Researchers at George Mason University are leading a Phase 2 clinical trial of ARD-201, an oral medication that works by activating bitter taste receptors to reduce appetite. The study aims to determine if the drug can help people maintain weight loss after GLP-1 injectable medications stop being used.
Researchers from OIST found that the Late Ordovician Mass Extinction drove an unprecedented richness of vertebrate life, with gnathostomes dominating all others. The study linked the mass extinction pulses to increased speciation after millions of years, highlighting their role in shaping the evolution of vertebrates.
A new study by Johns Hopkins Children's Center researchers found that as teens transition to young adults, they often skip yearly wellness visits with pediatricians or primary care providers. The study suggests that parents, pediatricians, and other primary care providers should encourage annual wellness visits to advance efforts in pr...
Researchers at MD Anderson have made significant advancements in cancer treatment, demonstrating the effectiveness of immunotherapy before and after surgery in improving lung cancer patient outcomes. Additionally, a new study shows promise in using CAR T cell therapy to treat large B-cell lymphoma, reducing relapse rates.
Researchers uncover a key ion channel, TRPM4, that regulates intestinal fluid balance and identify a new druggable site. This discovery provides a blueprint for designing targeted treatments for gastrointestinal disorders.
Researchers from Shedd Aquarium tracked queen conch movements to estimate the space needed to protect breeding populations. The study suggests establishing a 330-meter spatial buffer around breeding areas to help protect conch populations and serve as a practical tool for local management.
Scientists developed a cost-effective method to produce 3-Hydroxypropanoic acid (3-HP), an industrial chemical used in disposable diapers, microplastics, and acrylic paint. The new process using engineered microbes to ferment plant sugars into 3-HP has been validated for commercial potential.
Researchers at Vanderbilt Health found that both weight loss drugs and bariatric surgery induce a moderate loss of lean muscle and substantial reduction in fat, improving body composition in obese patients. This shift is associated with lower mortality risk from obesity-related diseases.
Researchers at Illinois Tech developed a new material with high ionic conductivity and low activation energy, enabling the efficient storage and release of energy. The material's unique structure allows lithium ions to move freely, even at cold temperatures, making it promising for applications in electric vehicles and energy storage.
Researchers have discovered that TB bacteria manipulate the immune system's Dectin-1 receptor to facilitate its survival. The study found that when this pathway is absent, both human and mouse cells can control MTB infection. This breakthrough provides new insight into why humans and animals are susceptible to contracting tuberculosis.
Researchers highlight shared and distinct immune features between neurodegenerative and neuroimmune diseases, pointing to novel treatment strategies. The study suggests that a deeper understanding of Parkinson's disease immunology informed by lessons from multiple sclerosis may bridge the therapeutic gap for PD.
An observational study of 168 second-time mothers found that breastfeeding for at least 12 months was associated with a lower risk of depression and anxiety later in life. The longer women breastfed, the greater the protective effect against depression and anxiety.
Researchers at ASHBi found a 'motivation brake' in the brain's ventral striatum and ventral pallidum pathways. This circuit dampens drive to act when tasks are stressful or unpleasant, impacting daily life and social functions. The discovery sheds light on conditions like depression and schizophrenia.
Bacteria move through liquids using propellerlike tails called flagella, which alternate between clockwise and counterclockwise rotation. Researchers propose a tug-of-war mechanism instead of the traditional equilibrium 'domino effect' model, where proteins lining the tail exert pressure on their neighbors.
The study reveals how shocks in one country or production stage can cascade across borders and life-cycle stages, triggering widespread failures throughout the global cobalt supply chain network. Systemic risks concentrate upstream but accumulate most severely at refining and manufacturing bottlenecks.
A study found that TRAP laws increase maternal morbidity among fertility care patients, while states without such laws have better health outcomes. The study suggests a significant association between TRAP laws and adverse pregnancy outcomes.
Researchers discovered how the Lsr2 protein in Mycobacterium tuberculosis (Mtb) protects against foreign DNA inserted into its genome. This mechanism involves the protein forming condensates that silence specific regions of Mtb DNA, preventing harm to the bacteria.
Both bariatric surgery and semaglutide treatment were associated with significant fat mass loss, moderate fat-free mass loss, and an improved FFM to fat mass ratio. These findings support interventions aimed at preserving muscle mass while promoting weight loss.
New research reveals that Indigenous communities in southern Brazil hunted large whales 5,000 years ago, long before previously thought. The study provides strong evidence of active hunting and sheds light on the economies, technologies, and lifeways of postglacial societies along the Atlantic coast of South America.
Scientists created three-dimensional pancreatic models to study the development of fluid-filled cavities. They found that low pressure and high cell proliferation rates produce complex, star-shaped lumens. The discovery can help understand organ development and diagnose diseases.
