Scientists have created a vaccine candidate against antibiotic-resistant Enterococcus faecium using membrane vesicles, which stimulate the immune system and are stable and non-infectious. The new vaccine showed promising results in killing resistant bacteria, including those resistant to Vancomycin.
A multicenter observational cohort study found that cannabis exposure was associated with a higher risk of small-for-gestational-age birth, medically indicated preterm birth, stillbirth, and hypertensive disorders of pregnancy. The risk was particularly pronounced among those who continued to use cannabis beyond the first trimester.
A Phase III trial demonstrates significantly improved progression-free survival and remission rates for patients with relapsed/refractory mantle cell lymphoma treated with the oral combination of ibrutinib and venetoclax. The treatment achieved an overall remission rate of 82% and a median PFS of 31.9 months.
The discovery sheds light on the underappreciated role of ancient Mongolians in spreading horse riding technology, which had a profound impact on mounted warfare and culture. The saddle is believed to have originated from local craftsmen in Mongolia, who created it using birch wood and wooden nails.
A recent study published in Biological Psychiatry: Global Open Science found that smoking causes brain shrinkage and increases the risk of age-related cognitive decline and Alzheimer's disease. Quitting smoking can prevent further loss of brain tissue, but stopping does not restore the brain to its original size.
Scientists have identified key stages in the 'wave of death' - a high-amplitude wave that marks the transition to complete brain silence after oxygen deprivation. The study found that this critical event induces neuronal death throughout the cortex and can be reversible with timely resuscitation.
Researchers at Johns Hopkins Medicine used liquid biopsies to monitor changes in circulating tumor DNA and detect immune cell expansions, predicting patient responses to immunotherapies and detecting early signs of toxic side effects. The test showed significant associations with progression-free and overall survival.
A study found that over 13% of cancer drug trials in China used suboptimal control arms, which may lead to biased results and patient harm. The researchers highlight the need for refining trial design to generate optimal clinical evidence.
A study found that individuals who perceive climate change as a health threat are more likely to endorse interest in cancer screening. Those with greater awareness of climate change impacts may also be more overall health conscious, driving their interest in preventive healthcare measures.
Researchers at UVA Health System created an 'atlas of atherosclerosis' revealing critical processes that form harmful plaque buildup. The study provides unprecedented insights into atherosclerosis and its impact on coronary artery disease, heart attacks, and strokes.
Researchers from Osaka University developed an online space for conversation and collaboration among patients with rare diseases, family members, researchers, and former policymakers. The project identified key themes and research priorities, including financial burden, daily life impacts, anxiety, and hospital visits, providing a uniq...
A large study of over 9,000 pregnant people found that cannabis exposure during pregnancy is associated with a composite measure of unhealthy pregnancy outcomes, including low birth weight. Higher levels of cannabis exposure were also linked to higher risks of complications.
A major study found that patients with inflammatory conditions can boost their antibody response to a COVID-19 booster vaccination by interrupting their treatment for two weeks. The improved protection lasts for six months, and patients who interrupted treatment reported more flare-ups but most were self-managed.
A study published in Molecular Cell describes how bacteria build a form of ubiquitin that helps cells communicate. The research sheds light on how different enzymes impact this protein during infection, providing an important first step towards understanding its role in diseases like Parkinson's and breast cancer.
A new study has identified protein expression patterns that can predict the progression of follicular lymphoma, an incurable type of cancer. By analyzing tumour samples from patients, researchers have found a correlation between specific proteins and disease transformation, enabling early detection of high-risk patients.
A new paper examines the challenges of adopting AI in the food industry, citing liability risks and potential costs, and proposes a temporary on-ramp to allow companies to trial AI technology while exploring benefits and mitigation strategies.
Researchers have found that increasing pressure suppresses a regular atomic arrangement called Peierls-like distortion, which is crucial for phase-change materials. This discovery may lead to the development of new materials for advanced phase-change memory and other applications.
A new study reveals disparities in the diagnosis and treatment of Lyme disease between Black and White patients. Black patients were more likely to have advanced stages of Lyme disease when clinically diagnosed, and experience a longer time before receiving antibiotic treatment.
A comprehensive study on HSR lifecycle carbon emissions reveals significant reductions in emissions. The research provides a per-person-per-kilometer evaluation unit to inform effective transportation combinations for reducing carbon emissions during travel.
The study found that urban design favours species with varying characteristics, with implications for ecosystem improvement and public health. Land-sparing areas support birds with short life cycles, while land-sharing areas host species with longer life cycles.
A new study published in PNAS found that a climate policy aimed at reducing carbon emissions would also lower nitrate levels in the Mississippi River Basin, benefiting the Gulf of Mexico. The policy could lead to a 3-4% reduction in the Gulf's dead zone.
