The ACROSS 2 Phase III trial demonstrates that combining aumolertinib with platinum-pemetrexed chemotherapy significantly improves progression-free survival in patients with advanced/metastatic NSCLC harboring EGFR sensitizing mutations and concomitant tumor suppressor gene mutations. The treatment regimen showed a manageable safety pr...
A Phase 3 trial found that crizotinib did not prolong disease-free survival in patients with resected early-stage ALK+ NSCLC. The study included 166 patients and followed them for a median of 58.3 months.
Zidesamtinib demonstrated clinically meaningful activity and durability in patients with ROS1-positive NSCLC who had progressed on prior TKI therapy. Durable responses were observed in patients with CNS involvement, ROS1 G2032R mutations, and multiple prior ROS1 TKIs.
The FLAURA2 trial shows osimertinib plus chemotherapy significantly improves overall survival compared to osimertinib monotherapy in patients with EGFR-mutated advanced NSCLC. The combination also demonstrates a manageable safety profile, extending survival for these patients.
The global Phase 3 HARMONi trial found that ivonescimab plus chemotherapy significantly prolonged progression-free survival (PFS) in patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations. Median PFS was 6.8 months, and the overall response rate was higher in the ivonescimab group.
Researchers developed a technique that uses infrared light and machine learning to determine the sex of blow fly larvae, improving time-of-death estimates. The method achieved over 90% accuracy and has potential applications in forensic entomology, agriculture, and biosecurity.
A novel antibody-drug conjugate iza-bren demonstrated an objective response rate of 66.0% and a confirmed ORR of 56.0% in EGFR-mutated NSCLC patients, with manageable safety profile. The median progression-free survival was 12.5 months.
A combination of iza-bren and osimertinib demonstrated a 100% objective response rate in patients with first-line EGFR-mutated locally advanced or metastatic non-small cell lung cancer. The regimen was also manageable from a safety perspective, with most treatment-related adverse events being hematologic.
The COMPEL trial demonstrates that patients with EGFR-mutated advanced non-small cell lung cancer benefit from continued osimertinib treatment in combination with platinum-based chemotherapy. This approach is associated with improved progression-free survival and overall survival compared to placebo plus chemotherapy.
The CheckMate 77T trial confirms that perioperative nivolumab does not compromise health-related quality of life in patients with resectable non-small cell lung cancer, including those with Stage III N2 disease. Nivolumab also reduces risk of symptom deterioration in these high-risk patients.
A new study validates the use of Sybil, a deep learning artificial intelligence model, for predicting future lung cancer risk in a predominantly Black population. The model demonstrated high predictive accuracy for lung cancer risk up to six years after a single low-dose CT scan.
The study found that adding baxdrostat to standard care can lower blood pressure and delay kidney damage in patients with chronic kidney disease and uncontrolled high blood pressure. Participants experienced a significant reduction in urine albumin levels, indicating potential benefits for delaying kidney progression.
Physicians rely on nuclear medicine scans to watch the heart pump, track blood flow and detect diseases. The new perovskite-based detector can capture individual gamma rays with record-breaking precision, leading to sharper, faster, cheaper and safer scans.
A new study in the Bulletin of the Seismological Society of America identifies 13 attributes of resilience in disaster response and preparedness. Agility and diversity are found to be crucial in both phases, while creativity and connectivity become vital during the response phase.
A team of scientists has estimated that an average cell line acquires and retains roughly 13 percent of its genes every million years through lateral gene transfer. This process enables microbes to adapt to new environments and access essential nutrients. The study provides the first quantitative analysis of gene transfer rates across ...
Researchers propose a new theory, Socio-Technical Exchange, to better understand human interaction with technology in the workplace. The study found that people form cognitive representations for both human and machine work partners and develop interdependence with machines.
Researchers found that individuals from African American, Hispanic and Asian groups were less likely to have elevated amyloid in the brain based on blood levels of p-tau217. This finding suggests that these groups may have a lower prevalence of amyloid and are not at sufficient risk to qualify for amyloid-lowering trials.
SkyNano, backed by Innovation Crossroads, receives $1.25M contract from U.S. Air Force to develop low-cost graphite for battery-grade applications. The project aims to create a secure domestic supply chain for lithium-ion battery materials.
The in vivo approach eliminates laboratory manipulation, leveraging viral and nonviral vectors for genetic modification of T cells. This method preserves T cell functionality, enhancing therapeutic efficacy compared to in vitro-produced CAR T cells.
Natural compounds normalize tumor vasculature, inhibiting pathological angiogenesis and reducing tumor growth. These agents complement conventional therapies, reduce toxicity, and enhance delivery of chemotherapeutic drugs.
