Researchers discovered PRMT1 promotes gastric cancer cell proliferation and metastasis through β-catenin signaling. The study identified a novel mechanism involving MLXIP recruitment to activate the β-catenin pathway.
A new study shows that XEN1101 can reduce seizure frequency by more than 50% in some patients and sometimes eliminate seizures altogether. The medication, a potassium-channel opener, boosts the flow of potassium out of nerves to stop them from firing.
Research reveals correlation between financial sector risks and increased carbon footprint in bank loans, hindering humanity's progress towards a green economy. The study analyzed CFBL data for 37 countries from 2010 to 2018, finding that systemic risk within the banking sector raised the CFBL in developed countries.
An international team of scientists recommends a global shift in food choices due to the potential for addiction. They suggest that certain ultra-processed foods have characteristics similar to addictive substances, which may improve global health.
The study found that MdMYB73 activates MdPH5 expression and enhances its activity, regulating malate transport into vacuoles. This results in increased malate accumulation and vacuolar acidification.
Researchers at Children's National Hospital used magnetic resonance spectroscopy to find new biomarkers that reveal how CHD changes an unborn baby's brain chemistry. The study found altered levels of choline and N-Acetyl aspartate-to-choline ratios, potentially representing disrupted brain development.
Research suggests that the gut microbiome plays a crucial role in forming a healthy placenta during pregnancy. Mice with depleted gut microbiomes had smaller placentas and less-developed blood vessels, which can deprive fetuses of nutrients. However, supplementing these mice with short-chain fatty acids restored placental growth.
A long-term study by Georgia Tech's James Stroud found that natural selection varies massively through time, canceling out any stabilizing effect. Species remained remarkably similar across the entire three-year period, contradicting the idea of constant evolution.
The University of Tennessee Institute of Agriculture is teaming up with AT&T Foundation to address the challenge of broadband access and education through a new digital literacy program. The program will engage, invest, and train citizens in skills that improve broadband adoption, particularly in economically distressed counties.
A new study by PIK researchers reveals that less privileged people in NYC face limitations in adapting their mobility behavior to heat, leading to increased health risks. The analysis of mobility data from 438 NYC subway stations shows that those already at higher risk have the fewest options to adjust their behavior.
The study found that offshore wind could generate up to 8% of the nation's electricity by 2050, with deployment ranging from 30 to 250 gigawatts. High levels of deployment are likely in scenarios with stringent decarbonization policies and low technology costs.
A pioneering international study led by UOC researchers finds that older people in Spain and Israel use smartphones more than those in Canada and Romania due to access to affordable internet rates. The study contradicts the stereotype that growing older leads to decreased digital technology use.
Approximately 1 in 5 adolescents had major depressive disorder, with less than half receiving mental health treatment. Racial and ethnic minority groups, particularly Latinx, experienced the lowest treatment rates.
A study found that people with a specific genetic mutation in the CARD9 gene have higher IL-17 protein levels, making them more responsive to IL-17 inhibitor biologics. This discovery may lead to targeted treatment recommendations for ankylosing spondylitis patients.
A study of over 850,000 Australian children born between 2009 and 2017 found a small increased risk of birth defects among those conceived through fertility treatment, partly attributed to parental infertility. The use of intracytoplasmic sperm injection (ICSI) was also associated with an increased risk for genitourinary abnormalities.
Researchers developed an analytical tool to spot stray DNA and RNA contamination in genetic analyses, increasing result accuracy. The software, SAHMI, can identify microbe-associated cells and study microbiome distribution in tissues.
Researchers found that individuals with previous environmental, social, and nutritional stressors were more likely to die from the flu. This contradicts the widespread belief that healthy young adults were disproportionately affected. The study analyzed skeletal remains of 369 victims and identified lesions as indicators of frailty.
Researchers found that wandering albatrosses orientate towards areas of 'loud' microbarom infrasound when flying on long distance foraging trips. This suggests that they may perceive and respond to microbarom infrasound propagated over long distances.
Researchers discovered that the short-chain fatty acid propionate can reduce metastases in mice with experimental lung cancer. The substance also increases the effectiveness of Cisplatin, a commonly used drug for lung cancer patients. Funding is now sought to identify patients who may benefit from propionate treatment.
A new study found that an alternative model to identify patients with lung cancer eligible for screening was more accurate than the currently used method based on the United States Preventive Services Task Force (USPSTF) criteria. The PLCOm2012 models had higher sensitivity and identified more people with lung cancer eligible for scree...
