A new AI model, SleepFM, uses large-scale sleep data to predict over 100 health conditions. The model analyzes various physiological signals and identifies patterns that can forecast disease onset with reasonable accuracy.
Plants deploy a faster communication system, using jasmonate-dependent immune signals to initiate systemic immunity within hours of infection. This discovery opens new possibilities for engineering crops that respond more quickly to infection, limiting disease spread and yield loss.
Scientists at the University of St Andrews have discovered a long-elusive molecular 'reshuffle,' unlocking an 80-year-old chemical puzzle. This breakthrough tackles one of chemistry's most persistent challenges, enabling faster, cleaner, and more selective ways to manufacture complex molecules with a single handedness.
Dr. Noritaka Ichinohe challenges the long-held assumption that averaging away individual differences is necessary in psychiatric research. Instead, biological heterogeneity is seen as a phenomenon demanding explanation. The author's work on primate brain mapping and molecular subtyping has identified convergence points between species ...
A recent genomic study by Dr. Mayana Zatz and colleagues reveals that Brazil's admixed population may hold the key to understanding exceptional aging. The study identifies over 8 million novel genetic variants in the Brazilian population, with potential protective mechanisms against age-related diseases.
Researchers at Flinders University discover a genetic mutation that silences a brain receptor, rendering it unresponsive to both natural trace amines and clinical drug candidates. The C182F variant eliminates receptor signaling and reduces cell surface expression, with profound implications for emerging psychiatric treatments.
A comprehensive review synthesizes emerging evidence on AMPKα isoforms' dual roles in Alzheimer's disease. The analysis proposes that this complexity may explain why pharmacological approaches have yielded mixed results in treating the disease. Isoform-specific targeting is proposed as a novel therapeutic strategy.
A comprehensive genetic investigation by Dr. Feng Liu and collaborators identifies shared genetic loci between schizophrenia and osteoporosis, suggesting overlapping biological pathways. The study found that psychiatric patients face elevated fracture risks due to these molecular connections.
Dr. Maria Margarita Behrens' work deciphers the molecular signatures defining every human brain cell type, shedding light on neural development and psychiatric disorders. Her single-cell epigenomic atlases will enable researchers to target specific cell types with unprecedented precision.
Scientists at ETH Zurich have discovered that electrons in flat layered materials like MXenes respond with a delay to the motion of atomic nuclei. This challenge to the standard Born-Oppenheimer approximation could lead to more precise mathematical models and novel opto-electronic devices.
A new paper proposes a way to calculate the thermodynamic costs of metabolic processes, ranking them according to their biological efficiency. The method estimates the improbability of a network behaving in a certain way, considering maintenance and restriction costs.
A new study from the Medical University of South Carolina suggests that the complement system, a part of the body's innate immune system, plays a major role in brain damage after repeated concussions. The research found that reducing complement activation can help protect the brain and reduce cognitive impairments.
Researchers developed DeepForest AI to capture under-canopy vegetation using synthetic-aperture imaging and 3D neural networks. The technology improves deep-layer reflectance accuracy by 2–12 times and supports vegetation-index calculation for ecological monitoring.
Researchers developed a method to efficiently identify and select haploid seeds in wheat using double-fluorescent proteins. The system, which combines fluorescence-based identification with molecular markers, allows for accurate detection of haploids independent of the recipient's genetic background.
Researchers created a comprehensive atlas of active autonomous TIR transposons across 1,007 plant genomes, revealing a strikingly uneven distribution and lineage differentiation patterns. This study provides critical insights into transposon-host coevolution and delivers a rich resource for plant biotechnology.
Researchers found that humic substances formed at higher temperatures stimulate microbial carbohydrate metabolism and promote the accumulation of antibiotic resistance genes (ARGs) in soils. The study highlights a balance between soil carbon sequestration and ecological risk, emphasizing the need for sustainable residue-return practices.
A team of scientists proposes a new scheme for 1D DTQW systems with coherent multiple long-range connectivity in the synthetic frequency lattice. This enables faster diffusion speed and breaks the weak coupling limit, facilitating quantum gate operations.
Researchers demonstrated that 40-Hz auditory stimulation significantly elevates beta-amyloid levels in the cerebrospinal fluid of aged rhesus monkeys, with effects persisting for over five weeks. The study provides evidence supporting 40-Hz stimulation as a non-invasive therapy for Alzheimer's disease.
Scientists have created a high-performance cathode material for aqueous zinc-ion batteries by converting a layered MXene into an amorphous form. The new material, a-V₂CT_x, shows remarkable improvements in capacity, charging speed, and durability.
