A study in mice found that paternal immune activation affects small RNAs in sperm, leading to changes in offspring phenotypes such as increased body size and impaired insulin sensitivity. The findings suggest a potential mechanism for intergenerational transmission of health disorders.
Researchers developed an open-source robotic system to automate passaging of cells in 96-well microplates, reducing manual labor by 61% and improving consistency in cell density. The system also showed improved imaging site usability and increased experimental reproducibility.
Researchers from Hanbat National University develop switchable thermochromic transparent woods for smart windows, blocking UV radiation and reducing thermal conductivity. The material enables energy-autonomous light regulation and protects skin without sacrificing visible light.
A meta-analysis of 18 studies found that playing linear number board games can meaningfully improve early math skills like counting, number recognition, and understanding quantity. Brief play sessions of 10 minutes or less have lasting benefits for young children's numeracy skills.
A new study at the University of Minnesota Twin Cities investigates how floodwaters transport and bury animal bones to understand fossil formation. The research provides clues for understanding animal extinction and environmental changes.
A new diet option has been shown to improve both physical symptoms and biological indicators of mild-to-moderate Crohn's disease. Participants in the fasting mimicking group experienced significant declines in fecal calprotectin, a protein indicating gut inflammation, and showed clinical benefits even after just one cycle.
A new study finds that electric vehicles combined with solar-powered off-grid charging systems could be viable in Africa sooner than expected. The research shows that the cost of charging accounts for a small portion of total vehicle costs, making electric scooters and motorbikes already an attractive option.
Researchers found that trees recovering twice as fast in tropical forests with sufficient nitrogen could be preventing the annual sequestration of 0.69 billion tonnes of carbon dioxide. The study suggests ways to boost carbon capture through reforestation by managing nutrients available to trees.
Cells use a complex rhythm to respond to different types of stress, such as starvation or salt stress, with insulin-driven protein DAF-16 acting as a key regulator. The research may contribute to understanding diseases like diabetes and cancer, as well as aging.
A new study reveals that tropical forests can regrow up to 95% faster when given sufficient nitrogen, allowing them to absorb more carbon dioxide. This finding suggests that targeting nitrogen pollution from farms and factories may be crucial in helping young forests recover and act as natural climate solutions.
Researchers developed a tool to measure gut inflammation levels using luminescent reporting, detecting high levels of granzyme A enzyme in inflamed gut tissue. The new technique shows promise for accurate IBD diagnosis and monitoring, reducing invasive procedures.
ACCESS-AD aims to address Alzheimer's disease challenges with a coordinated framework for diagnosis, treatment and monitoring. The project combines advanced neuroimaging with digital biomarkers to support early patient identification and personalized treatment pathways.
A new study from Nagoya University in Japan has found that petrolatum-based eye ointments can cause MicroShunt glaucoma implants to swell and potentially rupture. The study suggests that clinicians should avoid using these ointments on patients with the implant, particularly when it is exposed outside the conjunctiva.
A new study by the University of Waterloo found that consuming local waterfowl may lead to higher levels of mercury and omega-3 fatty acids in Indigenous communities. Researchers suggest including waterfowl in monitoring programs to balance nutrition and risk reduction.
The study analyzed Chang'e-6 samples from the South Pole-Aitken Basin, finding significantly heavier potassium isotopic compositions than previous lunar basalts. This suggests that a giant impact event had a profound influence on the Moon's deep interior, affecting its thermal history and geochemical properties.
Researchers build a robot to demonstrate how tropical bats spot insects perched on leaves using echolocation, revealing a plausible mechanism for the acoustic mirroring effect. The study suggests that bats can efficiently determine leaf occupancy by scanning sounds from an angle and listening for echoes.
Researchers at Colorado State University used AI to modify antibodies into stable intrabodies that can visualize histone modifications in real-time. This allows for better understanding of gene expression and its relationship with cancer and other disorders. The team created 19 new antibody-based probes with a 70% success rate, signifi...
A Dartmouth study identifies a novel target for using psilocybin to treat depression and anxiety without hallucinations. The serotonin 1B receptor is found to promote the therapeutic benefits of psilocybin, providing a potential new approach for developing safer and more cost-efficient medications.
Researchers have developed a novel porous carbon nanocomposite that achieves wide-temperature-range physical and chemical hydrogen sorption. The material, made with Mg/N-doped porous carbon, delivers high gravimetric and volumetric capacity at sub-ambient temperatures, outperforming compressed hydrogen.
A new additive, ammonia borane, is found to enhance perovskite solar cells by lifting certified efficiency to 25.98%. This improvement is achieved through a simplified coating process, cutting steps by 30% and enabling immediate upgrades for gigawatt-scale production lines.
