Researchers found that treatment intensification can improve blood pressure control in patients with varying levels of adherence, challenging a widely held assumption. The study's lead author recommends further studies to determine the most effective management strategy for uncontrolled hypertension and suboptimal adherence.
Scientists have identified PLA2R, a protein found in normal human glomeruli, as the target antigen in idiopathic membranous nephropathy. This discovery holds promise for developing a blood test to replace kidney biopsies and determining which patients are most likely to benefit from immunosuppressive treatment.
Researchers from Boston University compared three measures of treatment intensity in hypertension care and found that the standard-based method predicts blood pressure control most effectively. The norm-based method was not a valid predictor of blood pressure control due to its non-linear relationship with systolic blood pressure.
Researchers estimated the probability of male carriers having a child with Huntington's disease, finding it ranges from 1/6,241 to 1/951. This estimate provides a baseline for genetic counselors and high normal allele carriers for family planning.
The study reveals that each bacterial strain presents a unique outer surface protein, rendering current vaccines less effective against new strains. Researchers believe a tip protein-based vaccine strategy could provide better protection.
Research from Boston University School of Medicine sheds light on how airways form and provide insights into lung diseases like asthma and COPD. The study reveals that Notch signaling controls the balance between ciliated and secretory cells in developing airways.
Biomedical engineers at Boston University have developed synthetic gene networks that enable bacteria to count discrete events, opening up potential applications in drug delivery and environmental sensing. The researchers designed two separate systems, the Riboregulated Transcriptional Cascade and DNA Invertase Cascade, which can be us...
Researchers at Boston University School of Medicine found that conventional methods to adjust for confounding, such as restriction and multivariable regression, leave residual confounding because of unmeasured factors. Propensity scores and instrumental variable methods have limitations in resolving confounding by indication.
A Boston University-led team has identified the structural basis of acetoacetate decarboxylase (AADase), a key enzyme in carbohydrate metabolism. The discovery corrects previous assumptions about enzyme structure and provides new insights into predicting enzyme functions, enabling the development of novel biofuels.
The study explores the therapeutic process of mother-infant psychotherapy, highlighting its unique catalytic factors that promote change and growth through relational connection and the 'now moment'. The findings emphasize the importance of observing and responding to infant behavior, recognizing maternal experiences and capacities, an...
A new study found a link between childhood sexual abuse and early onset of menstruation, with 26% increased risk for 1-3 incidents of abuse. The study analyzed data from over 35,000 African-American women aged 21-69 years.
Dr. Michael Holick's work revolutionized the understanding of vitamin D and its role in disease prevention, redefining vitamin D deficiency as a national epidemic.
Infection control methods could reduce hospital-acquired neonatal infections, which account for one-third of global child deaths. Multidrug-resistant GNRs were found in over 1,900 colonizing and infecting neonates, with high-risk factors including mechanical ventilation and prematurity.
Researchers found that people with periodontal disease have a higher percentage of TLR4-expressing B cells, which alter the immune response during inflammation. These cells activate monocytes but inactivate B cells, highlighting a new strategy for regulating systemic inflammation.
Richard Junghans, MD, has been awarded a $5.9 million grant from the Department of Defense Breast Cancer Research Program to research gene therapy techniques to modify patients' T cells and create 'designer T cells' to fight breast cancer.
Research at Boston University School of Medicine found that prenatal cocaine exposure may compromise selective areas of neurocognitive development during middle childhood. The study suggests the possibility of 'sleeper effects' of IUCE, which may become more apparent with greater cognitive demands.