A clinical trial found that stem cell-based therapy reduced daily hardship and improved physical and emotional health in patients with advanced heart failure. Patients who received the treatment had lower death and hospitalization rates compared to those on standard care.
Researchers Kenneth J. Breslauer and George W. Breslauer investigate the concept of stability in both physical and political science, finding parallels between kinetic trapping and social metastability. They propose applying thermodynamic principles to analyze socio-political systems, revealing a continuity between nature and society.
A new study found that perivascular fibroblasts support the creation of an immunosuppressive tumor microenvironment, allowing glioblastoma to evade the immune system. The fibroblasts may also promote stem-like cancer cells that rarely divide, leading to poor survival outcomes.
A new study suggests that metastatic prostate tumors contain a rich variety of immune cells that can be roused by immunotherapy into attacking the cancer. Combining hormone therapy with immunotherapy further stimulates anti-tumor immune cells, potentially improving patient outcomes.
Research from the University of Georgia found that Black patients are significantly less likely to receive tissue plasminogen activator (tPA) and endovascular thrombectomy (EVT), leading to longer hospital stays and potentially poorer health outcomes. The study highlights racial disparities in stroke care and calls for increased educat...
A study found that saliva biomarkers sTNFR2 and sIgA can effectively detect pain in people with dementia, providing an alternative to invasive methods. The researchers discovered a decrease in sTNFR2 levels and an increase in sIgA in patients with dementia compared to a control group.
Researchers have developed an AI-powered algorithm that can detect the risk of atrial fibrillation (AFib) with high accuracy, even in people with infrequent AFib episodes. This new tool has the potential to reduce the incidence of stroke and heart failure by identifying patients at increased risk and guiding targeted interventions.
The initiative aims to standardize social risk factors data in EHRs, enabling clinicians to monitor and address patients' social and clinical needs comprehensively. This will positively impact individual patients and support efforts to track health inequities at the population level.
Biopolymer composites made from agarose and chitosan demonstrate enhanced strength, antibacterial properties, and water repellence. These sustainable materials could lead to eco-friendly packaging solutions for food and consumer goods.
Researchers develop methods to introduce chirality into materials, enabling tunable properties in thin films. The discovery has potential applications in pharmaceuticals, biomedicine, communication and energy.
A recent survey found that 18.5% of Ukrainian scientists had left the country since the start of the war, with those more productive and research-active being more likely to emigrate. The average time spent on research activities reduced from 13 hours to 10 hours, equating to a loss of about 20% of scientific research capacity.
Researchers at University of Jyväskylä have gained new understanding on the chemistry of electrochemical interfaces, focusing on electrolyte ion effects. This knowledge can enhance the development of improved electrochemical technologies, including fuel cells and hydrogen peroxide synthesis.
Researchers at the Centro Nacional de Investigaciones Cardiovasculares discovered the molecular mechanisms behind proper heart valve formation and prevention of calcification. They found that Notch signaling pathway disruption causes both valve defects and calcification.
Researchers found that commercial ship noise completely masks Cook Inlet beluga whales' most commonly used calls, compromising their critical communication. The study documents the complex vocal repertoire of the population and provides a quantified measure of masking by ship noise on their communication.
The 2023 Geothermal Rising Conference highlights growing interest in superhot rock geothermal, with papers validating its viability for high power output and small spatial footprint. Researchers are developing new technologies to access these resources, including millimeter wave energy to drill deeper holes.
A new study found no increased risk of major congenital malformations in infants exposed to second-line non-insulin antidiabetic medications during pregnancy compared to those treated with insulin. The study examined over 3.5 million pregnancies and provided reassurance on the safety of these medications for fetuses.
A groundbreaking study on Ryugu samples has revealed the impact of terrestrial weathering on primitive meteorite spectra. The findings suggest that actual CI chondrite parent bodies likely exhibit darker and flatter reflectance spectra than previously thought.
A recent study published in The Lancet Oncology found that the risk of dying from cancer in some poorer districts of England is over 70% higher than in wealthier areas. The study used death records to estimate the risk of dying from various cancers in each district, highlighting significant inequalities in cancer mortality across diffe...
Researchers have developed a new model for studying pulmonary neuroendocrine tumors, which may indicate that patients with EGF-dependent NETs can be treated with EGF receptor inhibitors. This discovery provides a promising route of treatment for aggressive pulmonary NETs.
Researchers have developed a new method called ambient noise differential adjoint tomography to visualize rocks with fluids, potentially advancing the discovery of water and oil resources. The technique uses portable seismometers to record natural vibrations, revealing tiny holes filled with fluids in rocks near active faults.
