatment.
Researchers found that clover grown with symbiotic nitrogen-fixing bacteria in Martian regolith experienced significant 75% more root and shoot growth compared to uninoculated plants. However, the regolith showed no excess production of nitrogen compounds, suggesting a potential role for these microbes in terraforming Mars soils.
A 10-year study in Panama's Barro Colorado Island found that liana density increased dramatically due to natural canopy disturbance, with most of the growth attributed to gaps in the canopy. The study suggests that environmental factors like climate change may also be contributing to this phenomenon, but to a lesser extent.
A groundwater market in California's Mojave desert stabilizes resources and increases property values by 200%, generating a net benefit of at least $400 million. The cap-and-trade system enables water to be used more productively while compensating original owners.
A new study found that nearly three in ten people with type 2 diabetes in Scotland were prescribed antidepressants before their diagnosis. Additionally, one in ten individuals received antipsychotic prescriptions prior to T2D diagnosis. These findings suggest a link between mental health and the development of type 2 diabetes.
A team of researchers at Bristol's Quantum Engineering and Technology Labs has developed a silicon photonic chip that can protect quantum bits from errors using photons. This breakthrough could lead to the creation of more powerful quantum computers by reducing the fragility of qubits.
A new study in mice reveals that fragile X treatment can incur resistance, but also identifies potential strategies to overcome this. Administering mGluR5 inhibitors at a young age and then stopping may produce lasting benefits in cognitive ability.
Lord Simon Woolley argues that UK drug laws are designed to be a tool of systemic racism and fail black communities. He calls for a root-and-branch review of the law to consider alternative approaches, including decriminalization and legal regulation of non-medical drug supplies.
A new study of over 17,000 participants found that sibling bullying in early adolescence is associated with poorer mental health outcomes in late adolescence. The research suggests that prevention and clinical interventions aimed at reducing sibling bullying can benefit from improving positive mental health during late adolescence.
The Patient-Centered Outcomes Research Institute (PCORI) has approved funding for a large-scale comparative clinical effectiveness research study to compare colonoscopy versus stool-based testing for monitoring patients ages 70 and older at low risk of developing colorectal cancer. The study will also implement an online weight managem...
Researchers have identified a common mutation in gliomas that sensitizes them to immunotherapy, which can lead to improved survival rates and tumor-free periods. The discovery may have broader therapeutic implications for all glioma patients, offering new hope for treatment.
A study on fruit flies found that intermittent time-restricted fasting increased longevity and improved healthspan. The study suggests that stimulating autophagy at night could provide humans with similar benefits without the need for drastic dietary changes.
Researchers found increased retinoic acid levels in the prefrontal cortex during mid-pregnancy, leading to the development of unique brain properties. The study suggests a link between RA, CBLN2 gene expression and human-specific cognitive abilities.
Researchers discovered zebrafish neurons that monitor prediction errors to efficiently avoid danger, creating a 'hazard map' in the brain. This study sheds light on brain circuits shared across vertebrates, including humans.
Researchers found a perovskite oxide that exhibits exotic behavior among Dirac electrons when strained, leading to unexpected correlations and entanglement. The discovery sets the stage for advanced electronics and potential breakthroughs in quantum computing.
A massive review of nearly 300 studies found strong associations between greenspaces near homes and schools and improved physical activity and mental health outcomes in kids. Exposure to nature, particularly for disadvantaged populations, offers greater health benefits by counteracting poverty's toxic effects.
A team of researchers from Lund University critiques the circular economy, highlighting inconsistencies and hidden assumptions in its supposed benefits. They propose a more modest approach to circularity, focusing on concrete problems rather than presenting it as a panacea.
The Buck Institute has been awarded a $14.3 million grant from the NIH to study cellular senescence, a hallmark of aging, as a driver of Alzheimer's disease and other age-related dementias. Researchers will investigate new mechanisms that can be developed into interventions to treat patients.
Researchers found that vitamin B12 supplementation improved movement in worms with Alzheimer's-like symptoms, suggesting a potential link between diet and disease progression. The team also discovered that vitamin B12 relies on an enzyme called methionine synthase to work, and its effects are limited to those with dietary deficiencies.
Researchers at UT Southwestern Medical Center found that stringent lineage tracing is essential for studies of nerve cell regeneration. The study identifies reliable lineage tracing tests and strongly recommends their use in all laboratories doing nerve cell regeneration research.
Researchers at OSU have developed a straightforward approach to assessing ecosystem health, which can be applied globally.
Researchers at Mount Sinai have developed a novel therapy called MS67 that effectively fights acute myeloid leukemia with mixed lineage leukemia rearrangement. The therapy degrades the WDR5 protein, which drives the proliferation of this type of leukemia and other cancers such as pancreatic cancer.
The article presents a new plate-based image cytometry method to measure endothelial barrier function, which can be adapted for high-throughput and high-content screening. This approach shows promise in addressing the need for efficient pharmacological therapies for acute respiratory distress syndrome (ARDS).
Ablative radioembolization has been found to have a high response rate and promising survival in patients with unresectable intrahepatic cholangiocarcinoma. The study also showed that the treatment is well-tolerated, with median overall survival not reached at 30 months.
A genetic analysis reveals that a rare type of blood cancer affecting immune T cells may be caused by exposure to smoking and aging-related mutations in blood precursor cells. The study found a potential link between the development of these tumours and second-hand smoke, suggesting cessation may prevent their occurrence.
Stephanie Grainger, Ph.D., awarded $2.375M grant to explore Wnt molecular pathway's role in healthy development and disease, including cancer, osteoporosis, and heart conditions.