Opioid toxicity-related deaths in the US increased substantially during the COVID-19 pandemic, with 1 in every 22 deaths attributable to unintentional opioid toxicity. This trend highlights the urgent need for support people at risk of substance-related harm, particularly men and younger adults.
An AI tool called CHARM rapidly decodes a brain tumor's DNA to determine its molecular identity during surgery. This information enables neurosurgeons to make informed decisions about how much brain tissue to remove and whether to use tumor-killing drugs directly into the brain.
A new machine learning-based simulation method called Materials Learning Algorithms (MALA) has been developed, enabling accurate electronic structure calculations at large scales. MALA achieves this by utilizing a hybrid approach that combines physics-based approaches with machine learning to predict the electronic structure of materials.
Researchers at Lawson Health Research Institute have discovered unique patterns of blood plasma proteins in patients with long COVID, which could lead to new diagnostic tests and treatment therapies. The study found prolonged inflammation associated with changes in immune cells and blood vessels, affecting organs like the brain and heart.
Male spider mites undress premature females by stripping off their skin before they molt, increasing the male's reproductive chances and reducing competition. This behavior is an example of sexual selection driving complex behaviors in arachnids.
Researchers developed a new method using Copula models to restore the true statistical model from data processed by Differential Privacy technology, even with many missing values. This enables highly accurate data analysis for pandemic mitigation and various societal applications.
Researchers at Boyce Thompson Institute discovered a unique tomato mutation that unlocks the potential for enhanced fruit quality and stress resistance. The mutation, called 'adpressa', shows major transcriptional and metabolic adjustments, including increased levels of soluble sugars and enhanced growth.
The June 2023 nTIDE report shows employment-to-population ratio for people with disabilities increasing to 37.0%, while labor force participation rate decreases slightly to 39.7%. Employment and labor force participation of people with disabilities may be negatively affected by Federal Reserve efforts.
The SELINA project launched its Demonstration Projects, featuring 15 innovative examples from 12 countries. These projects demonstrate how knowledge on biodiversity can inform public and private decision-making. Participants gained insights into their future plans and potential synergies between the public and private sectors.
Research found that seeing bad news about climate change can make people more afraid over time, but also may encourage audiences to think about what society can do to address the problem. Repeated exposure to threatening messages can lead to increased efficacy beliefs and a greater sense of control.
The EU-funded SUPERVAL project aims to convert post-combustion gases into valuable resources, reducing pollutants while generating chemicals. The technology involves solar-driven electrochemical conversion of CO2 into an organic molecule and transformation of NOx and N2 into ammonia.
The Las Kellys collective has constructed its identity through solidarity and resistance, uniting hotel room attendants and other feminized and precarious workers in Spain. Their strategy has led to increased media attention, public debate, and political repercussions, shedding light on the poor working conditions faced by these workers.
A phase I trial found that combining fecal transplants with immunotherapy is safe and shows promise in improving clinical responses in 65% of patients. The study used healthy donor microbiome to enhance immune system attack on cancer, offering a new paradigm shift in melanoma treatment.
Researchers at the University of Wisconsin-Madison found that ticks can harbor transmissible amounts of the protein particle causing CWD, potentially spreading the disease between deer. The study also suggests that better land stewardship and tick management could help manage CWD populations.
A nationwide produce prescription program for patients with diabetes and food insecurity could prevent 296,000 cases of cardiovascular disease and gain 260,000 quality-adjusted life years. The program is estimated to save $39.6 billion in healthcare spending and $4.8 billion in lost productivity costs.
A study published in Nature Communications found that infection rates in pregnant women attending antenatal care visits closely reflect the rates in children from cross-sectional studies, especially when molecular tests are used. This correlation can help estimate disease burden and inform control measures.
A new study found that people with low incomes in states that expanded Medicaid received more preventive care and overall health care compared to those in non-expansion states. The likelihood of high-value care, such as medications for heart problems or osteoporosis, increased in expansion states.
Researchers found that a triple combination therapy of elexacaftor, tezacaftor, and ivacaftor improves lung function and reduces inflammation in patients with cystic fibrosis. The treatment's positive effects last over 12 months, offering hope for better management of the disease.
Researchers analyzed dairy cows' uterine microbiota and found significant associations with fertility, including a correlation between microbial diversity and AI frequency. The study suggests that farm-to-farm variations in microbiota can impact fertility, paving the way for new diagnostic approaches to low fertility in dairy farms.
This study found that nucleo-cytoplasmic interaction is a crucial factor in male sterility of seedless cybrid citrus, affecting stamen development and pollen abortion. The researchers identified genes involved in stamen development and proposed a potential nucleo-cytoplasmic interaction network.
