The integration of OMOP Oncology into Mayo Clinic Platform enables faster analysis of complex cancer data, unlocking deeper insights and accelerating research. This expansion supports the development of next-generation therapies for patients worldwide.
A new global study finds that physical inactivity is a significant driver of diabetes complications, with up to 10% of cases potentially preventable. The research emphasizes the need for tailored approaches to promote physical activity among people with diabetes, particularly addressing social and gender inequalities.
Matthew J. Robson, PhD, a University of Cincinnati associate professor, received the 2026 Neuropharmacology Early Career Award for his research on serotonin neurotransmission and its impact on traumatic brain injury. The award honors young independent investigators in neuropharmacology.
Patients who stopped taking antidepressant medication during pregnancy had a nearly two-fold higher risk of experiencing mental health emergencies, with peaks in the first and ninth months. Researchers found no difference in prior mental health visits between those who continued or discontinued therapy.
Reducing air pollution levels may help delay and mitigate physical disability in aging adults, according to a new study published in JAMA Network Open. The findings suggest that lower air pollution levels are associated with slower progression of physical function limitations and disability.
Researchers found that the Southern Indian Ocean has decreased in salinity by 30% over the past six decades, bringing fresh water into the region. This could disrupt major ocean circulation systems and affect marine ecosystems, including plankton and sea grass.
An international team discovered that a specific viral component can trigger dangerous antibodies against human blood proteins, leading to rare blood clots. The study identifies the K31E mutation as the key mechanism behind this misdirected immune response.
A single injection of an oncolytic virus recruits immune cells to penetrate and persist deep within brain tumors, inducing long-term infiltration of immune T cells. This therapy expands pre-existing T cells in the brain, leading to a therapeutic benefit for patients with glioblastoma.
A new study reveals that seabird guano was a driving force behind the Chincha Kingdom's sociopolitical expansion on Peru's coast. The nutrient-rich bird droppings boosted corn yields and supercharged agriculture, fueling the kingdom's economy, trade, population growth, and regional influence.
Researchers have identified a microRNA that may enable abnormal cells to evade detection by the immune system, promoting progression to lung cancer. The study found that overexpressed miR-149-5p reduces expression of genes involved in immune recognition, leading to fewer immune cells in close proximity to abnormal cells.
Research on Mars' volcanic systems shows that they were shaped by long-lasting and evolving magma beneath the planet's surface. The study found that these volcanoes experienced multiple eruptive phases, transitioning from early fissure-fed lava emplacement to later point-source activity.
The Phase I/II multicenter international CADENZA trial found that 75% of patients with BPDCN treated with pivekimab sunirine achieved a complete response. The treatment delivered the therapeutic drug directly to cancer cells, resulting in rapid cancer cell death with limited targeting of healthy tissue.
Researchers found sustained high progesterone exposure during pregnancy improves menstrual cycle in PCOS patients and a mouse model. Progesterone treatment normalizes estrous cyclicity, reduces ovarian weight, and enhances estrogen production, supporting its role as a potential therapeutic agent for PCOS-related menstrual dysfunction.
A new HPV cancer vaccine developed by Northwestern University scientists has shown promising results in a preclinical model. The vaccine's carefully organized structure dramatically enhances the immune system's ability to attack tumors, shrinking them and extending animal survival.
A Phase II study presents significant overall survival benefits for women with platinum-resistant ovarian cancer treated with elenagen plus gemcitabine. Longer exposure to elenagen correlates with longer survival after treatment discontinuation, suggesting a fundamentally different therapeutic approach.
A new study finds that food chains on modern Caribbean coral reefs are 60-70% shorter than they were 7,000 years ago. Individual fish have lost dietary specialization, leading to a compression of the distance between different trophic levels.
UH Cleveland Medical Center ranked seventh in US and 15th globally as strongest academic medical center brand. The hospital received recognition for patient treatment, medical research, training, and education.
Researchers at Norway's NTNU are using advanced geophysical methods to improve the accuracy of carbon capture and storage site monitoring. A new laboratory equipped with a mock-up of an undersea storage site allows for real-time testing and validation of monitoring techniques. This breakthrough could reduce costs and improve the effici...
Researchers developed a metalated polymer brush coating that maintains high optical transmittance (86%) while exhibiting robust antibacterial performance (99.99% inhibition rate) against E. coli and S. aureus. The coating demonstrated antifouling properties, showing minimal adhesion of model proteins.
Research found that people experiencing economic disadvantages are more likely to smoke cigarettes, have higher levels of tobacco addiction, and find it harder to quit. Electronic cigarettes were the most common aid to help people quit, but those who rented or owned their houses had lower odds of quitting successfully.
