Researchers at Case Western Reserve University have developed a new method for target DNA sequence amplification, testing and analysis known as AMPLON. This technique offers an alternative to the previously accepted PCR method, allowing for more applications in medical diagnosis and expanding scientific innovation.
Astronomers have detected a neutron star spinning at an unprecedentedly slow rate, defying the typical mind-bending speeds of these ultra-dense stars. The object emits radio signals every 54 minutes, offering new insights into its complex life cycle and potential implications for our understanding of stellar objects.
Researchers have characterized the diversity of DNA transposons and expanded the genome engineering toolbox. They identified 40 novel transposons with activity in human cells, significantly expanding their evolutionary diversity.
A new paper reviews Tommie Shelby's book on prison abolition, arguing that Shelby misreads the intentions of the movement. The author contends that while prisons cause real harm, quibbling with abolition may be unproductive. The paper examines how mass incarceration structures US society through fear, racism, and police brutality.
A study found that mass incarceration contributes to social disorganization and increased firearm homicides among Black communities in Chicago. Targeted policies addressing mass incarceration may help reduce urban firearm violence.
According to MSU research, linguistically simple headlines engage readers more than complex ones. The study found that simplicity impacts how often people click on stories, leading to increased demand for good journalism. By writing simply, news organizations can make their content more approachable and accessible to a wider audience.
The University of Oklahoma has been awarded a $1.2 million grant to lead a Phase 1B clinical trial for the treatment of prostate cancer when it begins to spread beyond the prostate. The trial combines two existing drugs, relugolix and enzalutamide, which may provide more effective treatments for aggressive prostate cancer patients.
A recent study published in Science Advances found that simpler headlines tend to be clicked on more than complex ones. Researchers evaluated over 30,000 real-world field experiments from the Washington Post and Upworthy, finding that simplicity was a key factor in attracting online readers. The study identified three hallmarks of simp...
Researchers from Trinity College Dublin discover that eggshell waste can effectively absorb and separate rare earth elements from water, offering a new environmentally friendly method for their extraction. The innovative approach could help meet growing demand for rare earth elements while reducing environmental harm.
Researchers from the University of Cambridge developed a low-cost and energy-efficient method to make materials that can capture carbon dioxide directly from the air. The charged charcoal sponge uses reversible bonds with hydroxides to capture CO2, requiring lower temperatures and renewable electricity for regeneration.
A new study reveals that US Islamist extremist groups are characterized by small, close-knit clusters of co-offenders who share similar characteristics. These relationships are shaped by mutual contacts, ideological affiliation, spatial proximity, and shared socio-cultural traits.
A new study by the Society for Risk Analysis explores the impact of AI-driven cyberattacks on global economies, supply chains, and trade. The research found that these attacks can cause significant declines in real GDP, trade prices, and volumes, as well as disruptions to trade routes, particularly among heavily reliant digital economies.
A new study led by Yale researchers found that attending segregated schools significantly contributes to cognitive decline and cognition disparities between older Black and white Americans. The study analyzed data from a large representative sample of the U.S. population, assessing the quality of education provided and individuals' per...
A study by Max Planck Institute for Demographic Research found that Italian mothers with 3+ children have a significantly shorter working life (7.6 years) compared to fathers (18.3 years). In contrast, Finland shows minimal differences in working life between mothers and fathers, with both working for pay for about 17.4 years.
A team of researchers successfully demonstrated the principles of gravity-mediated entanglement in a photonic quantum simulation. This breakthrough provides crucial insights into the nature of gravity and its interaction with quantum mechanics.
Researchers developed a compact sensor system with infrared imaging capabilities that can be fitted to drones for remote crop monitoring. The system can rapidly switch between edge detection and detailed infrared imaging, allowing farmers to pinpoint specific crop needs and boost harvests.
Researchers found that Y2O3 adds solubility to the ceramics, suppressing secondary phases and improving transparency. The study also discovered that Y substitution reduces Verdet constant and thermal conductivity, with potential applications in magneto-optical ceramics for Faraday isolators.
Research reveals a correlation between warm ocean conditions and salmon movement into the Arctic. The study found that when both gates of ice-free water are open, salmon can expand their range in Canadian waters.
A systematic review and meta-analysis of over 20,000 patients found that one in six to seven patients will experience discontinuation symptoms directly caused by stopping the medication. Severe symptoms occurred in about 3% of patients, with certain antidepressants increasing the risk.
Researchers found high GDF15 levels in steatotic liver patients are associated with an increased risk of liver cancer. Combining blood GDF15 levels with liver stiffness indicators can efficiently identify patients at high risk of developing liver cancer and poor outcomes.
