The TAF/EVG fast-dissolving vaginal insert is being evaluated in a Phase 1 study to determine its safety and user acceptability. The study aims to assess the product's effectiveness as an on-demand HIV prevention method for women, particularly those who do not want or can't use daily PrEP or long-acting products.
A retrospective cohort study of 4,732 BRCA carriers found that pregnancy following breast cancer was not associated with decreased disease-free survival. 1 in 5 patients conceived within 10 years after diagnosis.
Researchers found lower levels of serotonin transporter and higher levels of amyloid-beta protein in brains of people with mild cognitive impairment, a potential target for treatments to slow or stop disease progression. Further research is needed to study the role of serotonin in disease progression.
A six-month multidrug regimen is being evaluated against the standard nine-month treatment for adults and adolescents with tuberculous meningitis. The trial aims to generate evidence that could lead to improved treatment options and reduced mortality rates, particularly for high-risk groups such as pregnant women and adolescent children.
Researchers found that ancient stars created elements with atomic masses greater than 260, challenging current knowledge. This discovery provides insight into the process of heavy element formation in stars and could help explain the diversity of elements on Earth.
A new study by Rice University researchers examines how scientists' social identities and national context shape their explanations for gender inequality in science. The study finds that viewing women's decisions to pursue careers in physics as individual choices may diminish efforts to promote gender equality in STEM fields.
A multidisciplinary study reconstructs the genomic history of the Balkan Peninsula during the Roman Empire's reign. The analysis reveals a large demographic contribution of people of Anatolian descent, highlighting the cosmopolitanism of the Roman frontier and the long-term consequences of migrations.
A recent study analyzing tree ring measurements from 122 species found that trees in wetter forests are more vulnerable to drought than those in drier regions. This suggests that land management policies focused solely on drier regions overestimate the resilience of forests in wetter areas.
A new study found that children born moderately early are at an increased risk of developmental disorders, including language delay, cognitive impairment, ADHD, and cerebral palsy. The study analyzed data from over 8 million children and identified a small but significant increase in risk for most developmental disorders.
A randomized clinical trial found that Mindfulness-Oriented Recovery Enhancement (MORE) plus usual care significantly decreased drug use, pain, and depression in individuals with opioid use disorder and chronic pain. Participants who received MORE also showed increased methadone treatment retention and adherence.
Researchers found correlations between flaxseed diets and changes in the gut microbiome and mammary gland miRNA profiles. Flaxseed lignans were shown to modify the relationship between the microbiota and miRNAs to be non-cancer causing.
Researchers developed an X-ray imaging technique that produces detailed images of living organisms at high resolution while minimizing radiation exposure. This advance enables small organisms to be studied over longer periods, revealing new insights into dynamic processes.
A study found that patients with hormone receptor-positive breast cancer who paused endocrine therapy to conceive did not experience worse short-term recurrence rates. Cryopreserved embryo transfer was associated with higher pregnancy rates, and younger age and menstrual cycles returning after pausing therapy were linked to improved ou...
Researchers developed a geoknowledge-guided GPT model that extracted location data from Hurricane Harvey tweets with an accuracy rate 76% better than default models. The model recognized complete location descriptions, enabling first responders to reach victims more quickly and potentially saving lives.
A new study published in the Journal of Nutrition found that consuming whole food omnivorous meals with lean beef resulted in significantly higher muscle protein synthesis rates compared to isocaloric and isonitrogenous vegan meals. The research, conducted on healthy older adults, demonstrated a 47% increase in muscle protein synthesis...
The study found that 3D integration can lead to significant heat spreading and crosstalk, reducing heater efficiency by up to -43.3% and increasing thermal crosstalk by up to +44.4%. However, optimizing design variables, such as spacing between µbumps and interconnect linewidth, can minimize the thermal penalty of 3D integration.
The study reveals the critical role of 6mA in lipid accumulation in Nannochloropsis oceanica under high light conditions. Disruption of 6mA levels affects gene expression and biomass production, highlighting its importance in optimizing microalgae for industrial uses.
Ferroptosis is characterized by lipid peroxidation, iron-dependent oxidative stress, and distinct morphological alterations. Recent research highlights the importance of compounds in targeting ferroptosis for therapeutic applications.
A University of Michigan study found that Black patients are less likely to receive a home health care referral after hospital discharge, despite having higher risk profiles. The disparity was observed even when adjusting for different risk factors.
Researchers at Helmholtz-Zentrum Dresden-Rossendorf have identified a promising phenomenon where certain iron alloys can be magnetized using ultrashort laser pulses. The team has now expanded its findings to an iron-vanadium alloy, revealing a new class of materials with potential applications in spintronics and magnetic sensors.
