Researchers have discovered a monoclonal antibody that is effective against multiple strains of influenza, including Avian H5N1, seasonal H1N1, and the 2009 Swine H1N1 influenza. The antibody targets a conserved region of the viral coat protein, providing broad-spectrum protection against various flu strains.
Researchers at NUI Galway have discovered a protein that enables cancer cells to withstand intense stress. Understanding this interaction could lead to the development of more effective anticancer drugs by blocking its function and encouraging tumor cell death.
A new Policy paper argues that the estimated $30 billion needed to improve maternal, neonatal and child health is insufficient due to overlooked service delivery costs. Donors need a more realistic understanding of the funding required to achieve MDG targets for child and maternal health.
African children suffer from an estimated 656 million fevers annually, with many cases likely due to non-malarial causes. A new study estimates that only 60-103 million of these fevers are caused by the most dangerous form of malaria.
Actin capping protein (CP) regulates filament elongation by capping the dynamic end of the filament. Two regulators, V-1 and CARMIL, modulate CP activity in different manners. The new study reveals that CARMIL uncaps filaments by suppressing twisting movement required for tight-barbed end capping.
Strong health research systems are needed to address bottlenecks in implementing effective interventions for maternal, newborn, and child health in sub-Saharan Africa. Investing in African scientists, institutions, and systems is crucial to deliver solutions tailored to local problems.
A recent study published in PLoS Pathogens has identified two molecules, PPARγ and LXR, that can inhibit specific aspects of HIV transmission. The findings suggest that these molecules may be targets for therapies targeting mucosal HIV transmission.
A study found that US hospitals in disadvantaged areas lag behind in treating heart failure and heart attack, despite improvement over time. The pay-for-performance program may exacerbate existing inequalities in the healthcare system.
A study published in PLOS Neglected Tropical Diseases found that community-based education increased treatment compliance from 50% to 90% in Orissa State, India. The intervention combined timely educational programs with lymphedema management, reversing the trend and increasing drug compliance.
Key findings from a PLOS Medicine series highlight the need to bridge the gap between scientific knowledge and policy-making in Africa. The authors emphasize developing innovative approaches and investing in local adaptation of global MNCH evidence to address regional constraints.
Researchers at NYU identified a key mechanism in the brain's computation of sound location, finding that neurons are sensitive to rise times and detect differences between input shapes on a microsecond scale. This contradicts previous theories, which held that biophysical properties were identical for both ears.
The African Network for Drugs and Diagnostics Innovation aims to stimulate health product research and development in Africa. Successful implementation requires sustainable capacity, infrastructure, funding, leadership, and understanding of health R&D in the African continent.
A mathematical model reproducing sleep patterns for multiple species suggests the neural circuitry controlling human sleep may be universal across mammals. The study reveals fundamental physiological mechanisms underlying diverse sleep patterns, with implications for understanding evolution and diversity in mammalian sleep.
A recent study found that 20.4% of peer-reviewed articles published in 2008 were freely available online, with the highest share in Earth Sciences (33%) and the lowest in Chemistry (13%). The study suggests that author-posted manuscript copies dominate certain fields, while OA journals are more common in Medicine and Biochemistry.
A postmortem study in South Africa reveals high TB prevalence and late diagnosis among HIV-positive patients. The study suggests that early tuberculosis screening and treatment can reduce the global death toll from TB.
Analyses of serological and social contact data reveal that childhood vaccination against pertussis has led to a shift in the disease's burden, with adolescents and adults becoming reservoirs for asymptomatic infection. The study suggests that life-long protection through a vaccine could potentially eliminate pertussis.
The importance of full reproductive and sexual health rights cannot be overstated when it comes to achieving international health goals aimed at improving maternal health. Access to family planning resources, including contraception and abortion, is vital for women's empowerment and control over their lives.
Two new articles analyze the current status of maternal, newborn, and child health in Africa, identifying interventions that hold the greatest potential for preventing maternal and child deaths. The studies conclude that prioritizing high-impact outreach interventions could save millions of lives and cost an estimated $1.21 per capita.
Researchers have discovered two mutations in the PTPN11 gene that cause metachondromatosis, a rare heritable disease. The study's findings suggest that next-gen sequencing may rapidly resolve familial diseases and provide insights into other related syndromes.
Research published in PLOS Medicine found that pregnant women with an inherited condition making them more likely to form blood clots only face a small increase in the risk of miscarriage or stillbirth. The study also showed no significant association between thrombophilia and placenta-related problems, suggesting that prescribing anti...
A study published in PLOS Medicine estimates that there were approximately 451 million clinical cases of Plasmodium falciparum malaria worldwide in 2007. The majority of this burden was attributed to India, Nigeria, the Democratic Republic of Congo, and Myanmar. These findings highlight the need for improved diagnosis and surveillance ...
Research by scientists at Rockefeller University shows that adult brain circuits continually modify themselves in response to experience. After removing a mouse's whisker, excitatory connections rapidly sprout and inhibit networks adjust to maintain balance between excitation and inhibition.
A mathematical model reveals that division of labor can occur through the evolution of developmental plasticity, requiring strong genetic relatedness and fitness trade-offs. The model suggests a straightforward path for division of labor and may be applied to various complex evolutionary processes.
A perfectly preserved shoe, 1,000 years older than the Great Pyramid of Giza and 400 years older than Stonehenge, has been found in a cave in Armenia. The 5,500-year-old cow-hide shoe dates back to ~3,500 BC and was made from a single piece of leather.
The article discusses different interventions for secondary suicide prevention, focusing on high-risk patients with psychiatric illnesses. The authors argue that physicians need to be taught about the association between mental disorders and suicide and should not hesitate to ask people about their thoughts of suicide.