Scientists have found that by controlling ion flow through nanopores, they can achieve cooling. At high concentrations, increased heat was measured, but at low concentrations, negatively charged ions interacted with the nanopore wall, resulting in a decrease in temperature.
Researchers found that Ukrainian-controlled territories gained forest area despite military conflict, while Russian-controlled territories experienced significant forest loss. The study highlights the impact of modern warfare on environmental sustainability and conservation in Ukraine's Emerald Network.
The University of Maryland School of Medicine has received a $29 million NIH grant to conduct a multicenter trial testing interventions to improve health outcomes in people who inject opioid drugs and are hospitalized with infectious complications. The study aims to reduce rehospitalizations and lower complications from infections.
Scientists at Johns Hopkins Medicine have identified a molecular pathway involving oxidative stress and the protein HIF-1 that contributes to both wet and dry age-related macular degeneration. Researchers found that while HIF-1 promotes blood vessel growth in retinal cells, it also protects against cell death in advanced dry AMD.
A new scheme for realizing nonreciprocal interlayer coupling in bilayer topological systems has been developed by researchers at Peking University. The scheme is based on constructing on-site gain/loss in bilayer non-Hermitian topological systems and reveals a relation between two microscopic provenances of the non-Hermiticity.
A new therapy, venetoclax, has improved survival rates for Non-Hispanic Black patients with acute myeloid leukemia, narrowing the racial disparity. The study analyzed over 3,000 adult patients diagnosed between 2014 and 2022 and found a significant increase in two-year overall survival rates.
Researchers have identified the genetic defect causing infantile cystinosis, a rare disease that shortens lifespan, and developed a protocol to differentiate stem cells into healthy kidney cells. The study suggests using CRISPR genome editing to repair the defective gene and potentially cure the disease.
A phase 1 clinical trial demonstrates the efficacy of third-generation anti-CD19 CAR T-cells in treating relapsed or refractory B-cell non-Hodgkin lymphomas without causing neurotoxicity. The study also shows a robust response rate of 52% and improved safety profile compared to previous CAR T-cell therapies.
The current emoji library underrepresents plant, fungus, and microorganism biodiversity while overrepresenting animals. This bias reflects known biases in biodiversity assessments and conservation analyses.
A new study from Indian Institute of Science finds that certain types of cancer cells respond well to IFN-γ activation, while others don't. The researchers suggest approaches to make non-responsive cancer cells better respond to immunotherapy by targeting their metabolism.
A systematic review has identified 29 primary risk factors associated with long-term arm morbidities following breast cancer treatments. The main risk factors include removal of lymph nodes, high body mass index, mastectomy, radiation therapy, chemotherapy, infection, and trauma to the affected arm.
A new study by the National Institute for Environmental Studies shows that current infrastructure deployment is insufficient to meet Paris Agreement targets, requiring a shift in how materials are used or consumed. The study estimates that feasible supply of steel and cement within a carbon budget will fall short of expected global dem...
A novel study has implicated granulocyte colony-stimulating factor (G-CSF) in both bronchopulmonary dysplasia and retinopathy of prematurity, making it a promising therapeutic candidate. G-CSF deficiency was shown to protect against these diseases, suggesting wide-ranging protection.
Researchers discovered that intestinal epithelium-derived exosomes, specifically containing miR-21a-5p and miR-145a-5p, reduce liver lipid deposition in mice. These findings suggest a novel pathway for the intestine to regulate liver lipid homeostasis, providing potential targets for NAFLD prevention and treatment.
Researchers found that compound energy droughts can occur nationwide, with varying frequencies and durations across regions. Understanding these droughts will help grid planners prepare for energy storage needs and inform deployment of long-duration energy storage projects.
Assistant Professor Amanda Madden at George Mason University has received a $48,911 NEH grant to create a digital edition of the late medieval text 'La sfera', featuring merchants, maps, and manuscripts. The project aims to integrate texts, images, and maps in an interactive digital framework for scholars and students.
Researchers from the University of Córdoba used machine learning models to predict reference evapotranspiration in Southern Spain until 2100. The projections indicate a significant increase in water needs, with air temperature being the key factor in calculating this parameter.
The American College of Physicians has published a new clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus in chronic kidney disease. The guideline includes recommendations for expanding treatment with sofosbuvir-based regimens to patients with CKD glomerular filtration rate categor...
Research compares US, Australian, and UK gun violence rates to mental illness rates, finding higher US rates without comparable differences in mental illness prevalence. Gun ownership and access to firearms are suggested as plausible but unproven explanations for the disparity.