A new study in mice shows a unique mRNA delivery method can successfully edit faulty genes in fetal brain cells. The technology has the potential to stop progression of genetic-based neurodevelopmental conditions like Angelman syndrome and Rett syndrome before birth.
A study found that anxiety related to food allergies increased significantly in children, leading to an average of 2.1 allergens per patient and a 69% incidence of food-related anxiety. Psychology referrals for these patients increased by 50% over four years, with 60% completing at least one appointment.
Researchers from Tsinghua University Press propose a novel simulation platform for on-demand ride service operations, providing a fair and public test bed for comparing optimization algorithms. The simulator efficiently tests various tasks related to on-demand matching, idle vehicle repositioning, and dynamic pricing.
A new study found that fast-growing fires account for nearly 90% of fire-related damages, despite being rare. The research shows a critical gap in hazard preparedness, as national-level fire risk assessments do not account for fire speed.
Understanding plant-to-plant communication through VOCs can lead to innovative strategies for crop protection and yield improvement, potentially revolutionizing sustainable agriculture. This review explores the molecular pathways behind this complex biochemical strategy and its potential applications.
Researchers developed an algorithm that splits obesity into 5 separate diagnostic profiles with contrasting risk of developing obesity complications. This can help clinicians identify individuals who need early interventions, improving disease prediction and treatment.
A survey of 298 parents with children diagnosed with atopic dermatitis found that parents' understanding of the condition and its dietary links significantly influenced their children's diets. The most frequently identified trigger foods were milk, tree nuts/seeds/peanuts, and eggs.
A study by Northwestern University found that cross-talk between the hippocampus and cortex can predict chronic pain, with higher anxiety levels increasing precision. The researchers suggest targeting anxiety after injury to prevent chronic pain, paving the way for novel treatments.
A CRISPR-Cas9 based gene editing therapy has been shown to reduce angioedema attacks and sustainably lower kallikrein levels in patients with hereditary angioedema, offering a potential treatment option. The therapy was tested on 27 patients across two dosages compared to placebo.
A study by a University of Mississippi professor found that the vocalizations of baby chickens, known as 'peeps' and 'whistles', can indicate stress levels in avian animals. This breakthrough could improve animal welfare in the poultry industry and lead to more humane practices.
A team of researchers at UPV/EHU has created an algorithm to map burnt areas on a global scale, detecting fires as small as 250 meters. The method uses data from various satellites and achieves a higher resolution than existing systems.
A team of bioethicists and legal scholars call for clear and concise regulations on exosome-based treatments due to the lack of scientific evidence and existing regulatory frameworks. These unproven interventions can cause serious harm to patients, highlighting the need for stronger protections.
A UNC Greensboro study of 299 women and their infants found that obesogenic feeding practices, such as watching TV while feeding or formula-feeding, are strongly correlated with rapid infant weight gain. The researchers also found that mothers' prenatal psychological risk increases the likelihood they will engage in these unhealthy pra...
New research from the University of Chicago shows that gut bacteria can acquire a gene that shuts down their own deadly weapon and activates a new one, allowing them to outcompete other bacteria. This transfer of genes enables the bacteria to carve out niches in the tightly packed recesses of the gut.
Researchers found that incineration of household waste containing fluoropolymers at temperatures typical for municipal waste incineration resulted in nearly complete mineralization, with over 99.99% reduction rate. This finding suggests that standard combustion conditions are sufficient to remove fluoropolymers from the environment.
Researchers have discovered a gene called NANOG that can improve nerve regrowth and re-establish innervation in damaged muscles after traumatic nerve injuries. This discovery has significant potential to help mitigate long-term disability for people with debilitating nerve injuries.
A study from Osaka University found a reliable wastewater surveillance method, tracking regional infection trends with high sensitivity and reproducibility. The research team concluded that at least three samples per week are required for accurate monitoring.
Researchers at NTNU have developed an 8-item scale assessing growth mindset, which was tested on 723 participants. The study found that the test is suitable for this age group and provides a better scale to measure growth mindset.
A new study by University of Southern Denmark researchers reveals that microbes cling to iron surfaces using sticky enzymes, extracting nutrients without wasting energy. This efficient corrosion method poses environmental concerns due to methane production and potential climate change implications.
Scientists at Peking University have discovered that hydrated electrons generated from water radiolysis can drive the synthesis of ammonia from nitrogen and water. The use of γ-ray radiation to synthesize a Ru/SiO2 catalyst improved NH3 production, with a conversion efficiency of up to 563.7 mg·MJ−1.
