Scientists at Stockholm University and SciLifeLab have uncovered a crucial missing link in how sugar transporters move nutrients into cells. Their study reveals that these transport proteins rely on a previously uncharacterized intermediate state, similar to the 'transition state' in enzyme catalysis.
Researchers have discovered a new method to make cancer cells more visible to the immune system by blocking NMD, allowing faulty RNA to be used by cells to produce abnormal proteins. This increased visibility of antigens on cancer cells could improve immunotherapy response rates and lead to better outcomes for patients.
The Frontiers Research Foundation has endorsed the One Health Data Convergence Declaration of Intent, aiming to make existing and future research data interoperable and coherent. This declaration sets out a shared framework to unlock data for the benefit of One Sustainable Health for All.
Engineers at UC San Diego developed a new chip design that combines piezoelectric resonators with capacitors for efficient voltage conversion, achieving peak efficiency of 96.2% and delivering four times more output current than earlier designs.
A research team at HKUST used large-scale molecular dynamics simulation to study liquid-liquid phase separation, discovering an electrochemical 'superhighway' that drives assembly at an incredible rate. This breakthrough provides a blueprint for creating materials with instant, biocompatible properties.
Researchers have developed a new method to reduce intermuscular bones in hybrid fish through hybridization, resulting in offspring with fewer IBs and improved processing efficiency. The study provides molecular biological insights into phenotypic changes in hybrid lineages and their derivatives.
Research identifies how maternal oxycodone exposure affects fetal heart development through altered placental signals. The study found that placental EVs are smaller and more numerous in oxycodone-exposed pregnancies, indicating stress-related changes.
A new study found that maintaining a healthy weight from early adulthood is associated with lower risks of premature death from various diseases. Excess weight at 25 years old has lasting effects on mortality risk, independent of subsequent weight changes.
Researchers have successfully detected an exotic atomic nucleus state, bound solely by the strong interaction, in a carbon isotope experiment. The discovery sheds new light on the properties of this fundamental force and its role in shaping particle masses.
Research by University of British Columbia researchers found that summer weather is arriving earlier, lasting longer and packing more heat. The average summer season has grown about six days longer per decade in the tropics and polar circles since 1990.
The HIT team developed FedPD to address model heterogeneity in FL by intelligently evaluating global ensemble knowledge and local features. This framework enables selective knowledge transfer, filtering conflicting information, and extracting beneficial traits for precise optimization.
Researchers have developed Cr³⁺-doped InP/ZnS quantum dots that exhibit pure blue emission and room-temperature ferromagnetism. The dual-functional QDs are achieved through a hot injection method, which effectively passivates surface defects and suppresses non-radiative recombination.
A collapse of the Atlantic Meridional Overturning Circulation (AMOC) would lead to a substantial release of oceanic carbon, contributing to additional global warming. Higher CO₂ concentrations in the atmosphere amplify this effect, potentially leading to a 0.2°C increase in global temperatures.
A team of physicists has confirmed the mass of the fundamental W boson particle using an ultra-precise measurement, reaffirming the Standard Model's predictions. The new measurement is based on over 1 billion proton-colliding events produced by the Large Hadron Collider and is in line with previous experiments.
The study introduces a spray-dried graphite/CNT/Si composite microsphere with improved cycling stability and capacity retention compared to conventional blends. The optimized composite delivers enhanced performance due to the presence of conductive carbon nanotubes and its mechanical resilient structure.
A study by the University of California, Davis, and State University of New York at Buffalo found that per- and polyfluoroalkyl substances (PFAS) were detected in over 90% of penguin leg bands in remote Patagonia. The non-invasive sampling method revealed a shift from legacy PFAS to newer replacement chemicals in the environment.
Researchers developed an S-scheme Sr₂MgSi₂O₇:(Eu,Dy)/CdS heterojunction catalyst that exhibits excellent catalytic performance. The catalyst can produce hydrogen continuously for up to 3 hours in the dark after UV-visible light irradiation.
Researchers have developed a novel composite material that combines high mechanical strength with exceptional electromagnetic wave absorption. The 'reinforced concrete' structure, inspired by traditional building materials, improves the material's toughness and effectiveness in absorbing electromagnetic radiation.
Researchers have identified a natural compound called PGG as a MAT2A inhibitor that promotes protein degradation while inhibiting enzymatic activity, offering a promising new strategy for cancer immunotherapy.
Researchers at Hokkaido University developed a mathematical model that can measure fish freshness in real time. The model uses the degradation pathway of adenosine triphosphate (ATP) in fish muscle after death to estimate current freshness and predict changes over time.
