Researchers discovered Fyn enzyme clusters when immobilized in synapses, forming toxic 'protein clumps' linked to dementia. Targeting Tau biomolecular condensates may prevent dementia progression.
A new study has shown that bivalirudin is a safer and more effective anticoagulant than heparin for treating heart attack patients. The trial found that bivalirudin significantly reduced death, major bleeding, and thrombosis in patients undergoing percutaneous coronary intervention.
A randomized study compared the effects of torsemide and furosemide in people with heart failure. The study found that both loop diuretics were effective in reducing death and hospitalization rates, with no significant clinical difference between the two medications.
A new study by Intermountain Healthcare found that following up a cardiac event with a statin prescription and cholesterol measuring blood test prevents 94% of patients from having or dying from a second cardiovascular event. Patients without follow-up care were at a 60% risk, compared to just 6% for those who received treatment.
Researchers have discovered a new gene, Schlafen11 (SLFN11), which correlates with chemotherapy response in medulloblastoma. The study's findings suggest SLFN11 can help improve treatment outcomes by increasing sensitivity to cisplatin.
Researchers at Intermountain Healthcare found that taking selective serotonin reuptake inhibitors (SSRIs) does not reduce the severity of COVID-19 illness or death. Not being on an SSRI was associated with a lower risk of hospitalization and death from COVID.
A clinical trial found that early use of ECMO devices did not improve outcomes for adults with rapidly deteriorating or severe cardiogenic shock. Participants who received immediate ECMO therapy showed similar clinical outcomes as those receiving early conservative therapy, including treatment with inotropes and vasopressors.
Researchers found that combining CAP and PAW leads to a synergistic effect, increasing fungicidal efficiency. The mechanism involves damage to cell wall and membrane structure via ·OH and O2, followed by irreversible damage to mitochondria with ONOO- entry.
A new AI technology has been developed to automatically diagnose lung diseases such as tuberculosis and pneumonia, freeing up radiographers and reducing waiting times for test results. The system, which uses X-ray imaging and deep learning algorithms, achieved a 98% accuracy rate during extensive testing.
Researchers evaluated the safety and efficacy of NTLA-2001 in patients with transthyretin amyloid cardiomyopathy. The results showed significant reductions in circulating TTR protein levels, which were sustained for up to six months after treatment.
Researchers at Intermountain Healthcare discovered that patients without standard modifiable heart risk factors who experience a heart attack fare better, with lower rates of revascularization procedures and subsequent major cardiac events. This finding highlights the need to identify patients at risk for an event before it happens.
A customized mindfulness program that incorporates skills like attention control and self-awareness has been shown to lead to lower systolic blood pressure measures in participants. The intervention, which also focuses on health behavior change, is promising as a novel way to improve blood pressure control.
The study presents UnityMol as a successful software tool for VR porting, enabling enhanced digital twin models. Interactive simulations also have great potential for research and collaborative problem-solving.
A new study has shown that SGLT-2 inhibitors, a type of diabetes medication, can decrease cardiovascular risk in adults with chronic kidney disease. The meta-analysis included results from 13 major clinical trials and found a 28% lower risk of worsening kidney disease and death from cardiovascular disease.
A large clinical trial found that administering steroids during infant heart surgery did not improve post-operative outcomes compared to placebo. However, secondary analysis revealed a small net benefit for some infants, with lower odds of bleeding requiring another operation.
The study proposes a balanced-partitioning treemapping method that maintains near-square aspect ratios for better small element visibility. It also creates stable layouts for time-dependent sequences, such as stock market variation with time.
Researchers at Brigham and Women's Hospital found that olpasiran, a small interfering RNA drug, significantly reduces lipoprotein(a) levels in patients with established cardiovascular disease. The treatment was associated with minimal serious side effects apart from injection site reactions.
A new study found that long-term treatment with intravenous iron improved symptoms and reduced recurrent hospitalizations among people with heart failure and iron deficiency. The treatment was associated with a significant benefit on reducing the risk of heart failure hospitalization and cardiovascular death.
A study published in the American Heart Association found that six common dietary supplements did not lower LDL cholesterol levels when compared to a low-dose statin medication or placebo. The research suggests that these supplements are unlikely to offer meaningful impact on cholesterol levels, and a heart-healthy lifestyle is still t...
The discussion focused on the impact of ocean acidification, compound events, sea-level rise, and climate injustice, with experts highlighting the need for youth involvement in decision-making. The panel agreed on the urgent need for climate action ahead of COP27, emphasizing cooperation between nations to mitigate the crisis.
Researchers developed a simulation software to study radiation damage accumulation mechanisms in nanocrystalline materials. The results showed improved radiation resistance due to high grain boundary density, which serves as sinks for radiation-induced vacancies and self-interstitial atoms.