Research by Politecnico di Milano finds offshore wind farms significantly reduce climate change impacts, with a 92% reduction in greenhouse gas emissions compared to fossil fuels. The study also highlights the importance of life cycle analysis for assessing environmental sustainability of renewable energy technologies.
A novel molecular pathway has been identified, explaining how a mutation in the ACTA2 gene can cause individuals in their 30s with normal cholesterol levels to develop coronary artery disease. The mutation leads to stress in smooth muscle cells, triggering the production of excess cholesterol and driving atherosclerotic plaque formation.
Researchers at Stanford Medicine found that cancer cells accumulate a series of specific genetic changes in a predictable and sequential way, years before they are identifiable as pre-malignancies. These changes affect pathways controlling cell division, structure, and internal messaging, leaving the cells poised to go bad long before ...
Using MRI instead of CT with CTA alone in patients presenting to the ED with dizziness was associated with greater critical neuroimaging results and more frequent echocardiography. Patients with dizziness undergoing MRI showed a lower frequency of 90-day ED readmissions compared to those discharged after CT with CTA alone.
Researchers at Nagoya University found that Arctic dust is a significant source of particles forming ice crystals in Arctic low-level clouds. The findings suggest that Arctic dust can act efficiently as an ice nucleating particle, increasing the number of ice nucleating particles by over 100 times.
A novel association of t(5;17) with t(8;21) has been reported in an acute myeloid leukemia (AML) patient, resulting in a RUNX1-RUNX1T1 rearrangement. The patient received chemotherapy and stem cell transplantation, highlighting the importance of this rare translocation.
The study found that education can protect individuals from undesirable state-level contexts, increasing their vulnerability to pain. States with more generous SNAP benefits and social cohesion had lower pain prevalence rates, highlighting the importance of macro contextual factors in shaping pain risk.
A new study published in Aarhus University found that women using birth-control pills do not exhibit the same reduced stress hormone levels as those who are not on the pill. The researchers measured ACTH levels before and after social activities to observe rapid changes in the body's stress response.
A study led by Dr. Dawen Yang finds that thawing permafrost on the Tibetan Plateau provides a considerable but unsustainable water supply, threatening regional water security. The research suggests that ground ice meltwater contributes significantly to river runoff, particularly in sub-regions with dense populations.
Scientists have discovered the first live culture of Candida auris in dogs, a drug-resistant pathogen that can cause severe infections. The finding suggests pets could act as reservoirs for superbugs, potentially transmitting infections to humans.
A new study suggests that wastewater monitoring can be an effective way to track the spread of infectious diseases. The research found that testing for COVID-19 in wastewater was an objective way to measure where the disease was spreading, with most samples processed in under four days.
A study by Pusan National University researcher Eunseok Ro examines the shift in instruction-giving practices for a book club conducted via video conference. As the facilitator adapts to the new virtual environment, she gradually changes her approach, adopting more recipient-designed and diversified instruction delivery.
The 'Ivory Lady', a Copper Age individual from Iberia, is re-dubbed as the highest status woman in ancient society. Peptide analysis revealed that she held a high social status through merit and achievements.
A new single-cell study provides deeper understanding of the evolution of the tumor microenvironment in gastric cancer. Researchers identified six unique ecotypes, or collections of cell states, within the tumor microenvironment and discovered a potential new therapeutic target, SDC2.
A new study reveals that mobile phone data can be skewed towards more accessible populations, leading to misleading predictions and ineffective outbreak responses. Researchers urge acknowledging and measuring bias in all types of data to ensure accurate public health decisions.
Researchers at UCL Institute of Archaeology discovered 800 stone artefacts, including giant handaxes, in deep Ice Age sediments. The tools are believed to have been used for butchering animals and cutting meat, with some exhibiting distinctive shapes and pointed tips.
Biotechnology holds promise for saving endangered tree species through a combination of traditional breeding approaches and innovative genetic engineering. The study emphasizes the need for public acceptance and regulators' support to harness biotech's potential.
Researchers at the University of St Andrews have developed an anti-biofilm cyclic peptide that targets a secreted aminopeptidase from P. aeruginosa, offering a novel strategy to combat bacterial biofilms and improve treatment of infections.
The team used a photonic resonator to create a multi-dimensional lattice in the synthetic frequency dimension and measured its band structure. The researchers unveiled properties related to nontrivial eigenvalue topology, which are associated with the non-Hermitian skin effect.