Researchers found that Astragalus polysaccharide-linked exosomes can reactivate latent HIV-1 in infected cells. Exposing reservoir cells to APS resulted in increased GFP+ proportions, elevated p24 levels, and upregulated Gag/LTR transcripts. The findings highlight APS-Lat-EXO as a promising candidate for latency-reversal research.
Researchers propose a novel design concept that utilizes a three-dimensional Cu/Fe3O4 Mott-Schottky nano-tip array to regulate electric fields and ion distribution. This structure suppresses lithium dendrite growth through a triple synergistic mechanism, enabling safe energy storage.
Researchers developed a novel approach to estimate the state of health of bipolar lead-acid batteries using partial charging profiles and a hybrid regression framework. The method achieved accurate results, with an average root mean squared error below 1.5%, outperforming other models.
The webinar highlighted the potential of combining NFI field data, EO disturbance products, and national statistics for robust forest carbon monitoring. Continental-scale carbon balance analysis showed a trend towards neutral over the past decade, with large interannual variability.
ISM6200 is a potent, potentially best-in-class preclinical candidate targeting NR3C1 for the treatment of ovarian cancer, Hypercortisolism (Cushing’s Syndrome), and other disorders related to excess cortisol. The molecule demonstrates low DDI risks and higher in vivo efficacy across multiple animal models.
A new 23andMe study reveals genetic predictors for GLP-1 weight loss efficacy and side effects, providing a personalized approach to obesity treatment. The findings identify specific genetic variants associated with increased weight loss efficacy and nausea/vomiting side effects.
Researchers uncover 289 million-year-old mummy of lizard-like creature Captorhinus aguti, preserving skin, cartilage, and protein remnants. The find reveals the oldest example of costal breathing system in amniotes, shedding light on early reptile evolution.
A study comparing two blood purification strategies for septic shock found that both CytoSorbⓇ and oXirisⓇ improved hemodynamic status by reducing lactate levels and vasopressor requirements. However, no significant differences were found in primary outcomes, suggesting comparable clinical benefits.
A new study confirms a direct link between good physical fitness and reduced risk of suffering from over 30 diseases. Individuals with high genetic predisposition to be physically fit exhibit lower risks of cardiovascular conditions, diabetes, and asthma, while also showing better health in metabolic and inflammatory aspects.
Long-term opioid therapy prescription rates declined in the US from 2015 to 2023, despite a growing population of older adults receiving these treatments. Approximately 4-5 million patients were prescribed long-term opioids in 2023, with Medicare covering a larger proportion, raising concerns about safety.
A multinational study of five psychedelic compounds has identified two consistent neural effects across different drugs, weakening internal brain networks and increasing communication between networks. This breakthrough could help guide the design of future treatments for mental health disorders.
Researchers isolated intact nanoparticles from boiled Pueraria lobata and found they modulated intestinal microbiota, reducing inflammation and repairing mucosal barriers. GGD-PDVLNs administered alone replicated therapeutic benefits of GeGen decoction, highlighting their role as core active ingredients.
A new soft multiaxial strain mapping interface combines with AI processing to capture complex throat muscle movements and decode silent speech. The system achieved 85.8% recognition accuracy for NATO phonetic words in controlled tests and real-world noisy environments.
The Finnish Institute for Health and Welfare is launching a century-long research initiative to understand the roots of mental health challenges, loneliness, and social uncertainty. The study, Future Finland, will follow 200,000 families over time, examining how biological, behavioral, and social factors influence wellbeing.
Researchers predict that glaciers in High Mountain Asia may threaten future water security due to rapid melting caused by warming temperatures. The study found significant losses in glacier mass between 2002 and 2023, which could intensify short-term flood risks and reduce long-term meltwater availability.
A research team from Tokyo University of Agriculture and Technology has developed a new type of photodetector that achieves impressive responsivity and detectivity. The device uses highly ordered superlattices to overcome the limitations of traditional quantum dot-based photodetectors.
Researchers mapped the maternal-fetal interface in unprecedented detail, identifying new cell types and insights into conditions such as preeclampsia and preterm birth. The study found a previously unknown cell type that responds to cannabis, which may explain its association with poorer pregnancy outcomes.
A team of researchers at ETH Zurich has successfully realised a high-quality swap gate using only geometric phases with extremely cold potassium atoms. This breakthrough enables the robust exchange of quantum states between qubits, a crucial step towards building large-scale quantum computers.
Researchers propose tailored approaches using CAR platforms, incorporating effector cells like macrophages and Tregs to modulate key processes in neurodegeneration. High-precision immunomodulation is essential for overcoming the complex nature of these diseases.
A global inventory reveals that bottom trawling catches over 3,000 fish species, including critically endangered and vulnerable species, highlighting the urgent need for better documentation and management of its impacts on marine biodiversity.
