Researchers at USTC discovered a dynamic map of chromatin accessibility during mitosis, revealing important bookmarking factors. The study found that certain chromatin regions remained open throughout mitosis and were enriched in rapidly reactivated genes.
A recent study has revealed two distinct types of cells in the locus coeruleus, a small nucleus in the brainstem, connected via gap junctions. This discovery has far-reaching implications for understanding neuropsychiatric and neurodegenerative conditions.
Carolyn R. Bertozzi is being recognized for advancing cancer research through bioorthogonal chemistry and chemical glycobiology. Her work enables targeted interrogations of biological systems, enabling the development of innovative imaging methods and therapeutic approaches.
A new study published in Current Biology found that the hippocampus and prefrontal cortex must synchronize their neural assemblies to support memory encoding, maintenance, and recall. Disruption of this synchronization leads to memory loss, presenting a viable target for therapeutic interventions.
A recent study published in Nature found that melted meteorites retain extremely low water content, making them unlikely to be the primary source of Earth's water. The research suggests that unmelted, or chondritic, meteorites are more likely to have delivered water to our planet.
Researchers explore biotechnologies that use microbes to extract rare minerals and fuels from wastewater. This innovation has the potential to reduce greenhouse gas emissions by utilizing previously unused resources.
The UK has experienced a decline in life expectancy over seven decades, ranking 29th globally in 2021. Income inequalities and structural weaknesses have contributed to this decline, with poorer groups also seeing a decrease in life expectancy.
Researchers at Pohang University of Science & Technology (POSTECH) created a multifunctional vortex beam capable of operating with a wide range of light frequencies using a metasurface. The breakthrough technology has the potential to store more information at the same frequency, paving the way for 6G communication systems.
Volunteer divers monitored the SS Thistlegorm wreck for eight years, discovering an artificial coral reef that supports a diverse fish community. The study, published in PLOS ONE, highlights the importance of citizen science in understanding marine ecosystems.
A multicenter study found that patients with cystic fibrosis can safely take a dual combination of CF modulator drugs for four years while maintaining previously achieved clinical improvement. This breakthrough therapy has improved the quality and length of patients' lives, with some even seeing a 15% increase in lung function.
A study published in PLOS ONE found that an online resilience programme, SPARK Resilience, reduced stress and improved well-being in adults during the COVID-19 pandemic. The programme, which combines training and group interaction, was effective in increasing resilience and psychological stability.
A new invention by ETH Zurich researchers uses 3D printing to create customized insoles with integrated pressure sensors that can measure foot pressure during various activities. This allows for more accurate and efficient creation of custom insoles, potentially improving athletic performance and treating musculoskeletal pain.
A secondary analysis of a randomized trial found that even a small reduction in sleep time per night can significantly affect health-related quality of life in children. The study suggests ensuring sufficient good-quality sleep is crucial for child health.
A new study from Cummings School of Veterinary Medicine at Tufts University found that highly pathogenic avian influenza (HPAI) was associated with the deaths of over 330 New England harbor and gray seals. The virus was detected in birds and seals on the same beach, highlighting a potential route of transmission.
The study found that COVID-19 mRNA vaccine effectiveness decreased with time since the last dose, while booster doses increased protection. The findings suggest that vaccination strategies should prioritize boosters to maintain protection against severe illness.
A metastudy found digital-based physical exercise interventions are at least as effective as face-to-face ones, but generic designs often fail to provide quality information. The researcher aims to improve the digital-health-based prescription of physical exercise to take account of patients' individual requirements.
A study led by UNSW Sydney found that Tasmanian devils in human-modified landscapes have limited diets compared to those in undisturbed environments. The researchers analyzed stable isotopes in whisker samples to determine the devils' prey, finding they fed on smaller animals and less varied food items in altered habitats.
Sarah Jurgensmeyer, MS, CGC, received the 2023 ACMG Foundation Carolyn Mills Lovell Genetic Counselor Award for her platform presentation on increasing access to pediatric genetic services. The award recognizes the increasingly important role of genetic counselors in clinical genetics and genomic medicine.
Archaeologists have discovered evidence of ritualistic belief and economic factors intertwined for Neolithic people in northwest Arabia. Excavations at a mustatil east of AlUla revealed animal offerings, human interment, and suggest repeated pilgrimages, challenging previous understandings of the region's culture.
Dr. Nara Sobreira has developed innovative tools like GeneMatcher and VariantMatcher to aid in rare disease diagnosis, earning her the 2023 Watson Genetic Medicine Innovation Award. She continues to work on expanding genome analysis accessibility through education and research initiatives.
