Researchers identified genetic regions responsible for animal tameness in a rat model of domestication. The study provides insight into the genetics and biology of tameness, potentially leading to more precise breeding strategies for tame animals.
Researchers have developed a credit card-sized device that can detect heart disease using just 200 microliters of blood, a significant improvement over current techniques. The device collects endothelial progenitor cells, which can be used to grow new vascular tissue for transplants and bypass surgeries.
Death receptors, which eliminate unwanted cells, may also be used to strengthen cells against illnesses. Researchers can develop new therapeutics that target these receptors to treat various diseases.
Researchers found a distinct link between the ABCC11 gene and excessively smelly armpits, wet earwax, and breast cancer risk. The study discovered that a specific SNP in the ABCC11 gene determines earwax type.
Scientists have created a new protein-based microbicide that can kill HIV when used as a preventative measure. The innovation involves combining two existing proteins into a single molecule, which is then produced in large quantities using plant cells.
A new editorial in the FASEB Journal examines the risks of dietary supplements, highlighting regulatory loopholes that enable toxic substances to enter the market. Gerald Weissmann argues that these supplements represent unregulated drugs with tangible personal and professional consequences.
Researchers discovered that the influenza virus can paralyze the immune systems of healthy individuals, leading to severe secondary bacterial infections like pneumonia. The study found that this immunological paralysis is long-lived and specific to influenza infection.
Researchers successfully transform human skin cells into mouse muscle cells and vice versa, providing insight into cell specialization and potentially bypassing stem cells. This breakthrough may lead to novel treatments for diseases by directly generating necessary cells.
Researchers identified a previously unknown cellular switch that regulates both allergic and asthmatic responses in the body. This discovery suggests that at least some people with asthma and allergies have genes that prevent this switch from working properly, leading to medication development targets.
Scientists have developed a new tool to identify big events in human history by examining tiny genetic differences. This research, published in the journal Genetics, confirms a major decline in European populations 32,500-47,500 years ago and helps pinpoint gene mutations linked to diseases such as cancer and heart disease.
A recent study has found that the Humanin peptide protects against neuronal cell death and regulates insulin metabolism, significantly improving glucose levels in diabetic rats. The discovery provides new insight into the role of the brain in glucose metabolism and suggests a potential therapeutic approach to diabetes.
Recent studies show that short sleep can disturb appetite control, leading to overeating and increased risk of Type 2 diabetes. Researchers also found that chronic sleep deprivation can lead to glucose intolerance without weight gain.
Researchers discovered an antioxidant, ellagic acid, which prevents collagen destruction and inflammatory response in human skin cells and mice exposed to UV-B. The study found that ellagic acid reduces MMP secretion and inflammation, demonstrating its potential to prevent wrinkle formation and photo-aging.
A study published at Experimental Biology 2009 found that regular exercise prevents the disruption of the blood-brain barrier caused by methamphetamine use. The study showed that exercising mice were protected from increased oxidative stress and permeability in the brain, while sedentary mice experienced damage.
Scientists discovered brain proteins bind to and activate THC receptors, similar to marijuana, sparking hope for new treatments for pain, appetite stimulation, and reduced marijuana abuse. The study may lead to effective drugs with fewer side effects.
A new nanoparticle has been developed to deliver a tumor suppressor gene to cancer cells, restoring normal gene function and bypassing healthy tissue. This breakthrough method shows promise in reducing the probability of recurrent tumors.
Scientists have discovered a compound that selectively targets the M1 receptor, implicated in diseases like AD and schizophrenia. This finding holds promise for developing an effective treatment with minimal side effects.
Higher frequency vibrations cause immediate changes in peripheral vascular systems, while lower frequency vibrations can lead to long-term vascular problems. Researchers found increased oxidative stress and pro-inflammatory factors in rats exposed to higher frequencies.
A recent lab study found that adolescent rats exposed to THC experienced lasting negative effects on learning and memory, even if they didn't have ovaries. The study suggests that THC use during critical developmental periods can sensitize females to the negative effects of THC later in life.
A humanized mouse infected with HIV has enabled researchers to test antiviral protection against AIDS. The study shows that pre-exposure treatment and post-exposure treatment can prevent both vaginal and rectal transmission of the virus.
Researchers found that chewing sugar-free gum reduced sweet snack consumption by 60 calories and overall snack intake by 40 calories in participants. The study suggests chewing gum can play a role in appetite control, weight management, and reducing calorie intake.
A new study found that transplanted liver cells from older donors work equally well in both young and old recipients, but have lower proliferation rates due to lower growth factor levels. The research suggests that injecting the growth factor IGF1 into older rats may increase hepatocyte cell proliferation.
Research shows that children in poor, rural Mississippi Delta areas are willing to try fresh fruits and vegetables, with many consuming a large variety and quantity. However, the lack of grocery stores, fast food options, and quality delivery of fresh produce hinders their ability to make healthy choices.
Researchers have identified an epidermal growth factor receptor aberrantly active in approximately a third of human pancreatic cancers, providing a new treatment target for this fatal disease. The discovery also holds promise for developing a blood or urine screening tool to detect pancreatic cancer earlier.
A new study published in The FASEB Journal reveals that poor nutrition during pregnancy can lead to permanent genetic changes in the offspring, causing health problems such as diabetes, growth retardation, and cardiovascular disease. The researchers found that rat fetuses receiving inadequate nutrition became genetically primed to be b...
Researchers have discovered a group of nerve ending receptors and chemicals that can activate them, providing a blueprint for the development of new laxatives. This breakthrough has the potential to make bowel movements easier, especially for infants and the elderly.
