A recent study published in JAMA found that prone positioning in infants with moderate to severe bronchiolitis receiving high-flow nasal cannula support did not significantly reduce escalation of care. The study suggests that further research is warranted due to the wide confidence interval around the observed odds ratio.
Researchers designed artificial proteins that simultaneously form pentagonal and hexagonal arrangements to create virus-like structures. These structures can stably carry drugs, genetic materials, and enzymes within their interior space.
Satellite remote sensing allows researchers to monitor water quality by tracking changes in light spectrum, identifying nutrients in the water. This technology holds promise for studying global river health and detecting toxic algal blooms that can shut down water treatment plants.
A Harvard-led team has demonstrated synthesizing 64 distinct DNA sequences on a silicon chip in parallel using a water-based enzymatic process. This breakthrough sets a new benchmark for parallel DNA synthesis and paves the way for smaller, safer, and more accessible DNA-writing instruments.
Researchers at Johns Hopkins Bloomberg School of Public Health discovered that a common yeast called Rhodotorula taiwanensis can lure and trap the Anopheles gambiae mosquito, the principal malaria-transmitting mosquito in Africa. The yeast's blend of scent chemicals attracts mosquitoes via their sense of smell, primarily through odoran...
A new culturomics-driven biobank, the Microbial Biobank of Acid Mine Drainage (mbAMD), has been established to decode the survival secrets of extreme acid mine drainage microbes. The collection contains 652 isolates spanning 42 species, including 21 novel taxa, and covers 86.7 percent of the global AMD core microbiome.
A study by researchers at Kyushu University suggests that continuous parameters in quantum gravity may not be freely adjustable, but rather emerge from operators within the theory. The findings support Einstein's century-old claim about the fundamental laws of nature and have implications for our understanding of quantum gravity.
The new superconducting TES array spectrometer at BESSY II offers unparalleled efficiency in detecting X-ray photons, enabling research on atomically thin layers and highly diluted samples. This breakthrough complements existing techniques like ARPES, providing new insights into molecular chemistry and quantum properties.
Insilico Medicine has completed the first-in-human dosing of its AI-driven NLRP3 inhibitor ISM8969 in a phase I clinical study. The trial achieved its first clinical milestone with partner Hygtia Therapeutics, evaluating the safety and efficacy of the treatment for chronic neuroinflammation.
Researchers identified a shared biological feature of these pathogens that targets the mucus layer, allowing for a potential combination vaccine against all three biomolecules. The discovery could lead to significant progress in developing an effective vaccine against severe diarrhea.
A team of researchers at Binghamton University developed a method to solve Wordle with a 99% success rate by applying information theory. By prioritizing guesses that provide the most information, they reduced the pool of possible words and solved puzzles in fewer guesses.
Climate change is projected to increase frequency and intensity of hydroclimatic whiplash events, with regions experiencing both floods and droughts. This may lead to increased flash flooding, water quality deterioration, and soil erosion, as well as challenges for flood and drought planning.
The Balkan Network of Science Journalists has published a new guide to help aspiring science journalists in North Macedonia cover scientific topics. The guide focuses on technology and investigative journalism, aiming to provide impactful science stories in the region.
The Huizhou Hadron Spectrometer aims to transform light hadron physics with its ultra-high event rate capability of 1–100 MHz. The spectrometer will accumulate large samples of η mesons, enabling searches for dark photons and dark Higgs bosons.
A new study integrates robotic exoskeletons with therapist-patient interaction to create a more personalized and effective approach to stroke rehabilitation. The therapy, called TEPI, has been shown to improve joint range of motion, step length, and muscle activation compared to conventional therapy.
A novel FAP-targeted radiopharmaceutical therapy approach has shown safety and effectiveness in treating various types of cancer, including breast, colorectal, gastric, and ovarian cancers. The treatment achieved objective responses in approximately two-thirds of patients and disease control in over 80%.
The Association for Computing Machinery (ACM) will publish Theory and Practice of Logic Programming (TPLP), an international venue for refereed papers on logic programming. The entire TPLP archive dating back to 2001 will be openly accessible via the ACM Digital Library.
A redesigned high-NA EUV lithography optical system has been proposed, which could enable the manufacture of smaller computer chips at lower cost than current methods. The new design eliminates troublesome optical effects, enhances resolution, and should be much cheaper to produce.
The California FAIR Plan, a state-mandated backstop, has seen its footprint grow as average homeowner insurance premiums rose 84% between 2020 and 2026. The plan now covers about 5% of single-family homes, backing approximately 6% of new mortgage originations.
A new species of bumblebee goby, Brachygobius jennie, has been discovered on Hengqin Island in Guangdong Province, China. It is the smallest species within its genus and possibly the smallest known fish in the world.