The journal is seeking original research on sustainable finance, including ESG considerations and climate risk, to capture recent advances in the field. Contributions will inform professional practice and policy development at both national and international levels.
A study demonstrates that combining silybin and carvedilol synergistically suppresses hepatic stellate cell activation and reverses liver fibrosis by targeting Wnt4/β-catenin signaling. This clinically feasible combination strategy has a promising new therapeutic approach for liver disease.
A recent study by HKUMed found that most hospital patients in Hong Kong have little to undetectable levels of neutralizing antibodies against the mutated H3N2 strain. The research team recommends early vaccination to reduce the risk of severe infection and emphasizes the importance of prompt medical care if infected.
Researchers identified a protein called Piezo1 that acts as the body's 'exercise sensor', detecting mechanical signals from physical activity to maintain strong bones. Activating this pathway may lead to the development of drugs that mimic exercise benefits for individuals with limited mobility.
High levels of ADARdd overexpression lead to abundant off-target RNA editing in rice protoplasts, characterized by pronounced stochasticity and low efficiency. The study provides guidelines for improving RNA editing accuracy in plants and highlights the need for rigorous validation of proximity-directed RNA editors.
A new sample prior based point spread function (PSF) decoupling method enables accurate system characterization without theoretical assumptions. Regular biological samples act as modulators to optimize the system PSF, allowing non-parametric and adaptive imaging.
HKU three research projects named among ‘Top 10 Innovation & Technology News in Hong Kong 2025’; a dual immunotherapy improves liver cancer survival rates, a hybrid photosensitive immunotherapy targets skin cancer, and the detection of newborn neutron star's 'heartbeat'.
A new pipeline, NLRSeek, identifies previously overlooked NLR genes in sequenced genomes, revealing functional genes and driving evolutionary expansion in non-model species. This tool enhances disease resistance breeding by providing a more complete set of NLRs.
The study developed a novel method, BacPhase, for constructing bin markers and genome phasing in polyploid crops. By using PacBio HiFi long-read sequencing, researchers generated high-confidence bin markers in potato, achieving 59.58% scaffold anchoring to chromosomes.
The quota_Anchor tool identifies collinear genes with control over alignment depth, revealing less similar expression patterns in relatively inverted genes. It also finds stronger purifying selection in these genes.
Researchers have developed a non-invasive technique, fast raster-scan optoacoustic mesoscopy, to observe microvascular endothelial dysfunction at the single-capillary level. The study found that this technology can resolve dynamics of individual cutaneous capillaries and provide better inter-day repeatability compared to existing methods.
A team led by Professor Leo Tianshuo Zhao developed the world's smallest fully printed infrared photodetectors, overcoming silicon-based technology limitations. The innovation uses a nano-printing platform to assemble solution-phase colloidal nanocrystals and create advanced optoelectronic devices.
Researchers have developed a novel approach to quantum memories using 3D-nanoprinted light cages filled with atomic vapor. The technology enables highly efficient conversion of guided light pulses into collective atomic excitations, with storage durations of several hundred nanoseconds. The platform's compact size and room-temperature ...
Researchers developed a triple-electrode integrated functional electrode for synchronized monitoring of neural signals and dopamine release during sleep-wake transitions. The study highlights the critical role of dopamine in regulating sleep-stage transitions and identifies distinct neuronal populations involved in this process.
ChargeFabrica, a Python-based simulation framework, models mesoporous perovskite solar cells in two dimensions to predict performance and understand charge transport mechanisms. The tool replicates experimental trends and enables optimized device design, paving the way for enhanced stability.
A Hong Kong-based educator won a Gold Award for his innovative teaching project, using immersive video gaming to enhance medical students' self-competence in coping with death and dying. The award recognizes the educator's efforts to promote emotional resilience and holistic growth among learners.
The University of Hong Kong (HKU) and Tsinghua University have expanded their partnership across five key areas: public health, engineering, law, and astronomy. The institutions aim to foster frequent and productive academic exchanges to nurture globally competitive talent.
The study identifies GmWOX1a and GmWOX1b as key regulators of mediolateral polarity in compound leaves. Multiple knockout mutants show altered leaf shape and reduced area, highlighting the functional redundancy among WOX1 genes.
Academician Yu-Zhong Wang's team proposes a novel recycling method that degrades polyethylene into oligomers, which are then assembled with functional monomers through dynamic imine bonds. The resulting material exhibits excellent mechanical properties and multiple functions such as flame retardancy, antistatic properties, and UV shiel...
Researchers at Northwestern University discovered a hidden molecular control switch inside the protein TRPM5, which regulates taste, blood sugar control and gut health. The switch can be activated or inhibited by small molecules, unlocking new opportunities for therapeutic development.
