Researchers used 2D infrared spectroscopy to investigate milk protein structures and dynamics in coffee beverages. The study found that milk proteins remained intact, retaining their original properties, even when exposed to caffeine and coffee grounds.
Researchers developed a novel immunotherapy approach using ultrasound to deliver chemotherapy and antibodies to the brain, boosting immune system recognition of glioblastoma cells. The treatment showed promise in improving responses to PD-1 blockade in patients with advanced brain tumors.
A new study reveals that the single-celled predator Lacrymaria olor's extreme shape-shifting ability is enabled by an origami-like cellular geometry. This unique structure allows for rapid hyperextensibility of its neck-like protrusion, making it a potential inspiration for innovative soft-matter engineering.
Researchers have developed a highly sensitive diamond quantum magnetometer that can achieve practical ambient condition magnetoencephalography. The novel magnetometer uses a single crystalline diamond to detect magnetic fields, achieving record sensitivities of up to 9.4 pT Hz-1/2 in the frequency range of 5 to 100 Hz.
A new study from Wake Forest University School of Medicine suggests that vigorous physical activity can lower the risk of cognitive decline in high-risk patients with hypertension. People who engage in one or more sessions of vigorous exercise per week had lower rates of mild cognitive impairment and dementia.
A novel combination of oncolytic virus and immune checkpoint inhibitor has shown remarkable efficacy in treating non-muscle invasive bladder cancer, with a complete response rate of 57.1% at 12 months. The therapy demonstrated durable responses, with a median duration of response not yet reached after a median follow-up of 26.5 months.
A team of researchers has identified the CDA gene as a key player in immunotherapy resistance in pancreatic cancer. Inhibiting this gene improves T-cell infiltration and increases the effectiveness of immunotherapy in a type of pancreatic cancer called PDAC.
Researchers found that restricting menthol flavor in cigarettes while making nicotine replacement therapy more available can decrease socioeconomic disparities in tobacco use. The study used an online platform to simulate the effects of policy changes on purchase behavior, showing that policies must consider interplay to be effective.
Researchers highlight strategies for improving agriculture with nanotechnology, including targeted delivery of pesticides and herbicides, and digital twin simulations. These approaches aim to reduce environmental pollution and increase crop resilience.
A new study from the University of Surrey reveals that political connections can drive innovation in emerging markets, but only with highly skilled employees. The research analyzed over 3,200 Chinese-listed businesses and found that companies with talented teams can better utilize resources and knowledge from political connections, lea...
Research published in the Stroke journal found that teenage women who were overweight or obese had a higher risk of ischemic stroke before age 55. The study analyzed data from over 50 years and suggested that even temporary excess weight may have long-term health effects.
Researchers are using a hyper-diverse group of herbs called bellflowers to understand relationships between species, origins, and human activity. The project combines genetic data, archaeological records, and computer modeling to create a playbook for answering similar questions in other regions.
Researchers at Texas A&M University have developed a method of monitoring infrastructure using Synthetic Aperture Radar (SAR) remote sensing systems. This technology allows for early detection of issues, reducing the need for time-consuming repairs.
A cohort study found lower moderate to vigorous physical activity levels linked to increased cardiovascular disease or mortality in normoglycemic Hispanic and non-Hispanic adults. Adults with prediabetes may gain from reducing sedentary behavior and improving lifestyle factors beyond exercise alone
The Association for Molecular Pathology has published guidelines for tumor mutational burden (TMB) testing, aiming to standardize calculation and reporting of TMB as a predictive biomarker for immune checkpoint inhibitor therapies. These recommendations emphasize the importance of comprehensive methodological descriptions in publications.
A team of scientists led by postdoctoral fellow Johan du Buisson has developed an information engine that can convert heat energy into work. By measuring the location of a tiny bead in a water bath with high accuracy, the engine is able to produce significant power output, approximately ten times faster than the speed of E. coli.
A new study reveals that praising and petting dogs enhances their learning success by reducing stress. Dogs who received a 'permissive' training style with praise and petting performed better than those in a 'controlling' style, which induced greater stress.
A team of researchers from Tokyo Institute of Technology has developed a new type of computational RNA droplet that can perform logical AND operations using microRNA sequences. These programmable droplets have the potential to be used in various applications, including biomolecular sensing and artificial cells.
The EU's Pathfinder program supports the development of innovative, exploratory technologies with major potential impact. Researchers aim to design concepts for sustainable, resilient microelectronic devices using readily available materials.
A study found that ACS, elevated HbA1c and TG levels, and higher SYNTAX scores are risk factors for the progression of native coronary atherosclerosis after PCI. Higher rates of hyperuricemia and acute coronary syndrome were also observed in patients with progressive disease.
