eQTLs modulate gene expression through various molecular mechanisms, providing insights into disease etiology. eQTL analysis has elucidated the functional relationship between genetic variants and complex traits in diseases such as RA, T2D, breast cancer, and SZ.
A study by Bielefeld University used anonymized WhatsApp metadata to show that personalized feedback can help people understand their communication habits. Many participants adjusted their views on response speed and chat participation after seeing data-based visualizations.
Research highlights overlooked social mechanisms connecting oral health, eating and speaking difficulties, and cognitive decline. A six-year longitudinal study found poor oral health is a strong predictor of weight loss in older adults.
Cyanobacteria can absorb and break down guanidine, using it as their sole nitrogen source, according to a new study. The ability to utilize guanidine is an advantage for colonization, despite its previous classification as a toxic substance.
A team of researchers from Keio University has developed a novel system that uses Gaussian process regression to model and reproduce complex human motions. This enables robots to adapt to touch and interact with objects in dynamic environments, improving their dexterity and versatility.
A novel 18F-labeled reversible-binding radioligand, [18F]MAGL-2011, was developed for imaging monoacylglycerol lipase with positron emission tomography. The compound demonstrated favorable brain uptake and excellent in vivo binding specificity.
Researchers discovered that protein intelectin-2 has broad-spectrum antimicrobial activity against bacteria in the GI tract. It strengthens the mucus barrier and can directly neutralize or restrain bacteria, making it a potential therapeutic agent.
MIT Energy Initiative researchers developed the largest combined dataset on global ammonia supply chains, examining economic and environmental impact of different scenarios. The study found that a full transition to clean ammonia production could cut greenhouse gas emissions by nearly 71% for a 23.2% cost increase.
A joint study by Tel Aviv University and the University of Haifa discovered that a soft coral's tentacles drive rhythmic movements through a decentralized neural pacemaker system. The system enables each tentacle to perform independent movement while achieving precise collective synchronization.
A landmark study finds that structural brain changes tied to memory decline are nonlinear, stronger in older adults, and not solely driven by known Alzheimer's-associated genes. The study suggests that cognitive decline reflects a broad biological vulnerability in brain structure that accumulates over decades.
A novel photodynamic platform combines antibacterial action, hemostasis and pain relief under natural sunlight, enabling painless, antibiotic-free therapy for infected diabetic wounds. The treatment demonstrates rapid hemostatic capability and a pronounced analgesic effect.
A new hypothesis article proposes that HPV E6 and SARS-CoV-2 spike proteins could cooperate in suppressing host defenses including tumor suppressor mechanisms involving p53. Laboratory studies suggest that combined viral pressures on tumor-suppressor pathways may contribute to cancer progression.
The study, which reviewed over 10,000 abstracts from ten international databases, found no statistically significant link between economic inequality and well-being or mental health. The researchers suggest that policies focusing solely on reducing economic inequality may not be effective in improving population mental health.
Researchers discovered peptidomimetic inhibitors that target the hydrophobic grooves on the surface of the CBP KIX domain, disrupting CREB/CBP interactions. These stapled sulfonyl-γ-AAp peptide derivatives exhibit effective antiproliferative activity in cell-based assays and inhibit tumor growth in vivo.
Researchers discovered the cerebellum's key role in regulating the brain's reward system in people with schizophrenia. Stronger cerebellar regulation is associated with reduced negative symptoms, while weaker regulation increases symptoms. This finding opens up new avenues for targeted therapeutic interventions.
A study in mice confirms the presence of two molecules that enable precise connection between inhibitory interneurons and target excitatory neurons. This link regulates information processing and maintains balance in brain circuits, with implications for understanding neuronal disorders such as schizophrenia and autism.
A new study published in the INFORMS Journal Management Science reveals that combining unisex and gender-specific restrooms can slash wait times and promote true inclusivity. By acknowledging diverse user needs, this approach promotes efficiency and inclusivity simultaneously.
Researchers have developed a new approach to targeting hematological malignancies using degradation tail-driven CELMoD–antibody conjugates. These conjugates, such as Dara-VA-I034, demonstrate potent antiproliferative effects and complete tumor eradication at low doses.
Scientists discovered a novel method to identify upper-layer ozone intrusion events, which substantially elevate surface ozone levels and intensify atmospheric oxidation capacity. ULOI events accelerate wintertime sulfate and secondary organic aerosol formation in the North China Plain.
A new foot-and-mouth disease vaccine developed by Diamond Light Source is projected to deliver over $1.3 billion in annual benefits, transforming global livestock resilience. The vaccine's unique features, including heat stability and scalability, make it a game-changer for farmers worldwide.