A systematic review of C-reactive protein studies found publication bias and low study quality, casting doubt on the marker's reliability. The authors propose improved research protocols to address these issues.
The article identifies six key public health challenges and data needs to prepare for future pandemics, including measuring age-specific immunity and accurately quantifying severity. Serological surveys and monitoring time-sources are crucial for gathering valuable pandemic data.
Scientists have found that plants deploy defensin proteins to facilitate the fertilization process, releasing male sperm cells through an explosive mechanism. This groundbreaking discovery provides new insights into the evolution of flowering plants and may lead to breakthroughs in breeding crops with improved fertility.
A new type of 95-million-year-old pterosaur has been discovered in Morocco, distinguished by its lance-shaped lower jaw and wing span of about six metres. The discovery suggests that several types of pterosaurs lived alongside one another in the same region, each probably specializing in a different ecological niche.
Researchers tracked orchid bees using tiny radio transmitters, revealing they travel surprisingly long distances through sparse tropical forest patches. The study opens doors to future research on temperate forests and highlights the importance of preserving plant pollination.
Researchers identified a genetic variant in the ISL1 gene that strongly raises the risk of congenital heart disease, affecting multiple subtypes of the condition. The study provides new insights into the molecular basis of heart disease and may lead to better understanding and treatment options for children with CHD.
Threespot damselfish are killing head corals and adding stress to Caribbean coral reefs due to habitat competition. Restoring staghorn coral, their preferred home, can alleviate pressure on other corals. The fish were not overfished, but rather limited by available real estate.
A large population-based study found a small increase in heart disease risk linked to higher blood sugar levels, but the changes were not substantial. The researchers confirmed their findings in a systematic review of existing literature.
Research published in PLOS Medicine found an association between greater early-infancy gains in weight and length and genetic markers for adult obesity risk. Early infancy weight gain is also linked to increased risk of overweight and obesity in children globally.
A new assessment tool, the Malawi Developmental Assessment Tool (MDAT), has been developed and evaluated for use in rural African settings. The tool accurately identified children with neurodisability and demonstrates high reliability and accuracy, making it a valuable resource for researchers and healthcare providers.
A new study reveals that drains are a significant vector for the development of lymphatic filariasis and malaria in Dar es Salaam. The researchers found that simple environmental management interventions can help reduce mosquito-borne disease transmission and promote a healthier environment.
Non-Suicidal Self-Injury (NSSI) is a common practice amongst adolescents, with medical providers uniquely positioned to detect its presence. Janis Whitlock's article discusses the epidemiology and care of adolescents undertaking NSSI, highlighting the need for standard assessment practices and effective treatment regimes.
Research published in PLOS Medicine found that the Mediterranean G6PD variant protects against Plasmodium vivax infection in Afghan refugees. The study suggests that G6PD deficiency may be retained in human populations due to its protective effects against Plasmodium vivax malaria.
Research by Robert M. Pringle and Todd M. Palmer reveals that termite mounds significantly enhance plant and animal productivity at local levels, while their even distribution maximizes ecosystem-wide biomass. The ordered distribution of these mounds creates an optimized network of plant and animal output.
The 'manifesto' outlines eight key points, including NTDs are tool ready with cost-efficient interventions, yet tool deficient, requiring sustained international support and community involvement to achieve global NTD control. The authors emphasize the need for urgent, renewed, and innovative efforts to tackle NTDs.
A study of over 10,000 breast cancer cases reveals the long-term prognosis for ER-negative disease subtypes is better than previously thought. The research also identifies two sub-types within triple negative tumors with differing outcomes.
The Biodiversity of Saba Bank collection provides critical information on the benthic communities and reef fish that inhabit the Saba Bank. The research reveals six new species potentially new to science collected from one of the largest coral reefs in the Caribbean, highlighting the need for marine protected areas to protect this uniq...
Researchers found that longevity treatments have different impacts on learning and memory in C. elegans, a nematode species. Dietary restriction improved early adult memory but declined with age, while reduced Insulin/IGF-1 signaling enhanced memory performance but failed to preserve it with age.
Researchers discover that most of the genomic output from dark matter transcripts is associated with existing genes. Only a small percentage of these transcripts remain unexplained and appear to be background noise.
A research team led by Professor Magdalena Götz has successfully converted glial cells of the brain into two different functional classes of neurons. The findings could lead to new neuron generation and therapy development for neurodegenerative diseases such as Alzheimer's.
Older adults living in residential communities are at increased risk of suicidal behavior due to social factors such as widowhood, divorce, substance abuse, and family discord. The study suggests that public health systems and residential communities can counter this risk by assessing resident populations and setting priorities for sui...
Experts argue for shifting focus from biomedical mechanisms to socio-environmental aspects of neglected tropical diseases. Mass drug administration is recognized as a cost-effective approach for controlling these diseases, while integrating biomedical and social approaches through 'social offsets' may complement this strategy.
Researchers reconstructed the initial 2009 H1N1 influenza outbreak in Ho Chi Minh City, finding that containment efforts may have delayed establishment of infection but did not prevent community spread. The study also showed that treatment clearance times varied depending on treatment timing and patient characteristics.
Researchers identified a gene in the yeast Saccharomyces cerevisiae that enables it to convert five-carbon sugars like xylose into ethanol. This discovery may lead to the development of new, industrially-applicable strains for large-scale bioethanol production.
A new study demonstrates that a first-person perspective of a life-sized virtual human female body can generate a body transfer illusion, where subjects experience ownership of the virtual body. This finding contradicts previous research assuming visuotactile synchrony as the critical factor in ownership illusions.