Researchers found a universal equation that approximates the frequency of wingbeats and fin strokes across different animal groups. The equation shows a proportional relationship between body mass, wing area, and wingbeat frequency, revealing a relatively constant pattern across diverse species.
A global research team identified 863,498 promising antimicrobial peptides in marine and soil environments, as well as human and animal guts, to combat antimicrobial resistance. The findings come with a renewed focus on combatting the growing number of superbugs resistant to current drugs.
A new study from Boston University finds that increased Black incarceration rates contribute to rising firearm violence in Black communities. The research highlights the impact of mass incarceration on social disorganization and single-parent households, exacerbating violence in already vulnerable populations.
Scientists studied genetic variation in African tropical rainforest frogs to identify areas vulnerable to the climate crisis. High environmental variation fosters high genetic variation, but populations with low genetic variation are at risk of extinction. The study suggests preserving habitats with high genomic variation could help sp...
Researchers developed a human pancreatic cancer fibrotic barrier model to assess treatment strategies and test efficacy of therapeutic interventions. Inhibition of ROCK2 pathway resulted in reduced ECM remodeling and improved tissue permeability for drugs, highlighting its potential for enhancing drug delivery in PDAC.
A randomized controlled trial found that patients who viewed virtual rooms with Feng Shui or evidence-based design reported lower anxiety and improved sense of control compared to those viewing standard rooms. However, golden ratio-based design showed no benefits.
A study of over 10,000 US adults found a strong association between pro-inflammatory diets and elevated NT-proBNP levels, indicating potential increased cardiovascular risk. The research suggests that dietary inflammatory index may be an important factor in heart failure biomarker levels.
A team of researchers led by Virginia Tech's Shuhai Xiao discovered a 550 million-year-old sea sponge that challenges previous theories about its evolution. The fossil, found in China, suggests that early sponges may have had soft-bodied skeletons and only later developed mineralized structures.
A new poll reveals that most older adults are unaware of available resources to help them navigate aging and caregiving. Only a small minority have used programs like Area Agencies on Aging, State Health Insurance Assistance Programs, and long-term services and supports. The findings highlight the need for more awareness about these se...
A new study found that combining histone deacetylase inhibitors, poly (ADP ribose) polymerase inhibitors, and decitabine resulted in synergistic cytotoxicity in all cell lines tested. This combination impaired DNA repair pathways and altered epigenetic regulation of gene expression.
Researchers at UCLA have identified a key protein MYCT1 that enables blood stem cells to sense and interpret signals from their environment. The study's findings could lead to the development of methods to expand blood stem cells in a lab dish, making life-saving transplants more available.
A Rutgers University study found that many firearm owners lack knowledge about proper cable lock installation, with only 98.3% correctly identifying correct installation on a rifle. The study suggests that education and awareness are crucial to ensure the effectiveness of cable locks in securing firearms.
A team of researchers at University of California San Diego has identified a biochemical mechanism that can interrupt cellular communication chains, disrupting the signaling pathways related to many diseases. The discovery highlights the importance of growth factors and G protein-coupled receptors in cell signaling.
Researchers from Mass General Brigham created an algorithm to generate personalized DBS treatment plans based on four major PD symptoms. The algorithm improved patients' symptoms in four of five cases, demonstrating its potential to improve treatment beyond standard-of-care approaches.
Researchers developed a computational model to understand key decision-making processes, showing how group rewards improve performance. A videogame model inferred sequences of decisions from visual data, revealing the importance of balancing exploration and resource usage in collective behavior.
Researchers found that chiral gold nanoparticles exhibit high selectivity for left- or right-handed circularly polarized light with a dissymmetry factor of approximately 0.7, outperforming previous materials. The findings suggest potential applications in anti-counterfeiting and quantum information using circularly polarized light.
Researchers found SARS-CoV-2 in male reproductive cells even when PCR testing failed, revealing a prolonged infection period of up to 90 days. The virus can remain in sperm for 110 days, reducing semen quality and raising concerns for natural conception and assisted reproduction.
A new 13-week group-based parent training program, Well Parent Japan (WPJ), has been shown to be effective in reducing parenting-specific stress, improving parenting efficacy, and reducing family strain for Japanese mothers of children with ADHD. The program provides social support and encourages shared learning amongst participants.
Researchers at Sun Yat-sen University have identified a tomato exocarp-specific promoter that enhances fruit quality, durability and shelf life. The SlPR10 promoter regulates genes for anthocyanin and wax production, resulting in fruits with improved defense systems against environmental stressors.
The team created a prediction model that generates sustainable products with high accuracy and explores the vast design space of aerogel assembly. Their strong and flexible aerogels have programmable mechanical and electrical properties, opening up new possibilities for green technologies.