A novel antibacterial lipopeptide produced by Serratia marcescens has been shown to be highly effective in killing Staphylococcus aureus. The lipopeptide targets the cell membrane, causing lesions and cell death.
A collaborative research study found that frequent, low-severity fires support Mexican spotted owl habitat, while high-severity fire is detrimental. This finding suggests that restoring historic fire regimes could benefit both owl conservation and forest resilience.
In the early 1600s, English clergy used discounting calculations to finesse finances amid rising prices and inflation. This adaptation of mathematical formulas resolved decades-long disagreements over rent and lease terms.
Novel OMTs involved in phenylphenalenone phytoalexins' biosynthesis enhance antifungal properties against Fusarium oxysporum. The study provides a genetic resource for improving banana disease resistance through molecular breeding.
Researchers created an artificial lymph node using hyaluronic acid, which connects with T-cells via a cell surface receptor. The noden acted as a learning hub, stimulating T-cells to recognize and kill cancer cells in mice with melanoma and colon cancers.
Research suggests nanoparticles can disrupt placental function and affect embryonic development, leading to potential health issues such as low birth weight and respiratory diseases. The study used human placentas and found that nanoparticles can inhibit blood vessel formation via messenger substances.
A substantial portion of young athletes are at risk of hypertension, with 21.3% meeting pre-HTN criteria and 8% diagnosed with Stage II HTN. Lifestyle interventions and screening for hypertension are crucial to prevent long-term health complications.
Researchers Manu Prakash and Eliott Flaum have discovered a new geometric mechanism in the single-cell organism Lacrymaria olor, enabling it to produce complex morphodynamics through curved-crease origami. The cell's cytoskeletal structure encodes this behavior, which is driven by a singularity that acts as a controller.
A study led by researchers from the University of Arizona Cancer Center identified a biological mechanism that could lead to more effective treatments for breast cancer that has metastasized to the brain. By targeting the autophagy pathway, the researchers were able to disrupt breast cancer cells' ability to form brain metastases.
The NIH is investing $30 million in a pilot program called CARE for Health, which aims to integrate clinical research with community-based primary care. The initiative seeks to improve health outcomes by providing access to clinical research and expanding opportunities for participation in clinical trials.
A study published in Heart Rhythm examined the potential dangers of energy drink consumption in patients with genetic heart diseases. The research found a temporal relationship between energy drink consumption and sudden cardiac arrest events, but caution is advised due to the small relative risk.
A special issue of the Journal of Pediatric Rehabilitation Medicine explores cerebral palsy beyond childhood, highlighting topics like mental health, sexuality, and independence in adults. The issue aims to address long-overlooked aspects of CP care, promoting a broader perspective for improved patient outcomes.
A team of scientists developed a method to quickly measure the frequency characteristics of photoreceptors' response to flicker stimulation, allowing for faster diagnosis of visual disorders. The new technique, called f-ORG, reduces the time required to conduct experiments and analyze data.
Researchers at Tohoku University have created a simple and environmentally friendly material that records past mechanical loading histories. The Pr-doped Li0.12Na0.88NbO3 (LNNO) material stores stress information for extended periods, enabling stress visualization and crack detection.
A new species of cordycipitoid fungi, Harposporium incensis sp. nov., has been identified with the ability to parasitize both Lepidoptera insects and nematodes, showcasing inter-phylum host-jumping capabilities. This finding suggests potential as a biological control agent for managing pest diseases.
A Europe-wide survey reveals that current crises distract from climate action and weaken public support. The study suggests emphasizing the urgency of climate change to increase support for measures like taxing fossil fuels.
The MIRI Mid-INfrared Disk Survey (MINDS) discovered a large variety of carbon-rich gases in the disk surrounding a very low-mass star. This finding suggests that rocky planets with Earth-like characteristics may form more efficiently than Jupiter-like gas giants in such disks.
Research from Stockholm University reveals that marsupials possess a not fully evolved form of brown fat, a crucial finding for understanding the origin and regulation of this heat-producing organ. The study suggests that the gene networks required to enable thermogenesis existed before the divergence of marsupials and placental mammals.
A new microneedle patch has been developed to treat autoimmune disease alopecia areata by delivering immune regulators to affected skin areas, promoting lasting hair regrowth. The approach restores immune balance and resolves T cell attack on hair follicles, offering a potential long-term solution without compromising the immune system.
A recent study published in JAMA Network Open found a positive association between heavy lifetime cannabis use and cardiovascular disease mortality among female participants. The study suggests that long-term cannabis use may have negative effects on mortality rates, highlighting the need for further research.