A new medication, pemafibrate, lowered triglyceride levels among adults with Type 2 diabetes, but did not decrease their cardiovascular risk. The study found that lowering triglyceride levels may not protect against cardiovascular disease in people with Type 2 diabetes.
Researchers at Hefei Institutes of Physical Science, Chinese Academy of Sciences, have discovered a potent and selective colony stimulating factor 1 receptor kinase inhibitor. The new compound, IHMT-CSF1R-833, shows high selectivity over human kinases and suppresses tumor-associated macrophage survival and activation.
Patients who survived cardiac arrest and received CPR reported lucid experiences of death, including separation from the body and meaningful evaluation of life. Researchers discovered rhythmic brain waves suggestive of near-death experiences, providing evidence for a unique human experience on the brink of death.
Researchers found that two common diuretics, chlorthalidone and hydrochlorothiazide, had no difference in cardiovascular outcomes among study participants. However, those taking chlorthalidone showed a reduced risk of heart disease and death by an average of 27% among patients with a history of heart attack or stroke.
Researchers developed a strategy combining urinary albumin:creatinine ratio (UACR) and glomerular filtration rate (GFR) slope to predict treatment effects on patient outcomes. This approach improved predictions in phase 2 clinical trials with sample sizes of 100–200 patients per arm or follow-up times ranging between 1 and 2 years.
The COVID-19 pandemic has significantly increased the mortality risk of hemodialysis patients, with risks persisting at higher levels for those with confirmed infections. Other patients on dialysis experienced slightly elevated mortality risk during peak pandemic periods.
A new decision support tool used in emergency departments has been shown to reduce 30-day all-cause death or cardiovascular hospitalization rates by 12% in heart failure patients. The validated tool, developed using data analytics, helps clinicians determine risk categories and inform admission or discharge decisions.
A recent analysis of COVID-19 cases in four waves found that individuals with chronic kidney disease were more likely to develop severe forms of COVID-19 and experience complications. Pre-existing conditions, including CKD, were consistent clinical predictors of COVID-19 severity across multiple pandemic waves.
Researchers from Tokyo Metropolitan University developed a VR system that enables users to share their visual and sensory experiences on Segways with remote collaborators. The system reduced VR sickness by 54% and improved user experience, promising new possibilities for remote collaboration.
Patients with advanced kidney disease may benefit from conservative non-dialytic management over dialysis for hospitalization prevention. Patients of Asian ethnicity show the highest hospitalization rates on early dialysis compared to late dialysis or conservative management. Conservative management underutilized in US due to uncertain...
A major randomized trial of pemafibrate found no reduction in rates of heart attack, stroke, or cardiovascular death over a five-year period, despite lowering triglycerides by 26 percent. Pemafibrate was effective at reducing remnant cholesterol levels but failed to demonstrate clinical benefits.
Researchers have published seven draft genomes for Nordic hare species, including three heath hares with distinct grey/blue winter pelage. The findings suggest the heath hare colonized Scandinavia from the south after the last ice age, diverging from the mountain hare population.
The 13th International Conference on Skin Ageing & Challenges will be held in Lisbon, Portugal, with over 61 communications and innovations presented. Key findings include the impact of olfactory receptors on microbiota & wound healing, as well as recent artificial intelligence developments for skin cancer detection.
Research analyzed 350,994 participants and found that higher air pollution concentrations increased the risk of developing chronic kidney disease. Individuals with high air pollution exposure and low genetic risk faced a significantly higher risk of developing CKD compared to those with high genetic risk.
A new study published in the Journal of Nutrition Education and Behavior found that mothers are least likely to recall being told to limit meals in front of electronic devices. The study analyzed data from the National Survey of Family Growth and found that more than half of mothers recalled only two or three feeding topics, with offer...
Researchers from Trinity College Dublin have identified an enhanced type I interferon response in women who resisted infection after exposure to hepatitis C. This finding has significant implications for understanding viral resistance and designing therapies to treat infected individuals.
The HUSH complex is involved in normal brain development, neuronal individuality, and connectivity. The complex also regulates repetitive-like gene clusters, including protocadherin gene clusters, which are essential for neuron-to-neuron interactions.
A team of cosmologists has reconstructed gravity to find a more robust way of understanding the cosmos, using new observational data from space and ground-based telescopes. The study explores whether modifying General Relativity could help resolve open problems in cosmology, with promising results that could pave the way for resolving ...
Scientists have successfully assembled linear metal nanoclusters using a novel strategy. The Ag-Cu alloy clusters exhibit spin transfer and distance-dependent spin coupling due to the interaction with sulfur ions. These findings open up new avenues for understanding nanocluster magnetism and developing functional materials.
