Researchers developed innovative techniques to treat challenging cancers and manage therapy side effects. Inhibitors targeting PRMT5, a histone-modifying enzyme, alleviated cisplatin-induced hearing loss, while nano-pills delivered combination drugs to liver cancer cells.
A new study suggests that requiring firms to disclose their true normal price can help protect consumers from deceptive pricing practices. The research found that providing this information largely eliminates the effect of an advertised regular price, which otherwise significantly raises the chance a consumer will buy.
Researchers have created a detailed map of HCMV particle interactions, revealing how viral proteins recruit host cell proteins to replicate efficiently. This knowledge is crucial for understanding the complex life cycle of HCMV and finding candidate anti-viral drugs.
Researchers developed an innovative optical tool, the Schistoscope, to capture microscopy images of urine samples for efficient detection of Schistosoma haematobium eggs. A two-stage diagnostic framework using deep learning accurately identified and counted eggs in field settings with high sensitivity, specificity, and precision.
Chronic pain is often accompanied by depression and anxiety, with a feedback loop creating a bi-directional linkage between the two. Successful treatment of depression and anxiety improves pain outcomes, but neglecting psychological symptoms can lead to long-term suffering.
A team of scientists has developed a technique that uses high-frequency terahertz radiation to slow down amyloid deposition in Alzheimer's disease. The research found that the radiation can modulate protein conformation and delay fibrillation, presenting a promising strategy for treating the disease.
A new study suggests that controlling air pollution could reduce antibiotic resistance, which is responsible for 480,000 premature deaths annually. The analysis indicates a significant link between PM2.5 levels and antibiotic resistance globally.
Researchers developed an AI model called OncoNPC that can analyze genetic data to predict cancer type and origin. The model accurately classified at least 40% of tumors with unknown origin, leading to a 2.2-fold increase in eligible patients for targeted treatments.
A study published in Nature Communications reveals unusual patterns of small and large particles in a model liquid, which can affect the formation of ideal glass. The findings raise doubts about whether this model liquid can be considered an ideal glass-forming liquid.
Researchers at Scripps Research have identified a unique mitochondrial protein structure, DELE1, that plays a crucial role in activating the cell's integrated stress response. This discovery could lead to the development of new therapies for age-related diseases such as neurodegeneration and cancer.
Researchers compared absorbency of 21 menstrual hygiene products using human red blood cells, finding that menstrual discs held the most blood, while super-absorbency period pants held the least. The study highlights the need for more research on menstruation to improve diagnostic accuracy and care for women.
Scientists successfully removed invasive spectacled caimans from specific areas of the Everglades, reducing competition with native alligators and crocodiles. The efforts demonstrate early detection, rapid response, and persistent removal can effectively control invasive species, with implications for other invasive species management.
A large study found that fully vaccinated individuals have lower concentrations of inflammatory markers than unvaccinated participants after symptomatic COVID-19 infection. This suggests that vaccination significantly reduces morbidity and mortality by reducing elevated levels of cytokines and chemokines.
Researchers at Johns Hopkins University have developed nanoscale tattoos that can stick to live cells, allowing for the first time to monitor and control individual cell health in real-time. This technology bridges the gap between living cells and conventional sensors, enabling early disease diagnosis and treatment.
Researchers at Kobe University have successfully synthesized polycarbonate using the photo-on-demand interfacial polymerization method, offering a safe and practical scale, high-yield synthesis. This new method reduces synthesis costs, saves on purification, and minimizes environmental impact compared to traditional methods.
Researchers found that Epstein-Barr virus induces B cell growth transformation through the activation of the cancer-related gene IMPDH2, leading to uncontrolled proliferation. The study used primary B cells and found that inhibiting IMPDH2 can suppress post-transplant lymphoproliferative disorder (PTLD) development.
Researchers at Tohoku University and MIT have unveiled the anomalous dynamics of non-collinear antiferromagnets, revealing a unique interaction between electron spins and chiral-spin structure. The findings provide essential insights for controlling these materials, which could lead to the development of functional devices in spintronics.
Researchers at George Mason University are developing domain-agnostic deception models that blend temporal logic and probabilistic models of human attention. The goal is to detect and defend against deceptive attacks, with potential visualizations and cognitive assistance tools to aid humans in intervening sooner.
A recent study published in Annals of Internal Medicine found that continued breast cancer screening after age 70 is associated with a greater incidence of cancer that likely would not have caused symptoms. Researchers estimate up to 47% of breast cancers found among women aged 74-84 were overdiagnosed.