Researchers have developed innovative strategies combining oncolytic viruses with immunotherapies to overcome limitations of OV monotherapy. These synergistic treatments amplify the body's natural defenses, creating a powerful dual attack against cancer cells while minimizing adverse effects.
Dr. Steven B. Heymsfield joins an elite group of scholars recognized for advancing knowledge and transforming their fields. He has authored over 1,300 scientific publications with nearly 79,000 citations, placing him among the top 500 most-cited researchers globally.
A new method called spVelo calculates RNA velocity to understand how cells become specialized. By incorporating spatial information and processing multiple batches at once, the method overcomes previous challenges.
Head and neck cancer's intricate connection between energy metabolism and immune regulation holds potential for effective therapies. Tumor cells' metabolic reprogramming fuels growth and supports invasion, while altering glucose transporters and lipid metabolism promotes immune evasion.
Dr. Julian Schrader will investigate the interaction between climate change and plant species spread on islands using a 1.5 million euro grant. He aims to close the knowledge gap on migration processes and their consequences for species communities.
Researchers have discovered that eels rely on signals from their bodies, like stretch and pressure, to adjust to different environments. These signals, combined with the nervous system's built-in rhythm, enable movement coordination even after a spinal cord injury.
The Mediterranean Sea is warming at a faster rate than the open ocean, posing significant risks to marine ecosystems. The study highlights the urgent need for action to protect these unique ecosystems, which could collapse or remain functional depending on political decisions made now.
A new study found that reducing dual antiplatelet therapy duration after coronary artery bypass grafting (CABG) improves graft patency while decreasing bleeding risk. Patients who received de-escalated DAPT had similar ischemic benefits and better bleeding safety compared to those on longer DAPT periods.
A new trial found that P2Y12 inhibitor monotherapy may reduce bleeding while preventing recurrent ischaemic events compared to 12 months of DAPT. However, the study failed to demonstrate noninferiority for death and ischaemic events between P2Y12 inhibitor monotherapy and dual antiplatelet therapy.
Researcher Manuel Krannich has been awarded a five-year ERC starting grant to investigate the connections between symmetries of high-dimensional manifolds and laws of algebra. His project, 'Manifolds and Functor Calculus' (MaFC), combines manifold theory with higher-level algebra.
Researchers have developed an immunotherapy drug STF-1623 that safely prevents cancer cells from hiding from the immune system's first responders. The drug works by inhibiting ENPP1 proteins that destroy cGAMP, allowing it to trigger a broader immune response and suppress tumor growth.
A research team from Tohoku University has developed a new organic redox polymer that addresses material compatibility issues in aqueous electrolytes. The polymer retains high hydrophilicity and can be broken down into its raw components under mild conditions, reducing resource consumption and plastic pollution.
A recent breakthrough in MXene nanomaterials could enable bespoke design tailored by AI. Researchers have discovered the thermodynamic forces underlying their unique structure and behavior, setting parameters necessary for AI-guided design.
Researchers at Max Planck Institute for Chemistry investigated α-pinene ratio in Amazon rainforest before, during, and after drought period. The results show that increasing drought stress shifts the ratio to higher values, indicating ecosystem stress.
A recent study has found that ivabradine, a medication used to treat angina and heart failure, was ineffective in preventing myocardial injury (MINS) after noncardiac surgery. In the trial, patients who received ivabradine had a higher risk of MINS compared to those who took a placebo.
A retrospective cohort study found system-based disparities in pre-dialysis nephrology care contribute to 1/3 of incident vascular access disparities among Hispanics. Targeted policies are needed to improve timely identification and referrals for equitable improvements in kidney failure outcomes.
Researchers found that beetle-attacked forests can heat up by as much as two degrees during summer days, but deciduous trees help to cool down these stands. Mixed stands with more deciduous trees are less vulnerable to beetle outbreaks and can keep the forest cooler afterwards.
A new ultrasound device has been developed to precisely stimulate areas deep in the brain without surgery, offering new possibilities for neurological research and treatment. The technology features a special helmet with 256 elements that target specific parts of the brain, and includes a soft plastic face mask to keep the head still.
Reintroducing native African catfish into Lake Victoria significantly reduced the number of snail hosts and lowered the intensity of schistosomiasis infections among primary school-age children. This biocontrol method provides an effective way to combat this parasitic disease in the region.
Researchers developed a method for efficient atomic migration under ambient conditions using molecular monolayers and localized surface plasmons. The process regulates atom movement through dipole-dipole interactions, enabling scalable atomic patterning.
Dilip Soman's Behaviourally Informed Organizations (BI-Org) partnership examined how behavioural insights can improve organizational processes and stakeholder engagement. The project led to significant direct impacts, including increasing pension contributions in Mexico and redesigning Ontario's organ donation system.