Researchers at Tampere University have developed a non-electric touchpad that can sense force, area, and location of contact without electricity. The device is made of soft silicone and contains 32 channels, enabling precise detection of handwritten letters and multiple simultaneous touches.
A new study published in PLOS Biology suggests that male birds contribute less to helping their families because they prioritize scouting for new habitats and breeding opportunities. This trade-off with dispersal may explain why one sex invests more in family help than the other across various animal societies.
A new hydrogel semiconductor has been developed by the UChicago Pritzker School of Molecular Engineering, enabling better brain-machine interfaces, biosensors, and pacemakers. The material's soft mechanical properties and high charge-carrier mobility make it ideal for tissue-level interfaces.
Researchers at the University of Barcelona have developed a method to rejuvenate brain neurons in mice using controlled cellular reprogramming cycles with Yamanaka factors. This process recovers altered neurological properties and functions, and has been shown to increase neuron count and brain plasticity.
Researchers have unveiled a complex interplay between liver X and thyroid hormone receptors that regulates critical brain functions and protects against neurodegeneration. LXRs play a crucial role in regulating thyroid hormone function in the brain, while both receptors are essential for normal brain development and maintenance.
Researchers have discovered key mutations in certain cancer cells that render WRN inhibitors ineffective. The study found that prolonged exposure to these inhibitors can lead to the acquisition of mutations in the WRN gene, allowing cancer cells to survive and develop resistance.
Researchers at Aarhus University have decoded part of the bacterial defense mechanism against antibiotics, providing a crucial step towards treating resistant MRSA infections. Understanding the molecular composition of the biofilm-forming protein PSMα1 could lead to new strategies and treatments to prevent biofilm formation.
A new study reveals that benzyl butyl phthalate (BBP) causes oxidative stress and DNA strand breaks, leading to cell death and abnormal chromosomes in egg cells. The research suggests that BBP exposure can lead to lower quality egg cells with compromised genomic integrity.
Researchers found that 57% of tested chemicals altered fruit fly larvae behavior significantly, even at non-lethal doses. Long-term survival was compromised in a dose-dependent manner, with a 60% drop in egg-laying rates observed among exposed mosquitoes and Painted Lady butterflies.
A new study at an allergy clinic in a diverse community found that self-identified non-White patients were less likely to show vaccine hesitancy than the White patient group. Ethnicities included in the study showed Black, Hispanic and Asian ethnicities with lower rates of refusal compared to Whites.
UTEP researchers developed a portable device that can detect colorectal and prostate cancer quickly and accurately, reducing the need for costly instruments. The device is low-cost, sensitive, and analyzes samples in just an hour.
A new study uses PCA and Mahalanobis distance to detect early bolt loosening in wind turbines, achieving accuracy of over 95%. This technology improves operational safety and efficiency by providing early warnings based on objective data.
Researchers have uncovered a new mechanism in the growth of amyloid β (Aβ) fibrils, which are closely associated with Alzheimer's disease. The team found that each Aβ fibril is composed of two thin strands called protofilaments, and when their ends align, the fibril enters a paused state where growth temporarily stops.
A review of carbon anodes for lithium-ion batteries highlights the importance of regulating the graphite interphase for high efficiency and stable performance. The research team notes potential future developments in carbon-silicon composite anodes and optimization of carbon-lithium metal composite anode.
A recent study by the University of California, Davis, reveals a staggering $79 billion in annual climate-related costs from the production of common materials in the United States. These costs, stemming from greenhouse gas emissions, create a massive subsidy for carbon-intensive industries.
Researchers at the University of Illinois are using a wearable device called LittleBeats to collect data on infant behavior in real-world settings. The first grant focuses on infant-parent interactions and emotional regulation, while the second grant explores infant sleep/wake patterns and health outcomes.
Researchers studied a newly identified species of tardigrade to gain insights into its ability to withstand radiation. The study found that the animal's robust DNA repair capabilities and expression of specific proteins protect it from radiation damage, offering potential inspiration for promoting human health.
Researchers developed a new method for creating stable zinc-ion batteries by intercalating charged organic carboxylic acid ligands into vanadium oxide nanomaterials. The resulting materials exhibit uniform morphology, large interlayer spacing, and stable ion channels, promoting rapid ion migration and high energy storage efficiency.
A study by Ohio State University found that ground ambulance providers raised their prices in response to a New York law aimed at preventing surprise, expensive out-of-network emergency ambulance bills. The law increased prices by 13%, which is likely to hit health consumers' bank accounts through elevated insurance premiums.
A new study reveals that increasing plant diversity in agriculture can significantly improve soil carbon retention by fostering stronger positive interactions between microbes. This practice not only promotes healthier ecosystems but also offers a viable solution for maintaining crop output while sequestering more carbon in soils.