Researchers developed new imaging approaches using specialized amino acid PET tracers to visualize aggressive breast, lung, and glioma cancers. The studies showed promising results, highlighting the potential of these tools for future cancer imaging and guiding targeted therapies.
A study found that vaccinating pregnant women increases protection for infants against whooping cough, a highly contagious disease. The research team also showed that whole-cell pertussis vaccines provide longer-lasting protection than acellular vaccines, and recommends vaccination during pregnancy as a double-layered defense.
Researchers analyzed nearly 1.5 million immune cells from bone marrow samples of 335 newly diagnosed multiple myeloma patients, revealing previously hidden patterns in immune system behavior. The study provides unprecedented insight into immune dysfunction in myeloma and could lead to improved tools for predicting patient relapse risk.
Researchers have identified a new class of molecules that specifically degrade the cancer-promoting enzyme IDO1, offering a potential solution to enhance checkpoint-based immunotherapy. These IDO1 degraders may overcome limitations of previous inhibitors and open new avenues for treating various types of cancers.
Researchers at the Paul Scherrer Institute have achieved a breakthrough in developing all-solid-state batteries with high energy density and durability. They successfully densified the solid electrolyte using gentle sintering and applied a thin passivation layer to prevent lithium dendrite formation.
Researchers at Umea University have identified two autophagy protein complexes as the long-sought sensors of lysosomal damage. These proteins respond to protons or calcium leakage, initiating the repair system that seals the hole, thereby preventing inflammation and cell death.
The SPINECRAFT project aims to create a cutting-edge, 4D human spinal cord construct that mirrors the architecture and functionality of the real spinal cord. This platform will enable detailed studies of spinal cord biology and integrate patient-derived cells to recreate disease-specific environments.
Physicists at Trinity College Dublin propose a new means of capturing useful energy from light sources like sunlight, lamps, and LEDs. Theoretical analysis may lead to the development of optical devices that can channel light energy into a concentrated beam.
A data-rich review suggests that forest biological resources can offset up to 750 gigatonnes of CO₂ by mid-century if processing efficiency rises and green premiums fall. Engineered beams, biochar, and bioethanol can store carbon for decades, offering a 74% lifecycle GHG cut versus gasoline.
A study by Anglia Ruskin University found that patients with underlying conditions such as type 1 diabetes are at a significantly higher risk of complications from cosmetic botulinum toxin injections. The researchers recommend restricting administration to medically qualified professionals.
Researchers used neutron diffraction to investigate the mechanical behavior of a Ni-Co-based superalloy, identifying a distinct transition in deformation resistance. The alloy's low stacking-fault energy promotes screw dislocation arrangements and Orowan looping bypassing mechanism.
The study reveals that diabetes poses a significant challenge for healthcare systems and economies worldwide. The economic impact of diabetes is substantial, with an estimated global cost of up to $152 trillion, equivalent to 1.7% of GDP, when informal care is factored in.
A study at Kindai University has identified a single gene in eggplant that provides resistance to begomovirus infection. This finding holds promise for developing naturally protected crop varieties, reducing the need for insecticides and promoting sustainable food production.
Mesenchymal stromal cell (MSC) therapy has been validated as a transformative solution for rheumatoid arthritis through preclinical and clinical evidence. MSCs target RA via immunomodulation, tissue repair, low immunogenicity, and targeted migration, resulting in sustained benefits with minimal side effects.
The study highlights the multifunctional natural substitute for antibiotics in swine production, demonstrating broad antimicrobial, antioxidant, anti-inflammatory, and immune-regulating effects. Dietary supplementation improves intestinal barrier integrity, increases growth metrics, and reduces fecal E. coli.
Researchers have developed a new approach to suppressing the shuttle effect in transition metal fluoride cathodes, leading to unprecedented discharge plateau voltage and high-performance thermal battery cathodes. The study focused on thermal batteries and utilized an ion-sieving concept to achieve selective confinement.
A three-year study by the University of Stirling has shown that Himalayan balsam disrupts riverbank stability, causing erosion during high-flow periods. This leads to increased sedimentation, damaging habitats and wildlife, and changes to river shape and structure.
A team of researchers has observed a massive galaxy cluster that challenges existing models of the universe's evolution. The cluster's unusual structure and high density of cold, neutral hydrogen gas suggest a different history than previously thought. This discovery raises questions about the fate of large structures in the universe.
Researchers developed a novel thin-film electrolyte design using samarium-doped cerium oxide, achieving record-setting oxide-ion conductivity at medium temperatures. This innovation addresses key technical limitations of existing solid oxide fuel cells, paving the way for widespread adoption.
Researchers found that the West Antarctic Ice Sheet retreated at least five times during warmer periods millions of years ago, indicating its extreme vulnerability to future warming. The study analyzed deep-sea sediments and identified 14 prominent melt events between 4.65 and 3.33 million years ago.
