A purified form of a modified sugar chain called COAM is shown to enhance early-stage immune defenses in mice against deadly virus infections. The compound speeds the response of white blood cells at the early stage of infection, almost completely blocking the killer virus.
The Federation of American Societies for Experimental Biology (FASEB) has awarded 7 MARC travel grants totaling $12,950 to support underrepresented minority students and postdoctorates at the 2010 ASHG Annual Meeting. The awards promote diversity in biomedical research and encourage young scientists' participation.
Researchers found that narciclasine, a natural compound in daffodil bulbs, markedly reduces cancer cell proliferation and migration. The study suggests that narciclasine selectively inhibits the growth of very aggressive cancer cells while avoiding adverse effects on normal cells.
Researchers developed a new animal model that uniquely identifies genes associated with increased resistance to disease in high-runners, which could help explore mechanisms underlying complex diseases and develop effective diagnostics and therapies.
Researchers identified a novel negative regulator called eye transformer that controls the flow of information from chemical signals to genes in the cell nucleus. When this regulator is turned off, the JAK/STAT pathway hyper-activates, leading to conditions such as cancer, severe immune deficiencies, and autoimmune diseases.
The FASEB MARC Program has awarded $7,400 to four poster/platform presenters and faculty mentors at the ASBMR 2010 Annual Meeting. The program aims to increase diversity in biomedical research by supporting underrepresented minorities.
A new study published in The FASEB Journal suggests that muscle inflammation after acute muscle injury is essential to muscle repair by means of insulin-like growth factor-1. Inflammation, once thought to be detrimental to healing, plays a crucial role in repairing damaged muscle tissue.
Researchers discovered that lipopolysaccharide and polyI:C stimulate factor B production in macrophages through distinct but overlapping mechanisms. This finding highlights the complexity of the immune system and its redundancy, enabling it to counter bacterial and viral strategies.
Researchers have identified a protein called P450 that metabolizes arachidonic acid in blood vessel walls to create EETs, which relax blood vessels and lower blood pressure. This discovery may lead to the development of new blood pressure-lowering agents and treatments for high blood pressure.
Researchers propose a new approach to combat cancer and autoimmune diseases by targeting the balance between NF-kB and p53 signaling pathways. This balance is believed to be a promising target for developing new drugs, with potential benefits including improved disease treatment outcomes.
The FASEB MARC Program has selected 5 recipients to receive travel awards totaling $12,500. The awards aim to promote diversity in biomedical research by encouraging participation of young scientists from underrepresented minority groups.
The FASEB MARC Program has announced travel awards for 22 recipients, including students and faculty mentors, to promote diversity in biomedical research. The awards total $31,250 and aim to increase underrepresented minorities engaged in biomedical research.
The FASEB MARC Program has awarded $18,500 to Ashley S. Triplett from the University of Louisville for participation at the 2010 SLB Meeting, aiming to increase underrepresented minorities in biomedical research. The program, funded by the National Institute of General Medical Sciences, supports young scientists and postdoctorates.
The FASEB MARC Program has conferred $16,650 in travel awards to 9 recipients at the 2010 BMES Annual Meeting. The program aims to promote underrepresented minority students and scientists in biomedical research.
The FASEB MARC Program has announced travel award recipients for the 2010 IPE Meeting, promoting diversity in biomedical research. The program conferred 12 awards totaling $22,200 to support underrepresented minority students and scientists.
A new study published in the Journal of Leukocyte Biology suggests that our innate immune systems are a major contributor to chronic lung diseases like silicosis. Researchers found that mice with an inactive adaptive immune system developed more severe silicosis, highlighting the importance of reducing chronic inflammation.
Researchers have identified a critical regulatory switch in mesenchymal stem cell lineage allocation, which could lead to the development of new treatments for obesity and osteoporosis. The 'Sprouty' protein has been shown to regulate body fat and bone mass, with potential applications for weight loss and bone density improvement.
A study published in the FASEB Journal finds that only a few highly cited scientists hold top leadership positions at research universities. The authors suggest that a glass ceiling may exist, limiting opportunities for highly cited researchers to pursue executive management roles.
Researchers found that blocking PD-1 improves survival in a model of severe infection by restoring the host's immune function. The study suggests new drugs to reduce severity of blood infections leading to sepsis.
A peptide derived from bee venom can deliver liposomes bearing drugs or diagnostic dyes to specific cells or tissues, improving the effectiveness of cancer treatment. This 'smart bomb' technology may help design personalized treatment regimens that can selectively target tumors and other diseases.
Research published in the Journal of Leukocyte Biology suggests that bortezomib induces cell death only in active and proliferating T cells, leaving resting T cells untouched. This could lead to a new treatment option for inflammatory diseases without affecting all T cells equally.
Researchers identified defensin-1 protein in honey as a potent antibacterial agent, showing promise in treating burns, skin infections, and combating antibiotic-resistant infections. The discovery sheds light on the inner workings of honey bee immune systems, potentially leading to healthier bees.
A new study in the FASEB Journal suggests that polyphenols in virgin olive oil can down-regulate atherosclerosis-related genes, leading to improved lipid profiles and reduced inflammation. This research provides insight into how specific foods can modify gene expression, offering potential therapeutic benefits for cardiovascular disease.
Researchers found that polyphenols in red wine and green tea inhibit cancer growth by disrupting the sphingosine kinase-1 survival pathway. This discovery could lead to the development of drugs targeting this pathway to stop or slow prostate cancer progression, improving current treatments.
Researchers discovered that Lactobacillus reuteri reduces muscle contractions in the gut within minutes of exposure. This bacterium naturally occurs in human breast milk, suggesting a potential treatment for various gut disorders.