A new study from researchers at the University of Chicago and the Johns Hopkins Bloomberg School of Public Health shows that mass public school closures in Chicago led to increases in gun violence in surrounding neighborhoods. Neighborhoods near closed schools saw a 9.9% increase in shootings, compared to similar areas without school c...
Researchers developed LiON, a fluorescent reporter that visualizes biologically active iron and oxygen inside living cells. The tool revealed striking differences in iron and oxygen distribution across organs and cells, offering new opportunities to study diseases like cancer, liver disorders, and neurodegenerative conditions.
A team of SUNY Optometry researchers will track children's real-world visual habits using wearable sensor technology and eye-tracking tools. The goal is to identify measurable signs of risk for myopia onset and progression.
Researchers have identified a previously unrecognized way the kidneys regulate water balance, which could lead to improved treatments for polycystic kidney disease. The discovery reveals an alternative mechanism that operates independently of the hormone vasopressin.
Researchers discovered a maximum amount of electrical resistance that can occur due to electron collisions, offering insights into what causes resistivity at the microscopic level. The study found that when interactions between atoms become too strong, the resistivity caused by collisions eventually stops rising and saturates.
Scientists create metasurface to generate singlet oxygen at molar-level concentrations, achieving six-orders-of-magnitude enhancement over conventional methods. This approach enables position- and pixel-selective cytotoxicity without additional molecular sensitizers.
Researchers have discovered rare radioactive isotopes in a deep-sea manganese crust, pointing to an ancient cosmic event that occurred at least 100 million years ago. The discovery provides new insights into the formation of heavy elements in the universe and helps refine our understanding of past astrophysical events.
A new study reveals that smell loss can have a devastating impact on quality of life, comparable to conditions like Parkinson’s, stroke, and diabetes. Patients with smell disorders experience significant emotional, social, and psychological suffering, often rivaling those with chronic illnesses.
A Concordia-led team developed an AI-based method for detecting toxic online content, which outperformed existing tools in accuracy and throughput. The Proximal Policy Optimization-based Cascaded Inference System (PPO-CIS) layers scanning tasks to quickly identify harmful material.
Researchers at Harvard's SEAS have developed a highly sensitive calorimeter that can detect metabolic heat signals on the order of 100 picowatts in living cells. The device tracks the growth of small populations of bacteria in real-time, including monitoring how bacterial growth changes in response to different antibiotics.
A new study reveals that threatened amphibian species are being inadvertently sold under incorrect names in digital marketplaces. Genetic barcoding analysis identified four frogs advertised as Chinese edible frogs as actually being Chinese spiny frogs, classified as Vulnerable by the IUCN.
Researchers found that successful crisis leadership depends on preparation before a crisis, decisive action during disruption, and reflective learning afterwards to improve future resilience. The study identified eight key leadership skills, including emotional regulation, ethical decision-making, collaboration, and strategic thinking.
A recent study found that tropical ocean temperatures have a significant impact on malaria cases in Malawi, with warmer oceans driving increased rainfall and mosquito breeding. The researchers analyzed global climate data and 20 years of malaria case data to identify the link between climate patterns and local disease risk.
A new study by Bar-Ilan University suggests that a 2,700-year-old standing stone found at Tel 'Eton may shed light on King Hezekiah's religious reforms. The discovery reveals a rare glimpse into the domestic cult practices of ancient Judah during the First Temple period.
Christa Thöne-Reineke and Birgit Schittek share the prize for their work on improving animal welfare in research, with Thöne-Reineke recognized for her long-standing commitment to refining methods. The researchers' contributions include developing alternative methods to animal experiments, advancing the use of 3D skin models in dermato...
A partnership between the National Center and the Pennsylvania Department of Aging is bridging the gap for senior community centers by creating evidence-based communication strategies. The research was informed by input from a representative sample of Pennsylvania residents, highlighting the importance of senior community centers as vi...
A new study published in Radiology found that embolization of abnormal blood vessels using rapidly resorbable gelatin-based microspheres is safe and effective in providing significant, lasting pain relief and functional improvement for patients with osteoarthritis-related knee pain. The procedure significantly reduces inflammation and ...
A new study suggests that 71% of Finns believe the international rules-based order has crumbled, and they hope Europe and Finland will respond with a robust foreign and security policy. Finns see developing closer cooperation with middle powers like Brazil and India as an acceptable strategy.
A study led by Brown University researchers found that older adults who received the shingles vaccine had a 24% lower risk of being diagnosed with dementia within four years. The study analyzed health records and Medicare data from over 500,000 adults age 66 and older who were admitted to skilled nursing facilities.