The 2026 ACMG Annual Clinical Genetics Meeting will bring together experts in medical genetics and genomics to present groundbreaking research on personalized medicine. Journalists can access leading experts and timely story ideas on emerging technologies like AI in genetics and gene editing, with complimentary registration available.
A study found that increased bone morphogenetic protein signaling is linked to impaired neurogenesis in Alzheimer's disease, particularly in female mice. The research suggests that activation of BMP signaling may be a key factor contributing to the sex-based differences observed in AD.
Researchers found that close to half of all dementia cases would not arise without the APOE gene's influence, and potentially more than 90% of Alzheimer's disease cases are linked to variants in this single gene. The study highlights the APOE gene as a powerful target for drug development.
A global report highlights fragmented data systems and lack of standardization hindering botanic gardens' contribution to biodiversity conservation and scientific research. Researchers call for a unified, equitable global data system to transform how living collections manage and share information.
Researchers developed a new method to measure how effectively antibiotics kill bacteria, crucial for treating complex infections. The 'antimicrobial single-cell testing' method predicts treatment success by observing individual bacteria under different conditions.
Researchers identified changes in RNA molecules involved in cell's splicing machinery, causing retinitis pigmentosa in ~30-40% of patients with genetic disorder. Variants in five non-coding RNA genes were found to be responsible for the disease, offering a new diagnostic pathway for families worldwide.
Researchers created an 'atlas' of immune cells in bone marrow cancer that provides insights into how the immune system interacts with cancerous plasma cells. The knowledge can improve survival predictions and guide treatment decisions for patients with multiple myeloma.
Researchers discovered a subcellular environment within the giant virus Acanthamoeba polyphaga mimivirus that enables efficient translation of viral mRNAs despite mismatched codon usage with its host. This specialized environment alleviates the unfavorable translation condition, allowing for optimal viral replication.
Researchers have discovered new genetic causes of inherited blindness, identifying changes in RNA genes as a key factor. This breakthrough provides clarity for dozens of families globally and opens new possibilities for diagnostics and counseling in hereditary conditions, offering hope for affected individuals and their loved ones.
The Earth's ocean stored more heat in 2025 than in any year since modern measurements began, with a record-high increase of 23 Zetta Joules. The findings indicate stronger ocean warming trends since the 1990s and highlight the importance of reducing emissions to mitigate climate change.
A new study from Karolinska Institutet reveals that long-term type 2 diabetes can cause red blood cells to become directly harmful to blood vessels. The researchers found that microRNA-210 plays a crucial role in this process, and its levels in red blood cells may serve as a biomarker for early detection of cardiovascular complications.
A new sea surface height prediction model, GTU-Net, combines deep learning and physics-informed constraints to improve accuracy. The model outperforms existing mainstream models across multiple metrics and demonstrates higher accuracy up to 60 days.
A team of scientists creates a dynamically reconfigurable topological photonic platform that can control local topological properties in real-time using spatially patterned optical pumping. This enables the topological edge mode to be steered, redirected or blocked entirely by adjusting an external pump profile.
A new study found that federal rental assistance distributed during the COVID-19 pandemic improved mental health and increased the appropriate use of mental health care among low-income renters. The program reduced symptoms of anxiety and depression, and more recipients sought mental health services when needed.
Researchers develop Sb/Nb co-doped TiNb2O7 anode for fast-charging lithium-ion batteries, achieving 140 mAh g^-1 at 20 C and 500 stable cycles at -30 °C. The material enables practical pouch cells with high capacity retention after extensive cycling.
Researchers have developed a PPy@N-TiO2 Z-scheme heterojunction photoelectrode that harvests sunlight to co-drive sulfur redox, delivering high performance and scalability. The innovation enables efficient lithium-sulfur batteries with potential applications in solar-assisted EV packs and stratospheric drones.
A new study found that more than one-in-four adults worldwide may be eligible for GLP-1 use, with women and older individuals among the most eligible. The research emphasizes the need to prioritize global access to these medications, particularly in low- and middle-income countries where obesity rates are highest.
A study analyzing personal injury claims data for England and Wales found that mental trauma succeeds 1 in 7 dog-related injuries, resulting in the need for time off work and/or loss of earnings. Most incidents occurred in public spaces, with unrestrained dogs being a common cause.
A new review highlights major advances in aptamer-based biosensors for viral detection, offering faster, cheaper and more portable testing. These biosensors use short DNA or RNA strands called aptamers that bind to viruses with high precision.
A study of 168 second-time mothers found that those who breastfed were less likely to experience depression and anxiety 10 years after pregnancy. Each week of lifetime exclusive breastfeeding was associated with a 2% lower likelihood of reporting depression and anxiety, after accounting for influential factors.