The University of Tennessee and UCOR have strengthened their partnership to provide training and educational opportunities for students and workforce development in nuclear and criticality safety. The MOU renewal will include projects, research, and curriculum focused on these areas.
A recent study found life expectancies for people with open spina bifida vary significantly by walking and feeding ability and bowel/bladder continence. Life expectancy decreases with age and is lower for males compared to females.
A large-scale study found that patients taking tirzepatide had a significantly lower risk of developing new diabetic retinopathy or progressing to more severe stages. This suggests that the medication may not worsen eye health, offering relief for patients concerned about their vision.
Researchers at UC San Diego identified a distinct biological pattern of chronic rhinosinusitis in veterans exposed to burn pits and other toxins. The study found that mast cells play a key role in this condition, which has no FDA-approved treatments.
A recent study found that adding biochar to cattle feed can create a cascading environmental benefit by improving soil carbon storage. The researchers discovered that approximately 70-90% of the biochar survived digestion and retained key characteristics associated with long-term stability.
A new study published in Redox Biology found that an experimental neuroprotective drug called P7C3-A20 can prevent the negative side effects of whole brain radiotherapy, including memory problems and depression. The drug was shown to reduce oxidative stress and protect nerve cells in mice with WBRT-induced brain damage.
Researchers used Caenorhabditis elegans to model chemotherapy-induced neurological dysfunction and tested two compounds for improved recovery. Both sildenafil citrate and Resveramorph-3 significantly reduced seizure-like behaviors and duration, suggesting their potential as therapeutic candidates.
A recent study by Columbia University researchers found that accidental drug overdose, homicide, and suicide are the top causes of maternal death in the US. These unexpected findings suggest a need for increased awareness and multidisciplinary care to prevent these deaths.
Researchers discovered that levetiracetam prevents the production of toxic amyloid-beta 42 peptides and plaques in neurons. Administering the drug to high-risk individuals may slow cognitive decline and prevent Alzheimer's symptoms if started early, possibly up to 20 years before symptoms appear.
A study published in Biological Psychiatry identified speech latency as a promising biomarker to enrich clinical trials for patients with schizophrenia. By analyzing speech latency, participants with a high placebo response can be identified and excluded, leading to significant improvements in treatment outcomes.
Researchers studied 434 children for signs of autism or neurodevelopmental problems, finding no link between mRNA vaccine and autism. The study suggests that COVID-19 vaccines are safe to receive during pregnancy to protect maternal and infant health.
A novel multilevel dispersion strategy has produced high-efficiency membranes for bioethanol recovery by improving capture capacity and mechanical durability. The optimization of granulation promoters led to a significant advancement in the performance of alkaline metal salt-promoted MgO sorbents.
A new study by Leopoldo Petreanu's team shows that different visual experiences result in distinct patterns of organization in feedback connections. Mice with miniature goggles biased to see edges oriented at specific angles had unique tuning properties and patterns in these connections.
The University of Cincinnati is conducting a clinical trial testing two new nonpharmacological treatments for depression in young adults. The trials focus on amino acid N-acetylcysteine (NAC) and mindfulness-based cognitive therapy (MBCT), with the goal of providing more treatment options for patients at higher risk of side effects fro...
A new study found that prescribing daily aspirin to all pregnant patients at the first prenatal visit reduces the development of severe preeclampsia by 29%. The study also showed that patients given aspirin had later onset or no severe preeclampsia, with no increase in maternal hemorrhage or placental abruption.
Research found that oak tree microbiomes are resilient to environmental stressors like drought and disease, with subtle changes in root microbiota after prolonged drought. The study suggests a potential role for beneficial bacteria in supporting tree resilience and stability.
Multiple Earth system components are closer to destabilization than previously believed, threatening a hothouse Earth path driven by climate feedback loops. The researchers recommend prioritizing climate resilience in governmental policy frameworks and a socially just phaseout of fossil fuels.
Primary biliary cholangitis (PBC) is associated with a high incidence of osteoporosis, characterized by reduced bone mass and increased fracture risk. The pathogenesis involves immune dysregulation, cholestasis, liver damage, and metabolic alterations, highlighting the need for PBC-specific management strategies.
A study by Silent Spring Institute identified dozens of hazardous chemicals in hair extensions, including products made from human hair. The analysis revealed chemicals linked to cancer, hormone disruption, and developmental problems, prompting calls for stronger oversight and policy change.
Researchers at McMaster University have developed wearable trackers that can detect depression relapse weeks before it occurs, providing a potential early warning system. The study monitored 93 adults with a history of depression using a research-grade actigraphy device, collecting over 32,000 days of sleep and activity data.