The study found that ME/CFS patients have a significantly larger brainstem compared to those without the condition. Smaller midbrain volumes were associated with more severe breathing difficulties in ME/CFS patients. The research suggests that brainstem dysfunction may contribute to neurological and cardiorespiratory symptoms.
A recent study found that the highly contagious chytridiomycosis fungus has become more prevalent and widespread in Africa since 2000, posing a new threat to amphibian populations. The disease, which can cause skin sloughing, lethargy, weight loss, and cardiac arrest, may be linked to climate change-induced stress.
A new way to identify higher-risk groups of older surgical patients can help surgeons make better care decisions and compare hospital performance. The new definitions label fewer patients as multimorbid and specify high-risk comorbidity combinations, which contribute to patient risk.
The CoDe tool enables precise edits to genetic codes, making vaccines safer and more effective. It can also modulate gene expression in small sections, aiding vaccine design and basic research.
A new study published in the New England Journal of Medicine found that lebrikizumab was effective in treating moderate to severe atopic dermatitis, improving skin clarity and reducing itching. The study involved two phase 3 trials with over 700 participants and showed promising results for the treatment.
Dr. Alexander M. Holtz received the award for his published article on heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies. The study highlights primary cilia-dependent defects in Hedgehog signaling, shedding light on a previously unknown autosomal dominant condition.
Researchers at Pusan National University have developed a novel solvent-resistant hole injection layer material, enabling the creation of efficient solution-processed OLED devices. The material exhibits high mobility and excellent film-forming properties, leading to improved efficiency and lifetime compared to existing materials.
Michael Alfano was awarded the 2023 AADOCR Honorary Membership for his significant contributions to dental, oral, and craniofacial research. He is a renowned expert in improving higher education, particularly in dental education, and has made notable advancements in periodontal disease research.
Researchers at Swansea University have created a low-cost and scalable method to manufacture fully printable perovskite photovoltaics using carbon ink. The devices achieved similar performance to conventional gold electrodes, with power conversion efficiencies of up to 14%.
Restoration of Brazil's dry forests and savannas can sequester up to 1.5 billion tonnes of carbon in the long term, while conservation is essential to meet its 2030 climate goal. The new study suggests a focus on these biomes could be more cost-effective than restoration.
Researchers have successfully developed chemically stable, tunable-bandgap 2D nanosheets from perovskite oxynitrides, opening new possibilities for sustainable technologies such as photocatalysis, electrocatalysts, and electronics. The nanosheets exhibit superior proton conductivity and excellent photocatalytic activity.
Researchers found encouraging responses with revumenib for advanced acute leukemias with KMT2A rearrangements or NPM1 mutations. The overall response rate was 53%, with 78% of patients achieving clearance of measurable residual disease.
New research from the University of Missouri establishes a link between western diets high in fat and sugar and non-alcoholic fatty liver disease. The study found that a specific bacteria called Blautia producta and a lipid caused liver inflammation and fibrosis, leading to non-alcoholic steatohepatitis.
A study analyzing over 300,000 European vegetation plots found that global climate gradients have relatively weak correlations with local plant community characteristics. The effects of climate change on plant species depend heavily on local factors such as soil conditions and microclimate.
Researchers at NTU Singapore have found a way to spur brain immune cells to clear toxic waste linked to Alzheimer’s disease by targeting their metabolism. The study reveals a ‘metabolic switch’ in the brain’s immune cells that can be manipulated to improve their function.
Researchers have successfully used AAV1.NT-3 gene therapy to improve muscle physiology and prevent age-related sarcopenia in mice. The treatment resulted in restored muscle mass, strength, and neural connections, offering a potential new option for managing this debilitating condition.
Implementation of post-overdose programs in Massachusetts municipalities associated with a 6% lower annual opioid fatality rate and a 7% lower opioid-related emergency encounter rate compared to non-programmed areas. The study suggests that these programs offer a critical opportunity to address overdose among high-risk individuals.
A global study found that while recovering tropical forests can remove significant amounts of carbon, the rate of regrowth is outpacing natural recovery. The study highlights the importance of sustainably managing forest areas that can recover from human disturbances.
A systematic review of 156 trials found that physical exercise improved motor symptoms and quality of life in people with Parkinson's Disease. Most types of structured exercise, including dance, water-based exercise, and endurance training, showed clinically meaningful benefits.
Researchers from Linköping University found that estrogen impairs the function of a specific ion channel, Kv7.1/KCNE1, which is associated with long QT syndrome and arrhythmia. This suggests that estrogen may be a risk factor for certain types of heart rhythm disturbances in women with hereditary mutations.