Researchers created a self-supervised AI model called GedankenNet that learns physics laws and thought experiments to reconstruct microscopic images. The model successfully reconstructed human tissue samples and Pap smears from holograms without relying on real-world experiments or data.
A study found that out-of-pocket costs for medication are a significant barrier to treatment, with those facing the highest daily costs having a higher risk of discontinuing their treatment. Researchers call for buprenorphine to be added to the list of clinically approved preventive services to alleviate the opioid crisis
Restoration of longleaf pine woodlands enhances stream flow while conserving an endangered ecosystem, addressing two pressing conservation issues. This approach promotes 17% more streamflow on average and 92% higher streamflow during droughts.
A human antibody that targets carfentanil, fentanyl, and related opioids has shown promising results in reversing overdose effects in a preclinical study. The antibody, developed by Scripps Research, binds tightly to the potent opioid variants and reverses respiratory depression caused by carfentanil.
Researchers investigated hcp-iron rheology at high pressure and temperature using deformation experiments. The study suggests the equatorial growth or translation mode model is dominant in the Earth's inner core, with an estimated viscosity of ≥ 10^19 Pa s.
Researchers at the University of Exeter have identified a Roman road network spanning Devon and Cornwall using LiDAR scans and geographical modelling. The network, which connected settlements with military forts, reveals that North Tawton was a strategically vital connection point.
Approximately 1 in 5 adults with past-year opioid use disorder received medication for opioid use disorder (MOUD), highlighting disparities in uptake. MOUD disparities affect Black adults, women, unemployed individuals, and those in nonmetropolitan areas.
A study found that small-molecule autocatalytic reactions can lead to the growth and division of compartments, mimicking cell reproduction. The reaction triggers the formose reaction, which consumes formaldehyde and produces glycolaldehyde, allowing compartments to grow and divide under external influence.
A preclinical study demonstrates the effectiveness of VIR-3434 in preventing viral dissemination and reducing viral particles in a mouse model for HBV/HDV coinfection. The monoclonal antibody neutralises all known genotypes of HBV and HDV, providing a potential new option for treating chronic hepatitis B and D.
Researchers identified a mechanism regulating tumor growth in the skeleton, which decreases with age and can result from hormonal changes or chemotherapy. Mineralization of bone matrix reduces tumor cell growth and promotes genes associated with better patient prognosis.
Amarda Shehu is leading a collaborative research project at George Mason University, using deep learning and experimentation to generate controlled properties in molecules. The project aims to address challenges in molecular biology, including resistant bacteria, with potential applications in antimicrobial compounds.
A team of researchers has successfully created a high-performance graphene-dielectric interface using a novel technique called UV-assisted atomic layer deposition. This breakthrough results in uniform atomic layer deposition without compromising graphene's properties, leading to improved electrical performance and reduced defects.
Researchers have exposed trap-assisted Auger-Meitner recombination as a major loss mechanism in blue and UV light-emitting diodes (LEDs). This phenomenon leads to higher loss rates compared to phonon-mediated processes, affecting device efficiency.
A randomized crossover trial involving 195 adults showed that using a regular cuff size resulted in inaccurate BP readings. The study emphasizes the need for individualized cuff selection to ensure accurate blood pressure measurements.
A team of researchers from China and the UK has discovered that a group of ancient marine reptiles used whale-like filter feeding methods 250 million years ago. The Hupehsuchus skull shows adaptations similar to baleen whales, including grooves and notches along the jaws.
A new study published in JNCCN found that the adoption of clinical research results led to a significant increase in the use of shorter adjuvant chemotherapy periods, with CAPOX becoming more widely used. The study also revealed disparities in treatment patterns, with Black patients being more likely to receive shorter chemotherapy reg...
A team of researchers developed a novel method that leverages temporal characteristics of blood pulse to estimate heart rates with improved accuracy, especially in scenes with ambient light fluctuations. The proposed method showed a 36.5% improvement in estimation accuracy compared to conventional methods.
A study found that only 22% of people with opioid use disorder received evidence-based medication treatments in 2021. Telehealth services were associated with a significantly increased likelihood of receiving these life-saving medications.
Researchers have proposed an explanation for the ion-specific properties of ion hydration in water-based solutions, revealing that ions with lower charge density interact with more water molecules. This result has broad applications across multiple disciplines, including chemistry, biology, and materials science.
A miniature human heart model, approximately half a grain of rice in size, has been developed to transform drug testing and cardiovascular research. This self-paced, multi-chambered model provides real-time measurements of essential parameters, enabling unprecedented insights into heart function and diseases.
