A new drug candidate, IHMT-15137, has been discovered to target key proteins involved in chemotherapy resistance. The compound blocks BMX activity, disrupting downstream signals and reducing E2F1 levels, making cancer cells more sensitive to treatment.
Researchers have identified a potential pathway for the coordinated cell death of harmful algae, driven by iron-catalyzed lipid peroxidation. This process not only kills individual algal cells but also releases active lipid peroxides that kill off neighboring cells, leading to the rapid collapse of an entire bloom.
A modelling study across 193 countries found armed conflict is associated with a higher measles burden. The study also suggests that conflict has an indirect impact on the spread of measles through its effects on lower socioeconomic development and greater population displacement.
A study at Baystate Medical Center identified factors such as emergency surgeries, chest and heart procedures, and taxing operations affecting surgeons' schedules. These insights aim to optimize surgical scheduling, reduce waste, and improve patient outcomes.
Researchers suggest that frequent asteroid strikes may have kept the early Earth hotter and more unstable, making it difficult for rocks to survive. This led to a lack of preserved rocks from the first 500 million years of Earth's history, with long-lived continents forming only after impact intensity declined.
A unique plant fossil cache in New Mexico reveals angiosperms flourished 10 million years before dinosaurs' demise, contradicting the view that they only took over after their extinction. The discovery showcases a thriving forest dominated by flowering plants with large fruits, challenging the traditional narrative.
Researchers developed a perovskite/In0.47Ga0.53As thin-film heterojunction to create high-sensitive DUV-SWIR photodetectors with optimal stability and performance. The device achieved 98.9% retention of initial performance after 30,000 cycles.
Researchers discovered that bacteria pool their resources to help dormant cells survive antibiotic attacks. Protein transfer between bacterial populations allows vulnerable members to persist in the face of deadly antibiotic attacks. Understanding this teamwork can lead to new approaches to improve antibiotic effectiveness.
A new study calls for formal recognition of toxoplasmosis as a neglected tropical disease by the World Health Organization. The disease, which can cause permanent vision loss, affects one third of the world's population and has significant impacts on global health.
Researchers have determined the three-dimensional structure of human cone opsins in their dark state, shedding light on how they rapidly activate with light. This breakthrough provides new insights into human vision and its evolution, potentially offering new avenues for treating eye diseases.
Researchers at Seoul National University developed an automated design platform using generative AI to create complex DNA origami structures with curved and irregular geometries. The technology, Generative SNUPI, enables users to fabricate DNA nanostructures that can undergo shape transformations and be assembled modularly.
Researchers used an egg shuffle experiment to study the pied flycatcher's non-breeding areas. The results show that both genetic inheritance and hatching environment play a role in determining these areas.
A recent study analyzing Late Cretaceous fossils found diverse fruit and seed morphologies in flowering plants, challenging the traditional timeline for their reproductive evolution. The discovery expands our understanding of forest ecology and plant-animal interactions during angiosperm evolutionary history.
Researchers develop methodology to precisely design and control degree of disorder in nanopattern structures, enabling new possibilities for wave-controlling devices. The technology also reveals tailored physical properties for functional materials with wide-range control over disorder.
Researchers tracked pied flycatchers from eight countries and found that genes and environment influence their migration routes. The study suggests that the birds' wintering locations are determined by a mixture of inheritance and natal environment.
Researchers found that a specific enzyme, GELP80, helps create flexible guard cells in plants, allowing them to conserve water and survive longer drought periods. This discovery could aid in optimizing crops for better water management and greater resilience to drought.
A recent hantavirus outbreak on a polar expedition cruise ship highlights the risk of person-to-person transmission and the need for multi-sectoral coordination. The incident, which resulted in three deaths, underscores the importance of microbiome surveillance and ecologically informed travel health regulations.
A new framework tests AI reliability in antibiotic development, highlighting its potential to speed up the discovery of new antibiotics. The study found that while AI models were good at spotting known antibiotic structures, they struggled to explain their reasoning, a critical step towards trustworthiness.
A recent study reveals that vegetation's water-saving effect under rising CO2 is overestimated due to atmospheric feedbacks. This indirect impact can increase surface energy balance, leading to warming and enhanced atmospheric evaporative demand.
A research team developed a high-performance laser-based Three-Dimensional methane gas cloud imaging telemetry system. The system enables accurate measurement of emissions, supporting more efficient monitoring and control of pipeline networks.
A research team at Hefei Institutes of Physical Science developed a low-temperature solution-processing strategy for fabricating CuInS2 thin-film solar cells with an efficiency up to 12.28%, outperforming previous records.