Elizabeth M. Jaffee, MD, FAACR, is being recognized for her exceptional leadership, scientific discoveries, and contributions to cancer immunotherapy. Her research has significantly broadened understanding of the interaction between the immune system and pancreatic cancer.
A new study has found that female participants with MS were no more likely to experience a disease flare-up after receiving fertility treatments than before. The study also discovered a link between the use of MS medications and a lack of increase in relapses during fertility treatments.
Doctors have criticized the General Medical Council (GMC) for its investments in fast food firms, pharmaceutical companies, and private healthcare providers. The regulator has nearly £870,000 invested in companies like Nestlé, McDonald's, and Unilever, sparking concerns over conflicts of interest.
A deadly fungus, Batrachochytrium dendrobatidis (Bd), has emerged in Africa over the past 165 years, causing a significant decline in amphibian populations. The fungus is lethal for many species but not others, with low prevalence and limited spread initially until 2000.
A recent review study led by UT Austin examines the planet's freshwater supplies and strategies for sustainably managing them. The study emphasizes the importance of recognizing surface water and groundwater as a single resource to ensure future water resilience.
A study by Texas A&M University researchers found that state policies improving data protection led to increased adoption of health information exchanges (HIEs) and health IT usage. States with favorable legal environments for HIEs saw a rise in HIE adoption, while those with restrictive laws experienced limited growth.
A large Canadian study finds no association between maternal opioid prescription after delivery and adverse infant outcomes. Infants of opioid-using mothers were slightly more likely to visit an emergency department, but this difference was minor.
A recent study published in the Strategic Entrepreneurship Journal suggests that individuals speaking languages with strong future time references are more likely to engage in social entrepreneurship due to their mindset placing a strong value on immediate results. The researchers found that countries with weak rule of law and corrupti...
Scientists create modified E. coli bacteria that cannot be infected by viruses while minimizing gene escape into the wild. This breakthrough technology has implications for reducing viral contamination in biotechnology production, such as insulin production and biofuel manufacturing.
A new study published in Journal of Clinical Microbiology shows that using multiple PCR panels can identify more pathogens, notably diarrhea-causing E. coli and enteric viruses, and do so more rapidly than a conventional workup. This results in lower healthcare costs, reduced hospitalizations, and decreased antibiotic use.
Researchers have developed a novel method to create single-atom catalysts with controlled pore size, using a self-assembly precipitation technique. The resulting Rhodium-based catalysts show improved catalytic activity and stereoselectivity in hydroformylation reactions.
Researchers at MIT have created a way for tiny robots to recover from severe damage to their wings, enabling them to sustain flight performance. The development uses laser repair methods and optimized artificial muscles that can isolate defects and overcome minor damage, allowing the robot to continue flying effectively.
A new study suggests that children's well-adjustment depends on their parents' views on co-parenting. Children of low-income couples with positive co-parenting relationships tend to have better outcomes, while those with poor or moderately good relationships may experience poorer adjustment, especially when fathers are less positive ab...
A study published in Neuron reveals the intricate neural mechanisms underlying fragmented feeding behavior in mice. The researchers identified three key populations: ARC AgRP neurons regulating non-feeding behavior, LH GABA neurons mediating feeding initiation, and DR GABA neurons maintaining feeding duration.
Researchers found that Matcha tea powder reduces depression in mice by activating dopaminergic neural circuits and improving mood. The study's results suggest that Matcha's antidepressant-like effects depend on the animal's prior mental state, with stress-susceptible mice showing a significant response.
A quality improvement initiative increased NICU social risk screening rates and connected 98% of requesting families with resources. Early engagement with services and cross-sector partnerships led to positive referral outcomes, improving caregiver presence in the NICU.
Researchers at Columbia University discovered how neurons connect into functional brains in fruit flies, revealing crucial axon-axon interactions that enable sensory differentiation. These interactions determine the correct wiring of neurons, which is essential for the fly's ability to discern and respond to different types of stimuli.
Researchers at Aalto University have made significant progress in understanding quantum wave turbulence by studying its behavior in ultra-low temperature refrigerators. They found that Kelvin waves transfer energy from macroscopic to microscopic scales, confirming a theoretical prediction about dissipation of energy at small scales.
Researchers found that strategically placing charging stations, especially at workplaces and in delayed home settings, can reduce peak electricity demand, store solar energy, and conveniently meet drivers' needs. This approach could help minimize the strain on the grid and avoid costly new power plants.
A study of 742 pregnant participants found that pandemic-related stress had a significant impact on mental health, particularly among those with low social support and high levels of worry. The research also showed that COVID-19 related stress during pregnancy was associated with poor postpartum maternal mental health outcomes and incr...