The study combines real and robotic insects to understand how they sense forces in their limbs while walking. Campaniform sensilla (CS) are force receptors found in insect limbs that respond to stress and strain, providing critical information for controlling locomotion.
The VVE method allows for testing of driverless cars in a perfectly safe environment, enabling the car to learn to avoid collisions and increase pedestrian safety. By replacing high-resolution sensor output with simulated data, researchers were able to show that the autonomous driving system behaves as if it's driving on real roads.
A new study suggests that while winter cover crops can reduce nitrogen pollution by up to 30%, their effectiveness will decrease under future climate scenarios. Illinois' corn yields are expected to suffer more than soybean yields, especially in southern regions, as warmer temperatures and changing rainfall patterns impact crop growth.
NLRP3 directly induces hepatic insulin resistance and steatosis by promoting PKCε activation. Inhibition of NLRP3 alleviates metabolic disorders in mouse models.
A new study published in National Science Review found that the Amazon rainforest releases oxidized organic molecules, which form aerosol particles in the tropical free troposphere. These particles play a significant role in global climate by serving as cloud condensation nuclei.
The team's breakthrough enables the production of bright visible-wavelength pulses in the femtosecond range directly with fiber lasers. This advance has significant implications for various fields, including high-precision ablation of biological tissues, two-photon excitation microscopy, and material processing.
A new study published in the BMJ confirms a trend where supplemental indications for new drugs decline in their likelihood of added value. By the third indication, the probability drops by 45% compared to the first approval.
A recent public engagement project uses street theatre to educate audiences on African Sleeping Sickness, a neglected tropical disease prevalent in rural Africa. The performance aims to enhance trust in scientists and public health professionals among affected communities.
New research uses MRI and CT scans to study the anatomy of primate clitoris, revealing stark differences in morphology across species. The findings suggest that female genitalia have been chronically understudied, with significant diversity in clitoral structure and function.
Scientists identified habitats and simulated solutions like conservation buffers and open-bottom culverts to allow safe passage for salamanders and other wildlife. The model boosts ecological connectivity while reducing costs compared to large-scale barrier removal.
Research in the BMJ Open journal suggests that mid-life structural changes to the jawbone may signal subsequent height loss in women. The study, conducted on a cohort of women in Gothenburg, Sweden, found that severe cortical erosion and sparse trabeculation in the jawbone predicted significant bone shrinkage over time.
A study found that changes in North Tropical Atlantic sea surface temperature drove the shift in Middle East dust activities. The research revealed a correlation coefficient of over 0.6 between the two, indicating a strong link.
A meta-analysis reveals that birds generally have a net benefit on production for some crops by controlling pests. Non-lethal measures to deter birds are effective in reducing crop losses. The study found that around 10% of bird species consume crops, with 65% showing a positive effect on woody crop yield.
Endometriosis suffers face significant barriers to timely diagnosis due to societal stigma surrounding periods, inadequate GP training, and challenges in distinguishing symptoms from normal menstrual pain. The study highlights the need for mandatory training on menstrual conditions during medical school to prioritize women's healthcare.
Songtao Chen, an assistant professor at Rice University, has won a prestigious NSF CAREER Award to study the interaction between photons and T center qubits. The research aims to address signal-loss during transmission, which is crucial for large-scale implementation of quantum communication.
Scientists at Rockefeller University identified distinct RNA changes in the brains of deceased patients with Parkinson's disease, which were also found in their living counterparts' blood. These changes are associated with various clinical symptoms, such as dementia and levodopa-induced dyskinesia.
A recent study led by the University of Colorado Boulder found that burning from the Marshall Fire left a mark on buildings, with elevated concentrations of carcinogenic materials like polycyclic aromatic hydrocarbons (PAHs) detected in dust samples. The research aims to inform best practices for recovering after future wildfires.
A global study shows atezolizumab significantly improved overall survival and resulted in a clinically meaningful long-term survival benefit for advanced stage non-small cell lung cancer patients who were not able to be treated with platinum-containing chemotherapy. The treatment also showed stabilised or improved health-related qualit...
The research discovered that T cells are especially sensitive to genetic disturbances in their mitochondrial power plants. Different types of T cells show varying degrees of tolerance to defects in the mitochondrial genome, with memory CD8+ T cells rarely affected.
Researchers used coastal surveys from 1993-2021 to find a dramatic delayed effect of warmer oceans on seabird mortality. Massive die-offs occurred roughly once per decade, with five events exceeding a quarter million birds between 2014 and 2019.
Researchers created artificial allosteric sites in protein complexes using computational design to regulate concerted functions. This breakthrough holds promise for industry, biology, medicine, and agriculture.