Corewell Health, Michigan State University, and Every Cure partner to advance the use of decades-old drug difluoromethylornithine (DFMO) to treat ultra-rare Bachmann-Bupp syndrome. Early observations show promising results in improving symptoms, paving the way for clinical trials.
Researchers at Corewell Health aim to create the world's first algorithm to design personalized treatment plans for individual patients using dynamic SPArc therapy. This technology could reduce treatment time from 30 minutes to just five and improve access to high-quality cancer care.
A new study found that long COVID patients with brain fog and cognitive issues have higher levels of inflammation in their brains and a lower ability to adapt to stress. The study suggests that physicians can identify individuals who are struggling sooner and provide wrap-around care to help them.
A patient with adenoid cystic carcinoma was successfully treated with step-and-shoot proton arc therapy at Corewell Health William Beaumont University Hospital. The treatment showed minimal side effects, including only light skin discoloration, and the patient remains cancer-free.
A new study published in Microorganisms highlights the importance of small molecule drugs that target the unchanging parts of the SARS-CoV-2 virus. The research suggests that these stable targets could provide a consistent and reliable treatment option for COVID-19, even as vaccines are updated to address changing viral strains.
A recent study analyzing over 1.5 million patients' electronic health records found that mild cognitive impairment (MCI) is significantly underdiagnosed in rural areas of West Michigan. Researchers discovered a higher rate of MCI skippers, where patients progress directly to dementia without a prior diagnosis, in these communities.
A new study suggests that MRI scans can help doctors identify patients with more aggressive prostate cancer, allowing for earlier treatment or active surveillance. The research found that suspicious lesions on an MRI test were associated with a higher risk of advanced disease in five years.
Researchers developed CT-Derived Functional Imaging, a software program that calculates lung volume changes and blood mass without contrast dye. The technology has improved diagnoses for up to 30% of patients who couldn't tolerate contrast dye, and also benefits all patients with lung issues such as COPD and cancer.
A simple MRI scan and a new metric for prostatic urethra length may help identify men at risk of chronic urinary side effects after radiation therapy. The study found that longer prostatic urethras are associated with a higher likelihood of these symptoms, which can impact quality of life.
A new study aims to identify environmental and social factors contributing to Alzheimer's disease in older Black adults, who are up to two times more likely to develop the condition. Using remote cognitive assessments and biomarkers, researchers hope to gain a better understanding of the biopsychosocial factors behind this disparity.
A new Michigan State University and Corewell Health research found that in-home prenatal services can significantly reduce the risk of premature births and infant deaths. Pregnant individuals receiving enhanced prenatal care saw a 57% reduced risk, while expectant Black mothers experienced an even greater reduction.
A team of researchers has discovered that a naturally produced chemical in the body helps glioblastoma cells go unrecognized by the immune system. The findings could lead to the development of new and more effective treatments for this aggressive brain cancer.
A Corewell Health study uses predictive analytics to identify and support patients at high risk of hospital readmission, resulting in a $5 million cost savings. The program uses a patient-centered approach to address barriers to recovery, including clinical challenges, behavioral health, and social determinants.
Research on COVID-19 variants reveals that infants and toddlers with co-infections are significantly more likely to need oxygen therapy and ICU-level care. Co-infection rates were highest during the delta variant, followed by omicron and alpha.
Researchers at MSU and Spectrum Health aim to find new treatments for rare 'orphan diseases' by repurposing existing approved drugs using advanced technology, focusing on three initial diseases: MODS, diffuse intrinsic pontine glioma, and hepatocellular carcinoma.
A new study has identified specific obesity-related factors that increase the risk of developing renal cell carcinoma, a type of kidney cancer. These factors include multiple measures of obesity, diastolic blood pressure, and fasting insulin, but not systolic blood pressure or circulating lipids.
A phase II clinical trial shows that DFMO, an oral medication, improves the nearly 50 percent rate of relapse in children with High Risk Neuroblastoma. The two-year survival rate for these children is 97 percent, a large increase compared to previous treatments.
Researchers identified a rare genetic disorder in a human patient caused by mutations in the ornithine decarboxylase 1 (ODC1) gene. The disorder is characterized by large birth weight, hair loss, and developmental delays, and may be treatable with the FDA-approved drug DFMO.
A new treatment for children with neuroblastoma has shown promise in a phase I study, with minimal side effects and long-term survival of three patients. The drug DFMO targets an important cancer stem cell pathway to 'turn cells off,' potentially preventing relapse.
The hospital has successfully integrated two common imaging techniques to produce a three-dimensional anatomic model of a patient's heart. The technology combines computed tomography (CT) and magnetic resonance imaging (MRI) with echocardiography, enabling more accurate diagnoses and treatment plans.
A recent study published in the British Journal of Neurosurgery found that surgery can be an effective treatment option for older epilepsy patients, with 74% remaining seizure-free compared to 58% of younger patients. However, caution is needed regarding postoperative memory decline in older adults.
Researchers used near-infrared spectroscopy to detect lipid core plaque in narrowed arteries of 20 patients experiencing a STEMI. The study found that the characteristic makeup of arterial plaque blocking an artery and causing a heart attack can be identified in living patients.
Fecal microbial transplantation has been shown to improve symptoms in most pediatric patients with active ulcerative colitis, with 78% achieving clinical response within one week. The procedure involves infusion of human stool from a healthy donor into the intestine of the patient to restore healthy microbial flora.