Researchers develop Csp–π–d conjugated system to enhance oxygen reduction performance, outperforming platinum-based catalysts in stability and cost-effectiveness. The new catalyst facilitates electron transfer and weakens OH adsorption, promoting intermediate desorption and accelerating reaction kinetics.
The study reveals a nearly isotropic upper critical field in trilayer nickelate La4Ni3O10-δ under high pressure, unlike most layered superconductors. This unusual feature arises from the combined effect of two types of electronic states that balance out to lead to an overall nearly isotropic superconducting response.
The study reveals that lampreys share gene-expression patterns with mice across many regions, suggesting a well-organized brain in their common ancestor. The research also shows unique innovations in lamprey brains, such as oversized Müller cells, and highlights the evolution of specialized neurons over time.
Researchers discovered that plankton emissions form acidic vapors that trigger aerosol particle growth and cloud formation over pristine ocean regions. This finding improves climate models by accounting for previously overlooked gas methanesulfonic acid.
Researchers have resolved the atomic-scale interplay between hole transfer dynamics and water oxidation intermediates on faceted BiVO₄ particles. A critical hole density threshold dictates pathway bifurcation, with the (010) facet becoming catalytically superior above this threshold.
Researchers at Rice University developed a custom Python-based software tool to rapidly analyze data from high-resolution X-ray diffraction, identifying dislocations and irregularities in the atomic lattice. The approach can accelerate the development of more reliable electronic and quantum devices.
The study found that sepsis continues to be a significant cause of mortality in China, with infections accounting for the majority of deaths. The analysis also revealed age-related differences in sepsis burden, with older adults and males consistently carrying the highest risk.
A new study by Flinders University reveals that targeting specific pain receptors in the bladder can reduce debilitating effects of cystitis. The research suggests that activating certain cannabinoid receptors could provide relief from bladder pain and urinary urgency associated with interstitial cystitis/bladder pain syndrome (IC/BPS).
A team of researchers extracted and analyzed protein fragments from fossil teeth of Homo naledi, finding zero male markers. This discovery suggests a sex-bias in mortuary practice among non-human species, unlike observed in contemporary human cultures.
The Mount Sinai Adolescent Health Center has received the 2026 Community Health Improvement Award from HANYS, recognizing its decades-long leadership in comprehensive, confidential, equitable care for adolescents and young adults. The award honors the Center's commitment to improving public health and advancing health equity.
Researchers discovered a combination regimen of two β-lactam antibiotics resulted in faster and greater killing of bacteria than using each antibiotic alone. The pairing suppressed resistance to both antibiotics, offering a promising approach to optimising and personalising antibiotic regimens against life-threatening infections.
Researchers developed a new catalyst that accelerates water dissociation and hydrogen adsorption, enabling faster hydrogen evolution reaction activity and stronger stability. The study presents a TiO₂ QDs/Co₃O₄ symbiotic oxide support that precisely regulates Pt clusters for alkaline hydrogen production.
A team of researchers from Science Tokyo has developed a new method to reversibly switch the chirality of semiconductor materials using electrochemistry. This innovation enables the creation of spin-polarized currents in layered non-chiral semiconductors, opening up new directions for developing ultrafast and energy-efficient devices.
Jorge Íñiguez-González leads a €2.5M ERC Advanced Grant project to explore reconfigurable materials with tunable properties. The research aims to create adaptive technologies for information storage and next-generation computing.
Researchers developed an AI framework to identify viable target antigens for CAR T cell therapy, using publicly available single-cell RNA sequencing data. The framework showed robust tumor-killing activity in mouse models of multiple cancer types, including melanoma, leukemia, and colorectal cancer.
A Brazilian study found that 86% of children and adolescents with musculoskeletal pain recover, but 32% experience recurring pain. The study identified factors such as quality of life and age as predictors of recovery.
Researchers identified a distinct fibrotic fibroblast population in hypertrophic scars, which they linked to the transcription factor Yin Yang 1 (YY1). Restoring YY1 expression reduced scar-associated fibroblast activation, providing new insights into scar fibrosis and potential therapeutic strategies.
A cohort study found that a dietary pattern with lower inflammatory potential was associated with lower dementia risk among individuals with Alzheimer disease pathology. Targeted dietary strategies may help prevent dementia in those already at elevated risk.
A new study identifies key degradation mechanisms in perovskite solar cells, including phase segregation, copper corrosion, and edge patterns. Accelerated aging tests can accelerate these processes, but may not reflect real-world degradation.
The TREM-1 receptor amplifies innate immune responses and is a promising therapeutic target for inflammatory diseases. The review highlights its pathogenic roles in acute systemic inflammation and chronic conditions like inflammatory arthritis and neurodegenerative disorders.