A high-resolution study of Jurassic mudstones in China's Sichuan Basin has discovered that astronomical cycles control climate, sedimentation, and organic matter accumulation. The research provides a detailed climatic and sedimentological framework that enhances the predictability of shale oil reservoirs.
Researchers detected Pteropine orthoreovirus (PRV) in five patients in Bangladesh with symptoms consistent with Nipah virus infection. The study highlights the importance of broad-spectrum surveillance programs to identify and mitigate public health risks from emerging bat-borne viruses.
Boston College researchers have developed an AI-assisted method to remove 'noise' from functional MRI brain data, a major obstacle for fMRI research. The new method, known as DeepCor, outperforms previous approaches and could pave the way for new discoveries about the brain and its disorders.
Researchers provide a comprehensive framework for removing emerging contaminants from wastewater through advanced oxidation processes. Key findings highlight the importance of understanding reaction pathways to optimize treatment systems.
A team of researchers from Rice University discovered that lakes on ancient Mars could persist under thin seasonal ice for at least decades, contradicting earlier climate models. The study suggests that surface features shaped by sustained liquid water coexist with the idea that early Mars was too cold to support such conditions.
A large population-based study found that SGLT-2 inhibitors reduced the risk of diabetic foot problems compared to GLP-1 receptor agonists. The difference was mainly due to fewer cases of nerve damage in the feet among SGLT-2 inhibitor users.
Climate change is altering the global nitrogen cycle, affecting food security, water quality, and biodiversity. The review finds that elevated CO2 boosts plant growth but dilutes protein quality, while rising temperatures reduce yields and increase nitrogen losses.
A Northwestern University study reveals that 2.3% of women experience unusual physical and emotional responses during orgasm, including laughter, crying, headaches, and more. These peri-orgasmic phenomena are normal but rare, with most women experiencing them only sometimes with orgasm.
A new study uses hyperspectral sensing and machine learning to analyze grapevine leaves for nutrient deficiencies. The approach delivers fast, non-destructive results with high spatial resolution, opening the door to earlier detection of nutrient imbalances and more targeted fertilization.
Researchers identified common aging-related alterations in genes involved in RNA splicing and processing across eight human tissues. These findings suggest a shared biological response to aging, pointing to the importance of RNA processing in accurate protein production.
Researchers found that narrative-only feedback was perceived as the fairest and provides clearer understanding of how to improve future performance. Purely numerical feedback without context can make employees feel negatively evaluated and is considered unfair.
Researchers from UC Irvine discover a DNA repair mechanism enabling Greenland sharks to maintain their vision for centuries despite extreme low-light conditions. The study challenges current understanding of aging, vision, and longevity, offering new insights into preserving vision as we age.
Researchers from UCL discovered a way to grow bacterial cellulose from beer waste, creating edible scaffolds for cultivated meat. The new approach could make lab-grown meat more sustainable and cost-effective.
Scientists have developed a groundbreaking system called Stomata In-Sight that allows them to watch and quantify plant respiration in real-time. This breakthrough could lead to more efficient crops that require less water to grow, crucial for food security in drought-stressed regions.
Researchers discover Vitamin A metabolite retinoic acid compromises anti-cancer immune response, but develop inhibitor KyA33 to restore DC maturation and function. The compound boosts efficacy of dendritic cell vaccines in preclinical studies.
A new study finds that infants' brain activity is influenced by their caregivers' reported income sufficiency, with delayed maturation seen in households where income was never adequate. The research suggests that policies strengthening families' basic needs during infancy may have lasting developmental benefits.
A study found that economic crises can have lasting negative impacts on children's physical development, including stunted growth and increased risk of obesity. The research used the Asian financial crisis in the 1990s as a case study, demonstrating how food price shocks can affect children's body measurements until they are young adults.
A recent study found that muscle impairment from anorexia nervosa persists even after weight regain, with significant reductions in muscle size and strength. This could have implications for treatment strategies and outcomes for individuals recovering from the condition.
A Cornell psychology professor argues that people make decisions based on intuition and core values rather than facts. Research found that considering the overall sense of risks and benefits (or
The Nanalysis Edition of KnowItAll combines Wiley's analytical software platform with Nanalysis' specialized NMR database, streamlining spectral interpretation workflows for users. The tailored solution provides immediate access to reference spectra optimized for benchtop NMR instruments, expanding compound identification coverage.
Researchers discovered a new class of highly interactive LINE-1 loci that modulate cancer gene expression by altering three-dimensional genome architecture. These structural changes allow for high-level expression of genes driving cancer cell proliferation.