Caroline Schuster and Catherine J. Frieman will succeed Laurence Ralph as co-editors of Current Anthropology on January 1, 2025. They are the first cross-disciplinary editorial team and first women to hold this role, bringing extensive editorial experience to the journal.
Researchers developed an AI-driven liquid biopsy to identify lung cancer through DNA fragment patterns in the blood, demonstrating a high negative predictive value of 99.8%. The test could quadruple lung cancer detection rates and prevent thousands of deaths if implemented nationwide.
Researchers suggest microscopic, ultradense black holes formed in first quintillionth of a second after Big Bang may have produced smaller, super-charged black holes with unprecedented nuclear charge. These tiny, 'super-charged' black holes could have influenced atomic nucleus formation and detection.
The widespread adoption of high-assay low-enriched uranium (HALEU) threatens the international system of controls preventing nuclear weapons proliferation for over 30 years. HALEU's high enrichment levels pose significant security risks, making it possible for a single reactor to contain enough material for a nuclear weapon.
Researchers created nanomicelles containing substances already approved for human use, which reduced inflammation in the tumor microenvironment and facilitated the action of the immune system. The treatment induced a reduction of over five times in tumor volume compared to untreated tumors.
Researchers used virtual reality to test whether humans can feel embodiment toward prosthetic
Researchers have developed a groundbreaking solution to overcome DAC challenges, achieving record-breaking data transmission performance. The innovative approach enables the transmission of signals at rates exceeding 124 GBd PAM-4/6 and 112 GBd PAM-8 over long distances using low-cost digital-to-analog converters.
Patients with atrial fibrillation who took low doses of direct oral anticoagulants experienced more bleeding episodes during the first three months of treatment. High blood levels of the medications were also associated with an increased risk of bleeding events.
A comprehensive, user-friendly repository has been created to help study Alzheimer's disease. The ssREAD database encompasses 277 integrated datasets from 67 scRNA-seq & snRNA-seq studies, totaling 7,332,202 cells, and includes interactive visualizations for comprehensive analysis interpretations.
An analysis published in Science found that high assay low-enriched uranium (HALEU) fuel can be used directly to make nuclear weapons, posing a significant threat to terrorism and nuclear proliferation. Many proposed reactors could contain enough HALEU to make a nuclear weapon, increasing security risks.
The study uses the Dermatological Vision Dataset and compares vision transformers with traditional CNNs, achieving an impressive 97.8% accuracy on validation sets. Integrating ViTs into dermatology represents a promising step toward more accurate diagnostics.
A new study from the University of Sheffield identifies the emotional challenges faced by patients with tooth loss and dentures, including feelings of embarrassment, shame, and difficulty with everyday activities. The research aims to improve patient outcomes and create a more compassionate approach to tooth replacement.
A comprehensive molecular portrait of KRAS has been established, revealing its key role in pancreatic cancer progression and resistance to treatment. The study identifies ERK as a critical regulator of KRAS activity, with implications for developing targeted therapies.
A study published in PLOS Medicine found that children born via frozen embryo transfer have similar metabolic profiles to those born via fresh embryo transfer. The research compared over 4,000 children aged 2-5 years and found no differences in blood glucose, insulin, or cholesterol levels.
Researchers at the University of Surrey challenge common misconceptions about habits, suggesting they are mental links between situations and actions. Forming new habits can help, but doesn't guarantee success; instead, strategies like avoiding triggers or replacing bad habits with good ones can increase chances of long-term change.
A strong belief in the Protestant Work Ethic may underpin people's choices for 'natural' approaches to healthcare. The study found a link between PWE values and preferences for vaginal birth, natural cold remedies, and caesarean sections, even when chemical composition is identical.
Researchers discovered that killifish early embryogenesis differs from other fish species, with the embryo's body axis formed through self-organization rather than maternal pre-patterning. This adaptation allows the species to survive dry periods without accumulating damaged cells.
A recent Cleveland Clinic-led study found that high levels of the sugar alcohol xylitol are associated with an increased risk of cardiovascular events like heart attacks and strokes. The research team identified a link between xylitol consumption and elevated platelet activity, which can lead to blood clots and thrombosis.
Scientists at Okinawa Institute of Science and Technology identify a positive glutamate-NO-glutamate feedback loop that blocks long-term potentiation and impairs learning and memory. The study suggests that this loop may explain memory loss in stroke patients and potentially offer a solution for treatment.
Researchers found that men exhibit grandiose narcissism, while women display vulnerable narcissism, which is associated with a greater risk of perpetrating intimate partner violence and bullying. Vulnerable narcissism in women can also lead to subtle but significant harm.