A recent trial found that shorter durations of dual antiplatelet therapy (DAPT) after a heart attack showed equivalent efficacy in reducing recurrent events, with a lower risk of major bleeding. The study suggests limiting DAPT duration to 3 months may be safer for patients.
Professor Joshua Gans, a renowned economist at the University of Toronto's Rotman School, has been elected a fellow of the Royal Society of Canada. He is recognized for his outstanding scholarly achievement in understanding economic drivers of innovation and scientific progress.
The new guidelines provide evidence-based recommendations for patient management, identifying high-risk individuals and enhancing outcomes. The guidelines address specific ILD management algorithms for underlying rheumatic diseases, supporting comprehensive care for patients with CTD-ILD.
Researchers at Tohoku University discovered a way to strengthen legs through daily etiquette, known as Rei-ho, which emphasizes slow and controlled movements. The study found that those who practiced Rei-ho for five minutes daily increased their knee extension strength by an average of 25.9%, compared to only 2.5% in the control group.
A new trial found sacubitril/valsartan to be superior to enalapril for heart failure patients with Chagas disease, driven by a significant reduction in NT-proBNP levels. The study provides evidence for a pharmacological treatment specifically for this high-risk population.
Researchers at the University of Colorado Boulder have created a new type of time crystal that can be observed directly under a microscope and even by the naked eye. The team used liquid crystals to achieve this feat, which could lead to technological applications such as counterfeiting prevention and data storage.
A recent study has found that surgical left atrial appendage occlusion does not reduce the risk of ischaemic stroke, transient ischaemic attack, or cardiovascular mortality in high-risk non-atrial fibrillation patients after valvular surgery. In contrast, there may be a slight benefit for high-risk patients with CHA₂DS₂VASc ≥3.
Using advanced microscopy and molecular biology, researchers visualized axis reconstruction in sea urchin embryos, tracking cellular movements and gene activation to understand self-organizing ability. This discovery sheds light on the long-standing question of monozygotic twinning emergence from one fertilized egg.
A randomized trial found that intravenous cangrelor provided immediate and effective platelet inhibition without increasing major bleeding, improving outcomes for patients with cardiogenic shock. The study's results suggest that IV cangrelor could represent a major advancement in treating this life-threatening condition.
Researchers at Case Western Reserve and the Cleveland VA are conducting a clinical trial to test sensory-enabled neural-controlled prostheses developed since 2015. The study will enroll 12 people with upper-limb amputation to compare standard prosthetic arms and hands to the sensory-enabled neural-controlled prostheses.
Scientists developed hollow microspheres with adjustable pore size, adhesion, and lubricity properties using mucus and polydopamine. These spheres can be used as drug delivery agents and may prevent tissue damage or provide a protective coating.
The addition of progesterone to gender-affirming hormone therapy leads to increased breast growth for transgender individuals. Progesterone, a key female sex hormone, was found to be safe and effective when added to oestradiol, with participants experiencing up to a 37% increase in breast volume.
Tayfun Tezduyar's space-time computational flow analysis enables accurate modeling of complex systems, from designing parachutes for astronauts to simulating blood flow through heart valves. The approach provides high-fidelity representations in both space and time, allowing for more realistic solutions.
The return of beavers in southern Finland has increased habitat biodiversity and created diverse habitats for species like moose and voles. Over a 54-year period, the habitat suitability index grew almost tenfold, thanks to beaver activity that improves habitat connectivity.
Researchers have discovered a large pipe swarm with remnants of hydrogen hydrothermal activity west of the Mussau Trench. The discovery suggests that a huge amount of hydrogen may have been formed deep in the ocean lithospheric mantle, potentially leading to economically mineable reserves.
Two trials found that drug-coated balloons and stents did not reduce the risk of amputation or improve quality of life compared to uncoated devices. Target vessel reinterventions were reduced in the first year, but differences disappeared with longer follow-up.
In a randomized trial, pulsed field ablation (PFA) showed comparable efficacy to radiofrequency ablation (RFA) for treating symptomatic paroxysmal atrial fibrillation in patients resistant to antiarrhythmic drugs. PFA also had a shorter procedure time and fewer complications.
Five University of Groningen scientists receive €1.5 million ERC Starting Grants to study brain waves and memory, develop robots with a sense of touch, create ultra-hard coatings for extreme conditions, simulate exoplanet evolution, and explore actin-based motility of human pathogens
A new study reveals that increased scrutiny of domestic fishing fleets at ports could help deter illegal fishing. The Port State Measures Agreement, which requires foreign vessels to undergo inspections when landing their fish in a country, has led to more vessels traveling longer distances to reach ports within countries that have rat...