Researchers discovered a new role for extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that leads to cancer cell death. Hyperactivation of ERK causes stress in cells, triggering cell death through specific proteins DR5 and NOXA.
The University of Louisville is increasing training for medical students in rural communities and West Louisville to prepare them for primary care careers. The grant will enhance programs that attract and train physicians to practice in medically underserved regions.
A Singaporean study found that unvaccinated COVID-19 survivors are at a heightened risk of heart complications almost a year after recovery. The study revealed a 56% higher risk of developing new heart complications among unvaccinated survivors compared to uninfected individuals.
The ISOOS system uses a smart carrier as the mobile base and control center, connecting multiple UAVs, USVs, and AUVs for simultaneous 3D observation of targeted regions. This enables fast mapping of ocean floor and studying submesoscale eddies, previously difficult to access due to variability in space and time.
A study using data from over 10,000 UK participants found that young children with warm parental relationships tend to display more socially-desirable behaviors like kindness, empathy and generosity. This association holds even after accounting for mental health factors.
Researchers found that training expectant mothers can improve their ability to recognize happy baby expressions, leading to fewer signs of depression. This new approach aims to promote healthier emotional development for both mother and child.
A major European study found that almost all patients with skin diseases face embarrassment, leading to a huge psychological toll. The study also revealed that stigmatization is a major impact of skin diseases on personal and professional life.
Researchers found that antidepressant escitalopram increases synaptic density in the brain over weeks, leading to greater brain plasticity. This explains why effects of antidepressants take time to kick-in, with significant differences in synapse density between treatment and placebo groups.
A recent study by Southern Cross University found nearly twice as much nitrogen enters the Great Barrier Reef from groundwater than river waters, highlighting the need for a new perspective in preserving its health. The research suggests that managing nutrients is crucial in preventing harmful algal blooms and other detrimental issues.
A team of researchers at Oak Ridge National Laboratory developed a framework for designing solid-state batteries with mechanics in mind. They highlighted the critical role of material properties and mechanical stressors in affecting SSBs during cycling, and proposed techniques to make electrolytes more ductile and anodes more stable.
Researchers found that combining alkaline pretreatment and air mixing improves methane yield kinetics and solids removal in co-digestion processes. This synergy promises even greater methane production and enhanced waste management efficiency.
Recent research highlights the excellent electrochemical performance of critical 3D printing materials in rechargeable batteries. The study outlines the typical characteristics of major 3D printing methods used in fabricating electrochemical energy storage devices and discusses crucial materials for 3D printing of rechargeable batterie...
Researchers develop novel combinatorial treatment strategy to reduce and overcome chondroitin sulfate proteoglycan's inhibitory effects on neuronal regeneration. The approach stimulates a good measure of recovery in paralyzed rats, paving the way for clinical translation.
A team of scientists constructed micro-mesoporous metal-organic framework and carbon nanotube-based composite catalysts showing excellent oxygen reduction reaction electrocatalytic activity. The presence of MNx sites was found responsible for the enhanced electrocatalytic activity.
Researchers simulated co-gasification of wood chip and potato peel to produce syngas, showing a positive synergistic interaction that increases carbon conversion efficiency. The study demonstrates the feasibility of this method for valorizing organic waste into valuable bioproducts while addressing environmental sustainability challenges.
The study reveals the genetic regulatory network underlying poplar leaf development, highlighting key transcription factors and miRNAs involved in leaf growth and senescence. The researchers identified a core regulatory network centered around MYB5, which plays a crucial role in regulating pigment synthesis and leaf development.
Researchers used AlphaFold technology to reveal the structure and function of pineapple's SWEET10 protein, a glucose transporter. The study found that SWEET10 has similar glucose transport capabilities as Arabidopsis SWEET8, with potential applications for improving crop yield and quality.
A study comparing exercise and antidepressants found that both treatments have similar benefits for mental health but exercise improved physical health markers. However, patients struggled to stick with the exercise routine due to higher drop-out rates.
African Americans at increased risk of kidney disease due to genetic mutation now have a protective genetic mutation that eliminates the risk. The study found that medicines blocking the hole in kidney cells are likely to be effective treatment options.
A 312-million-year-old fossil found in the Carboniferous Rhode Island Formation provides evidence of how internal feeding, known as leaf mining, may have originated. The discovery sheds light on the evolution and behavior of holometabolous insects, including modern-day moths, beetles, flies, and wasps.
