A study found that supercentenarians, people who live to 110 and beyond, have a higher proportion of cancer-killing immune cells called CD4 CTLs. This expansion may help the immune system adapt to age-related challenges, contributing to exceptional longevity.
Researchers have discovered lymph node-like structures in the skull bone marrow of mice that act as rapid first responders against brain cancer and neurodegenerative diseases. The discovery offers a new way to fight brain cancer and other neurological diseases.
A team of researchers at Harvard University sustained brain organoids for nearly six years, demonstrating a lifelike developmental clock. The organoids showed emergence and maturation of neurons, as well as functional maturity, mirroring human brain development.
Researchers analyzed ice cores from the Andes in Peru, revealing a 2,000-year-old record of global methane evolution. The findings support the hypothesis that tropical methane emissions dominated the Earth during the pre-industrial period, with human-driven agricultural and industrial emissions contributing to increases in later periods.
A large-scale study on Oregon psilocybin services found sustained benefits for anxiety, depression, and PTSD, with few adverse events. Participants reported lasting improvements in mental health and wellness, and the study provides valuable insights for policymakers considering expanded access to psychedelics for mental health conditions.
Researchers discovered that psilocybin reorganizes brain patterns, revealing hidden order, with stronger reorganisation linked to positive psychological changes. The study's findings have implications for developing therapies to improve clarity and psychological flexibility.
A recent study published in Nature found that Antarctica's brief rebound in 2021-2023 was caused by climate variability, not a new normal. The researchers linked the extra precipitation to the tropical warm pool, a warm patch of ocean in the western Pacific and eastern Indian oceans, which made an outsized contribution to extreme weath...
Mount Sinai scientists reveal how the brain represents leader and follower roles through prefrontal cortex activity, and create an AI that decodes hidden goals behind teamwork. The study shows that leadership is an asymmetric yet bidirectional partnership, and that followers play a crucial role in maintaining cooperation.
A randomized clinical trial found that daily zinc supplementation at 20 mg reduced all-cause infections in children with sickle cell anemia over 6 months compared to placebo. No adverse events were observed in the study, suggesting zinc supplementation may be a useful preventive measure for these children.
A randomized clinical trial found that preoperative high-dose corticosteroids did not improve major postoperative outcomes in elective digestive cancer surgery. The study suggests that routine use of high-dose corticosteroids in this setting is not justified
This study of 186,823 US adults reveals an increasing prevalence of moderate-to-severe cannabis use disorder among males and females between 2021 and 2024, while moderate-to-severe alcohol use disorder prevalence remained stable. The findings highlight significant age and sex disparities in cannabis and alcohol use disorders.
A cohort study of pregnant females with opioid use disorder found higher discontinuation rates for Black females compared to White females, with less disparity for methadone treatment. Persistent racial and ethnic inequities in treatment retention were observed during and after pregnancy.
A multisite cohort study of 346 adults receiving psilocybin services in Oregon found significant improvements in depression, anxiety, and PTSD symptoms, as well as enhanced well-being and life satisfaction. The study suggests that Oregon's regulated psilocybin services are generally safe and effective for mental health treatment
Researchers have developed an approach to quantify the errors in quantum simulators, allowing for more accurate calculations and enabling the study of complex many-particle systems. The new method was tested on a system of ten ions and then applied to a chain of 51 ions, demonstrating its effectiveness for larger systems.
Professors Etienne Cavalier and Roland Chapurlat assume leadership as Co-Editors-in-Chief, bringing complementary expertise in laboratory science, translational research, and clinical investigation. They aim to build on the journal's strong foundations and further enhance its role in musculoskeletal research.
Researchers at Murdoch Children's Research Institute have made a breakthrough in gene therapy, restoring heart function in lab-grown patient heart tissue and mouse models with genetic heart disease. The therapy may also correct other genetic heart diseases, including those caused by the MYH7 gene and TTN truncating variants.
A new Review explores whether a single class of molecules can inhibit both necroptosis and ferroptosis, two interconnected forms of regulated cell death. The concept of 'NecroFerrins' describes molecules with dual inhibitory activity against these pathways, potentially providing a broader approach to regulating pathological cell death.
A review highlights how reactive oxygen species (ROS) influence multiple inflammatory pathways, including NF-κB, Nrf2, HIF-1, and the NLRP3 inflammasome, and how their effects depend on biological context. ROS not only cause damage but also act as signaling molecules under physiological conditions.
Southwest Research Institute (SwRI) has developed a new framework for early detection of wildfires with real-time modeling, synthesizing various datasets and remote sensing capabilities. This tool helps emergency officials make life-saving decisions about wildfire prevention and mitigation.
Researchers uncover hidden populations of aggressive cancer cells in children with non-high-risk rhabdomyosarcoma, revealing gene expression patterns similar to high-risk tumours. The study identifies rare genetic changes affecting cellular pathways, suggesting multiple genetic routes leading to aggressive tumours.
