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Nonregistration, discontinuation, and nonpublication of randomized trials

09.03.25 | JAMA Network

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About The Study: Findings from this systematic review indicated that nonregistration, premature discontinuation due to poor recruitment, and nonpublication of randomized clinical trial (RCT) results remained major challenges, especially for non–industry-sponsored trials. To mitigate these challenges, requirements enforced by funders and ethics committees also taking into account legal obligations should be considered and empirically evaluated.

Corresponding Author: To contact the corresponding author, Matthias Briel, MD, PhD, email matthias.briel@usb.ch .

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.24440?guestAccessKey=d272dd36-3307-4ccd-88be-0d8095689054&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=090325

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Editor’s Note: Please see article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Media advisory: This study is being presented at the 10 th International Congress on Peer Review and Biomedical Publication. For more information on the Congress, go to peerreviewcongress.org .

JAMA Network Open

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JAMA Network Media Relations
JAMA Network
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How to Cite This Article

APA:
JAMA Network. (2025, September 3). Nonregistration, discontinuation, and nonpublication of randomized trials. Brightsurf News. https://www.brightsurf.com/news/LMJ7E5NL/nonregistration-discontinuation-and-nonpublication-of-randomized-trials.html
MLA:
"Nonregistration, discontinuation, and nonpublication of randomized trials." Brightsurf News, Sep. 3 2025, https://www.brightsurf.com/news/LMJ7E5NL/nonregistration-discontinuation-and-nonpublication-of-randomized-trials.html.