About The Study: The results of this randomized clinical trial support use of metformin for treatment of symptomatic knee osteoarthritis in people with overweight or obesity. Because of the modest sample size, confirmation in a larger clinical trial is warranted.
Corresponding Author: To contact the corresponding author, Flavia M. Cicuttini, PhD, email flavia.cicuttini@monash.edu .
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(doi:10.1001/jama.2025.3471)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the Osteoarthritis Research Society International World Congress.
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