Researchers developed a model demonstrating that chasing interactions can induce dynamical patterns in bacterial organization. The structure becomes visible on a higher level, without requiring adhesion or alignment.
A recent study found that integrated clinics can improve health outcomes and reduce costs for patients with multiple chronic conditions. The INTE-Africa study showed that retention rates were close to 90% and viral suppression rates remained unchanged, highlighting the benefits of integrating HIV and non-communicable disease care.
A new study from North Carolina State University finds that freshwater insects lack metabolic responses to salinity, unlike other aquatic animals like crustaceans and snails. Insects' constant metabolism in saline environments may be due to low demand for calcium, which can be toxic to them.
Researchers identified the integration site pattern of lentiviral gene therapies in patient cells, shedding light on treatment safety and efficacy. The study found that integration near nuclear pores is associated with improved safety and effectiveness, avoiding oncogene regions where earlier technologies failed.
A new RAND Corporation study reveals that drug overdose deaths have surged among Americans without a college education, nearly doubling over a three-year period. The findings highlight the potential association between the rise in overdose deaths and barriers to education access, a social determinant of health.
Scientists have developed perovskite photovoltaic cells with significantly improved optoelectronic properties using nanoimprinting method. The structure reduces optical losses and enables cheaper production on a large scale.
The labor force participation and employment-to-population ratio have remained relatively stable for people with disabilities, holding steady at all-time highs over the summer and into early autumn. In contrast, percentages for people without disabilities may have maxed out at their pre-pandemic baseline.
High-throughput terahertz imaging has made significant progress, enabling real-time imaging applications. Computational methods such as digital holography, spatial encoding, and diffractive processing have improved image resolution and capabilities.
A study in Frontiers in Psychology found that unconscious 'crossmodal' associations with our sense of smell can distort perception of colors. Participants adjusted sliders to change the color of a square, but their choices were influenced by the odor they smelled, such as perceiving coffee as a reddish-brown color instead of neutral grey.
Researchers have discovered that midbody remnants, thought to be cellular trash, contain working genetic material that can change the fate of other cells, including turning them into cancer. The study suggests that these remnants may play a key role in spreading cancer throughout the body.
A new study from the University of Delaware uses machine learning and social media reviews to show environmental injustices in urban green spaces. The research found that neighborhoods with predominantly white, college-educated residents have a disproportionate access to higher quality parks.
Research reveals that faster placental growth increases the risk of preeclampsia and shorter pregnancy duration. Genetic variations affecting placental size also influence baby weight and mother's health.
A multicenter clinical trial found that high-dose inhaled nitric oxide improved oxygenation and reduced the risk of sensory and motor neurologic symptoms in adults with severe COVID-19 pneumonia. The treatment was also linked to lower levels of SARS-CoV-2 in the blood and sputum.
A new study from Queen Mary University of London found that people may experience long-term symptoms after acute respiratory infections, such as coughing, stomach pain, and diarrhea. Researchers believe these symptoms may be related to COVID-19, but further research is needed to establish the cause.
The Cabo Verde Atmospheric Observatory is expanding with a new laboratory building on São Vicente, thanks to €3 million in funding from the German government. The facility will enhance international climate research capabilities in the tropical Atlantic.
A retrospective cohort study found COVID-19 substantially increases risk for autoimmune and autoinflammatory connective tissue disorders. Long-term management of COVID-19 patients should include evaluation for these disorders.
Researchers found that the thalamus is involved in the adaptation of the adult visual system, with plasticity taking place in both the thalamus and cortex. This discovery has implications for understanding learning disabilities and therapies, suggesting a different approach may be needed to treat conditions like lazy eye.
Researchers have developed a new technique for manufacturing 3D microlens arrays using holographic fs-laser processing-assisted wet-etching technology. This method offers high precision, efficiency, and versatility, enabling the fabrication of complex 3D patterns with high fidelity.
Scientists discovered a key regulator that balances X chromosome genes between male and female mosquitoes, which could help develop new ways to prevent the spread of malaria. The finding sheds light on how mosquitoes compensate for having only one X chromosome, offering potential strategies to reduce blood-sucking female mosquitoes.
Previous studies suggest that psychedelics can induce an altered state of consciousness leading to new thought patterns, which is promising in treating OCD. Research analyzing the experience of past users found dissipation of obsessive thoughts, reduced anxiety, and increased acceptance of OCD symptoms.