About the Study: In this randomized clinical trial, CT-155 improved motivation and pleasure negative symptoms with a small-to-moderate effect size comparable with psychosocial interventions and pharmacologic treatment in psychiatry and was well tolerated and safe, thus representing a novel adjunctive therapy for schizophrenia. CT-155 may represent a scalable, accessible option for improving schizophrenia negative symptoms.
Corresponding Author: Abhishek Pratap, PhD, Global Clinical Development Mental Health and Eye Health, Boehringer Ingelheim Pharmaceuticals Inc, 900 Ridgebury Rd, Ridgefield, CT 06877 ( abhishek.pratap@boehringer-ingelheim.com ).
10.1001/jamanetworkopen.2026.35753
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