Researchers created a nanocomposite of hexagonal and cubic boron nitride, which exhibits unexpected thermal and optical properties. The composite's low thermal conductivity makes it suitable for heat-insulating electronic devices, while its second-harmonic generation property is larger than expected after heating.
Researchers found that the hypothalamus, a key region controlling appetite, is larger in individuals who are overweight or obese compared to those with a healthy weight. The study suggests that increased volume may be linked to inflammation and altered hormone regulation.
Moderate and vigorous aerobic physical activity combined with muscle-strengthening activity may lower mortality risk. Higher levels of moderate and vigorous aerobic activity are associated with lower cancer and all-cause mortality rates.
Rice University scientists have developed a tiny, flexible spinal probe system that can record high-quality data from spinal cord neurons and provide localized stimulation. The new tool aims to improve our understanding of spinal cord function and potentially bring new hope to patients with injuries or conditions.
A team of researchers at the University of Florida has developed a new method for recycling plastics that promises to reduce energy requirements without sacrificing quality. This breakthrough approach uses chemical recycling and depolymerization, which can produce recycled plastic with similar or better properties than the original mat...
A meta-analysis of multiple studies found no association between depression and anxiety and most types of cancer. However, the study found a link between depression and anxiety with a 6% higher risk of developing lung cancer and smoking-related cancers.
A new study found that providing visual information about terms and conditions after purchase improves understanding and memory, with reading times increasing by 41-162% and comprehension improving by 14-21%. Researchers recommend combining textual and visual cues to improve transparency in online consumer transactions.
The NYU Tandon School of Engineering has been awarded a $1.2 million grant from the National Science Foundation to develop new technologies for securing the digital legal supply chain. The project aims to protect official laws and legal information from cyberattacks and malicious actors.
A new study by Northwestern University found that non-Hispanic Black individuals have a significantly higher rate of pre-term births compared to non-Hispanic white individuals. Pre-pregnancy cardiovascular health and social determinants of health explain racial differences in preterm birth rates.
Researchers have discovered a gene, B5, in Egyptian cotton that confers powerful resistance to bacterial blight. The gene enables strong resistance to the disease under Oklahoma field conditions and accumulates high amounts of defense chemicals.
Researchers at the University of Oklahoma's Natural Products Discovery Group have identified a broad-spectrum antifungal molecule called Percephacin. This breakthrough treatment shows promise for treating fungal infections that are resistant to existing treatments.
A new analysis shows that social media facilitated information flow across a controlled media ecosystem, while face-to-face communication remained key. The study highlights how UPND's online messaging resonated with users, portraying Hakainde Hichilema as an electorally viable alternative to President Edgar Lungu.
A study by Osaka Metropolitan University found that working in a shared space while performing craft activities boosts parasympathetic activity, leading to relaxation. The parallel group condition showed higher parasympathetic activity compared to the individual alone condition.
A new study highlights the difficulties in identifying and categorizing domestic and wildcats, threatening native biodiversity conservation efforts. In contrast, New Zealanders tend to be more accepting of killing feral cats to protect native species.
A study found that climate influences the spread of polycystic echinococcosis, a neglected disease with high mortality rates, in the Amazon region. Climate factors can predict potential infection hotspots.
Researchers developed an agent-based simulation model that incorporates memory, forgetting, and sharing information among group members. The study found that agents who forgot less useful behaviors made better choices, demonstrating the importance of forgetting in social learning.
A 10-year study found that golden-crowned sparrows resettled an average of just 90 feet away from the center of their previous year's range when returning to California after winter migration. The study suggests that social bonds and familiar faces help anchor the birds to specific spaces, even when resources are scarce.
A large long-term study found exposure to high levels of air pollution is associated with increased community mental health services use among people with dementia. Reducing nitrogen dioxide and particulate matter could help free up resources in overstretched psychiatric services.
Researchers at the University of Otago have found that gluten can cause brain inflammation in mice, a discovery that may have implications for human physiology. The study showed that gluten increased the number of immune cells in the brain, leading to hypothalamic inflammation.
Researchers at Massachusetts General Hospital developed a method to monitor critically ill patients with circulatory shock, which may help control blood pressure and heart function. The new approach uses tissue perfusion pressure to predict patient risk of death, length of hospital stay, and peak blood lactate level.
A new study found that nearly half of low-value care received by Medicare beneficiaries occurs outside of their health systems. Factors such as advanced age, gender, and geographic location are associated with higher risk of receiving out-of-system low-value care.