A systematic review of 35 studies involving 2,108 patients found that patients who underwent posterior spinal fusion with posterior column osteotomies had similar overall correction compared to those who underwent PSF without PCOs. PCOs may be useful in select patients with larger or stiffer curves.
Hiroshima University researchers demonstrate that food processing liquid waste can be reused to produce omega-3 fatty acids by cultivating Aurantiochytrium sp. The study shows that three types of pickle seasoning waste can be utilized by the thraustochytrid to produce DHA and EPA. Reusing the waste medium also produces DHA and EPA, but...
A team of 12 organizations, backed by a NOAA grant, worked together to collect eggs and sperm, fertilize embryos, and cryopreserve sperm to preserve genetic diversity. The effort resulted in over 1.5 million coral embryos, with 61,000 elkhorn larvae and 47,000 staghorn larvae produced.
Wiley launches its first Spectral Analysis API portfolio, extending its gold-standard spectral data and analytical intelligence into modern API-driven environments. This enables labs and platforms to integrate high-quality spectral intelligence directly into their workflows, reducing manual effort and increasing analysis speed.
A new study reveals that using cannabis in multiple forms may signal a higher risk of heavy use and addiction. About 1 in 7 cannabis users, who also use cannabis in nearly every form, are more likely to experience daily use and addiction.
The global burden of chronic kidney disease in women has grown, with 359 million cases in 2021, driving increasing mortality rates and disability-adjusted life years. Postmenopausal women and women of reproductive age are particularly vulnerable to metabolic and behavioral drivers that can be modified to reduce risk.
Researchers found that hemp-derived cannabinoid brands emphasize lifestyle and recreational marketing, with minimal attention to safety warnings, on social media platforms. The study highlights gaps in platform policies and enforcement, calling for clearer standards addressing youth-oriented features and misleading health claims.
Members of Parliament from the UK's three biggest parties overestimated public resistance to climate change policies by a significant margin. Researchers found that politicians consistently overestimated public opposition to climate policies, believing voters and other parliamentarians felt more strongly opposed than they actually did....
Researchers propose 'Thermal Justice' framework to address heat-related inequalities, combining emergency measures with structural changes. The framework prioritizes exposed residents, accessible cooling, and worker protection during heatwaves, while retrofitting housing and expanding green infrastructure between heatwaves.
Aging reprograms skin genetic activity by increasing inflammatory gene expression in the epidermis, leading to a loss of skin function. This mechanism is mediated by the collaboration of two proteins, BMAL1 and YAP, which normally maintain skin homeostasis.
A new study found that 2.5% of intoxicating hemp posts on Instagram carry health warnings, despite the majority using youth-oriented marketing tactics. Researchers analyzed 837 posts from nine brands and highlighted the need for stricter regulations to protect young audiences.
A global study suggests that traumatic brain injury causes vary widely worldwide, with motor vehicle crashes being the biggest single cause globally. The study found that causes of traumatic brain injury differ by country, with high rates of ground-level falls among older adults in wealthier countries.
A large genetic study of anorexia nervosa and binge-eating behaviour has identified six areas in the genome associated with binge eating and eight loci associated with anorexia nervosa. The study also found that genetic associations with binge eating and anorexia nervosa have similar positive correlations with psychiatric disorders, bu...
Researchers from Institute of Science Tokyo and Kyoto University created hierarchical DNA networks using DNA polymerase and kinesin nanomachines. The study demonstrates the importance of active molecular motion in network formation, a step toward materials that assemble and organize themselves like living systems.
The climate impact taxonomy provides a shared framework linking measurable climate changes with risks and adaptation options, helping policymakers and practitioners make informed decisions. The taxonomy identifies key patterns, including regional scales and the need for both mitigation and adaptation.
Professor Rizzoli brings extensive editorial experience to the role, along with a longstanding commitment to scientific excellence. He will work closely with the US Editor-in-Chief to advance scientific knowledge, inform clinical practice, and improve musculoskeletal health worldwide.
A new study estimates that decommissioning subsea oil and gas pipelines could release 4.5 to 500 tonnes of microplastics into the North Sea each year. The research highlights the potential environmental risks of legacy plastics and recommends integrating environmental consequences into decommissioning decision-making.
Research in Economic Inquiry reveals evidence of in-group bias in the judiciary, with sharing a law school with the presiding judge increasing a plaintiff's attorney's chance of winning damages by 2 percentage points. The effect is strongest when the judge is at least 10 years older than the lawyer, suggesting an age-dependent factor.
A study analyzing US women's data found a significant association between high antioxidant intake and lower cervical cancer prevalence. The researchers discovered a linear inverse association between the Composite Dietary Antioxidant Index and cervical cancer, suggesting potential prevention benefits.
