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Science News for January 11, 2025


Metallo-supramolecular complexes enantioselectively target monkeypox virus mRNA G-quadruplex and inhibit monkeypox virus replication by increasing the immune response

Researchers designed metallo-supramolecular complexes that selectively bind to MPXV mRNA G4, modulating A5L protein expression and immune response activation. These findings highlight the significance of G4s in viral immunodominant protein expression and offer potential avenues for developing antiviral therapeutics.

SourceScience China Press·JournalNational Science Review·DateJan 11, 2025