Researchers at UVM have developed a new framework, NextGen, to enhance flood forecasting by providing a common platform for hydrologic and hydraulic modeling. The framework enables scientists to experiment with and develop more accurate models, addressing the limitations of current operational models.
Researchers found that subtle changes in retinal blood vessel geometry triggered by postural shifts can predict disease progression. Abnormal increases in arteriolar tortuosity and changes in venular branching behavior were linked to higher or lower likelihood of retinopathy progression.
A new tool has arrived: a highly customizable, open-source robot design called The Robot of Theseus (TROT), developed at the University of Michigan. TROT can model most mammals and enable direct comparisons of variations on the same structure, helping researchers discover the advantages related to limb length and segmentation.
Researchers at Washington State University developed a wearable biosensor that measures sugar levels in the fluid around cells using microneedles and sensors. The sensor is more sensitive, smaller, and painless than current models, making it a potential game-changer for diabetes patients.
Researchers outline a transformative roadmap using AI to create fully integrated, self-optimizing production systems for polymer composites. The proposed framework uses machine learning and digital twins to simulate and optimize the entire production chain as a single process.
A study published in Carbon Research reveals that a unique Ca-modified biochar can act as a powerful catalyst for the composting process, transforming pig manure and rice straw into stable, nutrient-rich humus. The innovation helps improve waste management in tropical regions, reducing nitrogen loss and environmental footprint.
A new study found that specific management practices, such as no-till and cover crops, can strengthen plant defenses against pests by enhancing soil microbiome functions. The researchers linked these practices with improved pest-suppressing abilities in pea plants.
A modified fentanyl molecule with a new core structure reduces respiratory depression while maintaining its pain-relieving properties. This redesign preserves the essential anchor point for receptor activation, producing pain relief without significant side effects.
A Brazilian research team used non-formal education methods in science museums to improve high school students' interest and confidence in chemistry. The interactive exhibition explained advanced oxidation processes, increasing students' sense of competence and positive perception of the discipline.
A study found that childhood obesity can lead to premature vascular damage in children as young as six, increasing the risk of diseases such as atherosclerosis and heart attack. The research identified early signs of inflammation and dysfunction in the endothelium, highlighting the need for public policies to prevent childhood obesity.
Researchers at the University of Pennsylvania have developed HoloRadar, a system that enables robots to reconstruct hidden 3D spaces beyond their line of sight using radio waves processed by AI. This capability can improve safety and performance in driverless cars and cluttered indoor settings.
A drone equipped with low-cost air quality sensors has revealed unexpectedly high concentrations of particulate matter at around 100 meters above ground level in Delhi. The findings suggest that current model simulations underestimate PM2.5 mass concentrations during morning haze episodes, highlighting the need for better mitigation st...
Researchers used a novel nitrogen isotope method to reconstruct ancient reef food webs, revealing that modern reefs have shorter and less diverse food chains. This loss of functional diversity makes modern coral reefs more prone to collapse, highlighting the need for conservation efforts.
The Congressional Peripheral Artery Disease (PAD) Caucus will focus on legislative priorities including timely diagnosis, evidence-based treatment, and innovative therapies. The event brings together lawmakers, medical experts, and patient advocates to address the critical gap in PAD management.
Experts like Amber Chandler suggest solutions such as no-tech public spaces, phone-free bedtimes, and hands-on problem-solving to help teenagers cope with unprecedented anxiety. Chandler's book offers evidence-based strategies to nurture belonging in a 'scared new world'.
Researchers have developed a breakthrough technique to transform a patient's own T cells into soldiers trained to recognize and kill cancer cells, benefiting tens of thousands of individuals with blood cancers. The approach is now being explored for solid tumors and other diseases.
Researchers developed a novel plasma-assisted catalyst system converting CO2 to CO with high efficiency. The system demonstrates stable operation for 6 hours, achieving nearly a 4-fold improvement in energy efficiency compared to previous conditions.
Researchers at the Flatiron Institute and their collaborators applied an active liquid crystal theory to understand how chromosomes are separated during cell division. The study found that the theory largely succeeds in predicting how spindles self-organize, using a combination of light microscopy and electron microscopy data.
This study reveals a bidirectional causal link between MASLD and sarcopenia, mediated by liver-muscle communication. Altered pathways in both liver and muscle tissues contribute to the development of these conditions.
Researchers develop cascaded van der Waals heterostructures to simulate neural signal transmission and neuromorphic visual information processing. The novel material platform achieves efficient photoelectric-ion coupling, enabling synaptic plasticity and neural signal processing capabilities.