Researchers discovered a chain of molecular events that increase skin cancer risk, enabling doctors to assess genetic risk and develop new sunscreens. The study may lead to genetically tested sunscreens and personalized medicine for individuals carrying MC1R gene changes.
A new study in the FASEB Journal reveals that different coral species invest varying amounts of resources in immunity and defense, which may explain differences in susceptibility to negative environmental impacts. The research highlights the importance of maintaining favorable environmental conditions on reefs to maximize coral immune ...
Scientists have discovered that CCL5 plays a protective role in warding off tuberculosis by attracting immune cells to infection sites. The protein may lead to new therapies that help the immune system resist TB, providing hope for treating this global disease.
A study published in the Journal of Leukocyte Biology found that manipulating intestinal microbiota with probiotics and prebiotics could improve celiac disease quality of life. The research also discovered that different types of gut bacteria influence inflammation to varying degrees.
Researchers developed a novel noninvasive tool using fluorescent microspheres to detect early inflammation in the eyes. This breakthrough allows for early detection of diseases such as eye disease, potentially reversing damage before it occurs. The tool may also improve therapy evaluation and extend to other areas of the body.
Experts will present on techniques using digital technology to separate conjoined twins, develop facial prostheses, and analyze anthropologic specimens. The symposium aims to enhance outcomes through the use of digital tools, such as radiographic data and tactile medical modeling.
Research suggests that epigenetics plays a key role in the development of degenerative diseases. Environmental influences can alter gene expression, which can be passed on to offspring and impact life and death. HDAC inhibitors, found in foods like broccoli and garlic, may help prevent cancer by silencing tumor suppressor genes.
A new study has found that genetically short-circuiting the ability of cancer stem cells to absorb a key nutrient can kill many colon cancer cells. The approach targets tumor cell 'factories' and could potentially reduce recurrence rates of colon cancer. However, further research is needed to ensure the treatment does not harm normal s...
A study of young adults in Mexico City found that exposure to particulate matter and endotoxins can cause chronic inflammation in the heart, increasing the risk of heart disease. The research highlights the importance of understanding how air pollution affects the human heart, particularly in vulnerable populations.
Researchers have provided evidence-based data on changes in drug metabolism in obese children compared to healthy weight children. They found that obese children metabolized caffeine and dextromethorphan at different rates, which could impact optimal drug dosing in pediatric patients.
A study found that consuming a non-spicy pepper analog increased fat oxidation and boosted metabolism, potentially aiding in weight loss. The research suggests that eating peppers could be a simple way to enhance weight loss efforts.
Researchers have discovered a new avenue to overcome tuberculosis drug resistance by targeting an enzyme that breaks down beta-lactam antibiotics. Clavulanate and meropenem combination shows promise in sterilizing TB bacteria, including XDR-strains.
Research suggests that low to moderate alcohol consumption has no negative effects on bone health or circulating levels of vitamin D in postmenopausal women. The study also found that moderate alcohol intake does not affect markers influencing alcohol metabolism.
Researchers discovered that activated farnesoid X receptor (FXR) slows the growth of tamoxifen-resistant breast cancer cells. FXR inhibition reduced survivability in both sensitive and resistant cell types, with more significant effects on the resistant MCF-7TR cells.
A symposium at the American Association of Anatomists' Annual Meeting explores the evolution of human evolution through ancient mummies, skulls, and bones. Modern technology enables researchers to examine mummified remains without harming tissue, providing insights into disease evolution and death causes.
Recent evidence suggests that bones and muscles are interconnected, releasing signals to affect each other's function or disease state. The discovery could lead to novel therapies for age-related muscle and bone disorders, which cost the US $14 billion annually.
New research shows that high phosphate levels in sodas and processed foods can accelerate the aging process in mice, contributing to age-associated complications like chronic kidney disease. Humans need a balanced diet, and avoiding phosphate toxicity may be important for longevity.
Researchers found that SSRIs slowed platelet clumping in participants taking the medication to treat depression, suggesting a potential beneficial effect on cardiovascular health. The study's findings could indicate a lower risk of cardiovascular disease for people taking SSRIs to treat depression.
Women with preeclampsia have reduced incidence of breast cancer, possibly due to soluble endoglin inhibiting cell growth. However, pups born from mothers with preeclampsia are more likely to develop breast tumors.
A new imaging protocol allows scientists to visualize the activity of dopamine receptors in the brain, revealing a 15-20% decrease in receptor density among individuals with addictions. This finding could lead to better understanding of drug addiction and development of more effective treatment strategies.
Researchers found that African American boys have higher levels of angiotensin II, a hormone that contributes to high blood pressure, while African American girls have lower levels of protective angiotensin (1-7). These findings suggest that changes in hormone metabolism may occur before blood pressure changes, potentially leading to p...
Scientists have created an enzyme called CocE that can rapidly break down cocaine and its toxic metabolites. This breakthrough could lead to a new therapy for treating cocaine overdose, which causes over half a million emergency room visits annually.
Researchers found that the subaleurone layer of brown rice inhibits angiotensin II, a protein linked to high blood pressure and atherosclerosis. This discovery suggests that consuming half-milled or brown rice may offer cardiovascular protection.
Recent advances in microbial genomics have enabled researchers to study the human microbiome, revealing its essential role in digestion and immune system development. The Human Microbiome Project aims to optimize the beneficial effects of microbiota for each individual, improving health outcomes.
A new device, Walk n'Play, helps monitor low-level physical activity using a cell phone's motion sensors. The program encourages users to be more active by turning physical activity into a game, promoting incremental changes that can lead to better health.