Researchers have successfully tested a new drug, trastuzumab deruxtecan, which significantly extends the lives of breast cancer patients with advanced HER2-positive disease and brain metastases. The treatment has been shown to increase survival times substantially, with over 90% of patients alive one year after treatment.
Research led by Silvia Cappello reveals that extracellular vesicles play a crucial role in the development of the brain, facilitating communication between different cell types. The study found that these vesicles can transport specific molecular signals to the nucleus of recipient cells, inducing rapid transcriptional changes and infl...
Researchers have developed a DNA origami-based sensor that can detect lipid vesicles and deliver molecular cargo with precision. The system uses single-molecule Fluorescence Resonance Energy Transfer (smFRET) to measure the distance between fluorescent molecules.
Researchers have developed a new diagnostic algorithm using positron emission tomography (PET) to distinguish between Alzheimer's disease and primary tauopathy. The biomarkers enable doctors to identify the presence of a 4-repeat tauopathy with high accuracy, facilitating earlier diagnosis and personalized treatment strategies.
A research team led by Professor Monika Aidelsburger and Professor Immanuel Bloch found indications that chaotic many-body systems in the quantum realm can be described using fluctuating hydrodynamics. This approach simplifies the macroscopic description of such systems, obviating the need to engage with microscopic interactions.
Researchers have developed a method using physics-informed neural networks to model the complex light scattering in exoplanet atmospheres. This breakthrough enables more accurate analysis of exoplanet atmospheres, particularly with regard to cloud influence and chemical composition.
LMU researchers investigated how cell nuclei change shape to migrate through tight spaces, revealing reversible nuclear deformation and adaptation of pulling and pushing forces. The study suggests a biphasic dependence of migration speed on channel width, with maximal transition rates at widths comparable to the nuclear diameter.
A new study analyzing 199 cities worldwide reveals that adaptation efforts are mostly inadequate, with most measures focusing on sea level rise and flooding. The researchers emphasize the need for more comprehensive approaches considering socioeconomic factors and future trends in societal vulnerability.
LMU physicists have developed a new theoretical model that explains the formation of active foams from protein filaments and molecular motors. The research reveals that increasing microtubule density leads to the emergence of these complex patterns, which have an ordered structure and can rearrange themselves repeatedly.
A team of researchers developed a new model that incorporates all necessary physical processes in planet formation, showing that annular perturbations can trigger the rapid formation of multiple gas giants. The results match latest observations and indicate more efficient and quick planet formation than previously thought.
A recent study published in Cell discovered that strokes can change the epigenetics of the immune system, particularly in the heart, leading to scarring and impaired pumping function. The researchers identified IL-1b as the main culprit behind these epigenetic modifications, which can drive inflammatory cardiac dysfunction.
Researchers have developed a method to screen human health and its deviations at a population level using infrared spectroscopy and machine learning. The technique can detect multiple health conditions with just one measurement, identifying healthy individuals and complex conditions simultaneously.
Researchers at LMU University Hospital have discovered that plasmacytoid dendritic cells control the formation of new megakaryocytes from progenitor cells in bone marrow, regulating platelet production and potentially treating Covid-19. The study found pDCs precisely adjust MK quantities to meet bodily needs.
LMU researchers have developed strategies to repair mutated proteins that cause an inherited stroke disorder called CARASIL. The team used a combination of in-vitro and in-vivo methods to restore the function of the protease HTRA1, which plays a crucial role in maintaining equilibrium in the extracellular matrix.
Researchers developed a library of 27 polymers to improve RNA drug delivery, using design-of-experiment approach and statistical analysis. The study improves quality, efficiency, and precision of RNA drugs with optimized polymer nanoparticles.
A team led by Jamie McCullough and Daniel Grün has analyzed the largest dataset to date, shedding light on what the color of various galaxies says about their true distance. The results make it possible to statistically determine the true distance of each galaxy observed in images taken by Euclid or the Dark Energy Survey.
Researchers at LMU and Helmholtz Munich have shown that epigenetic modifications enable the reprogramming of glial cells into functional neurons. A novel protein, YingYang1, is necessary for this process, interacting with a transcription factor to open up chromatin.
Researchers found that specific basidiomycete yeasts play a key role in stabilizing assimilated carbon, enriching organic carbon content. Glacial recession exposes new landscapes with limited contact with air, light, and nutrients, making them ideal for studying soil formation.
Researchers successfully synthesized Ruddlesden-Popper nitrides for the first time, exhibiting rich variety of structural, electronic, and magnetic properties. The new compounds display exciting magnetic characteristics and potential applications in energy conversion and photovoltaics.
A study by LMU researchers reveals systematic bias in how political ads are delivered on Facebook and Instagram. The platforms' targeting systems favor campaign ads promoting incendiary issues, leading to unequal reach for different parties.
Using a novel microscopy technique, LMU researchers visualize the formation of covalent organic frameworks (COFs), crucial for battery technology and hydrogen production. The study reveals that tiny droplets control the reaction's kinetics at the beginning, leading to highly crystalline structures.
Researchers used iSCAT microscopy to visualize COF formation in real-time, gaining insight into the early stages of synthesis and identifying key factors controlling reaction kinetics. The study's findings aim to improve energy material manufacture.
Researchers have identified a new genus of fossil goby, †Simpsonigobius, measuring up to 34 mm, found in 18-million-year-old rocks in Turkey. The discovery provides critical insights into the evolutionary history of these fish and highlights the importance of analyzing fossil records using modern methods.
Studies found that even minor choices, such as picking a color, can increase the enjoyment of touch. The results suggest that providing patients with perceived control over their treatment may yield greater benefits in clinical settings. This study provides new insights into how choice shapes our experiences on a fundamental level.