A new treatment option for multi-resistant bacteria has been identified by a UNIGE team, which uses the drug edoxudine to weaken the defence mechanisms of Klebsiella pneumoniae, making it easier to eliminate. This approach could be a game-changer in the fight against antibiotic resistance.
A team of experts recommends adopting the Choosing Wisely campaign's principles to optimize administrative management practices, improving workforce satisfaction and retention. By applying these same principles, healthcare professionals can enhance their well-being and improve the value of clinical care.
Researchers at CABBI used unmanned aerial vehicles with machine learning methods to select the best candidate genotypes in miscanthus breeding programs. The new method leverages high-resolution aerial imagery and three-dimensional neural networks to estimate crop traits such as flowering time, height, and biomass production.
A Kennesaw State University professor has received a $400,000 grant to investigate the role of Akirin protein in building muscle, which could lead to treatments for damaged heart and skeletal muscles. The study may also shed light on personalized medicine and inform a cure for human diseases.
A University of Washington researcher claims that organizations like the World Health Organization and American Heart Association promoted high-carbohydrate diets over low-carb diets due to flawed nutritional guidelines. This shift led to increased use of fluoride to combat tooth decay, making it largely unnecessary.
A new nationwide study found that 34.7% of Canadians experienced severe loneliness in January 2021, with migrants and those experiencing job insecurity being most at risk.
A new research group aims to develop an interdisciplinary approach for secure operation of critical infrastructure systems using artificial intelligence. The goal is to create a 'hybrid architecture' that combines AI-based strategic development with rule-based systems, ensuring safe and reliable behavior.
A study published in The Lancet Public Health found a clear association between tiny air pollution particles and sudden cardiac arrests in Singapore. Researchers identified a short-term effect, with reduced risk of cardiac arrests after exposure to lower PM2.5 concentrations.
A comparative epidemiological analysis found a significant decrease in SARS-CoV-2 outbreaks and cases in German care homes following the introduction of COVID-19 vaccination. The median number of cases/outbreaks fell from 21 to 8, while the case-fatality rate decreased from 15.7% to 10.0%.
A new study published in JAMA Network Open found that extreme temperatures in Texas prisons without climate controls lead to a 30-fold increase in heat-related mortality compared to the general US population. The researchers analyzed data from 2001-2019, finding that even small temperature increases elevate daily risk of death.
Researchers discovered that topological insulators outperform graphene in generating terahertz electromagnetic waves, enabling efficient nonlinear terahertz photonics technology. The study achieved orders of magnitude improvement in output power approaching the milliwatt regime.
Assistant Professor Nourridine Siewe developed a new mathematical model to assess different approaches for treating metastatic cancer. The model evaluates the interactions among immune cells and cancer, helping clinicians decide on the best treatment strategies.
Idiopathic plasmacytic lymphadenopathy (IPL) has been confirmed as a distinct clinicopathologically uniform disease, which can be reclassified into an independent subtype of idiopathic multicentric Castleman disease (iMCD). IPL showed greater plasmacytosis and hyperplastic germinal centers compared to non-IPL groups.
The Devils Hole pupfish has the lowest genetic diversity among known vertebrates, with 58% of its genomes identical. This lack of diversity may doom the species to extinction as climate change and human impacts increase.
Researchers from the University of Queensland found that having more babies reduces a woman's risk of endometrial cancer by 50% compared to none. The study used genetic analysis and examined how many years women ovulated, with strong links pointing to childbirth.
Researchers at the University of Missouri have successfully used click chemistry to deliver radiopharmaceuticals specifically to tumors in large dogs with bone cancer, increasing effectiveness and minimizing circulation. This breakthrough could pave the way for click chemistry-based treatments for humans with cancer in the future.
A case study presents a 30-year-old man with painful itchy skin lesions primarily in the genital region, which evolved into centrally indented papules and hemorrhagic crusts. PCR analysis confirmed the diagnosis of West African variant monkeypox, highlighting the importance of considering clinical courses during outbreaks.
Researchers found nine locations on Mars with greater concentrations of silicon, indicating a more complex crustal history. The discovery challenges the previous assumption that Mars' crust was formed through simple volcanic processes.
A new study published in Science found that a highly magnetised dead star, known as a magnetar, is likely to have a solid surface with no atmosphere. The research team used data from the NASA satellite IXPE to observe the polarisation of X-ray light emitted by the star, which revealed a signature consistent with a solid crust.
The American Society of Nephrology presents results from high-impact clinical trials that could transform kidney-related medical care. The trials will focus on improving patient outcomes and advancing the treatment of kidney diseases.