A recent study published in Neuron provides new insight into how tau tangles spread from one brain region to another in people with Alzheimer's disease. Researchers found that tau seeds travel along individual's natural communication pathways, influencing the spread of Alzheimer's pathology and suggesting a potential therapeutic target.
A team of researchers at Kyoto University found that predatory mites avoid laying eggs on plant leaves bearing traces of caterpillars. Additionally, they discovered that even when predators are unlikely to encounter caterpillars, they still avoid their traces.
Researchers developed a quasi-dynamic mathematical model to optimize Thermally Integrated Carnot Batteries (TI-CB) under fluctuating conditions typical of factory environments. The study yielded crucial insights, including a clear roadmap for handling off-design fluctuations, bringing Carnot batteries closer to widespread deployment.
A cohort study found that individuals diagnosed with ADHD at a younger age tended to perform better academically, receiving more education and experiencing lower dropout rates compared to those diagnosed closer to age 16. This suggests that targeted support for early diagnoses could help prevent school dropout.
Researchers developed a lightweight lattice structure inspired by butterfly wings, exhibiting enhanced mechanical strength, impact resistance, and energy absorption capabilities. The new design outperforms conventional lattice designs under compression and dynamic impact loading.
A large U.S. study found that adults who never married have substantially higher rates of developing cancer compared to those who are or have been married. The association is strongest for cancers related to infection, smoking, and alcohol use, with women facing a significantly higher risk than men.
The American Society of Hematology and the International Society on Thrombosis and Haemostasis have released comprehensive guidelines for anticoagulant prophylaxis in non-cardiac pediatric patients at risk of venous thromboembolism. The guidelines outline best practices for preventing life-threatening complications in children.
RST2G automates tumor segmentation, reducing radiologist workload and improving accuracy. It captures complex tumor morphologies and boundaries, outperforming traditional methods in visual assessments.
Researchers tracked the impact of beach nourishment on nearshore conditions and marine life, finding that prolonged turbidity can interfere with blacktip shark hunting and increase accidental encounters. The study highlights a delicate balance between coastal engineering projects and marine ecosystem protection.
The Society for Cardiovascular Angiography & Interventions and Canadian Association of Interventional Cardiology will host a joint conference featuring the latest clinical data, procedural guidance, and advanced expertise. The event aims to empower clinicians with rigorous data, practical education, and leadership development.
A UCLA-led study found that unionization leads to lower turnover rates among direct care workers, with significant benefits including improved care quality and reduced stress. Unionization applies to both for-profit and non-profit organizations, suggesting its potential to save the healthcare system $1.5 billion a year in turnover costs.
A new study by the University of Manchester has developed a way to measure the impact of urban traffic on city temperatures, revealing that everyday vehicle use can raise temperatures in cities. The researchers found that traffic heat increases simulated air temperatures by around 0.16°C during summer and 0.35°C in winter.
The American Association for the Advancement of Science (AAAS) and DataSeer are collaborating on a six-month pilot to automate MDAR checklists for manuscripts submitted to Science using AI technology. The partnership aims to improve research quality, reproducibility, and editorial efficiency by reducing manual effort.
Researchers found that maternal anxiety about radiation exposure during the Fukushima nuclear accident was linked to increased rates of preterm births, lower birth weights, and severe birth outcomes. Socioeconomic factors, such as education level and income, played a role in mitigating these effects.
Researchers from Chiba University found that antibody therapeutics with stronger Fcγ receptor binding are more likely to be recognized as foreign and associated with higher anaphylaxis risk. High affinities for Fcγ receptors critical determinants of anaphylaxis, study suggests.
A randomized trial found that duloxetine does not prevent painful neuropathy caused by oxaliplatin-based chemotherapy in patients with stage II or III colorectal cancer. The study suggests that duloxetine should only be used for managing existing neuropathy, not prevention.
A new study by the University at Buffalo reveals that unequal access to recycling facilities plays a key role in shaping plastic waste management practices in the US. Wealthier and more college-educated communities are more likely to have convenient access to large-scale industrial recycling facilities, making recycling easier and more...
Researchers have developed a new single-cell technology called CIPHER-seq that captures the timing of cytokine activity with greater accuracy. This allows for a clearer view of immune cell behavior and strengthens the foundation for understanding cancer, inflammation, and treatment resistance.
A large study led by Cedars-Sinai Health Sciences University found that long-term use of antidepressants and some antidiarrheal medications may be associated with a higher risk of death. The study analyzed nearly two decades of electronic health records from over 650,000 US adults with IBS.
A new open-access framework, Rapid Evaluation Framework (REF), allows researchers to compare model outputs with real-world observations, providing immediate insight into model performance. The REF accelerates climate model evaluation, making it possible for policymakers and communities to respond quickly to future climate change.