The Sports Heat Tool, developed at the University of Sydney, provides personalized heat risk assessments for various sports. Users can input their location and chosen sport to receive a heat-risk score and practical steps to mitigate risks, taking into account factors such as temperature, humidity, and exertion.
A genome editing technique called base editing has been used to study the role of a master gene in human embryonic cells, revealing its crucial function in early development. The technique allows scientists to alter a single gene in human embryos, enabling them to better understand how human embryos develop.
Scientists at Universitatsklinikum Bonn developed a robust laboratory method to generate and study follicular regulatory T cells. The research found that TGF-β and IL-2 signaling pathways control the development of these cells, which regulate immune tolerance and antibody responses.
A team of scientists observed Jahn–Teller polarons in cobalt oxide crystals activated by tailored laser pulses. The study reveals the material's structural, electrical, and magnetic properties can be engineered using ultrafast laser pulses.
A study reveals that the rhythmic structure of laughter has remained constant in all living great apes, including humans, for at least 15 million years. This finding offers unexpected clues to the evolution of human speech, suggesting that sophisticated vocal control is a fundamental building block.
The Political Ecology Network will convene its biennial international conference POLLEN 2026 in Barcelona, Spain, from June 29 to July 3, 2026. The event will bring together researchers, activists, and creators to discuss contemporary crises and forge pathways toward peaceful alternatives.
Researchers found that puerarin significantly ameliorated serum biochemical abnormalities and histological changes associated with cholestatic liver fibrosis. The treatment promoted conjugation of hydrophobic bile acids into more hydrophilic forms, suggesting enhanced hepatic detoxification capacity.
Large language models can accurately identify reasons for medication discontinuation from doctors' electronic clinical notes, revealing that adverse reactions are a common cause. The study uses this approach to transform clinical free text into analyzable data, supporting evidence-based decision-making in health policy.
A new Cornell University study examines the relationship between cranial shape and body weight in dogs, identifying a link to syringomyelia, a painful spinal condition. Breeds prone to syringomyelia exhibit distinct skull shapes, highlighting the need for breed-specific treatment strategies.
Researchers at King's College London have developed an AI model that can improve a Formula One team's finishing position in simulations of the 2023 Bahrain Grand Prix. The model, which uses reinforcement learning and explainable AI, outperformed existing race strategy optimization techniques in many cases.
Researchers found that a daily spermidine supplement improved immune response to COVID-19 vaccination in older adults. Spermidine reduced markers of immunosenescence and stimulated autophagy, leading to higher antibody levels and better neutralizing activity against multiple viral variants.
Emerging evidence positions lactylation as a critical metabolic-epigenetic hub in lung cancer. Lactylation drives oncogenic programs and immune-evasion pathways, contributing to treatment resistance. Targeting this axis may restore treatment sensitivity.
A new study finds that young people from lower-income countries with limited internet access are at risk of being overlooked for mental health support due to climate change. This exclusion skews the evidence base, failing to adequately address the needs of those most affected by climate-related anxiety and depression.
Artificial intelligence is being harnessed to integrate multi-omics data from large-scale repositories such as TCGA and GDSC to decode tumour drug resistance. The review advocates for explainable AI frameworks, multimodal fusion strategies, and dynamic liquid-biopsy monitoring to address barriers to clinical adoption.
Researchers identified miR-29a as a pivotal regulator of cancer development, which can act as both a tumor suppressor and an oncogene. Natural bioactive compounds such as curcumin, EGCG, and resveratrol have been shown to restore normal miR-29a expression through epigenetic remodeling and inhibition of oncogenic signaling pathways.
A new study reveals rooftop solar panels can offset nearly half of increased electricity demand during peak cooling periods. Climate change alone is projected to push up residential cooling demand by 5%, but rooftop solar growth could halve this additional load, easing pressure on the grid.
Global newborn mortality from birth asphyxia and trauma has declined, but progress is slowing in low- and middle-income countries, particularly in sub-Saharan Africa. Countries with lower scores on human development indices experienced slower mortality declines, highlighting the need for targeted investments to close the equity gap.
A new prodrug and localized drug delivery platform have been developed by researchers to selectively target cancer cells. The platform uses carbamate masking of the 4-anilinoquinazoline hinge nitrogen to modulate exposure and enable controlled activation of EGFR-TKIs in tumour microenvironments.
A new artificial lateral-line sensing unit helps underwater robots estimate both magnitude and direction of local flow velocity. The sensor uses a flexible silicone spring, light-emitting diode, and photodiodes to detect subtle hydrodynamic changes in water flow.