Researchers at Meijo University have developed the world's first continuous-wave UV-B semiconductor laser diode operating at room temperature on a low-cost sapphire substrate. The achievement advances compact, energy-efficient UV light sources for various applications.
Researchers found that the bathing water in Pompeii's Republican Baths was contaminated with lead, zinc, and copper, compromising hygiene standards. The team also discovered cyclical patterns in carbonate deposits suggesting volcanic activity before the AD 79 eruption.
This study reveals synthetic asset-backed stablecoins as strong hedges for 21 of 30 international stock indices, while fiat-backed stablecoins show limited risk-mitigation capabilities. The findings underscore the importance of understanding stablecoin design and its impact on financial resilience.
Researchers at the University of Auckland have discovered a link between the lateral parafacial region of the brain and high blood pressure. This area, responsible for automatic functions such as breathing and digestion, is activated in conditions of high blood pressure, leading to increased blood vessel tension.
Researchers at Griffith University found a consistent biological feature of ME/CFS: faulty TRPM3 ion channel function in immune cells. This discovery provides clear evidence for developing a diagnostic test and guiding new therapeutic targets.
The study reports the synthesis of two novel boron-hexane Z-type and bilayer benzobenzenes, exhibiting narrow-spectrum fluorescence and amplified spontaneous emission properties. The researchers demonstrate their potential application as gain mediators in luminescent functions and spin properties.
Researchers found that blocking Caspase-2 enzyme in mice increased chronic liver damage and cancer risk as they aged. The study highlights the need for caution when targeting this pathway to treat fatty liver disease.
Researchers at Hong Kong Polytechnic University create a new machining method that combines laser and magnetic fields to machine advanced materials like high-entropy alloys. The dual-field approach produces smoother surfaces, reduced damage, and improved material removal rates.
A study published in Drug and Alcohol Review journal reveals that workplace factors like long hours, work-related stress, and shift work do not solely drive high-risk drinking. Personal and social factors have an even greater impact on alcohol consumption among workers. The research analyzed over two decades of data from the Household ...
A Carnegie Mellon-led team has secured a $28.5 million award from ARPA-H to develop a functional, 3D bioprinted liver for patients with acute liver failure. The project aims to provide a temporary liver that supports regeneration of a patient's own liver, reducing the need for full organ transplants.
Researchers at Kyoto University observe a peculiar supernova explosion, SN 2022esa, which reveals the birth of a black hole binary. The study provides new direction for understanding massive star evolution and black hole formation.
A team of researchers has developed a dual-response cellulose–WO3 composite film that can switch tint in seconds and survive 200 cycles. The membrane is made from wood and can be roll-coated on existing paper machines, making it a sustainable alternative to traditional smart glass.
Bernard Arulanandam, Tufts University vice provost for research and immunology professor, has been recognized by the Indian National Science Academy. His work focuses on translating scientific findings into real-world applications, particularly in infectious diseases.
New study finds psychosis delusions emerge from emotional experiences, bodily reactions, and linguistic fabric. Participants described intense emotional embodiment and disembodiment, with some experiencing positive feelings of awe and love.
Researchers have made a groundbreaking discovery about how bacteria swim upstream to cause infections, pointing to new designs for biomedical devices that can prevent contamination. The study found that wider channels with faster counterflows are more prone to invasion, but sharp corner designs can inhibit bacterial growth.
Researchers found that burned pit smoke exposure was strongly associated with higher levels of anthracotic pigment in the lungs of post-9/11 veterans with deployment-related lung disease. This study provides objective, tissue-based evidence that burn pit smoke exposure leaves a measurable impact on lung health.
Tufts researchers have developed a method to biosynthetically produce tagatose, a rare sugar with potential health benefits. Tagatose is 92% as sweet as sucrose and has about 60% fewer calories, making it an attractive alternative to conventional sugar substitutes.
The course, launched in 2017, equips faculty to prepare competitive grant proposals with confidence. Participants reported significant increases in confidence, particularly in understanding the NIH review and award process, leading to a 79% increase in receiving grant funding as principal investigators.
A recent analysis of 692 clinical trials found that industry-sponsored trials were nearly three times more likely to fail compared to government-funded studies. Trials with higher participant numbers and broader eligibility criteria were also more likely to complete successfully.
A recent study by researchers at the University of California, Riverside, found that a specific brain region known as the caudate nucleus is strongly linked to physical strength in older adults. The discovery could help detect and prevent frailty before it begins.