Researchers have developed an algorithm to train an analog neural network just as accurately as a digital one, decreasing energy consumption and eliminating the need for a digital twin. This approach is more biologically plausible and shows improved speed, robustness, and reduced power consumption compared to other methods.
Researchers leverage AI to analyze healthcare data and identify new targets for effective therapies and accelerate drug development in aging research. AI can tailor cancer treatment more precisely to individual patients' unique aging profiles, optimizing treatment outcomes and minimizing risks.
A new study published in the American Journal of Clinical Nutrition suggests that taking cocoa extract supplements containing 500 mg of flavanols daily may improve cognitive function in older adults with lower habitual diet quality. In contrast, participants with healthy dietary patterns showed no cognitive benefits.
Researchers validate a new Japanese version of the implementation leadership scale to promote evidence-based practice in Japan. The scale measures strategic leadership demonstrated by nurse managers and staff nurses in implementing evidence-based practices.
The study reveals that apoE-amyloid interactions depend on the exact amyloid structure, termed polymorph. The researchers used four different structures of Aβ fibrils from brains of patients with Alzheimer’s and other neurodegenerative diseases to build models of apoE in complexes with different fibrils.
Purdue University researchers have found that polaritons can contribute a larger share of thermal conductivity in semiconductors, overcoming phonon limitations. By understanding how to design materials and structures, manufacturers can incorporate these polariton-based nanoscale heat transfer principles into chip designs.
Researchers found that GLP-1 RAs significantly reduced the incidence of colorectal cancer in patients with diabetes, compared to those treated with other anti-diabetic drugs. The study's findings support the need for clinical trials to determine whether these medications could prevent one of the deadliest types of cancers.
A new stem cell treatment using mRNA technology from COVID-19 vaccines has shown promise in regenerating liver tissue, potentially reversing chronic and acute liver diseases. The treatment stimulates the natural repair mechanism of the liver by activating specific receptors on stem cells.
A study found that prenatal discrimination and acculturation stress can alter the strength of infant brain circuits, potentially leading to increased risk for mental health disorders. The research suggests a critical role in treating individuals with kindness during pregnancy.
Women who have had a C-section may face difficulties conceiving due to reduced fertility and increased risk of labor complications. The study found that women with fertility problems also had more C-sections.
A new study on wearable health monitors reveals that a failure to understand race leads to flawed technology, exacerbating existing racial health inequities. The researchers found significant challenges with 'race correction' in health technologies, which assumes biology over system racism.
A new AI-powered satellite analysis technique reveals the economic conditions of regions with limited data, such as North Korea. The approach combines human input with machine learning to provide detailed economic maps and monitor progress towards Sustainable Development Goals.
A Harvard University team has created the world's first logical quantum processor, which can encode up to 48 logical qubits and execute hundreds of gate operations. This breakthrough is a significant step toward reliable quantum computing and fault-tolerant quantum computation.
Research finds national parks and protected areas in Thailand are more prone to forest fires when located far from indigenous communities. Collaborative work with local communities reduces forest fires and air pollution, highlighting the importance of indigenous practices.
A study published in JAMA Oncology found that regular screening is not enough to prevent advanced breast cancer diagnoses, particularly among women of color who are overweight or obese. The researchers recommend primary prevention strategies to reduce the number of advanced cancer diagnoses.
A new study from the University of Illinois College of Agricultural, Consumer and Environmental Sciences examines how Illinois corn and soybean producers make marketing decisions. The research found that farms with lower financial positions tend to store more grain, while bigger and older farms have lower storage costs.
Researchers have created a high-fidelity record of atmospheric CO2 levels spanning the last 66 million years, revealing that current concentrations are unprecedented in recent geologic history. The study provides valuable insights into past climate conditions and helps scientists better understand future climate change.
A new study found that healthcare personnel who had the highest risk of exposure to SARS-CoV-2 were also more likely to report errors in their own adherence to infection prevention measures. The researchers recommend improvements to training and strategy to better protect healthcare workers.
A Mayo Clinic study found that patients who received the anticoagulant drug warfarin after bioprosthetic aortic valve replacement had lower incidence of mortality and decreased risk of blood clots. The use of warfarin was associated with a 32% reduction in mortality risk, making it an effective treatment for these patients.
A new study published in Frontiers found that working night shifts is associated with a higher occurrence of disordered sleep, particularly among young adults with lower education. The study revealed that 51% of people working nights scored positive for at least one sleep disorder.