Researchers developed a therapeutic approach to replace the missing protein in the brain, reducing symptoms of frontotemporal dementia. The approach uses modified viruses to produce progranulin, which is then released into the bloodstream and crosses the blood-brain barrier, rescuing pathologies in mouse models.
A Europe-wide survey reveals that current crises distract from climate action and weaken public support. The study suggests emphasizing the urgency of climate change to increase support for measures like taxing fossil fuels.
Researchers investigated how stigma affects women's menstrual health practices in Bangladesh. A study on group discussions found that normalizing the topic of menstruation empowers women to access better menstrual products. Women were willing to pay more for pads and showed increased interest in alternative products after open discussi...
A study by LMU researchers reveals that crab diversity is more complex than species numbers alone. The team found greater variety in shield shapes among 'false' crabs, which are related to their ecological roles.
Researchers have discovered two independent ways genetic variants in HTRA1 increase cardiovascular disease risk, including stroke. The study found that rare and common variants affect protease activity and concentration, respectively.
The study identified specific patterns in blood samples of patients who had different clinical outcomes after a heart attack. These patterns, known as 'immune signatures', are associated with either better or worse recovery of heart function. The findings could lead to the development of new diagnostics and treatments for heart failure.
Researchers found that neural activity in the visual thalamus is coupled with pupil dynamics during different phases of arousal. This modulation affects how sensory impressions are transmitted to higher areas of the brain like the visual cortex, influencing visual perception.
Scientists have developed a new approach for manufacturing semiconductors for visible light using DNA origami. The method uses a diamond lattice structure with periodicity of hundreds of nanometers, allowing for efficient solar cells and innovative optical waveguides.
Researchers found that audiences liked AI-generated videos as much as human-made ones when edited by humans. Hybrid video production with human supervision is key to maintaining quality standards and leveraging computers' strengths.
LMU researchers identified key enzymes involved in recognizing foreign RNA for TLR7 activation, including RNase T2 and PLD exonucleases. These findings provide important insights into the complex activation mechanism of TLR7, which plays a crucial role in defending against viruses.
A team of LMU researchers has deciphered the mechanism by which a tiny chromatin modifying enzyme called ISWI remains mobile in the cell nucleus. The study reveals that ISWI consumes ATP to navigate through densely packed chromatin and prevent it from becoming too rigid.
A new branch of AI, causal machine learning (ML), can estimate treatment outcomes better than traditional methods. This enables personalized treatment strategies and improved patient health.
Female cuckoos have two color variants: gray and rufous, linked to ancient mutations that emerged during the evolutionary arms race between host and cuckoo. The rarer color morph has an evolutionary advantage due to its rarity, causing genetic variation to be maintained for a long time.
Researchers have developed a revolutionary method to quantify how well biomarker molecules bind to target proteins using super-resolution fluorescence microscopy. This technique enables spatially resolved proteomics, allowing for the analysis of individual proteins' behavior and quantity in cells.
A deep learning tool has been developed to reliably diagnose moon blindness in horses based on photos, with a high accuracy rate of 93%. The tool supports veterinary doctors in making diagnoses, particularly valuable for less experienced professionals or horse owners in regions with limited vets.
Researchers found DNA traces of placozoans in the stomachs of predatory snails that live in seabed sediments, contradicting previous theories. The discovery indicates a more diverse genetic makeup than previously thought, with five genetically distinct lineages identified in just two snails.
Researchers have uncovered important details about the role of CSB/ERCC6 and CSA/ERCC8 genes in Cockayne syndrome. These genes encode enzymes associated with DNA repair that initiate transcription-coupled repair of toxic DNA-protein crosslinks, marking and breaking down damaged DNA.
Researchers observed a newly formed brown dwarf using ALMA and found spiral and streamer structures, suggesting chaotic interactions during formation. Simulations support two models: one involving collisions of collapsing clumps and another with the role of magnetic fields.
Researchers find that heat flows can selectively concentrate prebiotic building blocks, fostering the emergence of life. This process occurs through water convection and thermophoresis, leading to a directed movement of molecules in different places.
Researchers at LMU Munich find that hexagonal shapes are ideal for self-assembly due to their six binding sites, leading to faster assembly times. This discovery has potential applications in nanotechnology and medicine, particularly in the synthesis of artificial viral capsids for biomedical purposes.
Empathic concern in children develops between 6-18 months, influenced by parental sensitivity and social interactions. The study reveals that caregivers' behavior plays a crucial role in shaping their child's ability to feel empathic concern for others.
Researchers have mapped the protein composition of brain endothelial cells, revealing dysregulation of key molecules involved in cellular processes. This study provides a framework for understanding endothelial signaling pathways during aging and serves as a data basis for future analyses of brain endothelial function.
Researchers found that RNA molecules can recycle water, allowing for efficient copying and replication under low saline conditions with high pH levels. This process enabled the emergence of simple metabolic processes, paving the way for complex life.
A team of scientists has identified a key gene that influences visual preferences in tropical butterflies, specifically the Heliconius species. The researchers found that males prefer partners with similar color patterns, and genomic analysis revealed the connection to a genetic region shared by two red species.
Researchers at LMU have discovered that weak polar vortex states in the stratosphere lead to reduced uncertainty in long-range weather forecasts over Northern Europe. This allows for more accurate predictions of cold spells and storm activity, making the weather more predictable.
Research shows that sleep promotes the migratory potential of immune cells, specifically T cells, towards lymph nodes. This process is mediated by growth hormone and prolactin, two hormones that display sleep-dependent changes in concentration.