The Tufts University Center for Cellular Agriculture has teamed up with the Good Food Institute to salvage intellectual property from failed startups and make it publicly available. Eight commercially developed beef cell lines have been obtained, including two that have been engineered to remove antibiotic resistance markers, making th...
Researchers found that FDA decisions were based on safety considerations, with limited instances of political intervention. The agency acted cautiously, incrementally, and with a commitment to well-grounded scientific evidence.
A new study by the University of Tennessee shows that virus infection of cyanobacteria releases nutrients, fueling microbial growth and contributing to enhanced oxygen levels in the ocean. The findings suggest a direct link between viral activity and ecosystem functioning below the surface.
Researchers from The University of Osaka discovered that loss of heterochromatin can trigger genetic changes leading to chromosomal rearrangements and diseases like cancer. Accumulation of R-loops at pericentromeric repeats was found to be a key mechanism in this process.
Mars plays a measurable role in shaping Earth's long-term climate patterns, including ice ages, through its gravitational influence and orbital cycles. The study suggests that Mars' presence is necessary for the existence of major climate cycles, which have driven evolutionary changes on Earth.
A large-scale field trial in Ethiopia found no significant difference between fluorometholone and placebo treatments in reducing postoperative trachomatous trichiasis recurrence. The study, which involved over 2,400 participants, suggests that anti-inflammatory therapy may not be beneficial for improving TT surgery outcomes.
Researchers have found that El Niño and La Niña are driving total water storage extremes globally, with a synchronizing effect on water storage across continents. The study uses gravity data from NASA's GRACE and GRACE Follow-On satellites to track water extremes and their connections.
Researchers describe chemical journey of YCT-529, a non-hormonal male birth control pill, and its promising molecular science behind it. The compound effectively suppresses sperm counts, showing promise as a durable and reversible contraceptive option.
A new long-term prediction tool estimates the risk of dying from prostate cancer by combining PSA levels with factors like family history, race, age, and other health conditions. The tool showed higher accuracy in predicting prostate cancer death over decades compared to existing models.
A study of over 1.1 million people in England found that most COVID-19 vaccine hesitancy is addressable and can be reduced over time. Among those who initially expressed hesitation, 65% went on to get vaccinated at least once, highlighting the potential for targeted messaging and information to improve vaccine uptake.
A new Stanford-led analysis found that companies undercount emissions from their supply chains by billions of tons due to the use of single-region U.S. models. This can lead to missed opportunities to reduce emissions and associated costs by sourcing goods from countries with cleaner grids.
A new protocol models alcoholism in mice and shows that stimulating the FGF21-oxytocin-dopamine system with rare sugars can reduce alcohol consumption. The researchers believe that this system may play a role in regulating subconscious information processing, leading to effective dietary therapy for reducing over-drinking.
A new global study finds that nearly half of livestock production occurs in areas with destocking, a process that poses new ecological and land management challenges. Destocking can increase wildfire risk and biodiversity decline, but also enables ecosystems to capture more atmospheric carbon dioxide.
Researchers at Georgia State University found that segmented filamentous bacteria (SFB) provide marked protection against post-influenza bacterial pneumonia in mice. SFB reprograms alveolar macrophages to resist influenza virus-induced dysfunction, maintaining their defense against respiratory bacterial pathogens.
A study published in PNAS found that over 60% of pairs of damaging genetic variants can restore enzyme activity when combined, challenging long-held assumptions about genetics. This phenomenon, known as intragenic complementation, has implications for rare disease diagnosis and treatment.
Researchers use AI-driven target discovery platform to identify PRPF19 and MAPK9 as promising targets that suppress tumor cell proliferation while reducing senescence-associated signaling. The study suggests these dual-purpose targets may address both hepatocellular carcinoma progression and cellular senescence.
Researchers at UC San Diego have discovered a previously unrecognized treatment target for triple-negative breast cancer (TNBC). Disrupting the activity of PUF60 causes widespread errors in gene processing, resulting in DNA damage and tumor cell death.
New research simulates 10,000 years of seismic activity to show how underground temperature and sediment patterns control where earthquakes start, spread, and stop. This study provides a more accurate picture of the Main Marmara Fault's behavior, essential for building codes, emergency planning, and infrastructure decisions.
Ruth Harris has made outstanding contributions to the Seismological Society of America through her drive to create student presentation awards and support open access options. Her active participation in numerous committees has benefited nearly every SSA committee.
A new study found that silky sharks spent less than half their time within the Galapagos Marine Reserve despite its designation as a haven. The species' tendency to migrate towards unprotected waters poses a significant threat to their survival, emphasizing the need for expanded MPAs and improved fisheries management.