A study of 6,905 US adults aged 65 or older found that higher body mass index (BMI) was associated with lower mortality risk, while higher waist circumference was linked to higher mortality risk. Considering both BMI and waist circumference together may improve mortality risk assessment and support informed clinical decision-making.
The Oxford Smith School and Bank of America will examine how energy storage and next-generation fuels can reshape global energy markets and strengthen UK energy resilience. The research will also identify where bottlenecks may emerge, which technologies have the greatest commercial potential, and where investment could deliver the grea...
A randomized clinical trial found that pregnant women who followed a strength training program had a 0% incidence of gestational diabetes, compared to 7.3% in the control group. The program also improved quality of life and reduced pregnancy symptoms.
A novel AI model has been developed that can recognize yoga poses with high accuracy, paving the way for more effective digital coaching tools and movement-monitoring applications. The model achieved accuracy levels of over 93% during testing, significantly outperforming previous models.
Researchers create lead-free perovskite-based sensor for ammonia detection, achieving sensitivity at 1 ppm concentrations. The sensor's mechanism involves reversible ammonia intercalation and enhanced electrical conductivity, offering potential for safety monitoring in hydrogen and ammonia energy infrastructure.
A study confirms the 20-item prosopagnosia index questionnaire is an effective screening tool for detecting developmental prosopagnosia, a condition where individuals struggle to recognize familiar faces. The researchers also identified opportunities for refinement to improve the questionnaire's accuracy.
A new roadmap for stroke recovery prioritizes genetic and blood biomarkers to drive precision neuro-rehabilitation and biotherapy. The framework seeks to understand the underlying biology of brain repair after a stroke, with the goal of developing effective biotherapeutics.
Researchers used GPT-4 to arrange 99 emotion terms in a spatial layout, revealing a structure related to emotional intensity and arousal. The results showed that GPT-4 produced arrangements similar to those made by humans, with a more detailed analysis detecting variation in arousal.
Researchers from NUS have developed a method to turn waste from aircraft composite materials into aerogels that can be used for thermal insulation, sound absorption, and oil spill clean-up. The aerogels were found to be lightweight, non-toxic, and effective in absorbing sound and oil.
Researchers from Jilin University present a coordination–entropy regulation framework that bridges molecular solvation chemistry and macroscopic electrochemical stability. The framework delivers exceptional wide-temperature electrochemical stability, achieving ultrawide-temperature operation and high ionic conductivity.
Researchers have discovered a wave-interference effect that makes sound energy appear to outrun fundamental limits without breaking physics. This finding could improve whale tracking by pinpointing the location of whales based on the phase of their calls.
Older women in Australia are facing growing risk of hidden homelessness due to climate change, unpaid care work, and financial inequality. The problem is compounded by a lack of affordable housing and inadequate social protections, leaving them exposed to housing insecurity and poverty.
Researchers developed a deep reinforcement learning approach to predict network latency trends, enabling telesurgical systems to anticipate and adapt to changing communication conditions. The model achieved high accuracy in predicting direction and value of future latency changes, providing valuable information for latency mitigation.
Researchers found that fruit trees like apples benefit from rising temperatures due to reduced late-frost damage, while wheat yields decline due to heat stress. The study highlights the importance of pollinators for crop yields and suggests strategies to support pollinators and adapt to climate change.
Researchers examine bacterial persistence from multiple dimensions, highlighting its complex mechanisms and deep interactions with host-pathogen dynamics. Emerging strategies to eliminate persisters, such as phage-derived therapies and metabolic interventions, are also discussed.
Researchers developed a method to inhibit lipid nanoparticle migration into the liver by coating hepatic sinusoidal walls with polyethylene glycol. This coating reduced liver accumulation by several dozen times and increased protein expression in the spleen, promoting safer nanomedicine with lower dosages.
Surzen Biotherapeutics aims to develop effective pain relief without severe side effects by targeting opioid receptor pathways differently. The company plans to use peptides to block dimerization, reducing tolerance and improving efficacy.
Researchers developed a wearable patch that uses room light to treat skin wounds, promoting wound closure and tissue regeneration. The patch, made of a stretchable silicone elastomer, emits red light that activates a photosensitizer, inducing collagen crosslinking and alleviating inflammation.
Research at Kyoto University's gardens revealed seven species of frog and one species of newt, highlighting the importance of culturally managed water features as habitats for urban amphibians. The study's findings emphasize the need to consider these sites as biodiversity hotspots, promoting coexistence with nature.
Researchers used tensor tomography to visualize the nanometre-scale building blocks of narwhal tusks, finding two opposing helices that form an extremely stable structure. The findings challenge previous understanding of composite materials and provide new insights into the function and structure of narwhal tusks.
Nearly 4 million Japanese research outputs have been integrated into OpenAlex, significantly enhancing their global discoverability. This integration is driven by Japan's institutional repositories, such as IRDB, and is supported by high-quality, standardized metadata.