The two-year program will help recruit, teach, and graduate the next generation of water pipeline managers. The GLWA faces significant employee recruitment, training, and retention challenges due to technological advances in the water sector.
Researchers found that sessile invertebrates like mussels and barnacles became more abundant during the study period, while seaweed species like kelps declined. The rocky shore communities did not return to their baseline conditions after the epidemic ended, suggesting low resilience to changes in temperature and predator numbers.
A new study found that smart thermostats can identify three distinct sleep quality clusters with clear variations in duration, disturbances, and efficiency. Machine learning models were used to discern sleep quality indicators from eight terabytes of data collected from 178,706 households.
A study using diffusion tensor imaging found reduced white-matter structural features in maltreating mothers' brains, linked to impulsivity and voluntary movement control. The findings suggest potential physiological causes underlying child abuse and represent a crucial step towards developing effective prevention strategies.
A novel wearable brain scanner has given the clearest ever picture of young children's developing brains, measuring electrical brain activity with millisecond-by-millisecond precision. The study, published in eLife, opens up new possibilities for tracking developmental milestones and neurodevelopmental conditions like autism.
A recent study published in JAMA Cardiology found that dual direct-current cardioversion is significantly more effective than single cardioversion in restoring sinus rhythm in obese patients with atrial fibrillation. The study demonstrated a 98% success rate for dual cardioversion, compared to an 86% success rate for single cardioversion.
Researchers found two opportunistic bacteria significantly more abundant after three months of daily use, Fusobacterium nucleatum and Streptococcus anginosus. A decrease in Actinobacteria was also observed, crucial contributors to blood pressure regulation.
A 12-week health education program using videoconferencing software showed improved physical activity and adherence to health advice compared to a control group. The study suggests that videoconferencing can be an effective tool for promoting sustainable behavioral changes among older adults, regardless of location or distance.
A new AI model developed by researchers at the University of Jyvåskilö can predict and respond to human emotions, improving user experience. The model simulates cognitive evaluation processes to assess emotional responses to events, enabling computers to preemptively predict and mitigate negative emotions.
A novel mechanical metamaterial, 'Chaco,' exhibits history-dependent behavior, allowing it to remember the sequence of actions performed on it. This property enables potential applications in memory storage and robotics.
Sean McWilliams' team will study stellar-mass and massive binary inspirals, improving modeling accuracy for the Laser Interferometer Space Antenna (LISA). The project aims to enhance the instrument's science mission by making necessary dramatic improvements in modeling accuracy.
Researchers found that tumor-associated macrophages respond to physical properties of fibrosis by synthesizing injury-associated collagens, resulting in metabolic changes that suppress CTL function. This provides an alternative explanation for why anti-tumor immunity is impaired in fibrotic solid tumors.
Researchers developed a laser-based 3D printing method to fabricate high-quality micro-spheres for enhanced optical resolution. The new approach enabled the creation of a micro-sphere with near-perfect geometric quality and exceptional surface smoothness.
A study published in Radiology found that AI significantly improved breast cancer detection and reduced false-positive findings. The AI system detected more cancers while lowering the rate of unnecessary recalls, reducing radiologist workload by 33.4%.
A six-state hospital system reported significant decreases in surgical site infections, mortality, length of stay, and readmissions after implementing a comprehensive SSI prevention bundle. Orthopedic patients showed the most benefit, with a 32.8% reduction in SSI rates.
A new molecular test WID-qCIN detects significantly more cancers and precancerous stages than current methods, identifying 100% of invasive cervical cancer and 93% of serious precancerous lesions. The test reduces the need for colposcopy examinations by 40%, improving the effectiveness of screening programs.
Scientists at Duke-NUS Medical School have identified how mast cells release bioactive chemicals after encountering allergens, a critical step in anaphylactic shock. The discovery could lead to the development of drugs to prevent severe reactions and offers new hope for millions with asthma and food allergies.
Drug-involved infant deaths in the US increased by 120% from 10.8% in 2018 to 24.4% in 2022, with the highest proportion occurring in 2021. The most common causes of death were assault, poisoning, and psychostimulants.
Researchers investigate partition coefficients of first-transition row elements in olivine and silicate melt to understand petrogenetic processes in planetary basalts. The study reveals the role of Cr-rich cumulates in lunar basalts and implications for reducing conditions in the lunar mantle.
A Phase III trial led by the University of Texas M. D. Anderson Cancer Center found proton therapy to be non-inferior to traditional radiation therapy in treating head and neck cancer. The study revealed a significant reduction in malnutrition and feeding-tube dependency with proton therapy.