The Cyber-Resilience Resource Center will provide training and support to organizations across West Virginia, with a focus on small and medium-sized businesses. Over 200 students will gain real-world cybersecurity experience through the center.
Researchers developed a novel technique using liquid metal microdroplets to create stair-like structures forming vias that connect circuit layers without drilled holes. This approach enables rapid and parallel fabrication of soft electronic components, overcoming challenges in conventional rigid electronics.
Researchers have identified the first high-resolution experimentally determined structure in proteins that helps bacteria survive harsh conditions. SpoIVFB, a specialized enzyme, plays a critical role in sporulation and facilitating biochemical product creation.
Researchers found that chasing schools of prey at high speed leads to higher attack rates and increased hunting success for striped marlin. The study shows that group hunting is advantageous for predatory fish, as it allows them to isolate and catch individual prey more easily.
According to a new USGS study, approximately 71-95 million people in the Lower 48 states may rely on groundwater containing detectable concentrations of PFAS for their drinking water supplies. The predictive model helps understand the potential for PFAS contamination and informs strategic planning for water resources.
ICFO researchers have reported on a post-deposition in situ passivation strategy that improves surface passivation, yielding nanocrystal ink films with enhanced optoelectronic properties. This approach has led to the development of ultrathin solar cells with higher power conversion efficiency than their multi-step deposition counterparts.
Researchers have developed a 'mini-protein' that targets cancer cells expressing Nectin-4, allowing for direct delivery of radiation to tumours. The treatment shows promise in targeting multiple types of cancers and has the potential to be safe for repeated administrations.
The new fringe photometric stereo technique reduces scanning time by over two-thirds while achieving micrometer-level accuracy, ideal for real-time scanning applications such as industrial inspection and medical procedures. The approach 'feels' the surface by projecting light patterns, improving precision measurements.
The study proposes a more sustainable alternative to thermocatalytic route by utilizing renewable energy for ethylene oxide and ethylene glycol production. Electrocatylatic routes show promise in reducing carbon emissions and offer improved environmental sustainability.
A new study published in JNCCN found that Medicaid expansion was associated with longer survival rates and reduced treatment delays for patients with HR-negative, HER2-positive breast cancer. The study used data from the National Cancer Database to review results for women diagnosed with this type of breast cancer between 2010 and 2018.
Researchers analyzed over 16,000 biopsies from nearly 7,000 kidney transplant recipients to uncover key insights into microvascular inflammation. The study found reclassified patients with microvascular inflammation in the absence of antibody-mediated responses displayed an increased risk of graft failure.
A new study by MIT scholars finds that hospice care generates substantial savings for the US Medicare system, with $29,000 in cost savings over five years for patients with Alzheimer's Disease. Hospice care provides palliative-type care at a lower cost than elaborate medical procedures, saving lives and reducing suffering.
A new species of crustacean with unique black-and-white coloring, resembling a panda, has been discovered in Japan. The Melita panda was found in intertidal waters and is closely related to other amphipods with distinct physical characteristics.
Get With The Guidelines - Stroke has become an integral part of stroke clinical practice and research in the US, capturing nearly 8 million stroke cases. The study found increased adherence to evidence-based stroke care translates to better clinical outcomes and more patients being discharged home.
China's atmospheric gaseous elemental mercury concentrations decreased significantly over a decade, with a 38.6% decline from 2013 to 2022. The primary driver of this decline was the reduction in domestic anthropogenic emissions, largely due to air pollution control measures.
A study published in Science Advances has identified key characteristics of multiply recurrent meningiomas (MRMs), a highly aggressive form of brain tumor. Researchers found that MRMs are more numerous, larger and more common in men than women, with increased chromosomal instability and DNA methylation.
Researchers developed grain-sized soft robots that can transport up to four different drugs, release them in reprogrammable orders and doses, and navigate complex environments inside the human body. The robots' precision functions have the potential to significantly improve therapeutic outcomes while minimizing side effects.
Scientists have discovered a way to switch cellular activities on and off using light, opening up new possibilities for biological research and medical applications. The researchers created photoreceptors similar to those in the retina, which can be triggered by light pulses to initiate specific cellular signalling processes.
Researchers developed a nanomedicine that attacks bacteria at the molecular level, reducing antibiotic resistance and side effects. The technology releases medication only when required, ensuring patients take exact amounts to fight infections.
A new class of 1D perovskitoids enables robust stability and high photodetector performance. The π-conjugated cations improve carrier separation and transport capacity, leading to exceptional photocurrent on/off ratios.