Researchers developed a method to encapsulate nanodroplets of thyme extract, enabling small doses and avoiding evaporation. The technique demonstrates accurate thyme extract nanodosing is possible and can be extended to other aqueous extracts.
A new method harnesses differences in surface tension to efficiently transport liquids off microscopic surfaces, enabling efficient production of micro- and nanomaterials without damaging them. The technique uses a contact-free approach to steer fluid currents in the desired direction.
Physicists from the University of Illinois discovered a unique phenomenon where chiral materials respond to light by amplifying certain frequencies. The study sheds light on how interplay between symmetry and magnetism can lead to extraordinary effects in everyday systems.
Researchers identify a concrete biological mechanism that triggers MS, focusing on B cells and Epstein-Barr virus. This understanding may help guide future strategies to prevent or treat MS.
Researchers developed exosomes targeting myofibroblasts loaded with siFKBP10, which silenced FKBP10 gene expression, inhibiting fibroblast activation and extracellular matrix deposition. This study demonstrates a promising therapeutic strategy for idiopathic pulmonary fibrosis (IPF) treatment.
A new study by Concordia researchers explores how anxiety-inducing headlines fuel 'maternal responsibilization,' where mothers are expected to pick up the slack on addressing complex issues like climate change and social injustice. The research highlights the pressures of motherhood, including generational expectations to raise childre...
New study reveals how circular economy startups create new opportunities by reducing their environmental impact, engaging in experimentation and feedback-driven development. The research highlights three key practices that reshape markets and influence the competitive landscape for larger players.
Researchers developed an injectable hydrogel delivery system to co-deliver oncolytic adenovirus and melphalan for treating retinoblastoma. The treatment effectively controlled tumor growth, prevented brain metastasis, and preserved retinal structure and function.
PLOS has partnered with Charlesworth to expand access to publishing services for Chinese researchers and institutions, reinforcing its commitment to supporting open science globally. The partnership will enable PLOS to strengthen its presence in China through localized sales representation and innovative tools.
A new study finds that multinational firms approach patent litigation as part of a coordinated global strategy, concentrating lawsuits in jurisdictions with similar legal outcomes. When outcomes diverge, firms diversify their litigation locations to manage uncertainty and risk.
A new strategy for parallel adaptive Cartesian grid generation is introduced, combining features of generated grid cells and estimating iterations needed. This approach significantly speeds up grid generation using the same number of cores, improving computational efficiency and scalability.
A new study by ESMT Berlin shows that entrepreneurs can increase support from the silent majority by broadening their public replies to vocal commenters. By managing conversational pathways, founders can create multiple entry points without fragmenting the main story.
A novel parameterization method for orbits near collinear libration points has been developed, allowing for systematic cataloging and robust identification of cislunar objects. The method enables the characterization of motion along two directions, providing critical insight into spacecraft maneuvers and transfer events.
A study investigates dynamic changes in cardiac function and mitochondrial damage in a mouse model of cirrhotic cardiomyopathy. Key findings include progressive cardiac dysfunction, inflammation, and mitochondrial injury contributing to disease progression.
A new study examines behavioral mechanisms of rural distributed photovoltaic development, finding that collaboration between PV enterprises and village organizations is key to expanding adoption. The research also highlights the importance of balancing self-consumption requirements with grid capacity constraints.
A comprehensive genomic characterisation of E. coli strains isolated from diabetic foot ulcers reveals high diversity and antibiotic resistance. The study provides valuable insights into the specific pathogens involved in diabetic foot disease and suggests potential targets for improved treatment strategies.
A nationwide study found that depression frequently precedes the diagnosis of Parkinson's disease and Lewy body dementia. The risk of depression rises steadily in the years leading up to diagnosis, peaking before diagnosis, and remains elevated for several years afterward.
Aspiring nature writers will participate in a unique workshop and ecotour in the remote Smith Inlet, led by Lesley Evans Ogden. The program offers daily writing coaching and feedback sessions, with optional one-on-one coaching, and includes accommodations, meals, and wildlife tours.
A new approach to treating KRAS-mutated lung adenocarcinomas has been identified, using a combination of ERBB inhibitors and Aurora kinase inhibitors. This therapy shows significant effectiveness against existing treatments, offering hope for patients with limited options.
The FXYD family proteins have diverse physiological and pathological roles, influencing ion transport in different organs and tissues. Altered expression or dysfunction of these proteins is associated with numerous diseases, including cardiovascular, neurological, renal, and cancer disorders.