A new method developed at Karolinska Institutet can identify unique immune cell receptors and their location in human tissue. This breakthrough could lead to the development of novel therapies for diseases such as cancer and autoimmune disorders, by pinpointing the specific immune cells responsible.
Princeton researchers successfully entangle individual molecules, a breakthrough in quantum mechanics that could lead to faster quantum computers, simulators, and sensors. The achievement overcomes long-standing challenges in controlling molecular behavior, enabling new ways of storing and processing quantum information.
The American Heart Association offers a new individual certification for healthcare professionals in tobacco cessation, aiming to standardize training and improve patient outcomes. The certification is based on evidence-based therapies and will help reduce the nation's dependence on tobacco.
Researchers at the University of Turku found that bexmarilimab therapy alters macrophage behavior to promote anti-tumor immune defense. The therapy was well-tolerated and stabilized disease progression in patients with advanced-stage cancer, inducing tumor-associated macrophage and lymphocyte activation.
A new model predicts regional differences in water and electricity demand across 46 US cities due to climate change. Sister climate cities like Ciudad Mante, Mexico, were used to inform the projections, which show some areas experiencing up to 15% increase in summer water demand.
The study reveals that oil-built villas in the Gulf Cooperation Council countries have led to a significant increase in greenhouse gas emissions. The researchers found that while these structures are often energy-intensive, Oman stands out as an exception due to its adherence to Islamic building regulations.
A team of scientists has developed a new approach to form gold nanoparticles in tellurite glasses, enabling precise control over their formation and plasmonic properties. This innovation has potential for real-world impact in exciting photonics research and applications.
Researchers reviewed a method to reform metal nanocluster structures using phosphine ligands, enabling precise structure modification and property modulation. The study highlights the potential of phosphine ligand engineering in modulating metal nanoclusters' optical and catalytic activities.
Researchers develop a new approach to volumetric 3D printing using ultrasound waves, enabling fast and high-quality printing in opaque media. The technique, called deep-penetrating acoustic volumetric printing (DAVP), has promising applications in minimally invasive medicine and manufacturing.
A large-scale genome study of over 50,000 patients and 900,000 controls has identified 25 genetic markers associated with peptic ulcers, which may lead to new population-specific treatments. The study also found a link between Helicobacter pylori and peptic ulcer disease.
A new study by UCF researcher Jeff Gish found that former entrepreneurs can successfully transition into employees, especially in roles harnessing their entrepreneurial spirit. Identity conflict between old and new selves was associated with burnout and lower boosterism levels.
Researchers developed novel PDAC organoids that resemble the unique tumor microenvironment, enabling effective screening of anticancer drugs. The study used patient-derived cells and hiPSC-derived mesenchymal cells to create two distinct organoid types, one with strong chemo-resistance capabilities.
Researchers found that BCMA-positive extracellular vesicles (EVs) in plasma levels correlated with myeloma patient responses to belantamab-mafodotin therapy. High EV levels preceded FLC progression and were associated with mafodotin-induced eryptosis.
The University of Texas at Arlington is awarded a $1.1 million grant to train and mentor researchers in mathematical techniques for addressing cancer biology, neurology, and vector-borne diseases. The program aims to increase diversity in science research by recruiting underrepresented scholars.
Researchers found that a person-centered approach, trusting relationship, and proper training are crucial for effective peer support. Trained peer support can help plug gaps in medication advice and improve patient adherence to treatment.
Researchers propose three methods to meet EU climate goals: a carbon removal bank, extended land use regulation, and clear identification of difficult-to-tackle emissions. These measures aim to incentivize companies and countries to invest in new technologies and reduce emissions.
The University of Rochester's Laboratory for Laser Energetics leads a new national research hub focused on advancing inertial fusion energy science and technology. The IFE-COLoR hub aims to overcome laser-plasma instabilities, a major obstacle in achieving efficient laser coupling for inertial confinement fusion.
Multiple sclerosis affects over 2.8 million worldwide, and EU funding will investigate viral infections like EBV as potential causes and co-factors. The BEHIND-MS consortium aims to develop new cell models to test hypotheses on the disease's development.
A team of researchers identified the right inferior frontal gyrus as a key regulator of response inhibition in the brain. The study used dynamic causal modeling and fMRI to explore inhibitory circuits, revealing high intrinsic connectivity within the neural circuit.
Researchers from the Mass General Cancer Center presented studies on psychiatric and substance use disorders as independent predictors of treatment response and outcomes in United States Veterans with Newly Diagnosed Acute Myeloid Leukemia (AML) treated with Venetoclax Combinations. Additionally, a Phase 1 Study of CAR-T-ddBCMA for the...