Shedd Aquarium's membership with IUCN marks a significant milestone in its conservation efforts, with contributions including field research, policy initiatives, and educational programs. The aquarium has also partnered with the IUCN Species Survival Commission to establish the Center for Species Survival: Freshwater.
A deep learning model maps Arabidopsis gene regulation, identifying 14 broad clusters with shared biological functions. The model predicts transcription factor binding patterns, providing a molecular mechanism for plant traits like flowering time and disease resistance.
Researchers have developed a soft, custom-molded acoustic contact lens that actively corrects outgoing sound waves before they pass through an autonomous drone's protective shell. The lens boosts sonar signal strength by up to 10 decibels while cutting background reverberation without draining extra battery power.
Universities and hospitals conduct substantial numbers of late-stage clinical trials to repurpose generic drugs at reduced costs. This research has huge potential to provide society with affordable treatments for various conditions.
A study by University of Kansas researchers found that landback returns of Indigenous lands are occurring rapidly across the country. The findings show that over 75 distinct tribal nations have received lands, with private landowners, nonprofits, and corporations being among the most frequent returners.
Research team uncovers driving mechanisms behind population diversity in brain functional connectome. Lifestyle factors and gene expression shape brain functional topography, contradicting biological essentialism.
Jacques Ravel has been recognized for his foundational contributions to understanding the human vaginal microbiome, its links to pregnancy outcomes and susceptibility to infection. His work also laid the groundwork for live biotherapeutics designed to shape the vaginal microbiome in ways that could improve pregnancy outcomes.
Nikhil Bajaj's $649K NSF CAREER Award aims to develop a unified computational framework for designing nonlinear systems. The approach targets bifurcation behavior in devices such as ultrasensitive gas-leak detectors and energy harvesters. By starting from explicit behavior specification, researchers can engineer systems backwards.
The MOVEO general assembly showcased advancements in smart transport connections, with a focus on EU-funded research and innovation. The project aims to unite expertise from nine European countries to improve inspection, monitoring, logistics, mobility, and inclusiveness.
Dimensions Citation Check API detects self-citation, evaluates instances in context, and provides risk ratings for journal editors' decision-making. The tool aims to safeguard research integrity by addressing the challenge of excessive or gratuitous self-citation.
Amy Fitzpatrick, MD, MS, has been recognized for her groundbreaking work in advancing women's health in Massachusetts. Her research and curriculum development have improved diagnosis and treatment of breast conditions, particularly in high-risk populations.
Researchers found evidence that the Aleutian Islands' subduction beneath the North American Plate occurred at least 56 million years ago, significantly earlier than previously thought. This discovery has implications for understanding tectonic and climatic processes that shaped the Earth's history.
A new national publication offers instructors strategies for teaching in the age of AI, discussing the benefits and risks of AI use in higher education. The guide provides guidance on values, learning outcomes, and how to implement regulations that set expectations for students.
A recent study published in Life Metabolism found that exercise reduces inflammation, promotes pro-inflammatory gene expression, and improves glucose-stimulated insulin secretion in human and mouse islets.
Researchers at the University of Houston have discovered adding salt can help release therapeutic material from endosomes, improving delivery efficiency for mRNA vaccines and gene therapies. The simple strategy overcomes a major obstacle in gene medicine, potentially making these therapies more efficient and accessible worldwide.
Researchers at Institute of Science Tokyo have developed a novel culture system to produce stable, scalable, and low-cost clinical-grade intestinal organoids from patient biopsy samples. The innovative approach uses clinical-grade collagen and synthetic peptides to enhance growth and improve scalability.
The European Centre for Medium-Range Weather Forecasts (ECMWF) has appointed two Deputy Director-Generals to strengthen its leadership in delivering world-leading science and operational weather services. Dr Jørn Kristiansen will lead the Forecast Department, while Dr Irina Sandu will lead the Research Department.
The PAINT database offers a freely accessible dataset of operational data from the Jülich Solar Tower, covering 849 gigabytes of information on mirror positions, dimensions, and movements. This data can be used to develop digital twins, test power plant operation, and investigate effects of heliostat alignment.
Dwarf mongooses alter their behavior in areas where fights with rivals are most likely, even without another group present. The study shows that the biggest changes occur when the anticipated threat is greatest, allowing them to tailor their pre-emptive behavior accordingly.
Researchers developed a digital twin framework to predict permafrost degradation in Alaska's thawing permafrost. The framework uses real-time measurements and AI to simulate the physical properties of frozen soil, enabling more accurate predictions of climate change impact.
A recent study published in the Journal of Personality and Social Psychology found that loneliness plays a stronger role in cognitive impairment and shorter life spans than social isolation. Loneliness was consistently associated with a higher risk of cognitive decline and a shorter life, even after taking social isolation into account.