Research published in Genetics reveals genetic priming in females, making them more likely to choose certain males over others, influencing mating outcomes and future reproductive behaviors. The study's findings suggest that genetic compatibility is key to understanding love at first sight.
Astrocytes, star-shaped nerve cells, use specific machinery and recognition molecules to recognize viral invaders and initiate inflammation. This understanding may lead to new treatment strategies for viral infections of the brain and spinal cord.
A study published in the Journal of Leukocyte Biology found that bacterial remnants and genetics contribute to arthritis. The NOD2 gene is activated by muramyl dipeptide, leading to inflammation and disease progression. Researchers hope to find treatments that can either eliminate or mask this inflammatory signal.
A space experiment has shown that bone-destroying cells sense the absence of mechanical resistance and react by destroying bone. This discovery helps explain why bedridden patients and astronauts experience bone loss, providing a potential new drug target for stopping the process.
A team of American researchers has developed a genetic switch that allows mutations or light signals to be turned on in muscle stem cells, enabling monitoring of muscle regeneration in living mammals. This breakthrough could lead to the creation of a genetic switch or drug for humans to grow new muscle cells and treat muscular dystrophy.
New research published in The FASEB Journal suggests that slight dips in brain temperature can cause an increase in abnormal tau protein, which is associated with Alzheimer's disease. This finding highlights the need for caution when anesthetizing patients with Alzheimer's or at risk of developing the disease.
Researchers analyzed wheat gene expression to understand its adaptability across climates and developed new strains for higher yields. The study found over 1 in 10 genes may be affected by a phenomenon contributing to the wheat's hearty nature.
A new study published in the FASEB Journal reveals that a gene in the blind mole rat, which allows it to thrive in low-oxygen environments, is also active in human tumors. This discovery could lead to the development of new anti-cancer drugs that 'suffocate' tumors.
Researchers have successfully used stem cells to grow on a scaffold made from tissue extract, overcoming two key challenges for organ transplantation. This breakthrough enables the creation of bioengineered organs that can be transplanted without rejection.
A new study published in the Journal of Leukocyte Biology suggests that interferon can improve the effectiveness of the current tuberculosis vaccine by enhancing dendritic cell function. The research found that type I interferon stimulated dendritic cells to produce a stronger immune response against Mycobacterium tuberculosis.
A team of European scientists discovered that going gray is caused by a massive build-up of hydrogen peroxide, which blocks the normal synthesis of melanin, our hair's natural pigment. This research provides an important first step in understanding the root cause of gray hair.
Researchers have identified a way for the brain to compensate for problems with neurotransmitters like serotonin and dopamine, opening up new treatment options for addiction, depression, Parkinson's disease, and schizophrenia. The discovery was made using fruit flies with a genetic mutation that disrupted monoamine neurotransmitter rel...
Researchers discovered that omega-3 fatty acids protect against liver damage and insulin resistance caused by obesity. The study found that lipids called protectins and resolvins derived from omega-3 fatty acids reduced the incidence of liver complications in obese mice, leading to improved insulin tolerance.
Researchers have discovered how rhodopsin communicates with transducin in the retina, shedding light on vision's molecular processes. This breakthrough could lead to more targeted treatments for diseases like diabetes, allergies, and certain cancers.
Researchers identify eotaxin as a novel target for new class of allergy medications, which may help alleviate symptoms of asthma and other allergies. The study's findings could lead to breakthroughs in understanding the severity of allergic reactions and developing effective treatments.
Researchers have discovered a unique antibody that blocks the S1P receptor on T cells, reducing their numbers in the bloodstream and potentially treating autoimmune disorders such as colitis, lupus, and rheumatoid arthritis. The study's findings suggest a new horizon for reversing disabling and often fatal conditions.
Research published in the journal Genetics shows that fruit flies and humans regulate their circadian rhythms through similar cellular machinery. This discovery provides a viable animal model for circadian research and sheds light on the potential treatment of seasonal affective disorder, insomnia, and possibly some cancers.
Researchers developed an organic substance that attracts and supports cells necessary for tissue repair and can be directly injected into problem areas. The 'smart scaffolds' work by containing a protein that allows progenitor cells to adhere to damaged tissue and survive long enough to promote healing.
Scientists have discovered a new mechanism by which the human immune system adapts to infections, involving 'cluster mutations' in antibody genes. This discovery fills a significant gap in our understanding of how we survive microbial invasions and may lead to new ways to prevent illnesses or make them less dangerous.
A study published in the FASEB Journal found that even a low dose of caffeine ingested during pregnancy can affect fetal heart development and lead to decreased cardiac function and increased body fat in males. Researchers exposed pregnant mice to varying levels of caffeine, resulting in adverse effects on the offspring's health.
A new study published in The FASEB Journal suggests that infected gums may be a source of inflammation leading to heart disease. Proper dental hygiene can greatly reduce the risk of atherosclerosis, stroke, and heart disease independently.
Researchers at Boston University have found that consuming choline from eggs during pregnancy may affect breast cancer outcomes for a mother's offspring. The study suggests that genetic changes caused by prenatal choline exposure can impact tumor growth rates and survival rates.
A new study published in the FASEB Journal suggests that the quality of HDL cholesterol, not just its type, matters for good health. Researchers found that high levels of poor-quality 'good' HDL can increase heart disease risk.
Researchers found extensive bidirectional transfer of MHC molecules between donor and recipient cells, making transplanted organs 'invisible' to the immune system. This discovery has major medical implications for organ transplantation, potentially reducing rejection and increasing effectiveness.