New research suggests that messier, less-stuffed nanoparticles may actually deliver drugs more effectively than tightly packed ones. By measuring individual nanoparticles, scientists found two distinct subpopulations: organized particles with neatly structured cargo and amorphous particles with disorganized cargo.
Researchers discovered that TRPV4 acts as part of the nervous system's internal stop-scratching circuit, triggering a negative feedback signal to regulate itch behavior. Mice lacking neuronal TRPV4 scratched less frequently but with longer-lasting itchy bouts.
Researchers have found that proteins vital for sound signal transmission in the ear also manage the fatty molecules on the cell membrane. When these proteins malfunction, it can trigger permanent hair cell death and lead to hearing loss.
Researchers have developed a low-cost, open-source microscope called FlightScope to study living cells in zero-gravity conditions. The device successfully captured images of cells responding to fluorescently labeled glucose molecules, revealing slower uptake rates under microgravity compared to normal gravity conditions.
Scientists have discovered that mycobacteria release tiny packages called extracellular vesicles that fuse with immune cells' membranes, making them more rigid. This helps the bacteria avoid destruction and survive inside human cells. The study reveals an entirely new way of understanding how mycobacteria survive, opening promising ave...
Researchers have captured the first detailed images of TRPM8, a protein channel that responds to cold temperatures and triggers a nerve signal to the brain. The study reveals how menthol activates the channel through shared yet distinct allosteric networks, with implications for treating conditions like chronic pain and dry eye.
Denis V. Titov's paper, published in Biophysical Journal, presents a detailed biophysical model of glycolysis, solving a complex problem and providing insight into cell energy metabolism. The award recognizes outstanding early career work in biophysics.
Harvard researchers developed a multicolor electron microscopy technique that combines strengths of two powerful microscopy methods, allowing for vivid color and nanometer resolution. This breakthrough enables studying cell signaling, molecular clusters, and protein locations within cells.
Researchers at Tokyo Metropolitan University have created a neutral molecule that can carry DNA into biological cells using a process called annealing. This breakthrough promises more effective therapies by reducing inflammation and improving delivery efficiency.