A study found that the rate of opioid use disorder medication use among surgical patients increased significantly between 2016 and 2022. The majority of users were taking buprenorphine, which has advantages in safety and pain control compared to other options.
A landmark study identifies 11 lipid-related metabolites that are causally associated with major depressive disorder (MDD), including 8 protective effects. The research reveals shared genetic signals between lipid metabolites and MDD, clustering in key genomic regions involved in fatty acid metabolism.
Researchers create a powerful modular soft origami actuator that enables high-speed, agile movements in search and rescue applications. The Electrohydraulic Origami (EHO) actuator achieves remarkable dynamic performance, outperforming existing soft actuators.
A 12-month aerobic exercise program reduced brain age by 0.6 years, while a control group showed a slight increase. The study suggests that following current exercise guidelines may help keep the brain biologically younger in midlife, supporting clearer thinking and stronger memory.
Resonant breathing significantly reduced anxiety and insomnia symptoms and improved heart rate variability in hospitalised psychiatric patients with severe somatic symptoms. The intervention was well-tolerated and required minimal cognitive effort.
Researchers have developed a refined mouse model that mimics chronic Pseudomonas aeruginosa lung infection in old age, overcoming limitations in experimental respiratory infection research. The agar bead-based delivery strategy allows sustained observation of infection dynamics, tissue damage, and immune responses in aging lungs.
Researchers developed a novel aqueous electrolyte, MASSE, which improves AZMBs stability and reversibility at elevated temperatures. The multiphase design suppresses side reactions and promotes uniform zinc ion deposition, enabling stable battery operation in harsh thermal environments.
Scientists at Technical University of Munich create constructed soils by mixing excavated soil with compost and biochar, resulting in improved fertility and carbon accrual. These new urban soils can be tailored to specific use cases, such as protecting groundwater or enhancing plant growth in green areas.
The American Cancer Society's new 'Cancer Statistics, 2026' report reveals a historic milestone: US cancer survivorship has reached a record 70%, driven by major gains in cancers once considered difficult to treat. However, the report also highlights persistent disparities, concerning increases in cancer among women and younger adults.
Researchers identified bradycardia as a symptom of xylazine-opioid overdose, particularly in the Northeast, where xylazine is more prevalent. This finding may aid emergency medicine physicians in detecting xylazine exposure and providing harm reduction counseling.
A study of Western populations found broad public approval for supporting Ukraine to maintain its political and territorial sovereignty. Key findings include a strong endorsement of military support, rejection of Russia's positions on territorial claims, and limitations on public backing due to high casualty numbers and nuclear escalat...
Researchers developed a copper-palladium bimetallic catalyst that produces high-quality ammonia through an electrochemical nitrate reduction reaction. The catalyst's dynamic Cu-PdH x interface sites exhibit superior intrinsic activity, achieving remarkable production rates and durability.
The double swept waverider demonstrates outstanding comprehensive performance through numerical simulation verification. It maintains an ideal longitudinal static stability margin of approximately 2%, laying a solid foundation for practical engineering applications.
The Giant Magellan Telescope has appointed Daniel T. Jaffe as its new president, succeeding Robert Shelton, who announced his retirement last year. Jaffe brings decades of leadership experience in research, astronomy instrumentation, and academia to lead the observatory through its next phase of construction.
A team of researchers has developed a robust hydrogen-bond network in electrolytes to enhance the performance of aqueous zinc-ion batteries. The new design minimizes the reactivity of water molecules, suppressing deterioration on both electrodes and achieving long-lasting cycling stability with high capacity retention.
Scientists discovered that the brain sorts emotionally significant stimuli into three independent channels: salience, valence, and value. This allows the brain to evaluate information efficiently and guide decisions.
A new global modeling study introduces a differentiated carbon pricing mechanism to coordinate regional carbon prices with cost-fairness. This approach helps raise climate ambition by reducing trade and welfare imbalances, particularly for energy-intensive and trade-exposed industries.
Scientists used multiple space-based instruments to track the evolution of a solar eruption, observing how it reduced background cosmic-ray activity. This approach has potential for improving space-weather forecasting and protecting satellites, astronauts, and power grids.
Scientists successfully observed a quinoxalinyl radical forming within nanoseconds using µSR spectroscopy. The technique enabled real-time detection of highly reactive aromatic heterocyclic radicals in isocyanide insertion reactions.
A Korea University study successfully mimics heart mechanics in organoids using three-dimensional magnetic torque, enhancing cardiac differentiation, maturation, and vascularization. This breakthrough could improve drug safety testing by providing more accurate human-relevant models for cardiotoxicity screening.