This review highlights the 'youthful' gut microbiome characteristics of long-lived individuals, featuring increased α-diversity, beneficial bacteria, and anti-inflammatory metabolites. The study proposes a research paradigm for precision intervention and clinical translation, using AI-assisted screening to identify longevity resources.
Exogenous carbon addition to desert Chlorella sp. GTD4C-2 reshaped sugar metabolism and polysaccharide properties, leading to increased growth rates and antioxidant activity in glucose-supplemented cultures. Photoautotrophic conditions yielded polysaccharides with enhanced radical scavenging capacity.
Fungal communities in Chinese mangrove sediments exhibit scale-dependent assembly patterns, with regional-scale filtering by temperature and dispersal limitation, local-scale filtering by salinity and nutrient conditions, and micro-scale effects of cross-kingdom interactions.
Sporisorium scitamineum's pathogenicity and mating abilities increase with Ssppe1 overexpression, leading to severe physiological defects and increased sensitivity to stress. The gene is a potential target for antifungal agents.
The strain exhibited potent antagonistic activity against a broad range of phyllosphere microorganisms, including 13 pathogenic fungi and 12 non-pathogenic fungi. In field trials, X60 achieved 52.35% control efficacy against leaf spot diseases and significantly reduced phytopathogen abundance.
The A and B subunits of heat-labile enterotoxin trigger immune responses through the NF-κB pathway and NLRP3 inflammasome pathway, respectively. This discovery enables the engineering of safer, subunit-based mucosal vaccine adjuvants.
The fungus adapts its metabolic pathways to survive at low flavonoid levels, and activates a separate set of protective genes at high concentrations. This two-layer defense system enables it to maintain growth and enzyme production under stress conditions.
Researchers analyzed the nematicidal activity of two biocontrol bacterial strains, B133 and B104, against Meloidogyne incognita. The study reveals differences in genetic composition and metabolic mechanisms influencing nematicidal activity. These findings provide a theoretical foundation for targeted screening and genetic engineering o...
The journal Mycology invites submissions for an article collection on fungal biomanufacturing, a field that leverages microorganisms for bioproducts and pharmaceuticals. Guest advisors Yongjun Wei and Boyang Ji will guest edit the collection, bringing expertise in synthetic microbiology and genome-scale metabolic modeling.
The journal invites researchers to submit manuscripts on fungal secondary metabolism and biosynthesis. Guest advisors Professor Hideaki Oikawa, Professor Chengwei Liu, and Associate Professor Jianzhao Qi share their expertise in genome mining, biosynthetic pathways, and novel natural products.
Researchers optimized liquid fermentation for Cladophialophora guangxiense HX2, increasing chlamydospore yield by 145.13% and shelf life, promising a novel approach for low-cost biocontrol agents. The findings provide critical process parameters for large-scale fermentation and field application.
Researchers discovered Fur, a key regulator in Vibrio parahaemolyticus, helps balance iron and oxidative stress in the bacterium. The study found that Fur coordinates iron acquisition, storage, and utilization while adapting to oxidative stress, suggesting a complex role in bacterial survival.
AflHapX is critical for A. flavus's adaptive response to iron excess and starvation, influencing aflatoxin B1 production. The transcription factor regulates genes involved in iron homeostasis, aflatoxin biosynthesis, and oxidative stress responses.